Construction of the Design Space of Single-Loop Change-Point Mechanisms

2004 ◽  
Author(s):  
Craig P. Lusk ◽  
Larry L. Howell
Keyword(s):  
Change Point ◽  
Design Space ◽  
Local Approach ◽  
Single Loop ◽  
Inversion Operator ◽  
Global And Local ◽  
Insight Into

Change-point mechanisms are shown to be significant in the design of surface micromachined MEMS. The design space of change-point mechanisms is derived for an arbitrary single loop change-point mechanism using a global and local approach. A function on the design space, the mechanism’s length, is constructed for fourbars. An inversion operator, a mapping from the design space to the design space, is also constructed for fourbars. The method for constructing the function and the operator is shown to be capable of extension to single loop change-point mechanisms with five or more links. The results give insight into design possibilities and limitations of change-point mechanisms.

scholarly journals Design Space Identification and Visualization for Continuous Pharmaceutical Manufacturing

Pharmaceutics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 235 ◽  
Author(s):  
Samir Diab ◽  
Dimitrios I. Gerogiorgis
Keyword(s):  
Design Space ◽  
Flow Chemistry ◽  
Pharmaceutical Manufacturing ◽  
Design And Optimization ◽  
Pharmaceutical Ingredients ◽  
Continuous Pharmaceutical Manufacturing ◽  
Continuous Flow Chemistry ◽  
Material Usage ◽  
Novel Processing ◽  
Insight Into

Progress in continuous flow chemistry over the past two decades has facilitated significant developments in the flow synthesis of a wide variety of Active Pharmaceutical Ingredients (APIs), the foundation of Continuous Pharmaceutical Manufacturing (CPM), which has gained interest for its potential to reduce material usage, energy and costs and the ability to access novel processing windows that would be otherwise hazardous if operated via traditional batch techniques. Design space investigation of manufacturing processes is a useful task in elucidating attainable regions of process performance and product quality attributes that can allow insight into process design and optimization prior to costly experimental campaigns and pilot plant studies. This study discusses recent demonstrations from the literature on design space investigation and visualization for continuous API production and highlights attainable regions of recoveries, material efficiencies, flowsheet complexity and cost components for upstream (reaction + separation) via modeling, simulation and nonlinear optimization, providing insight into optimal CPM operation.

scholarly journals A Novel Method for Predicting Disease-Associated LncRNA-MiRNA Pairs Based on the Higher-Order Orthogonal Iteration

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Zhanwei Xuan ◽  
Xiang Feng ◽  
Jingwen Yu ◽  
Pengyao Ping ◽  
Haochen Zhao ◽  
...  
Keyword(s):  
Higher Order ◽  
System Level ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation ◽  
Great Insight ◽  
Novel Method ◽  
Global And Local ◽  
Novel Model ◽  
Insight Into ◽  
Orthogonal Iteration

A lot of research studies have shown that many complex human diseases are associated not only with microRNAs (miRNAs) but also with long noncoding RNAs (lncRNAs). However, most of the current existing studies focus on the prediction of disease-related miRNAs or lncRNAs, and to our knowledge, until now, there are few literature studies reported to pay attention to the study of impact of miRNA-lncRNA pairs on diseases, although more and more studies have shown that both lncRNAs and miRNAs play important roles in cell proliferation and differentiation during the recent years. The identification of disease-related genes provides great insight into the underlying pathogenesis of diseases at a system level. In this study, a novel model called PADLMHOOI was proposed to predict potential associations between diseases and lncRNA-miRNA pairs based on the higher-order orthogonal iteration, and in order to evaluate its prediction performance, the global and local LOOCV were implemented, respectively, and simulation results demonstrated that PADLMHOOI could achieve reliable AUCs of 0.9545 and 0.8874 in global and local LOOCV separately. Moreover, case studies further demonstrated the effectiveness of PADLMHOOI to infer unknown disease-related lncRNA-miRNA pairs.

scholarly journals Shapelet Discovery by Lazy Time Series Classification

2020 ◽  
Vol 2020 ◽  
pp. 1-19
Author(s):  
Wei Zhang ◽  
Zhihai Wang ◽  
Jidong Yuan ◽  
Shilei Hao
Keyword(s):  
Time Series ◽  
Training Dataset ◽  
Class Label ◽  
Considerable Research ◽  
Evaluation Dataset ◽  
Differential Ability ◽  
Global And Local ◽  
Insight Into ◽  
Specific Evaluation ◽  
Feature Frequency

As a representation of discriminative features, the time series shapelet has recently received considerable research interest. However, most shapelet-based classification models evaluate the differential ability of the shapelet on the whole training dataset, neglecting characteristic information contained in each instance to be classified and the classwise feature frequency information. Hence, the computational complexity of feature extraction is high, and the interpretability is inadequate. To this end, the efficiency of shapelet discovery is improved through a lazy strategy fusing global and local similarities. In the prediction process, the strategy learns a specific evaluation dataset for each instance, and then the captured characteristics are directly used to progressively reduce the uncertainty of the predicted class label. Moreover, a shapelet coverage score is defined to calculate the discriminability of each time stamp for different classes. The experimental results show that the proposed method is competitive with the benchmark methods and provides insight into the discriminative features of each time series and each type in the data.

Suction-Controlled Detachment of Mushroom-Shaped Adhesive Structures

2021 ◽  
Vol 88 (3) ◽  
Author(s):  
Marcela Areyano ◽  
Jamie A. Booth ◽  
Dane Brouwer ◽  
Luke F. Gockowski ◽  
Megan T. Valentine ◽  
...  
Keyword(s):  
Experimental Investigation ◽  
Critical Stress ◽  
Design Space ◽  
Asymptotic Result ◽  
Length Scale ◽  
System Parameters ◽  
Trapped Air ◽  
Attachment Strength ◽  
Remote Stress ◽  
Insight Into

Abstract Experimental evidence suggests that suction may play a role in the attachment strength of mushroom-tipped adhesive structures, but the system parameters which control this effect are not well established. A fracture mechanics-based model is introduced to determine the critical stress for defect propagation at the interface in the presence of trapped air. These results are compared with an experimental investigation of millimeter-scale elastomeric structures. These structures are found to exhibit a greater increase in strength due to suction than is typical in the literature, as they have a large tip diameter relative to the stalk. The model additionally provides insight into differences in expected behavior across the design space of mushroom-shaped structures. For example, the model reveals that the suction contribution is length-scale dependent. It is enhanced for larger structures due to increased volume change, and thus the attainment of lower pressures, inside of the defect. This scaling effect is shown to be less pronounced if the tip is made wider relative to the stalk. An asymptotic result is also provided in the limit that the defect is far outside of the stalk, showing that the critical stress is lower by a factor of 1/2 than the result often used in the literature to estimate the effect of suction. This discrepancy arises as the latter considers only the balance of remote stress and pressure inside the defect and neglects the influence of compressive tractions outside of the defect.

Comparative analyses of mean-variance and mean-semivariance approaches on global and local single factor market model for developed and emerging markets

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Mehmet Emin Yildiz ◽  
Yaman Omer Erzurumlu ◽  
Bora Kurtulus
Keyword(s):  
Emerging Markets ◽  
Stock Returns ◽  
Risk Measures ◽  
Emerging Market ◽  
Cost Of Equity ◽  
Content Type ◽  
The Cost ◽  
Global And Local ◽  
Insight Into ◽  
Better Than

PurposeThe beta coefficient used for the cost of equity calculation is at the heart of the valuation process. This study conducts comparative analyses of the classical capital asset pricing model (CAPM) and downside CAPM risk parameters to gain further insight into which risk parameter leads to better performing risk measures at explaining stock returns.Design/methodology/approachThe study conducts a comparative analysis of 16 risk measures at explaining the stock returns of 4531 companies of 20 developed and 25 emerging market index for 2000–2018. The analyses are conducted using both the global and local indices and both USD and local currency returns. Calculated risk measures are analyzed in a panel data setup using a univariate model. Results are investigated in country-specific and model-specific subsets.FindingsThe results show that (1) downside betas are better than CAPM betas at explaining the stock returns, (2) both risk measure groups perform better for emerging markets, (3) global downside beta model performs better than global beta model, implying the existence of the contagion effect, (4) high significance levels of total risk and unsystematic risk measures further support the shortfall of CAPM betas and (5) higher correlation of markets after negative shocks such as pandemics puts global CAPM based downside beta to a more reliable position.Research limitations/implicationsThe data are limited to the index securities as beta could be time varying.Practical implicationsResults overall provide insight into the cost of equity calculation and emerging market assets valuation.Originality/valueThe framework and methodology enable us to compare and contrast CAPM and downside-CAPM risk measures at the firm level, at the global/local level and in terms of the level of market development.

Finite and infinite structures of rational matrices: a local approach

2015 ◽  
Vol 30 ◽  
Author(s):  
A. Amparan ◽  
S. Marcaida ◽  
Ion Zaballa
Keyword(s):  
Local Structure ◽  
Complete System ◽  
Irreducible Polynomial ◽  
Rational Functions ◽  
Rational Matrix ◽  
Local Approach ◽  
Elementary Divisors ◽  
Ring Of Polynomials ◽  
Principal Ideal Domains ◽  
Global And Local

The structure of a rational matrix is given by its Smith-McMillan invariants. Some properties of the Smith-McMillan invariants of rational matrices with elements in different principal ideal domains are presented: In the ring of polynomials in one indeterminate (global structure), in the local ring at an irreducible polynomial (local structure), and in the ring of proper rational functions (infinite structure). Furthermore, the change of the finite (global and local) and infinite structures is studied when performing a Mobius transformation on a rational matrix. The results are applied to define an equivalence relation in the set of polynomial matrices, with no restriction on size, for which a complete system of invariants are the finite and infinite elementary divisors.

Mobility of Single Loop Linkages: A Final Word?

2007 ◽  
Author(s):  
Jose´ Mari´a Rico ◽  
J. Jesu´s Cervantes ◽  
Juan Rocha ◽  
Jaime Gallardo ◽  
Luis Daniel Aguilera ◽  
...  
Keyword(s):  
Mobility Analysis ◽  
Additional Insight ◽  
Final Word ◽  
Single Loop ◽  
Kinematic Chains ◽  
Recent Developments ◽  
The Subject ◽  
Insight Into

Setting aside paradoxical linkages such as Bennett’s, Bricard’s or Goldberg’s, the mobility of single loop linkages seemed, with the developments on mobility analysis carried out in the last five years, a closed chapter in kinematic research. However, recent developments on the mobility of parallel platforms have shed additional insight into the problem. This contribution attempts to unify the results obtained in the last five years in the area of mobility of single-loop kinematic chains to state what appears to be a final word on the subject.

scholarly journals Global and local aspects of entrainment in temporal plumes

2016 ◽  
Vol 812 ◽  
pp. 222-250 ◽  
Author(s):  
Dominik Krug ◽  
Daniel Chung ◽  
Jimmy Philip ◽  
Ivan Marusic
Keyword(s):  
Numerical Simulation ◽  
Numerical Data ◽  
Small Scale ◽  
Local Approach ◽  
Local Propagation ◽  
Entrainment Coefficient ◽  
Baroclinic Torque ◽  
Entrainment Process ◽  
Set Up ◽  
Global And Local

To date, the understanding of the role buoyancy plays in the entrainment process in unstable configurations such as turbulent plumes remains incomplete. Towards addressing this question, we set up a flow in which a plume evolves in time instead of space. We demonstrate that the temporal problem is equivalent to a spatial plume in a strong coflow and address in detail how the temporal plume can be realized via direct numerical simulation. Using numerical data of plume simulations up to $Re_{\unicode[STIX]{x1D706}}\approx 100$, we show that the entrainment coefficient can be determined consistently using a global entrainment analysis in an integral framework as well as via a local approach. The latter is based on a study of the local propagation of the turbulent/non-turbulent interface relative to the fluid. Locally, this process is dominated by small-scale diffusion which is amplified by interface convolutions such that the total entrained flux is independent of viscosity. Further, we identify a direct buoyancy contribution to entrainment by baroclinic torque, which accounts for 8 %–12 % of the entrained flux locally, comparable to the 15 % buoyancy contribution at the integral level. It appears that the baroclinic torque is a mechanism that might explain higher values of the entrainment coefficient in spatial plumes compared with jets.

Global Environmental Justice Documentaries

2021 ◽  
Vol 22 (3) ◽  
pp. 29-32
Author(s):  
Sue Wiegand
Keyword(s):  
Environmental Justice ◽  
Industrial Development ◽  
Environmental Issues ◽  
Environmental Literacy ◽  
Face To Face ◽  
Global Environmental ◽  
Universal Values ◽  
Global And Local ◽  
Insight Into ◽  
Global Environmental Justice

Global Environmental Justice Documentaries is a curated collection of 25 diverse, interdisciplinary documentaries produced by Face to Face Media, which plans to expand the collection over time. Offering creative responses to contemporary environmental issues, these films are insightful and will enhance students’ environmental literacy and inspire advocacy through artistic film imagery and authentic human stories. The environmental and social impacts of such global and local issues as consumerism, industrial development, colonization, and climate change provide dramatic insight into human stories and universal values.

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