scholarly journals Regional Left Ventricular Myocardial Contractility and Stress in a Finite Element Model of Posterobasal Myocardial Infarction

2011 ◽  
Vol 133 (4) ◽  
Author(s):  
Jonathan F. Wenk ◽  
Kay Sun ◽  
Zhihong Zhang ◽  
Mehrdad Soleimani ◽  
Liang Ge ◽  
...  
Keyword(s):  
Finite Element ◽  
Myocardial Contractility ◽  
Left Ventricular ◽  
Border Zone ◽  
Left Ventricular Aneurysm ◽  
Fe Model ◽  
Ventricular Aneurysm ◽  
Computationally Efficient ◽  
Lv Volumes ◽  
Formal Optimization

Recently, a noninvasive method for determining regional myocardial contractility, using an animal-specific finite element (FE) model-based optimization, was developed to study a sheep with anteroapical infarction (Sun et al., 2009, “A Computationally Efficient Formal Optimization of Regional Myocardial Contractility in a Sheep With Left Ventricular Aneurysm,” ASME J. Biomech. Eng., 131(11), p. 111001). Using the methodology developed in the previous study (Sun et al., 2009, “A Computationally Efficient Formal Optimization of Regional Myocardial Contractility in a Sheep With Left Ventricular Aneurysm,” ASME J. Biomech. Eng., 131(11), p. 111001), which incorporates tagged magnetic resonance images, three-dimensional myocardial strains, left ventricular (LV) volumes, and LV cardiac catheterization pressures, the regional myocardial contractility and stress distribution of a sheep with posterobasal infarction were investigated. Active material parameters in the noninfarcted border zone (BZ) myocardium adjacent to the infarct (Tmax_B), in the myocardium remote from the infarct (Tmax_R), and in the infarct (Tmax_I) were estimated by minimizing the errors between FE model-predicted and experimentally measured systolic strains and LV volumes using the previously developed optimization scheme. The optimized Tmax_B was found to be significantly depressed relative to Tmax_R, while Tmax_I was found to be zero. The myofiber stress in the BZ was found to be elevated, relative to the remote region. This could cause further damage to the contracting myocytes, leading to heart failure.

scholarly journals A Computationally Efficient Formal Optimization of Regional Myocardial Contractility in a Sheep With Left Ventricular Aneurysm

2009 ◽  
Vol 131 (11) ◽  
Author(s):  
Kay Sun ◽  
Nielen Stander ◽  
Choon-Sik Jhun ◽  
Zhihong Zhang ◽  
Takamaro Suzuki ◽  
...  
Keyword(s):  
Myocardial Contractility ◽  
Active Material ◽  
Left Ventricular ◽  
Left Ventricular Aneurysm ◽  
Fe Model ◽  
Mr Images ◽  
Material Parameters ◽  
Lv Volumes ◽  
Formal Optimization

A noninvasive method for estimating regional myocardial contractility in vivo would be of great value in the design and evaluation of new surgical and medical strategies to treat and/or prevent infarction-induced heart failure. As a first step toward developing such a method, an explicit finite element (FE) model-based formal optimization of regional myocardial contractility in a sheep with left ventricular (LV) aneurysm was performed using tagged magnetic resonance (MR) images and cardiac catheterization pressures. From the tagged MR images, three-dimensional (3D) myocardial strains, LV volumes, and geometry for the animal-specific 3D FE model of the LV were calculated, while the LV pressures provided physiological loading conditions. Active material parameters (Tmax_B and Tmax_R) in the noninfarcted myocardium adjacent to the aneurysm (borderzone) and in the myocardium remote from the aneurysm were estimated by minimizing the errors between FE model-predicted and measured systolic strains and LV volumes using the successive response surface method for optimization. The significant depression in optimized Tmax_B relative to Tmax_R was confirmed by direct ex vivo force measurements from skinned fiber preparations. The optimized values of Tmax_B and Tmax_R were not overly sensitive to the passive material parameters specified. The computation time of less than 5 h associated with our proposed method for estimating regional myocardial contractility in vivo makes it a potentially very useful clinical tool.

Mechanism underlying mechanical dysfunction in the border zone of left ventricular aneurysm: a finite element model study

2001 ◽  
Vol 71 (2) ◽  
pp. 654-662 ◽  
Author(s):  
Julius M Guccione ◽  
Scott M Moonly ◽  
Pavlos Moustakidis ◽  
Kevin D Costa ◽  
Michael J Moulton ◽  
...  
Keyword(s):  
Finite Element ◽  
Finite Element Model ◽  
Element Model ◽  
Left Ventricular ◽  
Border Zone ◽  
Left Ventricular Aneurysm ◽  
Ventricular Aneurysm ◽  
Model Study

MRI-based finite-element analysis of left ventricular aneurysm

2005 ◽  
Vol 289 (2) ◽  
pp. H692-H700 ◽  
Author(s):  
Joseph C. Walker ◽  
Mark B. Ratcliffe ◽  
Peng Zhang ◽  
Arthur W. Wallace ◽  
Bahar Fata ◽  
...  
Keyword(s):  
Finite Element ◽  
Myocardial Strain ◽  
Left Ventricular ◽  
Fe Analysis ◽  
Border Zone ◽  
Fe Model ◽  
Tagged Mri ◽  
Fiber Stress ◽  
Material Parameters ◽  
Biaxial Stretching

Tagged MRI and finite-element (FE) analysis are valuable tools in analyzing cardiac mechanics. To determine systolic material parameters in three-dimensional stress-strain relationships, we used tagged MRI to validate FE models of left ventricular (LV) aneurysm. Five sheep underwent anteroapical myocardial infarction (25% of LV mass) and 22 wk later underwent tagged MRI. Asymmetric FE models of the LV were formed to in vivo geometry from MRI and included aneurysm material properties measured with biaxial stretching, LV pressure measurements, and myofiber helix angles measured with diffusion tensor MRI. Systolic material parameters were determined that enabled FE models to reproduce midwall, systolic myocardial strains from tagged MRI (630 ± 187 strain comparisons/animal). When contractile stress equal to 40% of the myofiber stress was added transverse to the muscle fiber, myocardial strain agreement improved by 27% between FE model predictions and experimental measurements (RMS error decreased from 0.074 ± 0.016 to 0.054 ± 0.011, P < 0.05). In infarct border zone (BZ), end-systolic midwall stress was elevated in both fiber (24.2 ± 2.7 to 29.9 ± 2.4 kPa, P < 0.01) and cross-fiber (5.5 ± 0.7 to 11.7 ± 1.3 kPa, P = 0.02) directions relative to noninfarct regions. Contrary to previous hypotheses but consistent with biaxial stretching experiments, active cross-fiber stress development is an integral part of LV systole; FE analysis with only uniaxial contracting stress is insufficient. Stress calculations from these validated models show 24% increase in fiber stress and 115% increase in cross-fiber stress at the BZ relative to remote regions, which may contribute to LV remodeling.

Mechanical dysfunction in the border zone of an ovine model of left ventricular aneurysm

1995 ◽  
Vol 60 (4) ◽  
pp. 986-998 ◽  
Author(s):  
Michael J. Moulton ◽  
Stephen W. Downing ◽  
Lawrence L. Creswell ◽  
Douglas S. Fishman ◽  
David M. Amsterdam ◽  
...  
Keyword(s):  
Left Ventricular ◽  
Border Zone ◽  
Left Ventricular Aneurysm ◽  
Ventricular Aneurysm ◽  
Ovine Model

Plication of the left ventricular aneurysm using off-pump technique

2009 ◽  
Vol 56 (S 01) ◽  
Author(s):  
I Duvan ◽  
S Ates ◽  
M Kurtoglu ◽  
B Bakkaloglu ◽  
S Besbas ◽  
...  
Keyword(s):  
Left Ventricular ◽  
Left Ventricular Aneurysm ◽  
Ventricular Aneurysm ◽  
Off Pump

Dilated coronary sinus mimicking posterior left ventricular aneurysm

2001 ◽  
Vol 56 (3) ◽  
pp. 199-200 ◽  
Author(s):  
Theodor TIRILOMIS ◽  
Federico L. SALDAÑA ◽  
Harald DALICHAU
Keyword(s):  
Coronary Sinus ◽  
Left Ventricular ◽  
Left Ventricular Aneurysm ◽  
Ventricular Aneurysm ◽  
Dilated Coronary Sinus

Left Ventricular Aneurysm

2014 ◽  
Vol 370 (3) ◽  
pp. e5 ◽  
Author(s):  
Lindsay Ayers Lucas ◽  
Chris Somerville
Keyword(s):  
Left Ventricular ◽  
Left Ventricular Aneurysm ◽  
Ventricular Aneurysm

Subvalvular mitral aneurysm a rare pathology

2021 ◽  
pp. 1-2
Author(s):  
Odete R. Mingas ◽  
Ondina Fortunato ◽  
Sebastiana Gamboa
Keyword(s):  
Surgical Treatment ◽  
Left Ventricular ◽  
Left Ventricular Aneurysm ◽  
Ventricular Aneurysm ◽  
African Child ◽  
Cardiorespiratory Arrest ◽  
Previous Infection ◽  
History Of

Abstract We present a rare and challenging case of left ventricular aneurysm in an African child with no history of previous infection or trauma, admitted for surgical treatment, who presented non reversible cardiorespiratory arrest with cardiorespiratory resuscitation before surgery.

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