scholarly journals Separation of Solid Stress From Interstitial Fluid Pressure in Pancreas Cancer Correlates With Collagen Area Fraction

2017 ◽  
Vol 139 (6) ◽  
Author(s):  
Michael D. Nieskoski ◽  
Kayla Marra ◽  
Jason R. Gunn ◽  
Stephen C. Kanick ◽  
Marvin M. Doyley ◽  
...  
Keyword(s):  
Interstitial Fluid ◽  
Cellular Proliferation ◽  
Fluid Pressure ◽  
Tumor Location ◽  
Interstitial Fluid Pressure ◽  
Tissue Pressure ◽  
Solid Stress ◽  
Tissue Matrix ◽  
The Relationship ◽  
Total Tissue

Elevated total tissue pressure (TTP) in pancreatic adenocarcinoma is often associated with stress applied by cellular proliferation and hydrated hyaluronic acid osmotic swelling; however, the causal roles of collagen in total tissue pressure have yet to be clearly measured. This study illustrates one direct correlation between total tissue pressure and increased deposition of collagen within the tissue matrix. This observation comes from a new modification to a conventional piezoelectric pressure catheter, used to independently separate and quantify total tissue pressure, solid stress (SS), and interstitial fluid pressure (IFP) within the same tumor location, thereby clarifying the relationship between these parameters. Additionally, total tissue pressure shows a direct correlation with verteporfin uptake, demonstrating the impediment of systemically delivered molecules with increased tissue hypertension.

scholarly journals The Solid Mechanics of Cancer and Strategies for Improved Therapy

2017 ◽  
Vol 139 (2) ◽  
Author(s):  
Triantafyllos Stylianopoulos
Keyword(s):  
Tumor Progression ◽  
Interstitial Fluid ◽  
Solid Mechanics ◽  
Fluid Pressure ◽  
Lymphatic Vessels ◽  
Chemotherapeutic Agents ◽  
Interstitial Fluid Pressure ◽  
Mathematical Framework ◽  
Solid Stress ◽  
Stress Levels

Tumor progression and response to treatment is determined in large part by the generation of mechanical stresses that stem from both the solid and the fluid phase of the tumor. Furthermore, elevated solid stress levels can regulate fluid stresses by compressing intratumoral blood and lymphatic vessels. Blood vessel compression reduces tumor perfusion, while compression of lymphatic vessels hinders the ability of the tumor to drain excessive fluid from its interstitial space contributing to the uniform elevation of the interstitial fluid pressure. Hypoperfusion and interstitial hypertension pose major barriers to the systemic administration of chemotherapeutic agents and nanomedicines to tumors, reducing treatment efficacies. Hypoperfusion can also create a hypoxic and acidic tumor microenvironment that promotes tumor progression and metastasis. Hence, alleviation of intratumoral solid stress levels can decompress tumor vessels and restore perfusion and interstitial fluid pressure. In this review, three major types of tissue level solid stresses involved in tumor growth, namely stress exerted externally on the tumor by the host tissue, swelling stress, and residual stress, are discussed separately and details are provided regarding their causes, magnitudes, and remedies. Subsequently, evidence of how stress-alleviating drugs could be used in combination with chemotherapy to improve treatment efficacy is presented, highlighting the potential of stress-alleviation strategies to enhance cancer therapy. Finally, a continuum-level, mathematical framework to incorporate these types of solid stress is outlined.

Effect of local pH on interstitial fluid pressure

1991 ◽  
Vol 261 (3) ◽  
pp. H627-H631 ◽  
Author(s):  
M. Gilanyi ◽  
A. G. Kovach
Keyword(s):  
Electric Charge ◽  
Electrostatic Interactions ◽  
Time Course ◽  
Interstitial Fluid ◽  
Subcutaneous Tissue ◽  
Fluid Pressure ◽  
Interstitial Fluid Pressure ◽  
Tissue Elasticity ◽  
Net Charge ◽  
The Relationship

It has been suggested that electrostatic interactions between the electric charges on the interstitial gel matrix play a significant role in determining tissue elasticity and interstitial fluid pressure (IFP). The relationship between the net charge and IFP, however, has not been adequately established. Our purpose was to explore the net electric charge-IFP relationship, and in vivo experiments were performed to test its validity. IFP was measured in the subcutaneous tissue of anesthetized rats with the chronically implanted capsule method, and the acid-base status in blood and interstitial fluid was monitored. The net charge, which can be varied by pH, was altered by electrolysis procedure. H+ and OH- generated inside the capsule caused transient and dose-dependent IFP responses. The curve, describing the relationship between capsular pressure changes and amount of generated H+ and OH-, has a maximum at zero net charge, and the excess electric charge, either positive or negative, results in a significant decrease in capsular pressure in accordance with the hypothesis. The time course, as well as the dose dependency, of IFP suggests that the subcutaneous tissue gel in control condition has slightly positive net charge.

scholarly journals Tumor Solid Stress: Assessment with MR Elastography under Compression of Patient-Derived Hepatocellular Carcinomas and Cholangiocarcinomas Xenografted in Mice

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1891
Author(s):  
Gwenaël Pagé ◽  
Marion Tardieu ◽  
Jean-Luc Gennisson ◽  
Laurent Besret ◽  
Philippe Garteiser ◽  
...  
Keyword(s):  
Interstitial Fluid ◽  
Liver Tumors ◽  
Fluid Pressure ◽  
Interstitial Fluid Pressure ◽  
Collagen Content ◽  
Mr Elastography ◽  
Solid Stress ◽  
Hepatocellular Carcinomas ◽  
Malignant Liver Tumors ◽  
Malignant Liver

Malignant tumors have abnormal biomechanical characteristics, including high viscoelasticity, solid stress, and interstitial fluid pressure. Magnetic resonance (MR) elastography is increasingly used to non-invasively assess tissue viscoelasticity. However, solid stress and interstitial fluid pressure measurements are performed with invasive methods. We studied the feasibility and potential role of MR elastography at basal state and under controlled compression in assessing altered biomechanical features of malignant liver tumors. MR elastography was performed in mice with patient-derived, subcutaneously xenografted hepatocellular carcinomas or cholangiocarcinomas to measure the basal viscoelasticity and the compression stiffening rate, which corresponds to the slope of elasticity versus applied compression. MR elastography measurements were correlated with invasive pressure measurements and digital histological readings. Significant differences in MR elastography parameters, pressure, and histological measurements were observed between tumor models. In multivariate analysis, collagen content and interstitial fluid pressure were determinants of basal viscoelasticity, whereas solid stress, in addition to collagen content, cellularity, and tumor type, was an independent determinant of compression stiffening rate. Compression stiffening rate had high AUC (0.87 ± 0.08) for determining elevated solid stress, whereas basal elasticity had high AUC for tumor collagen content (AUC: 0.86 ± 0.08). Our results suggest that MR elastography compression stiffening rate, in contrast to basal viscoelasticity, is a potential marker of solid stress in malignant liver tumors.

Hypertension caused by salt loading. II: Fluid volume and tissue pressure changes

1964 ◽  
Vol 207 (3) ◽  
pp. 669-671 ◽  
Author(s):  
Ben H. Douglas ◽  
Arthur C. Guyton ◽  
Jimmy B. Langston ◽  
Vernon S. Bishop
Keyword(s):  
Arterial Pressure ◽  
Blood Volume ◽  
Interstitial Fluid ◽  
Salt Intake ◽  
Fluid Pressure ◽  
Renal Tissue ◽  
Interstitial Fluid Pressure ◽  
Experimental Hypertension ◽  
Tissue Pressure ◽  
Salt Loading

Experimental hypertension was produced in dogs by increasing their dietary intake of sodium chloride after removing approximately 70% of their renal tissue. The changes in mean arterial pressure, interstitial fluid pressure, blood volume, and sodium space were observed during the development and maintenance of the hypertension. During the periods of increased salt intake, the arterial pressure increased from a mean of 114.6 mm Hg to a mean of 150.6 mm Hg, and there were concomitant increases of 19.8% in blood volume, 16% in sodium space, and 4 cm H2O in interstitial fluid pressure. However, the increases in all the paramteers studied except arterial pressure were transient. The blood volume remained elevated above control values for a longer period of time than the sodium space and interstitial fluid pressure, but it reapproached normal after approximately 16–20 days.

scholarly journals The Mechanical Microenvironment in Breast Cancer

Cancers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1452
Author(s):  
Stephen J.P. Pratt ◽  
Rachel M. Lee ◽  
Stuart S. Martin
Keyword(s):  
Breast Cancer ◽  
Interstitial Fluid ◽  
Fluid Pressure ◽  
Normal Breast ◽  
Interstitial Fluid Pressure ◽  
Mechanical Stimuli ◽  
Solid Stress ◽  
Physical Cues

Mechanotransduction is the interpretation of physical cues by cells through mechanosensation mechanisms that elegantly translate mechanical stimuli into biochemical signaling pathways. While mechanical stress and their resulting cellular responses occur in normal physiologic contexts, there are a variety of cancer-associated physical cues present in the tumor microenvironment that are pathological in breast cancer. Mechanistic in vitro data and in vivo evidence currently support three mechanical stressors as mechanical modifiers in breast cancer that will be the focus of this review: stiffness, interstitial fluid pressure, and solid stress. Increases in stiffness, interstitial fluid pressure, and solid stress are thought to promote malignant phenotypes in normal breast epithelial cells, as well as exacerbate malignant phenotypes in breast cancer cells.

scholarly journals Coevolution of Solid Stress and Interstitial Fluid Pressure in Tumors During Progression: Implications for Vascular Collapse

2013 ◽  
Vol 73 (13) ◽  
pp. 3833-3841 ◽  
Author(s):  
Triantafyllos Stylianopoulos ◽  
John D. Martin ◽  
Matija Snuderl ◽  
Fotios Mpekris ◽  
Saloni R. Jain ◽  
...  
Keyword(s):  
Interstitial Fluid ◽  
Fluid Pressure ◽  
Interstitial Fluid Pressure ◽  
Solid Stress
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