scholarly journals The Envelope of Physiological Motion of the First Carpometacarpal Joint

2015 ◽  
Vol 137 (10) ◽  
Author(s):  
Joseph J. Crisco ◽  
Tarpit Patel ◽  
Eni Halilaj ◽  
Douglas C. Moore
Keyword(s):  
Hand Function ◽  
Helical Axis ◽  
Axis Orientation ◽  
Discrete Fourier Analysis ◽  
Joint Pathology ◽  
Physiological Motion ◽  
Thumb Carpometacarpal ◽  
Helical Axis Of Motion ◽  
Cmc Joint

Much of the hand's functional capacity is due to the versatility of the motions at the thumb carpometacarpal (CMC) joint, which are presently incompletely defined. The aim of this study was to develop a mathematical model to completely describe the envelope of physiological motion of the thumb CMC joint and then to examine if there were differences in the kinematic envelope between women and men. In vivo kinematics of the first metacarpal with respect to the trapezium were computed from computed tomography (CT) volume images of 44 subjects (20M, 24F, 40.3 ± 17.7 yr) with no signs of CMC joint pathology. Kinematics of the first metacarpal were described with respect to the trapezium using helical axis of motion (HAM) variables and then modeled with discrete Fourier analysis. Each HAM variable was fit in a cyclic domain as a function of screw axis orientation in the trapezial articular plane; the RMSE of the fits was 14.5 deg, 1.4 mm, and 0.8 mm for the elevation, location, and translation, respectively. After normalizing for the larger bone size in men, no differences in the kinematic variables between sexes could be identified. Analysis of the kinematic data also revealed notable coupling of the primary rotations of the thumb with translation and internal and external rotations. This study advances our basic understanding of thumb CMC joint function and provides a complete description of the CMC joint for incorporation into future models of hand function. From a clinical perspective, our findings provide a basis for evaluating CMC pathology, especially the mechanically mediated aspects of osteoarthritis (OA), and should be used to inform artificial joint design, where accurate replication of kinematics is essential for long-term success.

Quantitative analysis of in-vivo thumb carpometacarpal joint kinematics using four-dimensional computed tomography

2018 ◽  
Vol 43 (10) ◽  
pp. 1088-1097 ◽  
Author(s):  
Kemble K. Wang ◽  
Xin Zhang ◽  
David McCombe ◽  
David C. Ackland ◽  
Eugene T. Ek ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Proximal Phalanx ◽  
Joint Kinematics ◽  
Helical Axis ◽  
Carpometacarpal Joint ◽  
Thumb Carpometacarpal Joint ◽  
Instantaneous Axis Of Rotation ◽  
Axis Of Rotation ◽  
Thumb Carpometacarpal

The purpose of this study was to define the normal thumb carpometacarpal joint kinematics in-vivo during opposition and abduction using four-dimensional computed-tomography in four volunteers. Movement of the metacarpal relative to the trapezium was quantified using both Euler and helical axis representations. Articular surface contact patterns were also analysed. The overall axis of rotation for the movement of opposition and abduction passes through the trapezium and the base of the proximal phalanx, respectively. An abrupt change in instantaneous axis of rotation at terminal opposition was found. Ligament modelling shows dorsoradial ligament becomes tauter towards terminal opposition, whereas anterior oblique ligament becomes more slack. These results support the existence of the ‘screw-home’ pivot at terminal opposition and the importance of the dorsoradial ligament for stability in this position. The normal reference set in this study can help establish a diagnostic tool for subtle carpometacarpal instability, or for evaluating efficacy of surgery.

Effect of Extension Osteotomy of the 1st Metacarpal on Laxity of the Thumb Carpometacarpal Joint

2002 ◽  
Author(s):  
Matthew F. Koff ◽  
Niket Shrivastava ◽  
Amy E. Abbot ◽  
Benton E. Heyworth ◽  
Thomas R. Gardner ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Hand Function ◽  
Joint Stiffness ◽  
Joint Laxity ◽  
Carpometacarpal Joint ◽  
Thumb Carpometacarpal Joint ◽  
Common Solution ◽  
Clinical Literature ◽  
Thumb Carpometacarpal ◽  
Cmc Joint

Osteoarthritis (OA) of the human thumb carpometacarpal (CMC) joint is a debilitating disease. It has been proposed in the clinical literature that joint ligamentous laxity, or joint looseness, is a major etiological factor in OA of the CMC joint (Figure1) [1–4]. Previous investigations of laxity and stability of the human thumb CMC joint have been performed visually, with no quantitative measures of joint laxity recorded [5–7]. Surgical treatment has been a common solution to reduce the pain associated with CMC OA. One treatment, extension osteotomy of the 1st metacarpal, has been suggested not only to reduce the pain of OA, but also improve hand function [8], however, little is known about its biomechanical effects. A complete description of joint laxity requires that all physiological directions of motion be fully tested. A custom-designed, 4 degree of freedom tester was constructed and instrumented for displacement and load in the distraction-compression, dorsal-volar, pronation-supination, and radial-ulnar directions. The purpose of this study was to use this device to: 1) Measure the joint laxity and compliance of non-OA human thumb CMC joints and 2) Determine the effect that a simulated extension osteotomy has on joint laxity and joint stiffness. This study provides an accurate baseline for future comparisons with osteoarthritic, surgically corrected, and otherwise non-healthy CMC joints.

A Method for Measuring Euler Rotation Angles and Helical Axis of Upper Arm Motion

2002 ◽  
Vol 18 (4) ◽  
pp. 374-383 ◽  
Author(s):  
Suzanne LaScalza ◽  
Linda N. Gallo ◽  
James E. Carpenter ◽  
Richard E. Hughes
Keyword(s):  
Upper Extremity ◽  
Shoulder Girdle ◽  
Helical Axis ◽  
Rotational Axis ◽  
Arm Motion ◽  
Vitro Model ◽  
Helical Axis Of Motion ◽  
Shoulder Pathologies

Clinical observation suggests that shoulder pathologies such as rotator cuff disorders and shoulder instability may alter the normal shoulder rhythm or relative motions of the structures comprising the shoulder girdle. The purpose of this study was to assess the accuracy of using a skin-mounted humeral cuff that could be used in vivo to determine Euler rotation angles and the helical axis of motion (HAM) during upper extremity movements. An in vitro model was used to compare the kinematics determined from the externally applied humeral cuff to the kinematics measured directly from the humerus. The upper extremities of five cadavers were moved through several humerus and forearm motion trials. Measurements from the humeral cuff were compared directly to the bone measurements for all trials to determine the accuracy of the Euler rotation angles. In evaluating the HAM, the orientation, location, and magnitude of rotation were compared either to the bone measurements or to the known rotational axis of the testing fixture. Euler rotation angles and the helical axis of motion determined by the measurements taken from the skin-mounted humeral cuff were very similar to those using the measurements from the bone-mounted sensor. The humeral cuff was shown to provide a viable, noninvasive method for determining the Euler rotation angles and helical axis of motion during 3-D humeral movements. The validation makes the humeral cuff a valuable tool for examining the effect of shoulder pathologies on the kinematics of the upper extremity.

IN VIVO LOCATION OF JOINT CENTERS OF THE SHOULDER SYSTEM: GLENO-HUMERAL AND SCAPULO-THORACIC JOINTS BETWEEN TWO POSTURES DESCRIBING THE ARM ELEVATION IN THE PLANE OF SCAPULA USING TECHNIQUES BASED UPON BIPLANAR RADIOGRAPHY

2006 ◽  
Vol 06 (04) ◽  
pp. 385-397 ◽  
Author(s):  
ERIC BERTHONNAUD ◽  
GUILLAUME HERZBERG ◽  
DUANE MORROW ◽  
KAI-NAN AN ◽  
JOANNÈS DIMNET
Keyword(s):  
Helical Axis ◽  
Shoulder Joints ◽  
Functional Models ◽  
Arm Elevation ◽  
A New Technique ◽  
The Stability ◽  
Joint Center ◽  
Helical Axis Of Motion ◽  
External Loads

In biomechanics, the knowledge of accurate location of a joint center is essential because equilibration of the external loads and muscular forces about the joint is performed about this specific point. This paper focuses on the location of centers of gleno-humeral joint and scapulo-thoracic joint in a subject moving their arm in the scapular plane with a magnitude of 120°. Biplanar radiography with successive exposures has been used locating anatomical axes of bones. Geometric models of bones were defined allowing access to bone morphology by superposing model projections onto X-ray imaged bone contours. Functional models were used so as to represent the behavior in motion of shoulder joints. These techniques allowed us to access to results describing the linear and angular relative displacements of the shoulder bones between two different postures. The gleno-humeral and scapulo-thoracic finite joint centers (F H and F S ) are first defined through the location of the corresponding helical axis of motion (HAM) moving the joint from positions occupied in initial and final postures. The gleno-humeral and scapulo-thoracic mean joint centers (M H and M S ) are then calculated using a new technique, which defines that each joint center has the point having the smallest migrations while moving continuously from initial to final postures. This allows for the analysis of the linear and angular clearances, which affect joint center migration. The whole continuous movement has been parsed into several steps to test the stability of the mean joint center throughout the motion.

A Finite Helical Axis as a Landmark for Kinematic Reference of the Knee

1991 ◽  
Vol 113 (2) ◽  
pp. 215-222 ◽  
Author(s):  
R. A. Hart ◽  
C. D. Mote ◽  
H. B. Skinner
Keyword(s):  
Soft Tissue ◽  
Human Subjects ◽  
Helical Axis ◽  
Knee Motion ◽  
Axis Orientation ◽  
Motion Representation ◽  
Axial Translation ◽  
Six Degree Of Freedom ◽  
Finite Helical Axis

Reference coordinates based on the finite helical axis for flexion of the knee from 0 to 90 deg are proposed. Six degree-of-freedom tracking allows the use of such a helical axis as a kinematic landmark for knee motion representation. Data from five human subjects in vivo are presented as a path of finite helical axes for flexion of the knee from 20 to 80 deg. The finite helical axis rotates by an average of 11.4 deg, the centrode translates an average of 19.8 mm, and the total axial translation averages 0.1 mm during flexion from 20 to 80 deg. Error due to the transducer was measured on a fixed-pivot pendulum and found to be 1.0 deg and 1.9 mm rms for the helical axis orientation and position, respectively, and 0.1 mm for the axial translation. Reproducibility and soft tissue effects on the measurements were repeatable to 4.0 deg and 2.7 mm rms in orientation and position, respectively, and 0.1 mm for the axial translations. Soft tissue errors averaged 4.9 deg and 3.6 mmm in position and orientation, and 0.3 mm in the axial translations.

scholarly journals Biomechanics of the Distal Radioulnar Joint During In Vivo Forearm Pronosupination

2021 ◽  
Author(s):  
Bardiya Akhbari ◽  
Kalpit N. Shah ◽  
Amy M. Morton ◽  
Douglas C. Moore ◽  
Arnold-Peter C. Weiss ◽  
...  
Keyword(s):  
Treatment Strategies ◽  
Distal Radioulnar Joint ◽  
Helical Axis ◽  
Continuous Change ◽  
Dynamic Nature ◽  
Degree Polynomial ◽  
Forearm Rotation ◽  
Radioulnar Joint ◽  
Helical Axis Of Motion

Abstract Background Ulnar variance (UV) and center of rotation (COR) location at the level of the distal radioulnar joint (DRUJ) change with forearm rotation. Nevertheless, these parameters have not been assessed dynamically during active in vivo pronosupination. This assessment could help us to improve our diagnosis and treatment strategies. Questions/purposes We sought to (1) mathematically model the UV change, and (2) determine the dynamic COR's location during active pronosupination. Methods We used biplanar videoradiography to study DRUJ during in vivo pronation and supination in nine healthy subjects. UV was defined as the proximal-distal distance of ulnar fovea with respect to the radial sigmoid notch, and COR was calculated using helical axis of motion parameters. The continuous change of UV was evaluated using a generalized linear regression model. Results A second-degree polynomial with R 2 of 0.85 was able to model the UV changes. Maximum negative UV occurred at 38.0 degrees supination and maximum positive UV occurred at maximum pronation. At maximum pronation, the COR was located 0.5 ± 1.8 mm ulnarly and 0.6 ± 0.8 mm volarly from the center of the ulnar fovea, while at maximum supination, the COR was located 0.2 ± 0.6 mm radially and 2.0 ± 0.5 mm volarly. Conclusion Changes in UV and volar translation of the COR are nonlinear at the DRUJ during pronosupination. Clinical Relevance Understanding the dynamic nature of UV as a function of pronosupination can help guide accurate evaluation and treatment of wrist pathology where the UV is an important consideration. The dynamic behavior of COR might be useful in designing DRUJ replacement implants to match the anatomical motion.

A custom-made neoprene thumb carpometacarpal orthosis with thermoplastic stabilization: An orthosis that promotes function and improvement in patients with the first carpometacarpal joint osteoarthritis

2013 ◽  
Vol 38 (1) ◽  
pp. 79-82 ◽  
Author(s):  
Monireh Ahmadi Bani ◽  
Mokhtar Arazpour ◽  
Stephen William Hutchins ◽  
Fereydoun Layeghi ◽  
Mahmood Bahramizadeh ◽  
...  
Keyword(s):  
Grip Strength ◽  
Clinical Relevance ◽  
Hand Function ◽  
Pinch Strength ◽  
Conservative Approach ◽  
Carpometacarpal Joint ◽  
Custom Made ◽  
First Carpometacarpal Joint ◽  
Thumb Carpometacarpal ◽  
Improved Function

Background and aim: Patients with mild to moderate first carpometacarpal joint osteoarthritis report pain, a reduction in pinch and grip strength and hand function. The purpose of this study was to analyze the effect of a custom-made neoprene thumb carpometacarpal orthosis with thermoplastic stabilization on pain, function, grip strength, and key pinch in these patients. Technique: A total of 11 volunteer patients participated in this study. All the above-mentioned parameters were evaluated at baseline and also 30, 60, and 90 days after using the splint. Discussion: A decrease in pain was observed after 30 days, and this continued to improve during treatment with the splint. After 90 days of using the splint, grip strength was improved. Function and pinch strength also increased significantly and was maintained during the study period compared to baseline. Clinical relevance A custom-made neoprene thumb carpometacarpal orthosis with thermoplastic stabilization may be a suitable conservative approach for the treatment of first carpometacarpal joint osteoarthritis.

scholarly journals Oligonucleotide Therapies in the Treatment of Arthritis: A Narrative Review

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 902
Author(s):  
Susanne N. Wijesinghe ◽  
Mark A. Lindsay ◽  
Simon W. Jones
Keyword(s):  
Rheumatoid Arthritis ◽  
Articular Cartilage ◽  
Joint Diseases ◽  
Synovial Joint ◽  
Pharmacological Treatments ◽  
In Vivo Models ◽  
Inflammatory Joint Diseases ◽  
Joint Pathology ◽  
Cellular Pathways

Osteoarthritis (OA) and rheumatoid arthritis (RA) are two of the most common chronic inflammatory joint diseases, for which there remains a great clinical need to develop safer and more efficacious pharmacological treatments. The pathology of both OA and RA involves multiple tissues within the joint, including the synovial joint lining and the bone, as well as the articular cartilage in OA. In this review, we discuss the potential for the development of oligonucleotide therapies for these disorders by examining the evidence that oligonucleotides can modulate the key cellular pathways that drive the pathology of the inflammatory diseased joint pathology, as well as evidence in preclinical in vivo models that oligonucleotides can modify disease progression.

The development of the Kitasato thumb splint as a conservative therapy treatment for patients with thumb carpometacarpal (CMC) arthropathy

Impact ◽  
2021 ◽  
Vol 2021 (8) ◽  
pp. 64-66
Author(s):  
Shuichi Sasaki
Keyword(s):  
Quantitative Analysis ◽  
Low Temperature ◽  
Daily Living ◽  
Conservative Therapy ◽  
University Hospital ◽  
Joint Structure ◽  
Thumb Carpometacarpal ◽  
Additional Support ◽  
Cmc Joint ◽  
Therapy Treatment

Orthoses are devices that are applied externally to help in the rehabilitation of specific bones or joints. Dr Shuichi Sasaki, Department of Rehabilitation, Kitasato University Hospital, Japan, and his team is working to develop a new orthosis for repatriating thumb arthropathies called the Kitasato thumb splint. It is designed to improve usability of the thumb joint, especially in cases of thumb carpometacarpal (CMC) arthropathy, by taking into consideration the thumb CMC joint structure. It exerts force at the base of the CMC joint to move the thumb into the correct joint alignment, improving symptoms for patients. With the Kitasato thumb splint, Sasaki and the team are also eager to provide patients with an alternative to surgery as they believe that the use of more conservative measures with orthoses can prove effective and also prevent costly surgery. The Kitasato thumb splint is made of a low-temperature thermoplastic knit material and can be assembled in as little as 10 minutes, quickly and conveniently providing patients with additional support during painful daily tasks. In his work, Sasaki and the team are looking at orthoses used to treat thumb CMC osteoarthritis and analysing the pressure on CMC joints using quantitative analysis. So far, the Kitasato thumb splint has been found to help in pain reduction and improvements in the activities of daily living in patients with mild cases (Eaton Classifications I to II) of thumb CMC joints and to also provide some improvement in severe cases (Eaton Classifications III-IV).

scholarly journals The Rap1–Rgl–Ral signaling network regulates neuroblast cortical polarity and spindle orientation

2011 ◽  
Vol 195 (4) ◽  
pp. 553-562 ◽  
Author(s):  
Ana Carmena ◽  
Aljona Makarova ◽  
Stephan Speicher
Keyword(s):  
Cell Fate ◽  
Asymmetric Cell Division ◽  
Signaling Network ◽  
Spindle Orientation ◽  
Nucleotide Exchange ◽  
Loss Of Function ◽  
Axis Orientation ◽  
Division Axis ◽  
Guanosine Triphosphatase

A crucial first step in asymmetric cell division is to establish an axis of cell polarity along which the mitotic spindle aligns. Drosophila melanogaster neural stem cells, called neuroblasts (NBs), divide asymmetrically through intrinsic polarity cues, which regulate spindle orientation and cortical polarity. In this paper, we show that the Ras-like small guanosine triphosphatase Rap1 signals through the Ral guanine nucleotide exchange factor Rgl and the PDZ protein Canoe (Cno; AF-6/Afadin in vertebrates) to modulate the NB division axis and its apicobasal cortical polarity. Rap1 is slightly enriched at the apical pole of metaphase/anaphase NBs and was found in a complex with atypical protein kinase C and Par6 in vivo. Loss of function and gain of function of Rap1, Rgl, and Ral proteins disrupt the mitotic axis orientation, the localization of Cno and Mushroom body defect, and the localization of cell fate determinants. We propose that the Rap1–Rgl–Ral signaling network is a novel mechanism that cooperates with other intrinsic polarity cues to modulate asymmetric NB division.

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