The Effect of Small Intestine Heterogeneity on Irreversible Electroporation Treatment Planning

2014 ◽  
Vol 136 (9) ◽  
Author(s):  
Mary Phillips
Keyword(s):  
Finite Element ◽  
Small Intestine ◽  
Electric Field ◽  
Treatment Planning ◽  
Electric Fields ◽  
Irreversible Electroporation ◽  
Experimental Results ◽  
Heterogeneous Structure ◽  
Element Analysis

Nonthermal irreversible electroporation (NTIRE) is an ablation modality that utilizes microsecond electric fields to produce nanoscale defects in the cell membrane. This results in selective cell death while preserving all other molecules, including the extracellular matrix. Here, finite element analysis and experimental results are utilized to examine the effect of NTIRE on the small intestine due to concern over collateral damage to this organ during NTIRE treatment of abdominal cancers. During previous studies, the electrical treatment parameters were chosen based on a simplified homogeneous tissue model. The small intestine, however, has very distinct layers, and a more realistic model is needed to further develop this technology for precise clinical applications. This study uses a two-dimensional finite element solution of the Laplace and heat conduction equations to investigate how small intestine heterogeneities affect the electric field and temperature distribution. Experimental results obtained by applying NTIRE to the rat small intestine in vivo support the heterogeneous effect of NTIRE on the tissue. The numerical modeling indicates that the electroporation parameters chosen for this study avoid thermal damage to the tissue. This is supported by histology obtained from the in vivo study, which showed preservation of extracellular structures. The finite element model also indicates that the heterogeneous structure of the small intestine has a significant effect on the electric field and volume of cell ablation during electroporation and could have a large impact on the extent of treatment. The heterogeneous nature of the tissue should be accounted for in clinical treatment planning.

Endovascular Nonthermal Irreversible Electroporation: A Finite Element Analysis

2010 ◽  
Vol 132 (3) ◽  
Author(s):  
Elad Maor ◽  
Boris Rubinsky
Keyword(s):  
Finite Element ◽  
Electric Field ◽  
Electric Fields ◽  
Joule Heating ◽  
Arterial Wall ◽  
Thermal Damage ◽  
Irreversible Electroporation ◽  
Phospholipid Bilayer ◽  
Tissue Ablation ◽  
Nonthermal Irreversible Electroporation

Tissue ablation finds an increasing use in modern medicine. Nonthermal irreversible electroporation (NTIRE) is a biophysical phenomenon and an emerging novel tissue ablation modality, in which electric fields are applied in a pulsed mode to produce nanoscale defects to the cell membrane phospholipid bilayer, in such a way that Joule heating is minimized and thermal damage to other molecules in the treated volume is reduced while the cells die. Here we present a two-dimensional transient finite element model to simulate the electric field and thermal damage to the arterial wall due to an endovascular NTIRE novel device. The electric field was used to calculate the Joule heating effect, and a transient solution of the temperature is presented using the Pennes bioheat equation. This is followed by a kinetic model of the thermal damage based on the Arrhenius formulation and calculation of the Henriques and Moritz thermal damage integral. The analysis shows that the endovascular application of 90, 100 μs pulses with a potential difference of 600 V can induce electric fields of 1000 V/cm and above across the entire arterial wall, which are sufficient for irreversible electroporation. The temperature in the arterial wall reached a maximum of 66.7°C with a pulse frequency of 4 Hz. Thermal damage integral showed that this protocol will thermally damage less than 2% of the molecules around the electrodes. In conclusion, endovascular NTIRE is possible. Our study sets the theoretical basis for further preclinical and clinical trials with endovascular NTIRE.

Tire Cornering Simulation Using an Explicit Finite Element Analysis Code

1998 ◽  
Vol 26 (2) ◽  
pp. 109-119 ◽  
Author(s):  
M. Koishi ◽  
K. Kabe ◽  
M. Shiratori
Keyword(s):  
Finite Element Method ◽  
Finite Element Analysis ◽  
Finite Element ◽  
Test System ◽  
Experimental Results ◽  
The Finite Element Method ◽  
Element Analysis ◽  
Explicit Finite Element ◽  
Explicit Finite Element Analysis ◽  
Element Method

Abstract The finite element method has been used widely in tire engineering. Most tire simulations using the finite element method are static analyses, because tires are very complex nonlinear structures. Recently, transient phenomena have been studied with explicit finite element analysis codes. In this paper, the authors demonstrate the feasibility of tire cornering simulation using an explicit finite element code, PAM-SHOCK. First, we propose the cornering simulation using the explicit finite element analysis code. To demonstrate the efficiency of the proposed simulation, computed cornering forces for a 175SR14 tire are compared with experimental results from an MTS Flat-Trac Tire Test System. The computed cornering forces agree well with experimental results. After that, parametric studies are conducted by using the proposed simulation.

The Finite Element Analysis of the Large-Scale Converter Transformer Valve Side of the Electric Field

2013 ◽  
Vol 325-326 ◽  
pp. 476-479 ◽  
Author(s):  
Lin Suo Zeng ◽  
Zhe Wu
Keyword(s):  
Finite Element ◽  
Electric Field ◽  
Large Scale ◽  
Calculation Model ◽  
Simulation Software ◽  
Field Calculation ◽  
Element Analysis ◽  
Ansys Simulation ◽  
The Finite Element Analysis ◽  
Electric Field Calculation

This article is based on finite element theory and use ANSYS simulation software to establish electric field calculation model of converter transformer for a ±800kV and make electric field calculation and analysis for valve winding. Converter transformer valve winding contour distribution of electric field have completed in the AC, DC and polarity reversal voltage.

scholarly journals Finite Element Analysis of Artificially Frozen C-Phi soil

2019 ◽  
Vol 8 (4) ◽  
pp. 12722-12728
Keyword(s):  
Finite Element ◽  
Numerical Analysis ◽  
Frozen Soil ◽  
Experimental Results ◽  
Soil Freezing ◽  
Strength Parameter ◽  
Frozen Ground ◽  
Element Analysis ◽  
Test Setup ◽  
Geological Conditions

Artificial Ground Freezing techniques eliminate the need for structural supports during the course of an excavation, as frozen ground is solid and waterproof. At present, it is adopted as an effective way to deal with various construction ground control challenges such as the mitigation of seepage infiltration into tunnels and shaft excavations; or ground strengthening for excavation. In-depth knowledge of the frozen soil characteristics through experiments and the development of suitable constitutive models that suit the geological conditions of our country are necessary to predict the strength and behavior of the frozen soils. Numerical analysis of frozen soil can be used for mass works like tunneling which cannot be experimentally verified. This paper presents a validation of experimental results obtained from laboratory setup and soil freezing system for C-Phi soil. The main aim is to compare numerical and experimental results and hence obtaining the shear strength parameter of the soil, similar to the conventional triaxial test setup. To perform numerical analysis Finite element tool ANSYS 19 is used. Soil model is made in ANSYS 19 and required loads are inputted to performed the analysis similar to the experimental method. The result obtained from experimental test setup and numerical analysis was verified and compared and it was found that values of numerical results lies closer to experimental results

scholarly journals Transcranial Alternating Current Stimulation (tACS) Entrains Alpha Oscillations by Preferential Phase Synchronization of Fast-Spiking Cortical Neurons to Stimulation Waveform

2019 ◽  
Author(s):  
Ehsan Negahbani ◽  
Iain M. Stitt ◽  
Marshall Davey ◽  
Thien T. Doan ◽  
Moritz Dannhauer ◽  
...  
Keyword(s):  
Electric Field ◽  
Electric Fields ◽  
Cortical Neurons ◽  
Posterior Parietal Cortex ◽  
Phase Synchronization ◽  
Alternating Current ◽  
Arnold Tongue ◽  
Transcranial Alternating Current Stimulation ◽  
Neuronal Oscillators

SummaryModeling studies predict that transcranial alternating current stimulation (tACS) entrains brain oscillations, yet direct examination has been lacking or potentially contaminated by stimulation artefact. Here we first demonstrate how the posterior parietal cortex drives primary visual cortex and thalamic LP in the alpha-band in head-fixed awake ferrets. The spike-field synchrony is maximum within alpha frequency, and more prominent for narrow-spiking neurons than broad-spiking ones. Guided by a validated model of electric field distribution, we produced electric fields comparable to those in humans and primates (< 0.5 mV/mm). We found evidence to support the model-driven predictions of how tACS entrains neural oscillations as explained by the triangular Arnold tongue pattern. In agreement with the stronger spike-field coupling of narrow-spiking cells, tACS more strongly entrained this cell population. Our findings provide the firstin vivoevidence of how tACS with electric field amplitudes used in human studies entrains neuronal oscillators.

scholarly journals Experimental Results of SiC reinforced Al2O3 Matrix Ceramic Matrix Composites Validated with Finite Element Method

2019 ◽  
Vol 8 (12) ◽  
pp. 307-310
Keyword(s):  
Finite Element Method ◽  
Finite Element ◽  
Ceramic Matrix Composites ◽  
Experimental Results ◽  
Matrix Composites ◽  
Metal Oxidation ◽  
Element Analysis ◽  
Advanced Analysis ◽  
Al2o3 Matrix ◽  
Element Method

In this paper, SiCp /Al2O3 composites were fabricated through directed metal oxidation process. Experimental results of these composites validated or compared with Finite Element Method (FEM). Finite Element has become one in all the foremost necessary tools offered to an engineer. The finite part methodology is employed to resolve advanced analysis issues. In this paper, Finite Element Method based ANSYS software is used to FEM model to determine mechanical properties of SiC reinforced Al2O3 matrix composite by changing volume fractions of SiC. The comparison of experimental results with Finite element analysis provides detailed information about the results of these comparisons. The FA was competent of predict the information for several scenario quite fine

Experimental Research on the Magnetic Field Sensitive Polymeric Actuator

2011 ◽  
Vol 287-290 ◽  
pp. 603-607
Author(s):  
Chun Lin Xia ◽  
Yang Fang Wu ◽  
Qian Qian Lu
Keyword(s):  
Magnetic Field ◽  
Finite Element Analysis ◽  
Finite Element ◽  
Energy Conversion ◽  
Experimental Research ◽  
Experimental Results ◽  
Deformation Characteristics ◽  
Analysis Software ◽  
Element Analysis ◽  
The Magnetic Field

Using domestic MFSP membrane as a medium of energy conversion, a kind of MFSP actuator was designed. The dedicated test equipment was constructed for experimental research, and the experimental results were given. The strip and circular MSFP membrane were analyzed qualitatively to obtain the deformation characteristics of membrane by finite element analysis software.

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