Maintenance Factors Affecting Increased Lutetium-177 Production

2020 ◽  
Author(s):  
Niklas Danielsson
Keyword(s):  
Best Practice ◽  
Good Manufacturing Practice ◽  
Nuclear Industry ◽  
Aviation Industry ◽  
Competing Interactions ◽  
Energy Agency ◽  
Maintenance Strategies ◽  
Factors Affecting ◽  
Maintenance Factors ◽  
Reliability Centered Maintenance

Abstract With Lutetium (Lu-177) demand forecasted to increase following the conclusion of clinical trials and product registration in key jurisdictions, manufacturers are seeking to improve their production outputs. Naturally, the question falls to operation and maintenance of these production centers to ensure reliable supply to market. Maintenance in the radiopharmaceutical industry is a complex environment with many competing interactions between radiation safety and Good Manufacturing Practice (GMP) requirements. Since its development by the aviation industry in 1960s, the Reliability Centered Maintenance (RCM) concept has seen adoption by many industries. The International Atomic Energy Agency (IAEA) developed a technical document on RCM applications in nuclear industry in May 2007 while the International Society of Pharmaceutical Engineers (ISPE) refers to the concept in their own baseline guides. Too often, blame for reliability issues falls at the feet of the designers. Careful review of existing strategies against these baseline guidelines often tells a different story. With the view of doubling Lutetium production by the end of 2020 and continued increases over the coming years, there was a push to review the existing maintenance strategies in practice at ANSTO's facilities. This document details the results of that investigation, providing information on the gaps found and the systems implemented to bring maintenance strategies back in alignment with current best practice. It also offers commentary on situations requiring compromises between those best practices defined by IAEA and ISPE.

scholarly journals Application of SMR Regulators’ Forum Results for SMR Licensing in Ukraine

2020 ◽  
pp. 4-12
Author(s):  
Yu. Balashevska ◽  
O. Zhabin ◽  
O. Pecherytsia ◽  
H. Plachkov ◽  
D. Ryzhov ◽  
...  
Keyword(s):  
Nuclear Energy ◽  
Best Practice ◽  
Radiation Safety ◽  
Energy Development ◽  
General Information ◽  
Nuclear Industry ◽  
Energy Agency ◽  
Working Groups ◽  
Nuclear And Radiation Safety ◽  
Near Future

In the near future, small modular reactors (SMR) potentially will play a significant role in global sustainable energy development through the growing interest in SMR implementation in both countries with developed nuclear industry (for example, in Ukraine) and countries that only start launching their nuclear energy programs. At present, there are about 50 SMR designs developed using different reactor technologies in various stages of readiness. The novelty and uniqueness of some fundamental decisions that are the basis for the specified designs and the lack of resulting of real testing of such decisions have created challenges related to ensuring nuclear and radiation safety during installation and further operation of SMR. The paper provides general information on the activities of the SMR Regulators’ Forum (Forum) created by the International Atomic Energy Agency (IAEA) and countries that actively consider and address the use of SMR in the national energy sector to ensure efficient cooperation in dealing with the specified challenges. The paper presents the results obtained by Forum working groups, the main purpose of which is to develop common positions on issues that have already arisen or are likely to arise during the expected licensing of SMR designs in a number of countries, in particular: demonstration of comprehensive implementation of defense in depth strategy in design safety justification; use of the graded approach within the licensing process; approaches to defining zones and distances in emergency planning around NPPs with SMR. In addition, the working groups defined the best practice and approach to considering the specified issues in licensing SMR designs. Based on the performed review, the paper provides proposals for using the available Forum results during planning and licensing of SMR designs in Ukraine and states on the need for a detailed study of its further activities.

scholarly journals Factors Affecting the Rate of Fuel Consumption in Aircrafts

2021 ◽  
Vol 13 (14) ◽  
pp. 8066
Author(s):  
Thowayeb H. Hassan ◽  
Abu Elnasr E. Sobaih ◽  
Amany E. Salem
Keyword(s):  
Fuel Consumption ◽  
Positive Association ◽  
Pollutant Emissions ◽  
Aviation Industry ◽  
Factors Affecting ◽  
Fuel Flow ◽  
Homogeneity Of Variance ◽  
Strong Positive Association ◽  
Ground Distance ◽  
The Cost

The cost of fuel and its availability are among the most major concerns for aircrafts and the aviation industry overall. Environmental difficulties with chemical pollutant emissions emitted by aviation machines are also connected to fuel consumption. As a result, it is crucial to examine factors that affect the overall fuel usage and consumption in the airport-based aviation industry. Several variables were investigated related to the total fuel consumed, such as dry operating weight (DOW) (KG), zero-fuel weight (ZFW), take-off weight (TOW), air distance (AIR DIST) (KM), and ground distance (GDN DIST). Analysis of the correlation between total fuel consumed as well as the extra fuel and selected variables was conducted. The results showed that the most positively associated factors with the total used fuel were the air distance (r2 = 0.86, p < 0.01), ground distance (r2 = 0.78, p < 0.01), TOW (r2 = 0.68, p < 0.01), and flight time (r2 = 0.68, p < 0.01). There was also a strong positive association between the average fuel flow (FF) and actual TOW (r2 = 0.74, p < 0.01) as well as ZFW (r2 = 0.61, p < 0.01). The generalized linear model (GLM) was utilized to assess the predictions of total energy usage after evaluating important outliers, stability of the homogeneity of variance, and the normalization of the parameter estimation. The results of multiple linear regression revealed that the most significant predictors of the total consumed fuel were the actual ZFW (p < 0.01), actual TOW (p < 0.01), and actual average FF (p < 0.05). The results interestingly confirmed that wind speed has some consequences and effects on arrival fuel usage. The result reflects that thermal and hydrodynamic economies impact on the flying fuel economy. The research has various implications for both scholars and practitioners of aviation industry.

scholarly journals The Role of Collaboration in Innovation and Value Creation in the Aviation Industry

2021 ◽  
pp. 239496432110105
Author(s):  
Bruno Pereira ◽  
Gui Lohmann ◽  
Luke Houghton
Keyword(s):  
Value Creation ◽  
Cultural Context ◽  
Best Practice ◽  
Critical Role ◽  
Partner Choice ◽  
Strategic Decision ◽  
Aviation Industry ◽  
Key Factors ◽  
Management Communication ◽  
International Airlines

Collaboration plays a critical role in fostering innovation and value creation in the aviation sector. However, how factors and connections relate to the achievement of innovative outcomes in aviation require further investigation. This study investigates the key factors that create a conceptual framework by conducting a literature review and an archival analysis of news articles. The model proposed involves factors such as strategic decision-making; networking and partner choice; cultural context, values, behaviour and compatibilities; collaboration configuration; issues and risks shared; skills, capacities and experience; infrastructure and resources available; engagement activities; knowledge transfer, absorption and appropriation; collaboration management; communication flows; external environment and demand; and expectations and outcomes. Promising collaborations are also indicated in areas where the framework could be adopted to increase partnerships and outcomes. Also, we highlight best practice examples from leading organizations, such as International Airlines Group (IAG), Emirates Airline, Singapore Airlines, Boeing and JetBlue, to provide insights into existing collaborations that have led to innovation and value creation in this sector.

Case Study: Enhancing Human Reliability With Artificial Intelligence and Augmented Reality Tools for Nuclear Maintenance

2018 ◽  
Author(s):  
Geoffrey Momin ◽  
Raj Panchal ◽  
Daniel Liu ◽  
Sharman Perera
Keyword(s):  
Augmented Reality ◽  
Real Time ◽  
Human Error ◽  
Nuclear Industry ◽  
Industrial Accidents ◽  
Worker Productivity ◽  
Energy Agency ◽  
Computer Mediated ◽  
Critical Feedback

Human error accounts for about 60% of the annual power loss due to maintenance incidents in the fossil power industry. The International Atomic Energy Agency reports that 80\% of industrial accidents in the nuclear industry can be attributed to human error and 20\% to equipment failure. The Personal Augmented Reality Reference System (PARRS) is a suite of computer-mediated reality applications that looks to minimize human error by digitizing manual procedures and providing real-time monitoring of hazards present in an environment. Our mission is to be able to provide critical feedback to inform personnel in real-time and protect them from avoidable hazards. PARRS aims to minimize human error and increase worker productivity by bringing innovation to safety and procedural compliance by leveraging technologies such as augmented reality, LiDAR, computer machine learning and particulate mapping using remote systems.

scholarly journals Factors affecting removal of bacterial pathogens from healthcare surfaces during dynamic wiping

2018 ◽  
Vol 89 (4) ◽  
pp. 580-589 ◽  
Author(s):  
NWM Edwards ◽  
EL Best ◽  
P Goswami ◽  
MH Wilcox ◽  
SJ Russell
Keyword(s):  
Removal Efficiency ◽  
Surface Density ◽  
Pathogenic Bacteria ◽  
Best Practice ◽  
Regenerated Cellulose ◽  
Extrinsic Factors ◽  
Factors Affecting ◽  
E Coli ◽  
Liquid Removal ◽  
Fabric Surface

Wiping of surfaces contaminated with pathogenic bacteria is a key strategy for combating the transmission of healthcare associated infections. It is essential to understand the extent to which removal of bacteria is modulated by fiber properties, biocidal liquid impregnation and applied hand pressure. The influence of intrinsic and extrinsic factors on the removal efficiencies of pathogenic bacteria was studied. Nonwoven wipes made of either hydrophobic (polypropylene) or hygroscopic (lyocell) fibers were manufactured and dynamic removal efficiency of bacteria studied. The single most important parameter affecting bacterial removal efficiency was impregnation with biocidal liquid ( p < 0.05). For inherently hygroscopic 100% regenerated cellulose (lyocell) wipes impregnated with biocidal liquid, removal of E. coli, S. aureus and E. faecalis improved by increasing the fabric surface density and wiping pressure to their maximal values – 150 g.m–2 and 13.80 kN.m–2, respectively. For inherently hydrophobic 100% polypropylene nonwoven wipes, the same conditions maximized the removal efficiency of S. aureus, but for E. coli and E. faecalis a reduction in the wiping pressure to 4.68 kN.m–2 was required. Best practice involves the use of higher surface density wipes (150 g.m–2) containing regenerated cellulose fibers loaded with liquid biocide, and applied with the greatest possible wiping pressure.

Proving the Preclusion of Data Manipulation Using Parallel Data Acquisition in Chromatography

2018 ◽  
Vol 941 ◽  
pp. 2390-2394
Author(s):  
David Thomas Marehn ◽  
Detlef Wilhelm ◽  
Heike Pospisil ◽  
Roberto Pizzoferrato
Keyword(s):  
Data Acquisition ◽  
Best Practice ◽  
Sampling Rate ◽  
Good Manufacturing Practice ◽  
Special Role ◽  
Analytical Instruments ◽  
Data Collector ◽  
Parallel Data ◽  
Time Variations ◽  
Hplc Detector

Traceability has an enormous value for companies, but especially for those working in the regulated environment. It plays a special role in the field of pharmacy with respect to manufacturing, controlling and distributing batches of drugs. Through the guidance of Good Manufacturing Practice (GMP) traceability should be ensured. An increasing number of pharmaceutical companies are member of one of the global pharmacopoeias (United States Pharmacopeia, European Pharmacopeia and Japanese Pharmacopeia). The specifications of these pharmacopoeias describe the best practice in documentation, control, qualification and risk management. But however, the pharmacopoeias are written very generally and do not distinguish between the vendors of the analytical instruments. Here, we analyze how chromatographic analyses and data acquisition rely on a specific vendor of the device and the chromatography data system (CDS), the controlling software. We present a way to compare the data acquisition of different CDSs communicating with HPLC instruments. A newly developed software called Data Collector allows the acquisition of data from a HPLC detector parallel to the controlling CDS in the same run. Two HPLC systems and two different CDSs using a well defined sample standard have been tested. The direct comparison of the acquired data precludes unexpected data manipulations of both tested CDSs and shows that there are primarily deviations between the CDSs due to time variations only which depend on the sampling rate. All in all the Data Collector can be used for the traceability of data acquisition.

15 Years of the European Nuclear Education Network (ENEN Association)

2018 ◽  
Author(s):  
Leon Cizelj ◽  
Jörg Starflinger ◽  
Veronique Decobert ◽  
Behrooz Bazargan-Sabet ◽  
Filip Tuomisto ◽  
...  
Keyword(s):  
Nuclear Research ◽  
Nuclear Industry ◽  
Energy Agency ◽  
Master Of Science ◽  
European Nuclear ◽  
Education Network ◽  
National Networks ◽  
Further Development ◽  
And Training ◽  
The Coordinator

The European Nuclear Education Network (ENEN) was established in 2003 through an EU Fifth Framework Programme (FP) project, as a legal nonprofit-making body. Its main objective is the preservation and further development of expertise in the nuclear fields by higher education and training. This objective is realized through the cooperation between EU universities involved in education and research in nuclear disciplines, nuclear research centers and the nuclear industry. As of March 2018, ENEN has 66 members in 18 EU countries and has concluded Memoranda of Understanding (MoU) with partners beyond Europe for further cooperation, including organizations in, Russian Federation, Ukraine, Canada and Japan. ENEN also has good collaboration with national networks and international organizations such as the Belgian Nuclear Education Network (BNEN) and the International Atomic Energy Agency (IAEA). The main activities developed, and results achieved, within the first 15 years of the ENEN Association are presented and discussed. These include, for example, the launch of the European Master of Science in Nuclear Engineering (EMSNE), the annual ENEN Ph.D. competition and the portfolio of more than 10 EURATOM projects dealing with nuclear education, training and knowledge management through development of teaching methods and materials, courses, and exchange of students and teachers within EU and beyond. Those projects were all supported by the European Commission with the ENEN Association acting as the coordinator or as a partner.

SCAN-UK ? a network approach to environmental best practice in the aviation industry

2001 ◽  
Vol 8 (4) ◽  
pp. 240-247 ◽  
Author(s):  
Janet Maughan ◽  
David Raper ◽  
Callum Thomas ◽  
David Gillingwater
Keyword(s):  
Best Practice ◽  
Aviation Industry ◽  
Network Approach

scholarly journals Revealing Findings in Youth Sport Parenting Research

2019 ◽  
Vol 8 (3) ◽  
pp. 252-259 ◽  
Author(s):  
Camilla J. Knight
Keyword(s):  
Parental Involvement ◽  
Best Practice ◽  
Youth Sport ◽  
Future Research ◽  
Research Directions ◽  
Factors Affecting ◽  
The Status ◽  
History Of ◽  
Future Research Directions ◽  
Future Work

It is widely accepted that parents are a pivotal part of young people’s sporting journey, and over the last 4 decades there has been a substantial growth in research pertaining to youth sport parenting. The aim of this paper is to review the status of the literature pertaining to parenting in youth sport and suggest areas for future work. Specifically, the author provides a very brief history of sport parenting research before turning attention to the 3 areas of study that are currently attracting the majority of researchers’ attention: the influence of parental involvement in youth sport, factors affecting parental involvement in youth sport, and strategies to promote high-quality parental involvement. Future research directions pertaining to the sport parenting questions that are asked, the populations that are sampled, and the interventions that are developed and evaluated are subsequently provided. Finally, the paper concludes with some considerations for best practice in sport clubs and organizations that seek to foster more adaptive youth sport parenting.

scholarly journals Management of radioactive waste from application of radioactive materials and small reactors in non-nuclear industries in Canada and the implications for their new application in the future

2021 ◽  
Vol 8 (6) ◽  
pp. 619-640
Author(s):  
George Sikun Xu ◽  
◽  
Nicholas Chan ◽  
Keyword(s):  
Radioactive Waste ◽  
Management Practices ◽  
Oil And Gas ◽  
Nuclear Reactions ◽  
Industrial Applications ◽  
Nuclear Industry ◽  
International Standards ◽  
Waste Streams ◽  
Energy Agency ◽  
Intermediate Level Radioactive Waste

<abstract> <p>A large number of artificial-origin radionuclides from irradiation in small reactors and/or nuclear reactions in accelerators are currently used in non-nuclear industries such as education, oil and gas, consumer merchandise, research, and medicine. Radioactive wastes from the use of these radionuclides in non-nuclear industries include expired sealed radioactive sources, biological materials, radionuclide-containing chemicals, contaminated equipment, and very small quantities of used nuclear fuel. Although being less challenging and complex than nuclear energy production and research waste streams, these wastes are subject to the common nuclear regulations by the Canadian Nuclear Safety Commission, and are managed following domestic and international standards and guidelines made by the Canadian Standards Association, International Atomic Energy Agency, and International Organization for Standardization. Management practices used in the nuclear industry in Canada are commonly applied to the non-nuclear industry radioactive waste streams, such as waste handling, treatment, packaging, storage, transportation, clearance and exemptions, and disposal. The half-lives of radionuclides in non‑nuclear applications range from hours to thousands of years, and their activities in non-nuclear industrial applications can be as low as their clearance level or as high as the upper limits for intermediate level radioactive waste. Waste containing only short half-life radionuclides is placed in temporary storage to allow decay, and then is cleared and disposed of through non-radioactive waste routes. Non‑clearable waste materials are treated, consolidated, and managed along with radioactive waste generated from the nuclear industries at designated radioactive waste management sites.</p> </abstract>

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