Investigating the Effect of Prior Distributions on Posterior Estimates of Common Cause Failure Parameters Using Bayesian Method

2020 ◽  
Vol 6 (3) ◽  
Author(s):  
Edward Shitsi ◽  
Emmanuel K. Boafo ◽  
Felix Ameyaw ◽  
H. C. Odoi

Abstract Quantification of common cause failure (CCF) parameters and their application in multi-unit PSA are important to the safety and operation of nuclear power plants (NPPs) on the same site. CCF quantification mainly involves the estimation of potential failure of redundant components of systems in a NPP. The components considered in quantification of CCF parameters include motor operated valves, pumps, safety relief valves, air-operated valves, solenoid-operated valves, check valves, diesel generators, batteries, inverters, battery chargers, and circuit breakers. This work presents the results of the CCF parameter quantification using check valves and pumps. The systems considered as case studies for the demonstration of the proposed methodology are auxiliary feedwater system (AFWS) and high-pressure safety injection (HPSI) systems of a pressurized water reactor (PWR). The posterior estimates of alpha factors assuming two different prior distributions (Uniform Dirichlet prior and Jeffreys prior) using the Bayesian method were investigated. This analysis is important due to the fact that prior distributions assumed for alpha factors may affect the shape of posterior distribution and the uncertainty of the mean posterior estimates. For the two different priors investigated in this study, the shape of the posterior distribution is not influenced by the type of prior selected for the analysis. The mean of the posterior distributions was also analyzed at 90% confidence level. These results show that the type of prior selected for Bayesian analysis could have effects on the uncertainty interval (or the confidence interval) of the mean of the posterior estimates. The longer the confidence interval, the better the type of prior selected at a particular confidence level for Bayesian analysis. These results also show that Jeffreys prior is preferred over Uniform Dirichlet prior for Bayesian analysis because it yields longer confidence intervals (or shorter uncertainty interval) at 90% confidence level discussed in this work.

2019 ◽  
pp. 19-24

EL MÉTODO DE BAYES APLICADO EN LA IDENTIFICACIÓN DE LAS LOCALIZACIONES MÁS PROPENSAS A SUFRIR ACCIDENTES DE TRÁNSITO Rafael F. Feria Torres y Jorge A. Timaná Rojas DOI: https://doi.org/10.33017/RevECIPeru2008.0009/ RESUMEN La frecuencia y la razón de accidentes en una localización particular, son variables aleatorias cuyo verdadero valor no se puede predecir con absoluta certeza, esto origina que el proceso de identificación de las localizaciones más propensas a sufrir accidentes de tránsito (APL; por sus siglas en ingles) esté sujeto a cierta incertidumbre. Normalmente la identificación de los APL se realiza con técnicas estadísticas simples, tales como el método del intervalo de confianza y control de calidad. Sin embargo, debido a la limitación que estos métodos presentan ante fenómenos estadísticos propios de variables aleatorias, es conveniente la utilización de metodologías más elaboradas como el análisis Bayesiano que si considera los fenómenos estadísticos de regresión a la media y los efectos no relacionados. Aun cuando el análisis Bayesiano es un método estadísticamente superior respecto de otros métodos, su uso en el análisis de accidentes de tránsito no ha sido tan difundido como en la medicina. La razón principal radica no sólo en la propia complejidad del método, sino en la dificultad de organismos locales de contar con un soporte técnico adecuado. El presente trabajo tiene como objetivo presentar un ejemplo práctico de aplicación del método Bayesiano en la identificación los APL en la ciudad de Piura. ABSTRACT The frequency of and the reason for accidents in a particular location are random variables, variables whose true value cannot be predicted with absolute certainty. This means that the process of identification of the locations most prone to suffer traffic accidents (APL - accident-prone locations) is subject to uncertainty. Normally the identification of the APL is made with simple statistical techniques, such as the method of confidence intervals and quality control. Nevertheless, due to the limitations of these methods, the use of more elaborated methodologies, like Bayesian analysis, is advised. This type of analysis takes into account the statistical phenomena of regression to the mean and the unrelated effects. Even though Bayesian analysis is a statistically superior method, its use in the field of engineering, such as analysis of traffic accidents, is not as widespread as the use of this methodology in the field of medicine. The main reason for this is not only the complexity of the method, but also that is requires often unavailable technical support. The objective of this paper is to present a practical example of the application of the Bayesian method in the identification of the accident-prone locations (APL) in the city of Piura .


Kerntechnik ◽  
2006 ◽  
Vol 71 (1-2) ◽  
pp. 41-49 ◽  
Author(s):  
J. K. Vaurio

2021 ◽  
pp. 1-5
Author(s):  
Denizhan Bagrul ◽  
Ibrahim Ece ◽  
Arzu Yılmaz ◽  
Fatih Atik ◽  
Ahmet Vedat Kavurt

Abstract Background: Vasovagal syncope is the most common cause of syncope in childhood and its treatment is not at a satisfactory level yet. We aimed to investigate patients who were diagnosed with vasovagal syncope, did not benefit from conventional treatment, received midodrine treatment, and to evaluate their response to midodrine treatment. Methods: Files of 24 patients who were diagnosed with recurrent vasovagal syncope, did not benefit from non-pharmacological treatments, and received midodrine treatment during June 2017–October 2019 were retrospectively analysed. Results: In total, 24 patients received a treatment dose of midodrine at 5 mg/day (2.5 mg BID) included in the study. The mean number of syncope was 5.75 ± 2.67 prior to treatment. Following treatment, the mean number of syncope was 0.42 ± 0.89. It was observed that syncope episodes did not recur in 17 patients, but it recurred in 4 out of 7 patients in the first 3 months of the treatment and did not recur in the following months. The episodes improved in two patients with an increase in the treatment dose, but the syncope episodes continued in only one patient. Conclusion: It was concluded that midodrine treatment was effective and safe in adolescents with recurrent vasovagal syncope.


2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Li-Xia Zhang ◽  
Ning Dong ◽  
Rui-Xia Yang ◽  
Ang Li ◽  
Xuan-Mei Luo ◽  
...  

AbstractObjectivesGestational thrombocytopenia (GT) is the most common cause of thrombocytopenia during pregnancy. However, the occurrence and severity of thrombocytopenia throughout pregnancy in Chinese women are not fully defined.MethodsWe analyzed platelet counts in Chinese women who received prenatal care and/or delivered at the First Affiliated Hospital with Nanjing Medical University between January 2, 2018 and July 19, 2018 in China. These platelet counts were compared with those of nonpregnant women in the same study period.ResultsThe platelet counts of all women continued to decrease significantly each trimester (p < 0.0001). The mean platelet counts of the 818 women who had pregnancy-related complications were lower than those of the 796 women who had uncomplicated pregnancies during the third trimester (p = 0.047). At the time of delivery, platelet counts less than 150 × 109/L were more common in women with pregnancy-related complications than in women with uncomplicated pregnancy (26.7% vs. 19.7%, p = 0.03).ConclusionsPlatelet counts decrease throughout pregnancy in Chinese women and platelet counts less than 150 × 109/L were more common in women with pregnancy-related complications than in women with uncomplicated pregnancy. The pregnant women should be paid more attention for thrombocytopenia to avoid the occurrence of bleeding events.


2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Aristeidis A. Villias ◽  
Stefanos G. Kourtis ◽  
Hercules C. Karkazis ◽  
Gregory L. Polyzois

Abstract Background The replica technique with its modifications (negative replica) has been used for the assessment of marginal fit (MF). However, identification of the boundaries between prosthesis, cement, and abutment is challenging. The recently developed Digital Image Analysis Sequence (DIAS) addresses this limitation. Although DIAS is applicable, its reliability has not yet been proven. The purpose of this study was to verify the DIAS as an acceptable method for the quantitative assessment of MF at cemented crowns, by conducting statistical tests of agreement between different examiners. Methods One hundred fifty-one implant-supported experimental crowns were cemented. Equal negative replicas were produced from the assemblies. Each replica was sectioned in six parts, which were photographed under an optical microscope. From the 906 standardized digital photomicrographs (0.65 μm/pixel), 130 were randomly selected for analysis. DIAS included tracing the profile of the crown and the abutment and marking the margin definition points before cementation. Next, the traced and marked outlines were superimposed on each digital image, highlighting the components’ boundaries and enabling MF measurements. One researcher ran the analysis twice and three others once, independently. Five groups of 130 measurements were formed. Intra- and interobserver reliability was evaluated with intraclass correlation coefficient (ICC). Agreement was estimated with the standard error of measurement (SEM), the smallest detectable change at the 95% confidence level (SDC95%), and the Bland and Altman method of limits of agreement (LoA). Results Measured MF ranged between 22.83 and 286.58 pixels. Both the intra- and interobserver reliability were excellent, ICC = 1 at 95% confidence level. The intra- and interobserver SEM and SDC95% were less than 1 and 3 pixels, respectively. The Bland–Altman analysis presented graphically high level of agreement between the mean measurement of the first observer and each of the three other observers’ measurements. Differences between observers were normally distributed. In all three cases, the mean difference was less than 1 pixel and within ± 3 pixels LoA laid at least 95% of differences. T tests of the differences did not reveal any fixed bias (P > .05, not significant). Conclusion The DIAS is an objective and reliable method able to detect and quantify MF at ranges observed in clinical practice.


2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Ran Liu ◽  
Jinghui Peng ◽  
Shanyu Tang

The confidence level of negative survey is one of the key scientific problems. The present work uses generation function to analyse the confidence level and uses a greedy algorithm to calculate that, which is used to evaluate the dependable level of negative survey. However, the present method is of low efficiency and complex. This study focuses on an efficient approximation method for calculating the confidence level of negative survey. This approximation method based on central limit theorem and Bayesian method can get the results efficiently.


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