scholarly journals Carotid Bifurcation Hemodynamics in Older Adults: Effect of Measured Versus Assumed Flow Waveform

2010 ◽  
Vol 132 (7) ◽  
Author(s):  
Yiemeng Hoi ◽  
Bruce A. Wasserman ◽  
Edward G. Lakatta ◽  
David A. Steinman
Keyword(s):  
Magnetic Resonance ◽  
Older Adult ◽  
Blood Flow Rate ◽  
Carotid Bifurcation ◽  
Flow Waveform ◽  
Flow Conditions ◽  
Flow Rates ◽  
Relative Residence Time ◽  
Contrast Magnetic Resonance ◽  
Dynamics Models

Recent work has illuminated differences in carotid artery blood flow rate dynamics of older versus young adults. To what degree flow waveform shape, and indeed the use of measured versus assumed flow rates, affects the simulated hemodynamics of older adult carotid bifurcations has not been elucidated. Image-based computational fluid dynamics models of N=9 normal, older adult carotid bifurcations were reconstructed from magnetic resonance angiography. Subject-specific hemodynamics were computed by imposing each individual’s inlet and outlet flow rates measured by cine phase-contrast magnetic resonance imaging or by imposing characteristic young and older adult flow waveform shapes adjusted to cycle-averaged flow rates measured or allometrically scaled to the inlet and outlet areas. Despite appreciable differences in the measured versus assumed flow conditions, the locations and extents of low wall shear stress and elevated relative residence time were broadly consistent; however, the extent of elevated oscillatory shear index was substantially underestimated, more by the use of assumed cycle-averaged flow rates than the assumed flow waveform shape. For studies of individual vessels, use of a characteristic flow waveform shape is likely sufficient, with some benefit offered by scaling to measured cycle-averaged flow rates. For larger-scale studies of many vessels, ranking of cases according to presumed hemodynamic or geometric risk is robust to the assumed flow conditions.

Construction of a Physical Model of the Human Carotid Artery Based Upon In Vivo Magnetic Resonance Images

1999 ◽  
Vol 123 (4) ◽  
pp. 372-376 ◽  
Author(s):  
R. V. Yedavalli ◽  
F. Loth ◽  
A. Yardimci ◽  
W. F. Pritchard ◽  
J. N. Oshinski ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Physical Model ◽  
Flow Model ◽  
Carotid Bifurcation ◽  
Magnetic Resonance Images ◽  
Flow Conditions ◽  
Fused Deposition ◽  
Specific Geometry ◽  
Human Carotid

A method is described for construction of an in vitro flow model based on in vivo measurements of the lumen geometry of the human carotid bifurcation. A large-scale physical model of the vessel lumen was constructed using fused deposition modeling (a rapid prototyping technique) based on magnetic resonance (MR) images of the carotid bifurcation acquired in a healthy volunteer. The lumen negative was then used to construct a flow model for experimental studies that examined the hemodynamic environment of subject-specific geometry and flow conditions. The physical model also supplements physician insight into the three-dimensional geometry of the arterial segment, complementing the two-dimensional images obtained by MR. Study of the specific geometry and flow conditions in patients with vascular disease may contribute to our understanding of the relationship between their hemodynamic environment and conditions that lead to the development and progression of arterial disease.

scholarly journals Net-exergetic, hydraulic and thermal optimization of coaxial heat exchangers using fixed flow conditions instead of fixed flow rates

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Tobias Blanke ◽  
Markus Hagenkamp ◽  
Bernd Döring ◽  
Joachim Göttsche ◽  
Vitali Reger ◽  
...  
Keyword(s):  
Reynolds Number ◽  
Laminar Flow ◽  
Mass Flow ◽  
Flow Rate ◽  
Heat Exchangers ◽  
Circular Ring ◽  
Flow Conditions ◽  
Flow Rates ◽  
Mass Flow Rates ◽  
Pipe Radius

AbstractPrevious studies optimized the dimensions of coaxial heat exchangers using constant mass flow rates as a boundary condition. They show a thermal optimal circular ring width of nearly zero. Hydraulically optimal is an inner to outer pipe radius ratio of 0.65 for turbulent and 0.68 for laminar flow types. In contrast, in this study, flow conditions in the circular ring are kept constant (a set of fixed Reynolds numbers) during optimization. This approach ensures fixed flow conditions and prevents inappropriately high or low mass flow rates. The optimization is carried out for three objectives: Maximum energy gain, minimum hydraulic effort and eventually optimum net-exergy balance. The optimization changes the inner pipe radius and mass flow rate but not the Reynolds number of the circular ring. The thermal calculations base on Hellström’s borehole resistance and the hydraulic optimization on individually calculated linear loss of head coefficients. Increasing the inner pipe radius results in decreased hydraulic losses in the inner pipe but increased losses in the circular ring. The net-exergy difference is a key performance indicator and combines thermal and hydraulic calculations. It is the difference between thermal exergy flux and hydraulic effort. The Reynolds number in the circular ring is instead of the mass flow rate constant during all optimizations. The result from a thermal perspective is an optimal width of the circular ring of nearly zero. The hydraulically optimal inner pipe radius is 54% of the outer pipe radius for laminar flow and 60% for turbulent flow scenarios. Net-exergetic optimization shows a predominant influence of hydraulic losses, especially for small temperature gains. The exact result depends on the earth’s thermal properties and the flow type. Conclusively, coaxial geothermal probes’ design should focus on the hydraulic optimum and take the thermal optimum as a secondary criterion due to the dominating hydraulics.

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