A Means of Generating Polyethylene Wear Particles With Desired Size and Shape for Biological Studies of Osteolysis

Volume 1 ◽  
2004 ◽  
Author(s):  
Mohsen Mosleh ◽  
Vijay T. John
Keyword(s):  
Wear Debris ◽  
Cutting Edge ◽  
Biological Study ◽  
Wear Particles ◽  
Textured Surfaces ◽  
Surface Textures ◽  
Size And Shape ◽  
Uhmwpe Wear ◽  
Biological Studies ◽  
Uhmwpe Wear Particles

Metallic and ceramic counterfaces with artificial surface textures were rubbed against ultra high molecular weight polyethylene (UHMWPE) pins in water-lubricated wear tests and the characteristics of wear debris were studied. Two types of surface textures were utilized. In the first type, an array of wedge shaped features was created on silicon wafers by microfabrication. It was found that the mean size of UHMWPE wear particles strongly depended on the length of the cutting edge of the wedge. For instance, for wedges with a cutting edge length of 55 μm, 15 μm, and 7 μm, it was found that more than 75% of wear particles had a mean length of 30–60 μm, 6–15 μm, and 4–10 μm, respectively. In the second type of textured surfaces, unidirectional patterns were created on the stainless steel discs. These unidirectional patterns consisted of long, parallel edges and grooves and were created by abrading the discs by different grits of sand papers. The length of the majority of unidirectional edges was found to be approximately equal to the dominant size of elongated wear debris. The narrowly distributed wear debris produced in this investigation can be used in the biological study of the effects of size and shape of UHMWPE wear particles in total joint replacements on osteolysis.

Effects of Biological Lubrication on the Morphology of UHMWPE Wear Particles Generated With Surface Textures

2005 ◽  
Author(s):  
Hsu-Wei Fang ◽  
Yu-Chih Su
Keyword(s):  
Wear Particles ◽  
Textured Surfaces ◽  
Surface Textures ◽  
Total Joint Replacements ◽  
Size And Shape ◽  
Immunological Responses ◽  
Uhmwpe Wear ◽  
Uhmwpe Wear Particles ◽  
Particle Size And Shape ◽  
Uhmwpe Particle

Osteolysis induced by ultra-high molecular weight polyethylene (UHMWPE) wear particles has emerged as a critical failure mechanism of artificial joints. Many researchers have performed cell culture studies or animal tests to investigate the UHMWPE particles induced immunological responses. However, the effect of size and shape remains elusive. This is partly because of the difficulty in obtaining UHMWPE wear particles with specific sizes and shapes for bioactivity tests. Previously, we have shown the feasibility of producing narrowly distributed UHMWPE particle sizes and shapes by rubbing UHMWPE pins against textured surfaces [1]. The correlations between the surface texture dimensions and the size and shape of wear particles generated in water have been obtained [2]. In addition, this novel technique of UHMWPE particle generation enables the investigation of the effects of UHMWPE particle size and shape on bioactivity. It is concluded that the elongated particles and the particles which can be engulfed by macrophage cells induced stronger immunological responses [3]. Thus, it is possible to enhance the life of total joint replacements by reducing the production of the most toxic particle populations in terms of size and shape. Our idea is to apply surface textures on the articulating surface of joint implant in order to control the size and shape of UHMWPE wear particles. While maintaining a low wear rate of UHMWPE parts, further reduction of the most “toxic” particles released into human body shall prevent particle-induced osteolysis.

Modeling of the Generation of UHMWPE Particles With Microfabricated Surface Textures

2005 ◽  
Author(s):  
Hsu-Wei Fang ◽  
Stephen M. Hsu ◽  
Jan V. Sengers
Keyword(s):  
Particle Size ◽  
Surface Texture ◽  
Wear Particles ◽  
Surface Textures ◽  
Uhmwpe Wear ◽  
Joint Implants ◽  
Uhmwpe Wear Particles ◽  
Particle Size And Shape ◽  
Ultimate Purpose ◽  
Texture Design

Microfabricated surface textures have been utilized to generate narrowly distributed UHMWPE wear particles with different sizes and shapes. The ultimate purpose of the research is to study bioactivity effects induced by UHMWPE particles that lead to the failure of total joint implants. Previously we developed a method of surface-texture design to control the particle size and shape [1]. The objective of the present paper is to model the generation UHMWPE particles with surface textures containing wedge-shaped cutting edges.

Characterization of UHMWPE Wear Particles

2009 ◽  
pp. 409-422
Author(s):  
Joanne L.Tipper ◽  
Laura Richards ◽  
Eileen Ingham ◽  
John Fisher
Keyword(s):  
Wear Particles ◽  
Uhmwpe Wear ◽  
Uhmwpe Wear Particles

scholarly journals Impact of vitamin E-blended UHMWPE wear particles on the osseous microenvironment in polyethylene particle-induced osteolysis

2016 ◽  
Vol 38 (6) ◽  
pp. 1652-1660 ◽  
Author(s):  
Carl Neuerburg ◽  
Theresa Loer ◽  
Lena Mittlmeier ◽  
Christina Polan ◽  
Zsuzsanna Farkas ◽  
...  
Keyword(s):  
Vitamin E ◽  
Wear Particles ◽  
Uhmwpe Wear ◽  
Polyethylene Particle ◽  
Uhmwpe Wear Particles

New fast method for determination of number of UHMWPE wear particles

2004 ◽  
Vol 15 (12) ◽  
pp. 1267-1278 ◽  
Author(s):  
M. Šlouf ◽  
I. Šloufová ◽  
Z. Horák ◽  
P. Štépánek ◽  
G. Entlicher ◽  
...  
Keyword(s):  
Fast Method ◽  
Wear Particles ◽  
Uhmwpe Wear ◽  
Uhmwpe Wear Particles

Pathophysiologic Reactions to UHMWPE Wear Particles

2009 ◽  
pp. 341-353 ◽  
Author(s):  
Marla J. Steinbeck ◽  
Ryan M. Baxter ◽  
Theresa A. Freeman
Keyword(s):  
Wear Particles ◽  
Uhmwpe Wear ◽  
Uhmwpe Wear Particles
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