scholarly journals Magnetic Nanoparticle-Mediated Heating for Biomedical Applications

2021 ◽  
Author(s):  
Elyahb Kwizera ◽  
Samantha Stewart ◽  
Md Musavvir Mahmud ◽  
Xiaoming He
Keyword(s):  
Magnetic Nanoparticles ◽  
Biomedical Applications ◽  
Magnetic Nanoparticle ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Superparamagnetic Nanoparticles ◽  
Heating Effect ◽  
Facile Synthesis ◽  
Magnetic Heating ◽  
Different Types

Abstract Magnetic nanoparticles, especially superparamagnetic nanoparticles (SPIONs), have attracted tremendous attention for various biomedical applications. Facile synthesis and functionalization together with easy control of the size and shape of SPIONS to customize their unique properties, have made it possible to develop different types of SPIONs tailored for diverse functions/applications. More recently, considerable attention has been paid to the thermal effect of SPIONs for the treatment of diseases like cancer and for nanowarming of cryopreserved/banked cells, tissues, and organs. In this mini-review, recent advances on the magnetic heating effect of SPIONs for magnetothermal therapy and enhancement of cryopreservation of cells, tissues, and organs, are discussed, together with the non-magnetic heating effect (i.e., high Intensity focused ultrasound or HIFU-activated heating) of SPIONs for cancer therapy. Furthermore, challenges facing the use of magnetic nanoparticles in these biomedical applications are presented.

Simulated Clustering Dynamics of Colloidal Magnetic Nanoparticles

Nanoscale ◽  
2021 ◽  
Author(s):  
Frederik Laust Durhuus ◽  
Lau Halkier Wandall ◽  
Mathias Hoeg Boisen ◽  
Mathias Kure ◽  
Marco Beleggia ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Magnetic Nanoparticle ◽  
Bottom Up ◽  
Novel Materials ◽  
Nanoparticle Clusters ◽  
Clustering Dynamics

Magnetically guided self-assembly of nanoparticles is a promising bottom-up method to fabricate novel materials and superstructures, such as, for example, magnetic nanoparticle clusters for biomedical applications. The existence of assembled...

Toward the Fabrication of Hierarchically-Structured Porous Polymers for Tissue Engineering Scaffords

2005 ◽  
Author(s):  
Hai Wang ◽  
Wei Li
Keyword(s):  
Tissue Engineering ◽  
Focused Ultrasound ◽  
Acoustic Power ◽  
High Intensity Focused Ultrasound ◽  
Acoustic Energy ◽  
Porous Polymer ◽  
Porous Polymers ◽  
Heating Effect ◽  
Foaming Process ◽  
Transfer Behavior

Hierarchically-structured porous polymers play an important role in scaffold-based tissue engineering. However, the fabrication of these polymers presents a significant challenge because of the requirements of controllable pore size, distribution and interconnectivity. In this work, we report on a novel porous polymer fabrication method using high-intensity focused ultrasound (HIFU). The measurements of both spatial and temporal temperature field are reported for biocompatible PMMA (polymethyl methacrylate) samples insonated with a 1.1 MHz/3.3 MHz HIFU transducer. The acoustic power and insonation duration were both varied. The results have shown that HIFU has a dramatic heating effect on polymers: the temperature increasing rate can exceed 20°C/second and the final temperature can be higher than 120°C. This rapid, localized heating effect is exploited to foam CO2 saturated PMMA samples selectively and generate hierarchical microstructures. The created microstructures were characterized using the scanning electron microscopy (SEM). The results have shown that the amount and rate of acoustic energy dissipation during the HIFU insonation directly affect the polymer foaming process. Preliminary theoretical modeling of the acoustic field and heat transfer behavior in the porous polymers are also presented.

scholarly journals Grid-characteristic numerical method for medical ultrasound

2021 ◽  
Vol 2090 (1) ◽  
pp. 012164
Author(s):  
Katerina Beklemysheva ◽  
Alexey Vasyukov ◽  
Alexey Ermakov
Keyword(s):  
Numerical Method ◽  
3D Model ◽  
Focused Ultrasound ◽  
High Accuracy ◽  
High Intensity Focused Ultrasound ◽  
Medical Ultrasound ◽  
Viscoelastic Media ◽  
Material Parameters ◽  
Different Types ◽  
Wave Effects

Abstract Grid-characteristic method (GCM) is a fast and reliable numerical method that allows to model wave effects in viscoelastic media with high accuracy, including surface and contact waves. This research is dedicated to the application of GCM to the problem of medical ultrasound. Calculations for High-Intensity Focused Ultrasound (HIFU) were performed on 3D model statements for homogenous and inhomogeneous media, and a qualitative correspondence with experimental data was achieved. Numerical results include estimation of consumed energy (based on Maxwell viscosity model), velocity vector and stress tensor components. Various material parameters were considered, including relaxation time and inclusions of different types.

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