Nanotechnology in Neurosurgery

2010 ◽  
Vol 1 (3) ◽  
Author(s):  
Kelly L. Collins ◽  
Daniel A. Orringer ◽  
Parag G. Patil
Keyword(s):  
Carbon Nanotubes ◽  
Superparamagnetic Iron Oxide ◽  
Nerve Tissue ◽  
Brain Machine Interface ◽  
Oxide Nanoparticles ◽  
Clinical Neurology ◽  
Neurologic Disease ◽  
Nerve Tissue Engineering ◽  
Machine Interface ◽  
The Many

Clinical neurology and neurosurgery are two fields that face some of the most challenging and exciting problems remaining in medicine. Brain tumors, paralysis after trauma or stroke, and neurodegerative diseases are some of the many disorders for which effective therapies remain elusive. Nanotechnology seems poised to offer promising new solutions to some of these difficult problems. The latest advances in materials engineered at the nanoscale for applications relevant to the clinical neurosciences, such as medical imaging, nanotherapies for neurologic disease, nerve tissue engineering, and nanotechnological contributions to neuroelectrodes and brain-machine interface technology are reviewed. The primary classes of materials discussed include superparamagnetic iron oxide nanoparticles, gold nanoparticles, liposomes, carbon fullerenes, and carbon nanotubes. The potential of the field and the challenges that must be overcome for the current technology to become available clinically are highlighted.

Carbon nanotubes: a promise for nerve tissue engineering?

nano Online ◽  
2016 ◽  
Author(s):  
Susanna Bosi ◽  
Alessandra Fabbro ◽  
Laura Ballerini ◽  
Maurizio Prato
Keyword(s):  
Carbon Nanotubes ◽  
Tissue Engineering ◽  
Nerve Tissue ◽  
Nerve Tissue Engineering

TARGETING CYCLIN B1 WITH ANTISENSE OLIGONUCLETOTIDES- COATED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES

2018 ◽  
Vol 6 (10) ◽  
Author(s):  
Hosam Zaghloul ◽  
Doaa A. Shahin ◽  
Ibrahim El- Dosoky ◽  
Mahmoud E. El-awady ◽  
Fardous F. El-Senduny ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cellular Uptake ◽  
Superparamagnetic Iron Oxide ◽  
Cyclin B1 ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Mcf7 Cells ◽  
M Phase ◽  
The Impact

Antisense oligonucleotides (ASO) represent an attractive trend as specific targeting molecules but sustain poor cellular uptake meanwhile superparamagnetic iron oxide nanoparticles (SPIONs) offer stability of ASO and improved cellular uptake. In the present work we aimed to functionalize SPIONs with ASO targeting the mRNA of Cyclin B1 which represents a potential cancer target and to explore its anticancer activity. For that purpose, four different SPIONs-ASO conjugates, S-M (1–4), were designated depending on the sequence of ASO and constructed by crosslinking carboxylated SPIONs to amino labeled ASO. The impact of S-M (1–4) on the level of Cyclin B1, cell cycle, ROS and viability of the cells were assessed by flowcytometry. The results showed that S-M3 and S-M4 reduced the level of Cyclin B1 by 35 and 36%, respectively. As a consequence to downregulation of Cyclin B1, MCF7 cells were shown to be arrested at G2/M phase (60.7%). S-M (1–4) led to the induction of ROS formation in comparison to the untreated control cells. Furthermore, S-M (1–4) resulted in an increase in dead cells compared to the untreated cells and SPIONs-treated cells. In conclusion, targeting Cyclin B1 with ASO-coated SPIONs may represent a specific biocompatible anticancer strategy.

Evaluation of Surface-modified Superparamagnetic Iron Oxide Nanoparticles to Optimize Bacterial Immobilization for Bio-separation with the Least Inhibitory Effect on Microorganism Activity

2020 ◽  
Vol 10 (2) ◽  
pp. 166-174
Author(s):  
Mehdi Khoshneviszadeh ◽  
Sarah Zargarnezhad ◽  
Younes Ghasemi ◽  
Ahmad Gholami
Keyword(s):  
Iron Oxide ◽  
Amino Acid ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Surface Coating ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Surface Charges ◽  
Surface Modified

Background: Magnetic cell immobilization has been introduced as a novel, facile and highly efficient approach for cell separation. A stable attachment between bacterial cell wall with superparamagnetic iron oxide nanoparticles (SPIONs) would enable the microorganisms to be affected by an outer magnetic field. At high concentrations, SPIONs produce reactive oxygen species in cytoplasm, which induce apoptosis or necrosis in microorganisms. Choosing a proper surface coating could cover the defects and increase the efficiency. Methods: In this study, asparagine, APTES, lipo-amino acid and PEG surface modified SPIONs was synthesized by co-precipitation method and characterized by FTIR, TEM, VSM, XRD, DLS techniques. Then, their protective effects against four Gram-positive and Gram-negative bacterial strains including Enterococcus faecalis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa were examined through microdilution broth and compared to naked SPION. Results: The evaluation of characterization results showed that functionalization of magnetic nanoparticles could change their MS value, size and surface charges. Also, the microbial analysis revealed that lipo-amino acid coated magnetic nanoparticles has the least adverse effect on microbial strain among tested SPIONs. Conclusion: This study showed lipo-amino acid could be considered as the most protective and even promotive surface coating, which is explained by its optimizing effect on cell penetration and negligible reductive effects on magnetic properties of SPIONs. lipo-amino acid coated magnetic nanoparticles could be used in microbial biotechnology and industrial microbiology.

scholarly journals Reversible magnetism switching of iron oxide nanoparticle dispersions by controlled agglomeration

2021 ◽  
Author(s):  
Stephan Müssig ◽  
Björn Kuttich ◽  
Florian Fidler ◽  
Daniel Haddad ◽  
Susanne Wintzheimer ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Light Scattering ◽  
Superparamagnetic Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticles ◽  
X Ray ◽  
X Ray Scattering ◽  
Nanoparticle Dispersions ◽  
Oxide Nanoparticle

The controlled agglomeration of superparamagnetic iron oxide nanoparticles (SPIONs) was used to rapidly switch their magnetic properties. Small-angle X-ray scattering (SAXS) and dynamic light scattering showed that tailored iron oxide...

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