MEMS Foundry for High Volume Manufacturing and Product Reliance

2002 ◽  
Author(s):  
David A. Koester ◽  
James P. Baumhover
Keyword(s):  
Product Development ◽  
Process Development ◽  
Early Stage ◽  
Stable Process ◽  
Cost Effective ◽  
High Volume ◽  
Reliability Testing ◽  
Technology Standard ◽  
Mems Technology ◽  
Stage Development

The establishment of standard processes has become increasingly important in the growth of MEMS technology. Standard processes enable developers to leverage stable process platforms without the risk, time and costs associated with extensive process development. JDS Uniphase has established multi-user programs in three different process technologies—polysilicon, SOI and metal—that provide easy, cost-effective vehicles for early stage development. These processes also provide low-risk pathways to manufacturing in high volume. This paper discusses these processes and provides additional background on the importance of a quality system in the management of foundry product development. Product reliability testing is discussed in the context of a customer/foundry model.

Applying system modeling to define 2.5 - d and 3 - d packaging roadmaps

2014 ◽  
Vol 2014 (DPC) ◽  
pp. 001983-002007
Author(s):  
Dev Gupta
Keyword(s):  
Flip Chip ◽  
Process Development ◽  
System Modeling ◽  
New Technology ◽  
Smart Phone ◽  
Cost Effective ◽  
High Volume ◽  
Organic Substrate ◽  
Chip Technology ◽  
D Modules

Though work on 3-d and later 2.5-d packaging has been going on now for over 5 years, we do not yet see large applications in areas other than traditional heterogeneous integration e,g. in camera modules. Adoption of 2.5-d Si interposer technology in 2010-11 to build FPGA modules on a commercial scale had generated much enthusiasm and expectation that floodgates will open for wide use of this technology e,g. in every Smart Phone but that has not yet materialized, giving rise to a shift in attention in Blogs and Conferences from purely digital applications e,g. processor - memory modules to more performance driven and cost insensitive applications e,g. heterogeneous modules for electro - optic I/O in servers etc. Roadmaps for emerging technologies like 3-d stacking or 2.5-d modules are developed taking process maturity into consideration but they must also anticipate major applications. Such applications using a new technology can succeed only if there are overwhelming advantages in performance and system cost that negate increases in module costs. When the author and his team developed electroplated solder bump flip chip technology and their high volume implementation at two of the leading IDMs over 2 decades ago, both performance ( electrical ) and cost modeling were used to short list applications most likely to succeed and limit process development only for those applications. Countless users & providers of flip chip technology since then have benefited from this original work on electroplated solder and pillar bumps as well as build up type organic substrate technologies. A similar theoretical approach is sorely needed in the development of 2.5-d and 3-d technologies to define the most cost - effective configurations and focus development work on only those. In this work we will discuss the Bandwidth and Power consumption ( two of the key drivers for die stacking ) of various 2.5-d and 3-d package configurations and based on simulation results compare them. Key takeaways : 3-d stacking of dice using TSVs may not necessarily produce improved performance compared to less complicated packaging. Expensive interposers with high interconnect density may not even be necessary for most volume applications. Most likely configurations for processor - memory 3-d modules to get good enough bandwidth at lowest cost.

A design contribution to the entrepreneurial experience

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Juan David ROLDAN ACEVEDO ◽  
Ida TELALBASIC
Keyword(s):  
Product Development ◽  
Qualitative Analysis ◽  
Design Research ◽  
Recent Literature ◽  
Early Stage ◽  
Entrepreneurial Activity ◽  
Value Proposition ◽  
Structured Interviews ◽  
User Centric ◽  
Constant Growth

In recent history, different design approaches have been entering fields like management and strategy to improve product development and service delivery. Specifically, entrepreneurship has adopted a user-centric mindset in methodologies like the business canvas model and the value proposition canvas which increases the awareness of the users’ needs when developing solutions. What happens when a service design approach is used to understand the entrepreneurs’ experience through the creation of their startups? Recent literature suggests that entrepreneurial activity and success is conditioned by their local entrepreneurship ecosystem. This study investigates the Entrepreneurship Ecosystem of Medellín, Colombia - an ecosystem in constant growth but that lacks qualitative analysis. The sample consists of 12 entrepreneurs in early-stage phase. The data was gathered with two design research methods: Cultural Probes and Semi-structured interviews. The analysis of the information collected facilitated the development of 4 insights about the entrepreneurs and an experience map to visualise and interpret their journey to create a startup. The results of this study reflected the implications of the ecosystem, the explanation of the users’ perceptions and awareness and propose a set of ideas to the local government to improve the experience of undertaking a startup in Medellín.

Review of Various Tasks Performed in the Preprocessing Phase of a Diabetic Retinopathy Diagnosis System

2020 ◽  
Vol 16 (4) ◽  
pp. 397-426
Author(s):  
Muhammad Nadeem Ashraf ◽  
Muhammad Hussain ◽  
Zulfiqar Habib
Keyword(s):  
Diabetic Retinopathy ◽  
Blood Vessels ◽  
Early Stage ◽  
Spherical Shape ◽  
Cost Effective ◽  
Lesion Detection ◽  
Diabetic Patients ◽  
Cad System ◽  
Non Invasive ◽  
Optic Discs

Diabetic Retinopathy (DR) is a major cause of blindness in diabetic patients. The increasing population of diabetic patients and difficulty to diagnose it at an early stage are limiting the screening capabilities of manual diagnosis by ophthalmologists. Color fundus images are widely used to detect DR lesions due to their comfortable, cost-effective and non-invasive acquisition procedure. Computer Aided Diagnosis (CAD) of DR based on these images can assist ophthalmologists and help in saving many sight years of diabetic patients. In a CAD system, preprocessing is a crucial phase, which significantly affects its performance. Commonly used preprocessing operations are the enhancement of poor contrast, balancing the illumination imbalance due to the spherical shape of a retina, noise reduction, image resizing to support multi-resolution, color normalization, extraction of a field of view (FOV), etc. Also, the presence of blood vessels and optic discs makes the lesion detection more challenging because these two artifacts exhibit specific attributes, which are similar to those of DR lesions. Preprocessing operations can be broadly divided into three categories: 1) fixing the native defects, 2) segmentation of blood vessels, and 3) localization and segmentation of optic discs. This paper presents a review of the state-of-the-art preprocessing techniques related to three categories of operations, highlighting their significant aspects and limitations. The survey is concluded with the most effective preprocessing methods, which have been shown to improve the accuracy and efficiency of the CAD systems.

scholarly journals High-throughput microbioreactor provides a capable tool for early stage bioprocess development

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mathias Fink ◽  
Monika Cserjan-Puschmann ◽  
Daniela Reinisch ◽  
Gerald Striedner
Keyword(s):  
High Throughput ◽  
Process Development ◽  
Early Stage ◽  
Explanatory Power ◽  
Batch Mode ◽  
E Coli ◽  
Speed Up ◽  
Bioreactor System ◽  
Cell Densities ◽  
Microbial Systems

AbstractTremendous advancements in cell and protein engineering methodologies and bioinformatics have led to a vast increase in bacterial production clones and recombinant protein variants to be screened and evaluated. Consequently, an urgent need exists for efficient high-throughput (HTP) screening approaches to improve the efficiency in early process development as a basis to speed-up all subsequent steps in the course of process design and engineering. In this study, we selected the BioLector micro-bioreactor (µ-bioreactor) system as an HTP cultivation platform to screen E. coli expression clones producing representative protein candidates for biopharmaceutical applications. We evaluated the extent to which generated clones and condition screening results were transferable and comparable to results from fully controlled bioreactor systems operated in fed-batch mode at moderate or high cell densities. Direct comparison of 22 different production clones showed great transferability. We observed the same growth and expression characteristics, and identical clone rankings except one host-Fab-leader combination. This outcome demonstrates the explanatory power of HTP µ-bioreactor data and the suitability of this platform as a screening tool in upstream development of microbial systems. Fast, reliable, and transferable screening data significantly reduce experiments in fully controlled bioreactor systems and accelerate process development at lower cost.

scholarly journals Comparison of saliva with healthcare workers- and patient-collected swabs in the diagnosis of COVID-19 in a large cohort

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mitnala Sasikala ◽  
Yelamanchili Sadhana ◽  
Ketavarapu Vijayasarathy ◽  
Anand Gupta ◽  
Sarala Kumari Daram ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Early Stage ◽  
Cost Effective ◽  
Hospitalized Patients ◽  
Detection Sensitivity ◽  
Nasopharyngeal Swab ◽  
Predictive Values ◽  
Qrt Pcr ◽  
Asymptomatic Patients ◽  
Sensitivity Specificity

Abstract Background A considerable amount of evidence demonstrates the potential of saliva in the diagnosis of COVID-19. Our aim was to determine the sensitivity of saliva versus swabs collected by healthcare workers (HCWs) and patients themselves to assess whether saliva detection can be offered as a cost-effective, risk-free method of SARS-CoV-2 detection. Methods This study was conducted in a hospital involving outpatients and hospitalized patients. A total of 3018 outpatients were tested. Of these, 200 qRT-PCR-confirmed SARS-CoV-2-positive patients were recruited for further study. In addition, 101 SARS-CoV-2-positive hospitalized patients with symptoms were also enrolled in the study. From outpatients, HCWs collected nasopharyngeal swabs (NPS), saliva were obtained. From inpatients, HCWs collected swabs, patient-collected swabs, and saliva were obtained. qRT-PCR was performed to detect SARS-CoV-2 by TAQPATH assay to determine the sensitivity of saliva detection. Sensitivity, specificity and positive/negative predictive values (PPV, NPV) of detecting SARS-CoV-2 were calculated using MedCalc. Results Of 3018 outpatients (asymptomatic: 2683, symptomatic: 335) tested by qRT-PCR, 200 were positive (males: 140, females: 60; aged 37.9 ± 12.8 years; (81 asymptomatic, 119 symptomatic). Of these, saliva was positive in 128 (64%); 39 of 81 asymptomatic (47%),89 of 119 symptomatic patients (74.8%). Sensitivity of detection was 60.9% (55.4–66.3%, CI 95%), with a negative predictive value of 36%(32.9–39.2%, CI 95%).Among 101 hospitalized patients (males:65, females: 36; aged 53.48 ± 15.6 years), with HCW collected NPS as comparator, sensitivity of saliva was 56.1% (47.5–64.5, CI 95%), specificity 63.5%(50.4–75.3, CI95%) with PPV of 77.2% and NPV of 39.6% and that of self-swab was 52.3%(44–60.5%, CI95%), specificity 56.6% (42.3–70.2%, CI95%) with PPV 77.2% and NPV29.7%. Comparison of positivity with the onset of symptoms revealed highest detection in saliva on day 3 after onset of symptoms. Additionally, only saliva was positive in 13 (12.8%) hospitalized patients. Conclusion Saliva which is easier to collect than nasopharyngeal swab is a viable alternate to detect SARS-COV-2 in symptomatic patients in the early stage of onset of symptoms. Although saliva is currently not recommended for screening asymptomatic patients, optimization of collection and uniform timing of sampling might improve the sensitivity enabling its use as a screening tool at community level.

scholarly journals Insights from an early stage development mixed methods study on arts-based interventions for older adults following hospitalisation

2021 ◽  
pp. 102745
Author(s):  
Amanda M. Clifford ◽  
Joanne Shanahan ◽  
Hilary Moss ◽  
Triona Cleary ◽  
Morgan Senter ◽  
...  
Keyword(s):  
Older Adults ◽  
Mixed Methods ◽  
Early Stage ◽  
Mixed Methods Study ◽  
Stage Development

Simulations Based Approach for Vehicle Idle NVH Optimization at Early Stage of Product Development

2011 ◽  
Author(s):  
Kumbhar S. Mansinh ◽  
Atul Miskin ◽  
Vishal Vasantrao Chaudhari ◽  
Ashish Rajput
Keyword(s):  
Product Development ◽  
Early Stage

Cost-effective, high-volume molecular beam epitaxy using a multi 6-in wafer reactor

2001 ◽  
Vol 227-228 ◽  
pp. 143-149
Author(s):  
Larry Leung ◽  
Damian Davison ◽  
Arthur Cornfeld ◽  
Frederick Towner ◽  
Dave Hartzell
Keyword(s):  
Molecular Beam Epitaxy ◽  
Molecular Beam ◽  
Cost Effective ◽  
High Volume
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