Structural Manipulation of Microcone Arrays for Microsurgical Modification of Ophthalmic Tissues

2014 ◽  
Vol 8 (3) ◽  
Author(s):  
B. J. Wing ◽  
D. A. Schaeffer ◽  
T. R. Hendricks ◽  
D. Bennett ◽  
E. Chaum ◽  
...  
Keyword(s):  
Vision Loss ◽  
Cost Effective ◽  
Drawing Process ◽  
Treatment Alternative ◽  
Visual Axis ◽  
Structural Manipulation ◽  
Process Controls ◽  
Subsequent Staining ◽  
Effective Procedures ◽  
Viable Treatment

The purpose of this study was to utilize controllable fiber-drawing techniques in order to fabricate glass microcone arrays for use in office-based optical surgery instruments. The cone spacing is controlled via the drawing process while an etching process controls the cone height-to-base ratio. The device viability was tested by imprinting, and subsequent staining, of low-density polyethylene and porcine corneas, resulting in a consistent patterned structure of micron-sized perforations. After imprint, the device was examined and no evidence of microcone fracture or overpenetration was present during the course of these experiments. This research promises to lead to advances in optical surgery for the treatment of recurrent corneal erosions, providing quicker, safer, and more cost-effective procedures with decreased risk of vision loss and scarring associated with current procedures such as anterior stromal puncture. The ease of procedure and micron-sized incisions could potentially replace current techniques and provide a viable treatment alternative for recurrent corneal erosions in the visual axis.

scholarly journals Nanogel-Facilitated In-Situ Delivery of a Cataract Inhibitor

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1150
Author(s):  
Dixa Gautam ◽  
Michelle G. Pedler ◽  
Devatha P. Nair ◽  
Jonathan Mark Petrash
Keyword(s):  
Cataract Surgery ◽  
Vision Loss ◽  
Effective Means ◽  
Lens Capsule ◽  
Posterior Capsular Opacification ◽  
Surgical Removal ◽  
Visual Disability ◽  
Visual Axis ◽  
Number Of Patients ◽  
Subsequent Degradation

Cataracts are a leading cause of blindness worldwide. Surgical removal of cataracts is a safe and effective procedure to restore vision. However, a large number of patients later develop vision loss due to regrowth of lens cells and subsequent degradation of the visual axis leading to visual disability. This postsurgical complication, known as posterior capsular opacification (PCO), occurs in up to 30% of cataract patients and has no clinically proven pharmacological means of prevention. Despite the availability of many compounds capable of preventing early steps in PCO development, there is currently no effective means to deliver such therapies into the eye for a suitable duration. To model a solution to this unmet medical need, we fabricated acrylic substrates as intraocular lens (IOL) mimics scaled to place into the capsular bag of the mouse lens following a mock-cataract surgery. Substrates were coated with a hydrophilic crosslinked acrylate nanogel designed to elute Sorbinil, an aldose reductase inhibitor previously shown to suppress PCO. Insertion of the Sorbinil-eluting device into the lens capsule at the time of cataract surgery resulted in substantial prevention of cellular changes associated with PCO development. This model demonstrates that a cataract inhibitor can be delivered into the postsurgical lens capsule at therapeutic levels.

Reimplantation of an Inverted Maxillary Premolar: Case Report of a Multidiscplinary Treatment Approach

2009 ◽  
Vol 33 (4) ◽  
pp. 279-282 ◽  
Author(s):  
Ayca Ulusoy ◽  
Murat Akkocaoglu ◽  
Seden Akan ◽  
Ilken Kocadereli ◽  
Zafer Cehreli
Keyword(s):  
Case Report ◽  
Root Resorption ◽  
Treatment Approach ◽  
Multidisciplinary Treatment ◽  
Rare Condition ◽  
Treatment Alternative ◽  
Normal Position ◽  
Sufficient Space ◽  
Viable Treatment

Inversion of premolars is an extremely rare condition, which usually requires extraction. This case report describes the inversion of an impacted maxillary second premolar in an 11-year-old male, and the multidisciplinary treatment approach for bringing the tooth into a normal position within the arch. In order to provide sufficient space for surgical reimplantation of the tooth, the mesially-drifted neighbouring maxillary first molar was first endodontically treated, followed by orthodontic distalization of the tooth. The inverted tooth was removed surgically and reimplanted without the use of splints for stabilization. After a 12-month follow-up period, the tooth maintained its vitality without any root resorption. Reimplantation of impacted inverted premolars can be a viable treatment alternative to extraction

scholarly journals Autotransplantation of Premolars and Esthetic Rehabilitation in a Traumatized Teenage Patient with Challenging Oral Problems: A Case Report

2020 ◽  
Vol 47 (2) ◽  
pp. 213-218
Author(s):  
Junhee Kho ◽  
Howon Park ◽  
Juhyun Lee ◽  
Hyunwoo Seo
Keyword(s):  
Case Report ◽  
Oral Hygiene ◽  
Periodontal Ligament ◽  
Poor Prognosis ◽  
Treatment Alternative ◽  
Poor Oral Hygiene ◽  
Minimal Resistance ◽  
Patients With Poor Prognosis ◽  
Viable Treatment

The loosely structured periodontal ligament and low mineralized bone surrounding erupting teeth provide minimal resistance to an extrusive force. The maxillary central incisors are the most frequently avulsed due to trauma. The prognosis of replanted teeth is affected by extra-alveolar period and conditions. Implant-supported restorations are contraindicated in adolescent patients with poor prognosis traumatized teeth. Autotransplantation of premolar to the anterior region provides a viable treatment alternative.<br/>This case report describes the autotransplantation of premolars and esthetic rehabilitation in a teenage patient with traumatized incisors, poor oral hygiene, and severe crowding. Comprehensive and long-term treatments were performed to improve complex and challenging oral problems.

Markedly Elevated Intracranial Pressure Treated With Cranial Vault Expansion, Instead of CSF Shunting, in a Child With Hurler-Scheie Syndrome and Multiple Suture Craniosynostosis

2018 ◽  
Vol 56 (3) ◽  
pp. 395-399
Author(s):  
Jessica A. Ching ◽  
Jared S. Troy ◽  
Ernesto J. Ruas ◽  
Joshua M. Beckman ◽  
Gerald F. Tuite
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracranial Pressure ◽  
Cranial Vault ◽  
Elevated Intracranial Pressure ◽  
Treatment Alternative ◽  
Unique Case ◽  
Shunt Placement ◽  
Scheie Syndrome ◽  
Csf Shunting ◽  
Viable Treatment

Despite a known association of mucopolysaccharidoses (MPS) and craniosynostosis, treatment of elevated intracranial pressure (ICP) in these patients is primarily cerebrospinal fluid (CSF) shunting. We present a unique case of Hurler-Scheie syndrome with multisuture craniosynostosis and elevated ICP, without ventriculomegaly, where elevated ICP was successfully treated with extensive cranial vault expansion and shunt placement was avoided. Patients with MPS should be evaluated for craniosynostosis, and calvarial vault expansion may be considered as a viable treatment alternative to CSF shunting for elevated ICP in select patients.

scholarly journals A Review on Management of Amblyopia

2021 ◽  
pp. 211-217
Author(s):  
Khushboo Kolhe ◽  
Sachin Diaghvane
Keyword(s):  
Visual Cortex ◽  
Vision Loss ◽  
Contact Lenses ◽  
Abnormal Development ◽  
Neutral Density Filter ◽  
Visual Axis ◽  
Internet Resources ◽  
Clear Vision ◽  
Density Filter ◽  
Lazy Eye

Amblyopia is a visual cortex neurodevelopmental condition cause am vision abnormalities during childhood. It is one of the most typical causes of vision loss at an early age. It occurs due to abnormal development of the visual cortex. The part receiving signals from the diseased eye does not receive it correctly and thus develops abnormally. This abnormal development during the critical period of growth of child results in brain damage. Depending on its aetiology the  types of amblyopia are Strabismic amblyopia, Visual deprivation amblyopia, Anisometric, Ametropic, Meridional, Toxic amblyopia. Clinical features are visual acuity is reduced, the effect of neutral density filter, the Crowding phenomenon is present. Complications of amblyopia include a Lazy eye becoming weak permanently, the eye may move out from the visual axis (squints). When treating amblyopia, our goal is that the eyes will work together in unison at an equal level; this will create a clear vision in the lazy eye. Amblyopia is treated in various ways depending on the seriousness of the disease and the patient's age. Patching of the non-amblyopic eye, as well as treatment with drugs like atropine, are common treatments. Vision therapy and some modifications to spectacles and contact lenses have been discovered to be effective in treating amblyopia in recent years. Modern Treatment- Falling Blocks, Occlu-pad. With current breakthroughs in amblyopia therapy, the success rate of a multimodal strategy is also improving. The purpose of this review article is to present information on the management of amblyopia. Literature on AMBLYOPIA MANAGEMENT has been taken from PubMed, Scopus, Science Direct, and other internet resources.

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