scholarly journals Errata: “A Simulation Protocol for Exercise Physiology in Fontan Patients Using a Closed Loop Lumped-Parameter Model” [Journal of Biomechanical Engineering, 2014, 136(8), p. 081007, DOI:10.1115/1.4027271]

2014 ◽  
Vol 136 (10) ◽  
Author(s):  
Ethan Kung ◽  
Giancarlo Pennati ◽  
Francesco Migliavacca ◽  
Tain-Yen Hsia ◽  
Richard Figliola ◽  
...  
Keyword(s):  
Closed Loop ◽  
Exercise Physiology ◽  
Lumped Parameter Model ◽  
Lumped Parameter ◽  
Simulation Protocol ◽  
Biomechanical Engineering ◽  
Fontan Patients

scholarly journals A Simulation Protocol for Exercise Physiology in Fontan Patients Using a Closed Loop Lumped-Parameter Model

2014 ◽  
Vol 136 (8) ◽  
Author(s):  
Ethan Kung ◽  
Giancarlo Pennati ◽  
Francesco Migliavacca ◽  
Tain-Yen Hsia ◽  
Richard Figliola ◽  
...  
Keyword(s):  
Clinical Data ◽  
Closed Loop ◽  
Exercise Physiology ◽  
Clinical Findings ◽  
Lumped Parameter Model ◽  
Patient Specific ◽  
Specific Reference ◽  
Fontan Patient ◽  
Lumped Parameter ◽  
Fontan Patients

Background: Reduced exercise capacity is nearly universal among Fontan patients, though its etiology is not yet fully understood. While previous computational studies have attempted to model Fontan exercise, they did not fully account for global physiologic mechanisms nor directly compare results against clinical and physiologic data. Methods: In this study, we developed a protocol to simulate Fontan lower-body exercise using a closed-loop lumped-parameter model describing the entire circulation. We analyzed clinical exercise data from a cohort of Fontan patients, incorporated previous clinical findings from literature, quantified a comprehensive list of physiological changes during exercise, translated them into a computational model of the Fontan circulation, and designed a general protocol to model Fontan exercise behavior. Using inputs of patient weight, height, and if available, patient-specific reference heart rate (HR) and oxygen consumption, this protocol enables the derivation of a full set of parameters necessary to model a typical Fontan patient of a given body-size over a range of physiologic exercise levels. Results: In light of previous literature data and clinical knowledge, the model successfully produced realistic trends in physiological parameters with exercise level. Applying this method retrospectively to a set of clinical Fontan exercise data, direct comparison between simulation results and clinical data demonstrated that the model successfully reproduced the average exercise response of a cohort of typical Fontan patients. Conclusion: This work is intended to offer a foundation for future advances in modeling Fontan exercise, highlight the needs in clinical data collection, and provide clinicians with quantitative reference exercise physiologies for Fontan patients.

An Automated Simulation Protocol for Exercise Physiology in Fontan Patients Using a Closed-Loop Lumped-Parameter Model

2013 ◽  
Author(s):  
Ethan Kung ◽  
Alessandro Giardini ◽  
Francesco Migliavacca ◽  
Giancarlo Pennati ◽  
Tain-Yen Hsia ◽  
...  
Keyword(s):  
Exercise Physiology ◽  
Fontan Procedure ◽  
Pulmonary Arteries ◽  
Standard Of Care ◽  
Lumped Parameter Model ◽  
Lumped Parameter ◽  
Simulation Protocol ◽  
Automated Simulation ◽  
Clinical Measurements ◽  
The Right

Single ventricle physiology is one of the most severe forms of congenital heart disease in which an infant is born with only one functional pumping chamber. These patients must go through a series of surgical procedures concluding with the Fontan procedure, which connects the superior and inferior vena cavae to the pulmonary arteries, bypassing the right side of the heart entirely. Reduced exercise capacity is a common morbidity in Fontan patients1, leading to decreased quality of life, and the etiology of lowered exercise performance remains unclear. Exercise conditions place high demands on the cardiovascular system; any good surgical design must consider the behavior of the system at stress. Invasive clinical measurements during exercise pose many challenges and are typically not standard of care. There is a need to better understand Fontan exercise physiology and to predict clinical outcomes using computational tools.

scholarly journals A Distributed Lumped Parameter Model of Blood Flow

2020 ◽  
Vol 48 (12) ◽  
pp. 2870-2886
Author(s):  
Mehran Mirramezani ◽  
Shawn C. Shadden
Keyword(s):  
Blood Flow ◽  
Lumped Parameter Model ◽  
Lumped Parameter

scholarly journals Design of External Rotor Ferrite-Assisted Synchronous Reluctance Motor for High Power Density

2021 ◽  
Vol 11 (7) ◽  
pp. 3102
Author(s):  
Md. Zakirul Islam ◽  
Seungdeog Choi ◽  
Malik E. Elbuluk ◽  
Sai Sudheer Reddy Bonthu ◽  
Akm Arafat ◽  
...  
Keyword(s):  
Rare Earth ◽  
Permanent Magnets ◽  
Design Procedure ◽  
Lumped Parameter Model ◽  
High Power Density ◽  
Analytical Design ◽  
Synchronous Reluctance Motor ◽  
Lumped Parameter ◽  
Reluctance Motor ◽  
External Rotor

The rare-earth (RE) permanent magnets (PM) have been increasingly adopted in traction motor application. However, the RE PM is expensive, less abundant, and has cost uncertainties due to limited market suppliers. This paper presents a new design of a RE-free five-phase ferrite permanent magnet-assisted synchronous reluctance motor (Fe-PMaSynRM) with the external rotor architecture with a high saliency ratio. In such architecture, the low magnetic coercivity and demagnetization risk of the ferrite PM is the challenge. This limits the number of flux barriers, saliency ratio, and reluctance torque. A precise analytical design procedure of rotor and stator configuration is presented with differential evolution numerical optimizations by utilizing a lumped parameter model. A 3.7 kW prototype is fabricated to validate the proposed idea.

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