scholarly journals Site-Specific Quantification of Bone Quality Using Highly Nonlinear Solitary Waves

2012 ◽  
Vol 134 (10) ◽  
Author(s):  
Jinkyu Yang ◽  
Sophia N. Sangiorgio ◽  
Sean L. Borkowski ◽  
Claudio Silvestro ◽  
Luigi De Nardo ◽  
...  
Keyword(s):  
Bone Quality ◽  
Solitary Waves ◽  
Hertzian Contact ◽  
Mineral Density ◽  
Site Specific ◽  
Bone Properties ◽  
Highly Nonlinear ◽  
Specific Assessment ◽  
Granular Crystal ◽  
Hertzian Contact Law

Osteoporosis is a well recognized problem affecting millions of individuals worldwide. The ability to diagnose problems in an effective, efficient, and affordable manner and identify individuals at risk is essential. Site-specific assessment of bone mechanical properties is necessary, not only in the process of fracture risk assessment, but may also be desirable for other applications, such as making intraoperative decisions during spine and joint replacement surgeries. The present study evaluates the use of a one-dimensional granular crystal sensor to measure the elastic properties of bone at selected locations via direct mechanical contact. The granular crystal is composed of a tightly packed chain of particles that interact according to the Hertzian contact law. Such chains represent one of the simplest systems to generate and propagate highly nonlinear acoustic signals in the form of compact solitary waves. First, we investigated the sensitivity of the sensor to known variations in bone density using a synthetic cancellous bone substitute, representing clinical bone quality ranging from healthy to osteoporotic. Once the relationship between the signal response and known bone properties was established, the sensor was used to assess the bone quality of ten human cadaveric specimens. The efficacy and accuracy of the sensor was then investigated by comparing the sensor measurements with the bone mineral density (BMD) obtained using dual-energy x-ray absorptiometry (DEXA). The results indicate that the proposed technique is capable of detecting differences in bone quality. The ability to measure site-specific properties without exposure to radiation has the potential to be further developed for clinical applications.

scholarly journals Ultrasounds could be considered as a future tool for probing growing bone properties

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Emmanuelle Lefevre ◽  
Cécile Baron ◽  
Evelyne Gineyts ◽  
Yohann Bala ◽  
Hakim Gharbi ◽  
...  
Keyword(s):  
Bone Quality ◽  
Material Properties ◽  
Biochemical Parameters ◽  
Bone Growth ◽  
Mineral Density ◽  
Stiffness Coefficients ◽  
Bone Properties ◽  
Ultrasonic Measurements ◽  
Microstructure Parameters ◽  
Adult Bone

Abstract Juvenile bone growth is well described (physiological and anatomical) but there are still lacks of knowledge on intrinsic material properties. Our group has already published, on different samples, several studies on the assessment of intrinsic material properties of juvenile bone compared to material properties of adult bone. The purpose of this study was finally to combine different experimental modalities available (ultrasonic measurement, micro-Computed Tomography analysis, mechanical compression tests and biochemical measurements) applied on small cubic bone samples in order to gain insight into the multiparametric evaluation of bone quality. Differences were found between juvenile and adult groups in term of architectural parameters (Porosity Separation), Tissue Mineral Density (TMD), diagonal stiffness coefficients (C33, C44, C55, C66) and ratio between immature and mature cross-links (CX). Diagonal stiffness coefficients are more representative of the microstructural and biochemical parameters of child bone than of adult bone. We also found that compression modulus E was highly correlated with several microstructure parameters and CX in children group while it was not at all correlated in the adult group. Similar results were found for the CX which was linked to several microstructure parameters (TMD and E) only in the juvenile group. To our knowledge, this is the first time that, on a same sample, ultrasonic measurements have been combined with the assessment of mechanical and biochemical properties. It appears that ultrasonic measurements can provide relevant indicators of child bone quality (microstructural and biochemical parameters) which is promising for clinical application since, B-mode ultrasound is the preferred first-line modality over other more constraining imaging modalities (radiation, parent–child accessibility and access to the patient's bed) for pediatric patients.

scholarly journals Wireless Module for Nondestructive Testing/Structural Health Monitoring Applications Based on Solitary Waves

Sensors ◽  
2020 ◽  
Vol 20 (11) ◽  
pp. 3016 ◽  
Author(s):  
Ritesh Misra ◽  
Hoda Jalali ◽  
Samuel J. Dickerson ◽  
Piervincenzo Rizzo
Keyword(s):  
Structural Health Monitoring ◽  
Solitary Waves ◽  
Health Monitoring ◽  
Hertzian Contact ◽  
Spherical Particles ◽  
Structural Health ◽  
Mechanical Waves ◽  
Highly Nonlinear ◽  
Monitoring Applications ◽  
Wireless Module

In recent years, there has been an increasing interest in the use of highly nonlinear solitary waves (HNSWs) for nondestructive evaluation and structural health monitoring applications. HNSWs are mechanical waves that can form and travel in highly nonlinear systems, such as granular particles in Hertzian contact. The easiest setup consists of a built-in transducer in drypoint contact with the structure or material to be inspected/monitored. The transducer is made of a monoperiodic array of spherical particles that enables the excitation and detection of the solitary waves. The transducer is wired to a data acquisition system that controls the functionality of the transducer and stores the time series for post-processing. In this paper, the design and testing of a wireless unit that enables the remote control of a transducer without the need to connect it to sophisticated test equipment are presented. Comparative tests and analyses between the measurements obtained with the newly designed wireless unit and the conventional wired configuration are provided. The results are corroborated by an analytical model that predicts the dynamic interaction between solitary waves and materials with different modulus. The advantages and limitations of the proposed wireless platform are given along with some suggestions for future developments.

scholarly journals Effect of Age on Bone Structure Parameters in Laying Hens

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 570
Author(s):  
Masayoshi Yamada ◽  
Chongxiao Chen ◽  
Toshie Sugiyama ◽  
Woo Kyun Kim
Keyword(s):  
Cortical Bone ◽  
Bone Quality ◽  
Bone Mineral ◽  
Volume Fraction ◽  
Bone Structure ◽  
Bone Volume ◽  
Egg Laying ◽  
Medullary Bone ◽  
Mineral Density ◽  
Tibial Diaphysis

Changes in medullary and cortical bone structure with age remain unclear. Twenty Hy-Line W36 hens, 25 or 52 weeks of age, were euthanized, and both tibiae were collected when an egg was present in the magnum. Serial cross sections of the tibiae were stained with Alcian blue. The bones were scanned using micro-computed tomography. Trabecular width (Tb.Wi) was significantly higher (p < 0.05) in 25-week-old hens, whereas medullary bone tissue volume (TV) was significantly higher (p < 0.01) in 52-week-old hens. 25-week-old hens had significantly higher (p < 0.01) bone volume fraction (BVF = calcified tissue / TV). Moreover, the cortical bone parameters were significantly higher (TV and bone mineral content (BMC) at p < 0.05, and bone volume (BV) and BVF at p < 0.01) in younger hens. Open porosity and total porosity, which indicate less density, were significantly higher (p < 0.01) in older hens. Older hens showed significantly higher (p < 0.01) tibial diaphysis TV than younger hens. Younger hens had significantly higher (p < 0.01) BV, BVF and bone mineral density (BMD) of the tibial diaphysis. These findings reveal that reductions in medullary bone quality might be associated with age-related low estrogen levels and stimulation of osteoclastic bone resorption by parathyroid hormone. Cortical bone quality decreased with enlargement of the Haversian canals and loss of volume, with a longer egg-laying period leading to osteoporosis.

scholarly journals Molecular characterisation of osteoblasts from bone obtained from people of Polynesian and European ancestry undergoing joint replacement surgery

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Dorit Naot ◽  
Jarome Bentley ◽  
Cluny Macpherson ◽  
Rocco P. Pitto ◽  
Usha Bava ◽  
...  
Keyword(s):  
Gene Expression ◽  
Real Time ◽  
Joint Replacement ◽  
Real Time Pcr ◽  
S Phase ◽  
European Ancestry ◽  
Mineral Density ◽  
Differentiation Markers ◽  
Joint Replacement Surgery ◽  
Bone Properties

AbstractPopulation studies in Aotearoa New Zealand found higher bone mineral density and lower rate of hip fracture in people of Polynesian ancestry compared to Europeans. We hypothesised that differences in osteoblast proliferation and differentiation contribute to the differences in bone properties between the two groups. Osteoblasts were cultured from bone samples obtained from 30 people of Polynesian ancestry and 25 Europeans who had joint replacement surgeries for osteoarthritis. The fraction of cells in S-phase was determined by flow cytometry, and gene expression was analysed by microarray and real-time PCR. We found no differences in the fraction of osteoblasts in S-phase between the groups. Global gene expression analysis identified 79 differentially expressed genes (fold change > 2, FDR P < 0.1). Analysis of selected genes by real-time PCR found higher expression of COL1A1 and KRT34 in Polynesians, whereas BGLAP, DKK1, NOV, CDH13, EFHD1 and EFNB2 were higher in Europeans (P ≤ 0.01). Osteoblasts from European donors had higher levels of late differentiation markers and genes encoding proteins that inhibit the Wnt signalling pathway. This variability may contribute to the differences in bone properties between people of Polynesian and European ancestry that had been determined in previous studies.

scholarly journals Site-Specific Variations in Bone Mineral Density under Systemic Conditions Inducing Osteoporosis in Minipigs

2017 ◽  
Vol 8 ◽  
Author(s):  
Matthias C. Schulz ◽  
Jan Kowald ◽  
Sven Estenfelder ◽  
Roland Jung ◽  
Eberhard Kuhlisch ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
Site Specific

In-Line-Inspection (ILI) of a Pipeline in Constrained Condition and Establishing Integrity of the Pipeline

2021 ◽  
Author(s):  
Partha Bose
Keyword(s):  
Thermal Expansion ◽  
Natural Gas ◽  
Gas Pipeline ◽  
Bridge Structure ◽  
Site Specific ◽  
Integrity Assessment ◽  
Natural Gas Pipeline ◽  
Pipe Line ◽  
Specific Assessment ◽  
Mumbai City

Abstract One 24” Diameter and around 40 km length Natural Gas pipeline caters as energy life line for Mumbai city; supplying app 4.5 MMSCMD Gas for Auto Sectors (CNG), House Hold (PNG), Power, Fertiliser, Petrochemical Sectors. Though line is equipped with Launcher & Receiver; but onward became challenging one for executing pigging for many constraints: - Presence of One SR bend - Presence of 1.5 D bends - Presence of 1.5 D bends with Back to Back configuration - Three (3) no Thermal Expansion Loops, in 2 Km stretch passing as above ground pipeline through bridge (above Creek) section The pipe line is passing through High Consequence areas, including its interim stretch of 2km passing as above ground section through bridge structure. Intelligent pigging is an obvious first preference for online precise integrity assessment for any pipeline. Site Specific Assessment, Detail Engineering & Committed approach resulted in Feasibility & Development of ILI Tool, Practical Testing in fore hand before actual pigging & onward Integrity Assessment of the pipeline conducted by accomplishing Successful ILI run.

scholarly journals Bone quality associated with daily intake of coffee: a biochemical, radiographic and histometric study

2010 ◽  
Vol 21 (3) ◽  
pp. 199-204 ◽  
Author(s):  
Suzie Aparecida Lacerda ◽  
Renata Inahara Matuoka ◽  
Rander Moreira Macedo ◽  
Sergio Olavo Petenusci ◽  
Alessandra Aparecida Campos ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Quality ◽  
Bone Mineral ◽  
Bone Repair ◽  
Daily Intake ◽  
Male Rats ◽  
Lower Amount ◽  
Caffeine Intake ◽  
Mineral Density ◽  
Coffee Intake

Caffeine induces loss of calcium and influences the normal development of bone. This study investigated the effects of coffee on bone metabolism in rats by biochemical measurement of calcium, bone densitometry and histometry. Male rats, born of female treated daily with coffee and with coffee intake since born, were anesthetized, subjected to extraction of the upper right incisor, and sacrificed 7, 21 and 42 days after surgery. Blood and urine samples were taken, and their maxilla radiographed and processed to obtain 5-µm-thick semi-serial sections stained with hematoxylin and eosin. The volume and bone quality were estimated using an image-analysis software. The results showed significantly greater amount of calcium in the plasma (9.40 ± 1.73 versus 9.80 ± 2.05 mg%) and urine (1.00 ± 0.50 versus 1.25 ± 0.70 mg/24 h) and significantly less amount in bone (90.0 ± 1.94 versus 86.0 ± 2.12 mg/mg bone), reduced bone mineral density (1.05 ± 0.11 versus 0.65 ± 0.15 mmAL), and lower amount of bone (76.19 ± 1.6 versus 53.41 ± 2.1 %) (ANOVA; p≤0.01) in animals treated with coffee sacrificed after 42 days. It may be concluded that coffee/caffeine intake caused serious adverse effects on calcium metabolism in rats, including increased levels of calcium in the urine and plasma, decreased bone mineral density and lower volume of bone, thus delaying the bone repair process.

scholarly journals Influence of Hyponatremia on Spinal Bone Quality and Fractures Due to Low-Energy Trauma

Medicina ◽  
2021 ◽  
Vol 57 (11) ◽  
pp. 1224
Author(s):  
Katharina Jäckle ◽  
Friederike Klockner ◽  
Daniel Bernd Hoffmann ◽  
Paul Jonathan Roch ◽  
Maximilian Reinhold ◽  
...  
Keyword(s):  
Bone Quality ◽  
Serum Sodium ◽  
Quantitative Computed Tomography ◽  
Low Energy ◽  
Fracture Rate ◽  
Mineral Density ◽  
Body Fracture ◽  
Increased Risk ◽  
Chronic Hyponatremia ◽  
Trauma Group

Background and Objectives: Hyponatremia is the most common electrolyte disorder in elderly and associated with increased risk of falls. Clinical studies as well as small animal experiments suggested an association between chronic hyponatremia and osteoporosis. Furthermore, it has been assumed that subtle hyponatremia may be an independent fracture risk in the elderly. Therefore, this study was designed to evaluate the possible influence of chronic hyponatremia on osteoporosis and low-energy fractures of the spine. Materials and Methods: 144 patients with a vertebral body fracture (mean age: 69.15 ± 16.08; 73 females and 71 males) due to low-energy trauma were treated in a level one trauma center within one year and were included in the study. Chronic hyponatremia was defined as serum sodium < 135 mmol/L at admission. Bone mineral density (BMD) of the spine was measured using quantitative computed tomography in each patient. Results: Overall, 19.44% (n = 28) of patients in the low-energy trauma group had hyponatremia. In the group with fractures caused by low-energy trauma, the proportion of hyponatremia of patients older than 65 years was significantly increased as compared to younger patients (p** = 0.0016). Furthermore, there was no significant gender difference in the hyponatremia group. Of 28 patients with chronic hyponatremia, all patients had decreased bone quality. Four patients showed osteopenia and the other 24 patients even showed osteoporosis. In the low-energy trauma group, the BMD correlated significantly with serum sodium (r = 0.396; p*** < 0.001). Conclusions: The results suggest that chronic hyponatremia affects bone quality. Patients with chronic hyponatremia have an increased prevalence of fractures after low-energy trauma due to a decreased bone quality. Therefore, physicians from different specialties should focus on the treatment of chronic hyponatremia to reduce the fracture rate after low-energy trauma, particularly with elderly patients.

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