Simultaneous Determination of Disassembly Sequence and Disassembly-to-Order Decisions Using Simulation Optimization

2016 ◽  
Vol 138 (10) ◽  
Author(s):  
Mehmet Ali Ilgin ◽  
Gökçeçiçek Tuna Taşoğlu
Keyword(s):  
Simultaneous Determination ◽  
Simulation Optimization ◽  
Public Awareness ◽  
Cost Effective ◽  
Product Recovery ◽  
Optimization Approach ◽  
Order Problem ◽  
Disassembly Sequence ◽  
Disassembly Sequencing

Strict environmental regulations and increasing public awareness toward environmental issues force many companies to establish dedicated facilities for product recovery. All product recovery options require some level of disassembly. That is why, the cost-effective management of product recovery operations highly depends on the effective planning of disassembly operations. There are two crucial issues common to most disassembly systems. The first issue is disassembly sequencing which involves the determination of an optimal or near optimal disassembly sequence. The second issue is disassembly-to-order (DTO) problem which involves the determination of the number of end of life (EOL) products to process to fulfill the demand for specified numbers of components and materials. Although disassembly sequencing decisions directly affects the various costs associated with a disassembly-to-order problem, these two issues are treated separately in the literature. In this study, a genetic algorithm (GA) based simulation optimization approach was proposed for the simultaneous determination of disassembly sequence and disassembly-to-order decisions. The applicability of the proposed approach was illustrated by providing a numerical example and the best values of GA parameters were identified by carrying out a Taguchi experimental design.

scholarly journals Spectrodensitometric simultaneous determination of esomeprazole and domperidone in human plasma

2017 ◽  
Vol 15 (1) ◽  
pp. 293-298
Author(s):  
Pakinaz Y. Khashaba ◽  
Hassan Refat H. Ali ◽  
Mohamed M. El-Wekil
Keyword(s):  
Ethyl Acetate ◽  
Factorial Design ◽  
Simultaneous Determination ◽  
Human Plasma ◽  
Mobile Phase ◽  
Fractional Factorial Design ◽  
Cost Effective ◽  
Fractional Factorial ◽  
Tlc Plates

AbstractA simple, rapid, cost-effective, and sensitive TLC-spectrodensitometric method for simultaneous determination of esomeprazole and domperidone was developed and tested in human plasma. Ethyl acetate: methanol: benzene: acetonitrile (5: 4: 8: 3, v/v/v/v) mobile phase was used for separation on TLC plates detected at 286 nm. The linearity ranges were 5-1200 and 2-600 ng/ spot for esomeprazole and domperidone, and limits of detection were 1.73 and 0.59 ng/spot. The effects of four variables affecting Rf were evaluated by fractional factorial design. The benzene volume and saturation time had significant effects.

Development and validation of a new RP-HPLC method for the simultaneous determination of hydroquinone, kojic acid, octinoxate, avobenzone, BHA and BHT in skin-whitening cream

2016 ◽  
Vol 8 (5) ◽  
pp. 1170-1180 ◽  
Author(s):  
Fanny Galimany-Rovira ◽  
Pilar Pérez-Lozano ◽  
Josep Ma Suñé-Negre ◽  
Encarna García-Montoya ◽  
Montserrat Miñarro ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Kojic Acid ◽  
Cost Effective ◽  
Hplc Method ◽  
Simultaneous Analysis ◽  
Skin Whitening ◽  
Rp Hplc ◽  
Development And Validation

Simultaneous analysis with a single HPLC run allows for a much more cost-effective and less time-consuming analysis of skin-whitening cream.

A simple, cost-effective and rapid method for simultaneous determination of Strychnos nux-vomica alkaloids in blood and Ayurvedic medicines based on ultrasound-assisted dispersive liquid–liquid microextraction–thin-layer chromatography-image analysis

2020 ◽  
Vol 58 (5) ◽  
pp. 477-484 ◽  
Author(s):  
Rajeev Jain ◽  
Rohitashva Mani Tripathi ◽  
Archna Negi ◽  
Shishir Pratap Singh
Keyword(s):  
Image Analysis ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Simultaneous Determination ◽  
Cost Effective ◽  
Ultrasound Assisted ◽  
Dispersive Liquid Liquid Microextraction ◽  
Layer Chromatography ◽  
Liquid Microextraction

Abstract A simple, rapid, cost-effective and green analytical method is developed based on ultrasound-assisted dispersive liquid–liquid microextraction (US-DLLME) coupled to thin-layer chromatography (TLC)-image analysis for the simultaneous determination of two major alkaloids of Strychnos nux-vomica L i.e., strychnine and brucine. The method is composed of three steps, namely (i) US-DLLME by injecting a mixture of 100-μL chloroform (extraction solvent) and 1-mL methanol (disperser solvent) in 5 mL of aqueous sample, followed by ultrasonication and centrifugation, (ii) TLC of 20 μL of sedimented phase with methanol: ammonia (100:1.5, v/v) as the mobile phase and visualization under ultraviolet radiation (254 nm) and (iii) photography of TLC plate and quantification of spots by image analysis using freely available imageJ software (National Institute of Health, Bethesda, MD, USA). The limit of detection and limit of quantification for both alkaloids were found to be in the range of 0.12–0.15 and 0.36–0.48 μg/spot, respectively. The method was found to be linear in the range of 0.5–5 μg/spot with correlation coefficient (R2) of 0.995 and 0.997 for strychnine and brucine, respectively. The developed method was successfully applied for the determination of strychnine and brucine in Ayurvedic formulations and blood samples. The method does not require any sophisticated instrument and handling skills and can be adopted for rapid analysis of strychnine and brucine in forensic toxicological laboratories.

scholarly journals Simultaneous determination of methanol, ethanol and isopropanol in human blood and white spirit samples

2020 ◽  
Vol 3 (4) ◽  
pp. 16-22
Author(s):  
Phuong Vu Anh ◽  
Ngan Nguyen Thi ◽  
Trang Do Thi ◽  
Luong Dinh Son ◽  
Anh Huong Nguyen Thi ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Human Blood ◽  
Internal Standard ◽  
Cost Effective ◽  
Sampling Procedure ◽  
White Spirit ◽  
Good Resolution ◽  
Flame Ionization ◽  
Chromatographic Peaks

A simple and cost-effective method for simultaneous determination of methanol, ethanol, and isopropanol in human blood and white spirit samples using headspace gas chromatography coupled with flame ionization detection (HS-GC-FID) was developed and validated for clinical and toxicological purposes. In this study, the headspace sampling procedure was investigated, indicating optimized temperature of 70 °C in 20 min. Concentrations of target compounds were determined by internal standard (IS) method with acetonitrile as IS compound. A good resolution of chromatographic peaks was achieved. The linear ranges for all the compounds were from 1 to 500 mg/dL. Our method was validated with adequate accuracy (recovery > 98%) and precision (RSD < 0.1%) in whole human blood and white spirit samples. The limits of detection were below 0.5 mg/L for the three compounds. This method is easy to perform, making it suitable for routine analysis in clinical biochemistry and forensic laboratories.

An Improved GA with Matrix-Coding for Optimizing a Complex Disassembly Sequence Problem on ELV

2021 ◽  
Author(s):  
Chunliang Zhang ◽  
Can Liu
Keyword(s):  
Cost Effective ◽  
Improved Genetic Algorithm ◽  
Evolutionary Time ◽  
Elite Strategy ◽  
Sequencing Method ◽  
Disassembly Sequence ◽  
Np Hard Problem ◽  
Pareto Fronts ◽  
Disassembly Sequencing ◽  
The Relationship

Optimal disassembly sequencing is an NP-hard problem and has always been an ambition for industry production. In the context of increasing public concerns over environmental impacts, in addition to the feasibility of a disassembly sequence, dismantling enterprises have to consider the relationship between potential profits and the impacts. Thus, an ideal disassembly sequence should weight these three factors comprehensively. Up to now, an appropriate ELV disassembly sequence still mainly relies on people’s intuitive experience and seeking an optimal disassembly sequencing method assumes enormous importance. This paper aims to address the optimal disassembly sequencing problem of ELVs by means of an improved genetic algorithm, in which a matrix coding mechanism and an elite strategy are employed. The weight of different factors can be adjusted according to the actual conditions of factories. The paper gives a case and a series of Pareto fronts are obtained. The effects of population size and maximum evolutionary time on the Pareto solutions were investigated. Ultimately, the optimal Pareto disassembly sequence corresponding to balanced profit and environmental impact is achieved, thereby providing an appropriate disassembly depth defined by the aforementioned disassembly sequence. This can contribute to timely disassembly decisions for end-of-life vehicle (ELV) dismantling enterprises, achieving a cost-effective disassembly process for survival in the context of growing environmental concerns. This paper seeks to offer a viable decision-making approach prior to real disassembly of ELVs by detailing a Pareto disassembly depth and sequence.

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