A Dual-VENC Four-Dimensional Flow MRI Framework for Analysis of Subject-Specific Heterogeneous Nonlinear Vessel Deformation

2020 ◽  
Vol 142 (11) ◽  
Author(s):  
J. Concannon ◽  
N. Hynes ◽  
M. McMullen ◽  
E. Smyth ◽  
K. Moerman ◽  
...  
Keyword(s):  
In Silico ◽  
Cardiac Cycle ◽  
Human Aorta ◽  
4D Flow Mri ◽  
4D Flow ◽  
Full Spectrum ◽  
Imaging Protocol ◽  
Subject Specific ◽  
Flow Mri

Abstract Advancement of subject-specific in silico medicine requires new imaging protocols tailored to specific anatomical features, paired with new constitutive model development based on structure/function relationships. In this study, we develop a new dual-velocity encoding coefficient (VENC) 4D flow MRI protocol that provides unprecedented spatial and temporal resolution of in vivo aortic deformation. All previous dual-VENC 4D flow MRI studies in the literature focus on an isolated segment of the aorta, which fail to capture the full spectrum of aortic heterogeneity that exists along the vessel length. The imaging protocol developed provides high sensitivity to all blood flow velocities throughout the entire cardiac cycle, overcoming the challenge of accurately measuring the highly unsteady nonuniform flow field in the aorta. Cross-sectional area change, volumetric flow rate, and compliance are observed to decrease with distance from the heart, while pulse wave velocity (PWV) is observed to increase. A nonlinear aortic lumen pressure–area relationship is observed throughout the aorta such that a high vessel compliance occurs during diastole, and a low vessel compliance occurs during systole. This suggests that a single value of compliance may not accurately represent vessel behavior during a cardiac cycle in vivo. This high-resolution MRI data provide key information on the spatial variation in nonlinear aortic compliance, which can significantly advance the state-of-the-art of in-silico diagnostic techniques for the human aorta.

scholarly journals A dual-VENC 4D Flow MRI Framework for Analysis of Subject-Specific Heterogeneous non-linear Vessel Deformation

2020 ◽  
Author(s):  
Jamie Concannon ◽  
Niamh Hynes ◽  
Marie McMullan ◽  
Evelyn Smyth ◽  
Kevin Mattheus Moerman ◽  
...  
Keyword(s):  
In Silico ◽  
Cardiac Cycle ◽  
Human Aorta ◽  
4D Flow Mri ◽  
4D Flow ◽  
Imaging Protocol ◽  
Subject Specific ◽  
Non Linear ◽  
Flow Mri

Advancement of subject-specific in-silico medicine requires new imaging protocols tailored to specific anatomical features, paired with new constitutive model development based on structure/function relationships. In this study we develop a new dual-VENC 4D Flow MRI protocol that provides unprecedented spatial and temporal resolution of in-vivo aortic deformation. All previous dual-VENC 4D Flow MRI studies in the literature focus on an isolated segment of the aorta, which fail to capture the full spectrum of aortic heterogeneity that exists along the vessel length. The imaging protocol developed provides high sensitivity to all blood flow velocities throughout the entire cardiac cycle, overcoming the challenge of accurately measuring the highly unsteady non-uniform flow field in the aorta. Cross sectional area change, volumetric flow rate, and compliance are observed to decrease with distance from the heart, while pulse wave velocity is observed to increase. A non-linear aortic lumen pressure-area relationship is observed throughout the aorta, such that a high vessel compliance occurs during diastole, and a low vessel compliance occurs during systole. This suggests that a single value of compliance may not accurately represent vessel behaviour during a cardiac cycle in-vivo. This high-resolution MRI data provides key information on the spatial variation in non-linear aortic compliance which can significantly advance the state-of-the-art of in-silico diagnostic techniques for the human aorta.

scholarly journals Towards high-resolution 4D flow MRI in the human aorta using kt-GRAPPA and B1+ shimming at 7T

2016 ◽  
Vol 44 (2) ◽  
pp. 486-499 ◽  
Author(s):  
Sebastian Schmitter ◽  
Susanne Schnell ◽  
Kâmil Uğurbil ◽  
Michael Markl ◽  
Pierre-François Van de Moortele
Keyword(s):  
High Resolution ◽  
Human Aorta ◽  
4D Flow Mri ◽  
4D Flow ◽  
Flow Mri

scholarly journals In vivo validation of 4D flow MRI for assessing the hemodynamics of portal hypertension

2013 ◽  
Vol 37 (5) ◽  
pp. spcone-spcone
Author(s):  
Alejandro Roldán-Alzate ◽  
Alex Frydrychowicz ◽  
Eric Niespodzany ◽  
Ben R. Landgraf ◽  
Kevin M. Johnson ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
4D Flow Mri ◽  
4D Flow ◽  
Flow Mri ◽  
In Vivo Validation

Percutaneous transluminal septal myocardial ablation markedly reduces energy loss in hypertrophic obstructive cardiomyopathy: a four-dimensional flow magnetic resonance imaging study

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
Z Dai ◽  
N Iguchi ◽  
I Takamisawa ◽  
M Takayama ◽  
M Nanasato ◽  
...  
Keyword(s):  
Energy Loss ◽  
Aortic Root ◽  
Cardiac Cycle ◽  
Hypertrophic Obstructive Cardiomyopathy ◽  
Resonance Imaging ◽  
4D Flow Mri ◽  
4D Flow ◽  
Flow Mri ◽  
Percutaneous Transluminal

Abstract Background Functional follow-up modalities of hypertrophic obstructive cardiomyopathy (HOCM) subjected to percutaneous transluminal septal myocardial ablation (PTSMA) are limited mainly to echocardiography and catheterization. Recent advancements in four-dimensional (4D) flow magnetic resonance imaging (MRI) have enabled us to assess patients from the perspective of fluid dynamics by visualising blood flow and calculating quantitative parameters such as wall shear stress and energy loss within cardiac chambers or blood vessels. Several reports have demonstrated that the intra-cardiac energy loss decreased along with improvement of cardiac function achieved by treatment of cardiac diseases. Whether changes in energy loss occur along with PTSMA in HOCM patients and the underlying mechanism remain unknown. Purpose This study sought to investigate the influence of PTSMA in patients with HOCM on energy loss in the left ventricle (LV) and aortic root measured by 4D flow MRI. Methods We retrospectively recruited HOCM patients who underwent PTSMA at a referral centre from May to November 2019. Patients who underwent 4D flow MRI both before and after PTSMA were included. We collected demographic and clinical data from electronic health records. MRI scans implemented two-dimensional phase-contrast imaging of the three-chamber plane with three-directional velocity, using a 1.5 T scanner. Furthermore, 4D blood flow analysis was performed on off-line saved data, using iTFlow version 1.9. We assessed energy loss in one cardiac cycle within the three-chamber plane of the LV and aortic root (area surrounded by the LV endocardium, sinotubular junction, and mitral annulus). Results This study finally included 12 patients, whose mean age was 66±12 years, and 5 (42%) of whom were men. The pressure gradient between the LV apex and ascending aorta was 81±32 mmHg before and 20±22 mmHg immediately after PTSMA (P<0.005, paired). Before PTSMA, 6 patients were in New York Heart Association functional class III and the other 6 in class II. However, after PTSMA, 10 patients improved to class I and 2 to class II. PTSMA reduced energy loss in one cardiac cycle within the three-chamber plane of the LV and aortic root, from 79±36 mJ/m to 55±19 mJ/m (P=0.001, paired). Conclusions PTSMA in patients with HOCM reduced energy loss within the LV and aortic root, indicating significant decrease with cardiac workload. Four-dimensional flow MRI of the three-chamber plane to assess energy loss within the LV and aortic root is a time-efficient and reproducible quantitative method to evaluate the effects of PTSMA. Given its non-invasive nature, it also enables to sequentially follow-up HOCM patients who underwent PTSMA. Periprocedural changes of energy loss Funding Acknowledgement Type of funding source: None

scholarly journals 1050: Cross-modality, in-vivo validation of 4D-Flow MRI evaluation of uterine artery blood flow in human pregnancy

2019 ◽  
Vol 220 (1) ◽  
pp. S673-S674
Author(s):  
Nadav Schwartz ◽  
Eileen Hwuang ◽  
Ana Rodriguez-Soto ◽  
Felix Wehrli ◽  
Marta Vidorreta ◽  
...  
Keyword(s):  
Blood Flow ◽  
Uterine Artery ◽  
Artery Blood Flow ◽  
4D Flow Mri ◽  
4D Flow ◽  
Human Pregnancy ◽  
Flow Mri ◽  
Mri Evaluation ◽  
In Vivo Validation

scholarly journals Impact of Pulmonary Venous Inflow on Cardiac Flow Simulations: Comparison with In Vivo 4D Flow MRI

2018 ◽  
Vol 47 (2) ◽  
pp. 413-424 ◽  
Author(s):  
Jonas Lantz ◽  
Vikas Gupta ◽  
Lilian Henriksson ◽  
Matts Karlsson ◽  
Anders Persson ◽  
...  
Keyword(s):  
4D Flow Mri ◽  
4D Flow ◽  
Flow Simulations ◽  
Flow Mri

scholarly journals Assessment of turbulent blood flow and wall shear stress in aortic coarctation using image-based simulations

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Romana Perinajová ◽  
Joe F. Juffermans ◽  
Jonhatan Lorenzo Mercado ◽  
Jean-Paul Aben ◽  
Leon Ledoux ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Turbulent Flows ◽  
Patient Specific ◽  
4D Flow Mri ◽  
4D Flow ◽  
Local Flow ◽  
Flow Mri ◽  
Wall Shear

AbstractIn this study, we analyzed turbulent flows through a phantom (a 180$$^{\circ }$$ ∘ bend with narrowing) at peak systole and a patient-specific coarctation of the aorta (CoA), with a pulsating flow, using magnetic resonance imaging (MRI) and computational fluid dynamics (CFD). For MRI, a 4D-flow MRI is performed using a 3T scanner. For CFD, the standard $$k-\epsilon $$ k - ϵ , shear stress transport $$k-\omega $$ k - ω , and Reynolds stress (RSM) models are applied. A good agreement between measured and simulated velocity is obtained for the phantom, especially for CFD with RSM. The wall shear stress (WSS) shows significant differences between CFD and MRI in absolute values, due to the limited near-wall resolution of MRI. However, normalized WSS shows qualitatively very similar distributions of the local values between MRI and CFD. Finally, a direct comparison between in vivo 4D-flow MRI and CFD with the RSM turbulence model is performed in the CoA. MRI can properly identify regions with locally elevated or suppressed WSS. If the exact values of the WSS are necessary, CFD is the preferred method. For future applications, we recommend the use of the combined MRI/CFD method for analysis and evaluation of the local flow patterns and WSS in the aorta.

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