Liquid Metal Ink Enabled Rapid Prototyping of Electrochemical Sensor for Wireless Glucose Detection on the Platform of Mobile Phone

2015 ◽  
Vol 9 (4) ◽  
Author(s):  
Liting Yi ◽  
Jingjing Li ◽  
Cangran Guo ◽  
Lei Li ◽  
Jing Liu
Keyword(s):  
Liquid Metal ◽  
Mobile Phone ◽  
Detection System ◽  
Point Of Care ◽  
Low Cost ◽  
Smart Phone ◽  
Disease Diagnosis ◽  
Glucose Detection ◽  
Sensor Material ◽  
Liquid Metal Ink

Pervasive detection of blood glucose is rather critical for the real-time disease diagnosis which would provide valuable guidance for treatment planning. Here, we established a health care platform for this purpose through incorporating the glucose detection with liquid metal printed sensor and the smart phone monitoring system together. The liquid metal ink composed of bismuth indium stannic (BIS) alloy was identified as an appropriate sensor material to be quickly written or printed on polyvinyl chloride (PVC) substrate at around 59 °C to form desired electrodes. It thus eliminated the complicated procedures as usually required in conventional sensor fabrication strategies. The alloy electrodes were characterized via cyclic voltammetry to demonstrate their practical functionality. Further, unlike using the commonly adopted glucometer, a smart phone was developed as the data acquisition and display center to help improve the portability and ubiquitous virtue of the detection system. Glucose solution in different concentrations was assayed via this platform. It was shown that there is a good linear relationship between the concentration and the integral value of the curve recorded by the mobile phone, which confirms the feasibility of the present method. This quantitative point-of-care system has pervasive feature and is expected to be very useful for future low-cost electrochemical detection.

scholarly journals Recent Developments of Electrochemical and Optical Biosensors for Antibody Detection

2019 ◽  
Vol 21 (1) ◽  
pp. 134 ◽  
Author(s):  
Wei Xu ◽  
Daniel Wang ◽  
Derek Li ◽  
Chung Chiun Liu
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Disease Diagnosis ◽  
Antibody Detection ◽  
Recent Developments ◽  
Care Systems ◽  
Point Of Care Systems ◽  
Detection Of Biomarkers

Detection of biomarkers has raised much interest recently due to the need for disease diagnosis and personalized medicine in future point-of-care systems. Among various biomarkers, antibodies are an important type of detection target due to their potential for indicating disease progression stage and the efficiency of therapeutic antibody drug treatment. In this review, electrochemical and optical detection of antibodies are discussed. Specifically, creating a non-label and reagent-free sensing platform and construction of an anti-fouling electrochemical surface for electrochemical detection are suggested. For optical transduction, a rapid and programmable platform for antibody detection using a DNA-based beacon is suggested as well as the use of bioluminescence resonance energy transfer (BRET) switch for low cost antibody detection. These sensing strategies have demonstrated their potential for resolving current challenges in antibody detection such as high selectivity, low operation cost, simple detection procedures, rapid detection, and low-fouling detection. This review provides a general update for recent developments in antibody detection strategies and potential solutions for future clinical point-of-care systems.

scholarly journals Applications of CMOS Devices for the Diagnosis and Control of Infectious Diseases

Micromachines ◽  
2020 ◽  
Vol 11 (11) ◽  
pp. 1003
Author(s):  
Saghi Forouhi ◽  
Ebrahim Ghafar-Zadeh
Keyword(s):  
Infectious Diseases ◽  
Influenza A ◽  
Point Of Care ◽  
Low Cost ◽  
Emerging Infectious Diseases ◽  
Cmos Technology ◽  
Disease Diagnosis ◽  
Oxide Semiconductor ◽  
Lab On Chip ◽  
Symptom Screening

Emerging infectious diseases such as coronavirus disease of 2019 (COVID-19), Ebola, influenza A, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) in recent years have threatened the health and security of the global community as one of the greatest factors of mortality in the world. Accurate and immediate diagnosis of infectious agents and symptoms is a key to control the outbreak of these diseases. Rapid advances in complementary metal-oxide-semiconductor (CMOS) technology offers great advantages like high accuracy, high throughput and rapid measurements in biomedical research and disease diagnosis. These features as well as low cost, low power and scalability of CMOS technology can pave the way for the development of powerful devices such as point-of-care (PoC) systems, lab-on-chip (LoC) platforms and symptom screening devices for accurate and timely diagnosis of infectious diseases. This paper is an overview of different CMOS-based devices such as optical, electrochemical, magnetic and mechanical sensors developed by researchers to mitigate the problems associated with these diseases.

scholarly journals P207 A quality improvement intervention to increase pneumococcal and influenza vaccination rates in immunosuppressed inflammatory arthritis patients

Rheumatology ◽  
2020 ◽  
Vol 59 (Supplement_2) ◽  
Author(s):  
Kieran Murray ◽  
Candice Low ◽  
Francis Young ◽  
Anna O'Rourke ◽  
Ian Callanan ◽  
...  
Keyword(s):  
Quality Improvement ◽  
Influenza Vaccination ◽  
Point Of Care ◽  
Low Cost ◽  
Smart Phone ◽  
Binary Logistic Regression ◽  
Quality Improvement Intervention ◽  
Binary Logistic Regression Analysis ◽  
Post Intervention ◽  
Vaccination Rates

Abstract Background Pneumococcal and influenza vaccination rates have been suboptimal in studies of immunosuppressed patients. We aimed to assess barriers to and increase rates of 23-valent pneumococcal polysaccharide vaccine (PPSV23) and influenza vaccination in this group. Methods In 2017, Rheumatology outpatients completed an anonymous questionnaire recording vaccination knowledge, status and barriers. Simultaneously, a low-cost multifaceted quality improvement (QI) intervention was performed. All outpatients on oral steroids, immunosuppressant conventional synthetic disease modifying antirheumatic drugs (csDMARDs) or biologics (bDMARDs) were included in the study. In 2018, post-intervention, the clinic was re-assessed. Demographics, diagnosis, medications, smart phone access and willingness to use this for vaccination reminders were assessed for independent vaccination predictors using binary logistic regression analysis. Results 425 patients were included (72.6% rheumatoid arthritis, 74% women, 45.6% ≥60 years old). From 2017-2018, vaccination rates increased for PPSV23 {41.0% to 47.2% (p = 0.29)} and influenza {61.8% to 62.1% (p = 0.95)}. The most common reason for non-vaccination was lack of awareness. Following the intervention, this decreased for influenza (36.7% to 34.2%) and PPSV23 (82.1% to 76.4%). General Practitioners performed most vaccinations, only 3.6% were delivered in hospital. Significant predictors of PPSV23 vaccination were older age {≥80 years had an OR 41.66 (95% CI 3.69-469.8, P = 0.003), compared to ≤ 39 years}, bDMARD use (OR 2.80, 95% CI 1.24-6.32, P = 0.013) and adequate influenza vaccination (OR 9.01, 95% CI 4.40-18.42, P < 0.001). Up to date PPSV23 vaccination (OR 8.93, 95% CI 4.39-18.17, P < 0.001) predicted influenza vaccination. Conclusion PPSV23 and influenza vaccination rates were suboptimal and increased marginally. Point-of-care vaccination may be more effective. Disclosures K. Murray: None. C. Low: None. F. Young: None. A. O'Rourke: None. I. Callanan: None. E. Feeney: None. D. Veale: None.

scholarly journals Mobile Messaging Services-Based Personal Electrocardiogram Monitoring System

2009 ◽  
Vol 2009 ◽  
pp. 1-7 ◽  
Author(s):  
Ashraf A. Tahat
Keyword(s):  
Mobile Phone ◽  
Monitoring System ◽  
Low Cost ◽  
Vital Signs ◽  
Smart Phone ◽  
Ecg Signal ◽  
Area Network ◽  
Application Software ◽  
Data Services ◽  
Electrocardiogram Monitoring

A mobile monitoring system utilizing Bluetooth and mobile messaging services (MMS/SMSs) with low-cost hardware equipment is proposed. A proof of concept prototype has been developed and implemented to enable transmission of an Electrocardiogram (ECG) signal and body temperature of a patient, which can be expanded to include other vital signs. Communication between a mobile smart-phone and the ECG and temperature acquisition apparatus is implemented using the popular personal area network standard specification Bluetooth. When utilizing MMS for transmission, the mobile phone plots the received ECG signal and displays the temperature using special application software running on the client mobile phone itself, where the plot can be captured and saved as an image before transmission. Alternatively, SMS can be selected as a transmission means, where in this scenario, dedicated application software is required at the receiving device. The experimental setup can be operated for monitoring from anywhere in the globe covered by a cellular network that offers data services.

3D Printing of Microfluidics for Point of Care Diagnosis

2017 ◽  
Author(s):  
John P. Sibbitt ◽  
Mei He
Keyword(s):  
3D Printing ◽  
Low Income ◽  
Point Of Care ◽  
Low Cost ◽  
High Sensitivity ◽  
Disease Diagnosis ◽  
Low Income Countries ◽  
3D Design ◽  
Resource Limited ◽  
Production Techniques

Microfluidic lab-on-a-chip (MLOC) technology is a promising approach for point-of-care (POC) diagnosis; low reagent consumption, high sensitivity and quick analysis time are the most prominent benefits. However, microfabrication of MLOCs utilizes specialized techniques and infrastructure, making conventional fabrication time consuming and difficult. While relatively inexpensive production techniques exist for POC diagnoses, such as replication of polymer-based (e.g., PDMS) microfluidic POC devices on lithographic molds, this approach has limitations including: further hydrophilic surface modifications of PDMS, inability to change lithographic mold Z dimensions, and slow prototyping. In contrast, stereo-lithographical (SLA) printing can integrate all of the necessary fabrication resources in one instrument, allowing highly versatile microfluidic devices to be made at low cost. In this paper, we report two microfabrication approaches of microfluidics utilizing (SLA) 3D printing technology: I) Direct SLA printing of channels and structures of a monolithic microfluidic POC device; II) Indirect fabrication, utilizing SLA 3D printed molds for PDMS based microfluidic device replication. Additionally, we discuss previous work providing a proof of concept of applications in POC diagnosis, using direct 3D printing fabrication (approach I). The robustness and simplicity of these protocols allow integrating 3D design and microfabrication with smartphone-based disease diagnosis as a stand-alone system, offering strong adaptability for establishing diagnostic capacity in resource-limited areas and low-income countries.

scholarly journals A Disposable Paper-Based Electrochemical Sensor Made of Pencil Graphite and Its Modification with Au for Detection of Glucose in Alkaline Solutions

2020 ◽  
Author(s):  
Mustafa Sen
Keyword(s):  
Environmental Monitoring ◽  
Electrochemical Sensor ◽  
Point Of Care ◽  
Low Cost ◽  
Cost Effective ◽  
Alkaline Solutions ◽  
Glucose Detection ◽  
Electrochemical Modification ◽  
Point Of Care Diagnostics

Paper-based sensors have great potential to be used in a variety of fields ranging from environmental monitoring to clinical and point-of-care diagnostics. These sensors are disposable, cost effective, flexible and easy to use. The aim of this study was to fabricate a low cost, disposable, reliable and easy to use paper-based electrochemical sensor and its electrochemical modification with nanostructured Au for glucose detection in alkaline solutions.

scholarly journals Electrochemical Biosensors as Potential Diagnostic Devices for Autoimmune Diseases

Biosensors ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 38 ◽  
Author(s):  
Anca Florea ◽  
Gheorghe Melinte ◽  
Ioan Simon ◽  
Cecilia Cristea
Keyword(s):  
Autoimmune Disease ◽  
Early Diagnosis ◽  
Point Of Care ◽  
Low Cost ◽  
Therapy Monitoring ◽  
Specific Interaction ◽  
Sample Pretreatment ◽  
Disease Diagnosis ◽  
Clinical Analysis ◽  
Electrochemical Biosensors

An important class of biosensors is immunosensors, affinity biosensors that are based on the specific interaction between antibodies and antigens. They are classified in four classes based on the type of employed transducer: electrochemical, optical, microgravimetric, and thermometric and depending on the type of recognition elements, antibodies, aptamers, microRNAs and recently peptides are integrating parts. Those analytical devices are able to detect peptides, antibodies and proteins in various sample matrices, without many steps of sample pretreatment. Their high sensitivity, low cost and the easy integration in point of care devices assuring portability are attracting features that justify the increasing interest in their development. The use of nanomaterials, simultaneous multianalyte detection and integration on platforms to form point-of-care devices are promising tools that can be used in clinical analysis for early diagnosis and therapy monitoring in several pathologies. Taking into account the growing incidence of autoimmune disease and the importance of early diagnosis, electrochemical biosensors could represent a viable alternative to currently used diagnosis methods. Some relevant examples of electrochemical assays for autoimmune disease diagnosis developed in the last several years based on antigens, antibodies and peptides as receptors were gathered and will be discussed further.

scholarly journals Smart Phone based Cost Effective Visitor Management System for Smart Offices

2018 ◽  
Vol 12 (6) ◽  
pp. 112
Author(s):  
Santhosha Rao ◽  
Smitha A ◽  
Kunal Kulkarni
Keyword(s):  
Mobile Phone ◽  
Low Cost ◽  
Smart Phone ◽  
Cost Effective ◽  
Access Point ◽  
Automation System ◽  
Effective Implementation ◽  
Wireless Transmitter ◽  
Display Unit ◽  
The Internet Of Things

<p><span style="font-family: Times New Roman; font-size: medium;">In recent years, the proliferation of the Internet of Things (IoT) has kick started the home and office automation in a very rapid manner. The paper demonstrates a cost effective implementation of an IoT system for managing the visitors in an office environment. The automation system comprises low cost NodeMCU based Wireless Transmitter, NodeMCU based Wireless Display Unit and an android mobile phone. The mobile phone also serves as wireless Access Point to which the Wireless Transmitter and the Wireless Display Units are wirelessly connected for exchanging the messages using UDP protocol. The Wireless Transmitter and the Wireless Display Units are kept in the visitor’s waiting area. The consulting person possesses an android mobile phone in which the automation software is installed. The visitor enters a message using the Wireless Transmitter and notes down the acknowledgement token number sent by the automation software. When the consulting person checks this message, the same token number is sent to the Wireless Display Unit signaling the visitor to consult the person. </span></p>

scholarly journals A Disposable Paper-Based Electrochemical Sensor Made of Pencil Graphite and Its Modification with Au for Detection of Glucose in Alkaline Solutions

2020 ◽  
Author(s):  
Mustafa Sen
Keyword(s):  
Environmental Monitoring ◽  
Electrochemical Sensor ◽  
Point Of Care ◽  
Low Cost ◽  
Cost Effective ◽  
Alkaline Solutions ◽  
Glucose Detection ◽  
Electrochemical Modification ◽  
Point Of Care Diagnostics

Paper-based sensors have great potential to be used in a variety of fields ranging from environmental monitoring to clinical and point-of-care diagnostics. These sensors are disposable, cost effective, flexible and easy to use. The aim of this study was to fabricate a low cost, disposable, reliable and easy to use paper-based electrochemical sensor and its electrochemical modification with nanostructured Au for glucose detection in alkaline solutions.

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