scholarly journals Accuracy of 3D Cartilage Models Generated From MR Images Is Dependent on Cartilage Thickness: Laser Scanner Based Validation of In Vivo Cartilage

2009 ◽  
Vol 131 (12) ◽  
Author(s):  
Seungbum Koo ◽  
Nicholas J. Giori ◽  
Garry E. Gold ◽  
Chris O. Dyrby ◽  
Thomas P. Andriacchi
Keyword(s):  
Laser Scanning ◽  
Shape Matching ◽  
Three Dimensional ◽  
3D Models ◽  
Cartilage Thickness ◽  
Mr Images ◽  
Mr Image ◽  
Scanning Method ◽  
Thickness Measurements

Cartilage morphology change is an important biomarker for the progression of osteoarthritis. The purpose of this study was to assess the accuracy of in vivo cartilage thickness measurements from MR image-based 3D cartilage models using a laser scanning method and to test if the accuracy changes with cartilage thickness. Three-dimensional tibial cartilage models were created from MR images (in-plane resolution of 0.55 mm and thickness of 1.5 mm) of osteoarthritic knees of ten patients prior to total knee replacement surgery using a semi-automated B-spline segmentation algorithm. Following surgery, the resected tibial plateaus were laser scanned and made into 3D models. The MR image and laser-scan based models were registered to each other using a shape matching technique. The thicknesses were compared point wise for the overall surface. The linear mixed-effects model was used for statistical test. On average, taking account of individual variations, the thickness measurements in MRI were overestimated in thinner (<2.5 mm) regions. The cartilage thicker than 2.5 mm was accurately predicted in MRI, though the thick cartilage in the central regions was underestimated. The accuracy of thickness measurements in the MRI-derived cartilage models systemically varied according to native cartilage thickness.

Application of laser scanning technology for modelling real estate objects in 3D cadastre

2018 ◽  
Vol 939 (9) ◽  
pp. 52-63
Author(s):  
M.A. Altyntsev ◽  
A.V. Chernov
Keyword(s):  
Real Estate ◽  
3D Modeling ◽  
Laser Scanning ◽  
Experimental Studies ◽  
Three Dimensional ◽  
3D Models ◽  
Scanning Method ◽  
The Real Estate ◽  
Theoretical Part ◽  
3D Cadastre

The authors present the results of theoretical and experimental studies on the use of laser scanning technology for the 3D-modeling of real estate objects in the cadastre. The result of the theoretical part of the research was a set of parameters for 3D modeling of real estate objects influencing the choice of the scanning method (ground, air or mobile), which showed that when creating separate 3D models of real estate objects (buildings, structures, premises and objects of unfinished construction) the method of ground-based laser scanning should be used. Based on the theoretical part, an experiment on 3D-modeling of a typical real estate object (building) was performed on the basis of data obtained with the method of ground- based laser scanning. The model of the real estate object was built with various degrees of detail to demonstrate its accuracy characteristics, depending on the distance from the scanner stations, the use of photographic materials, etc. The results of the experimental part of the studies show that the model obtained is in full conformity with the current requirements of the legislation in the field of cadastre. The proposed solution can be used as a methodological basis for constructing three-dimensional models in the transition of the Russian Federation to a 3D-cadastre system.

Validation of Cartilage Thickness Calculations Using Indentation Analysis

2010 ◽  
Vol 132 (4) ◽  
Author(s):  
Matthew F. Koff ◽  
Le Roy Chong ◽  
Patrick Virtue ◽  
Dan Chen ◽  
Xioanan Wang ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Measurement Techniques ◽  
Magnetic Resonance Images ◽  
Cartilage Thickness ◽  
Mr Images ◽  
Data Set ◽  
Data Points ◽  
Indentation Analysis ◽  
Thickness Measurements

Different methods have been used to cross-validate cartilage thickness measurements from magnetic resonance images (MRIs); however, a majority of these methods rely on interpolated data points, regional mean and/or maximal thickness, or surface mean thickness for data analysis. Furthermore, the accuracy of MRI cartilage thickness measurements from commercially available software packages has not necessarily been validated and may lead to an under- or overestimation of cartilage thickness. The goal of this study was to perform a matching point-to-point validation of indirect cartilage thickness calculations using a magnetic resonance (MR) image data set with direct cartilage thickness measurements using biomechanical indentation testing at the same anatomical locations. Seven bovine distal femoral condyles were prepared and a novel phantom filled with dilute gadolinium solution was rigidly attached to each specimen. High resolution MR images were acquired, and thickness indentation analysis of the cartilage was performed immediately after scanning. Segmentation of the MR data and cartilage thickness calculation was performed using semi-automated software. Registration of MR and indentation data was performed using the fluid filled phantom. The inter- and intra-examiner differences of the measurements were also determined. A total of 105 paired MRI-indentation thickness data points were analyzed, and a significant correlation between them was found (r=0.88, p<0.0001). The mean difference (±std. dev.) between measurement techniques was 0.00±0.23 mm, with Bland–Altman limits of agreement of 0.45 mm and −0.46 mm. The intra- and inter-examiner measurement differences were 0.03±0.22 mm and 0.05±0.24 mm, respectively. This study validated cartilage thickness measurements from MR images with thickness measurements from indentation by using a novel phantom to register the image-based and laboratory-based data sets. The accuracy of the measurements was comparable to previous cartilage thickness validation studies in literature. The results of this study will aid in validating a tool for clinical evaluation of in-vivo cartilage thickness.

Measurement of erosion state and refractory lining thickness of blast furnace hearth by using three-dimensional laser scanning method

2020 ◽  
Vol 118 (1) ◽  
pp. 106
Author(s):  
Lei Zhang ◽  
Jianliang Zhang ◽  
Kexin Jiao ◽  
Guoli Jia ◽  
Jian Gong ◽  
...  
Keyword(s):  
Blast Furnace ◽  
Laser Scanning ◽  
Refractory Lining ◽  
Three Dimensional ◽  
3D Laser Scanning ◽  
Scanning Method ◽  
Blast Furnace Production ◽  
Severe Erosion ◽  
Residual Thickness ◽  
Minimum Depth

The three-dimensional (3D) model of erosion state of blast furnace (BF) hearth was obtained by using 3D laser scanning method. The thickness of refractory lining can be measured anywhere and the erosion curves were extracted both in the circumferential and height directions to analyze the erosion characteristics. The results show that the most eroded positions located below 20# tuyere with an elevation of 7700 mm and below 24#–25# tuyere with an elevation of 8100 mm, the residual thickness here is only 295 mm. In the circumferential directions, the serious eroded areas located between every two tapholes while the taphole areas were protected well by the bonding material. In the height directions, the severe erosion areas located between the elevation of 7600 mm to 8200 mm. According to the calculation, the minimum depth to ensure the deadman floats in the hearth is 2581 mm, corresponding to the elevation of 7619 mm. It can be considered that during the blast furnace production process, the deadman has been sinking to the bottom of BF hearth and the erosion areas gradually formed at the root of deadman.

scholarly journals High-speed volumetric two-photon fluorescence imaging of neurovascular dynamics

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Jiang Lan Fan ◽  
Jose A. Rivera ◽  
Wei Sun ◽  
John Peterson ◽  
Henry Haeberle ◽  
...  
Keyword(s):  
Blood Flow ◽  
High Speed ◽  
Laser Scanning ◽  
Three Dimensional ◽  
Laser Scanning Microscopy ◽  
Fluorescence Signal ◽  
Imaging Method ◽  
Spatiotemporal Resolution ◽  
Two Photon

AbstractUnderstanding the structure and function of vasculature in the brain requires us to monitor distributed hemodynamics at high spatial and temporal resolution in three-dimensional (3D) volumes in vivo. Currently, a volumetric vasculature imaging method with sub-capillary spatial resolution and blood flow-resolving speed is lacking. Here, using two-photon laser scanning microscopy (TPLSM) with an axially extended Bessel focus, we capture volumetric hemodynamics in the awake mouse brain at a spatiotemporal resolution sufficient for measuring capillary size and blood flow. With Bessel TPLSM, the fluorescence signal of a vessel becomes proportional to its size, which enables convenient intensity-based analysis of vessel dilation and constriction dynamics in large volumes. We observe entrainment of vasodilation and vasoconstriction with pupil diameter and measure 3D blood flow at 99 volumes/second. Demonstrating high-throughput monitoring of hemodynamics in the awake brain, we expect Bessel TPLSM to make broad impacts on neurovasculature research.

Prevascularized, Co-Culture Model for Breast Cancer Drug Development

2012 ◽  
Author(s):  
Lauren Marshall ◽  
Isabel Löwstedt ◽  
Paul Gatenholm ◽  
Joel Berry
Keyword(s):  
Breast Cancer ◽  
Drug Development ◽  
Three Dimensional ◽  
Human Tumor ◽  
3D Models ◽  
Cancer Drug ◽  
Cancer Therapies ◽  
Anti Cancer

The objective of this study was to create 3D engineered tissue models to accelerate identification of safe and efficacious breast cancer drug therapies. It is expected that this platform will dramatically reduce the time and costs associated with development and regulatory approval of anti-cancer therapies, currently a multi-billion dollar endeavor [1]. Existing two-dimensional (2D) in vitro and in vivo animal studies required for identification of effective cancer therapies account for much of the high costs of anti-cancer medications and health insurance premiums borne by patients, many of whom cannot afford it. An emerging paradigm in pharmaceutical drug development is the use of three-dimensional (3D) cell/biomaterial models that will accurately screen novel therapeutic compounds, repurpose existing compounds and terminate ineffective ones. In particular, identification of effective chemotherapies for breast cancer are anticipated to occur more quickly in 3D in vitro models than 2D in vitro environments and in vivo animal models, neither of which accurately mimic natural human tumor environments [2]. Moreover, these 3D models can be multi-cellular and designed with extracellular matrix (ECM) function and mechanical properties similar to that of natural in vivo cancer environments [3].

scholarly journals The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma

2020 ◽  
Vol 21 (15) ◽  
pp. 5499
Author(s):  
Hannah L. Smith ◽  
Stephen A. Beers ◽  
Juliet C. Gray ◽  
Janos M. Kanczler
Keyword(s):  
Three Dimensional ◽  
Chorioallantoic Membrane ◽  
3D Models ◽  
In Ovo ◽  
Future Directions ◽  
3 Dimensional ◽  
In Vivo Animal Models

Treatment for osteosarcoma (OS) has been largely unchanged for several decades, with typical therapies being a mixture of chemotherapy and surgery. Although therapeutic targets and products against cancer are being continually developed, only a limited number have proved therapeutically active in OS. Thus, the understanding of the OS microenvironment and its interactions are becoming more important in developing new therapies. Three-dimensional (3D) models are important tools in increasing our understanding of complex mechanisms and interactions, such as in OS. In this review, in vivo animal models, in vitro 3D models and in ovo chorioallantoic membrane (CAM) models, are evaluated and discussed as to their contribution in understanding the progressive nature of OS, and cancer research. We aim to provide insight and prospective future directions into the potential translation of 3D models in OS.

scholarly journals USE OF IMAGE BASED MODELLING FOR DOCUMENTATION OF INTRICATELY SHAPED OBJECTS

2016 ◽  
Vol XLI-B5 ◽  
pp. 327-334
Author(s):  
M. Marčiš ◽  
P. Barták ◽  
D. Valaška ◽  
M. Fraštia ◽  
O. Trhan
Keyword(s):  
Laser Scanning ◽  
Three Dimensional ◽  
Image Data ◽  
3D Models ◽  
Architectural Elements ◽  
Advantages And Disadvantages ◽  
Interior Spaces ◽  
Automated Processing ◽  
2D Drawing ◽  
Photogrammetric Measurement

In the documentation of cultural heritage, we can encounter three dimensional shapes and structures which are complicated to measure. Such objects are for example spiral staircases, timber roof trusses, historical furniture or folk costume where it is nearly impossible to effectively use the traditional surveying or the terrestrial laser scanning due to the shape of the object, its dimensions and the crowded environment. The actual methods of digital photogrammetry can be very helpful in such cases with the emphasis on the automated processing of the extensive image data. The created high resolution 3D models and 2D orthophotos are very important for the documentation of architectural elements and they can serve as an ideal base for the vectorization and 2D drawing documentation. This contribution wants to describe the various usage of image based modelling in specific interior spaces and specific objects. The advantages and disadvantages of the photogrammetric measurement of such objects in comparison to other surveying methods are reviewed.

scholarly journals Creation of virtual 3D models of the existing architectonic structures using the web resources

Spatium ◽  
2016 ◽  
pp. 30-36 ◽  
Author(s):  
Petar Pejic ◽  
Sonja Krasic
Keyword(s):  
Laser Scanning ◽  
Three Dimensional ◽  
3D Models ◽  
Three Dimensional Model ◽  
Web Resources ◽  
Existing Structures ◽  
Software Packages ◽  
Physical Presence ◽  
The Creation ◽  
Three Dimensional Models

Digital three-dimensional models of the existing architectonic structures are created for the purpose of digitalization of the archive documents, presentation of buildings or an urban entity or for conducting various analyses and tests. Traditional methods for the creation of 3D models of the existing buildings assume manual measuring of their dimensions, using the photogrammetry method or laser scanning. Such approaches require considerable time spent in data acquisition or application of specific instruments and equipment. The goal of this paper is presentation of the procedure for the creation of 3D models of the existing structures using the globally available web resources and free software packages on standard PCs. This shortens the time of the production of a digital three-dimensional model of the structure considerably and excludes the physical presence at the location. In addition, precision of this method was tested and compared with the results acquired in a previous research.

scholarly journals 3D MODELS OF OBJECTS IN PROCESS OF RECONSTRUCTION

2018 ◽  
Vol 13 (1) ◽  
Author(s):  
Jovana Radović
Keyword(s):  
Laser Scanning ◽  
Laser System ◽  
Three Dimensional ◽  
Laser Scanner ◽  
Terrestrial Laser Scanning ◽  
3D Models ◽  
Terrestrial Laser Scanner ◽  
Accurate Data ◽  
Final Model ◽  
Airborne Laser

Within the last years terrestrial and airborne laser scanning has become a powerful technique for fast and efficient three-dimensional data acquisition of different kinds of objects. Airborne laser system (LiDAR) collects accurate georeferenced data of extremely large areas very quickly while the terrestrial laser scanner produces dense and geometrically accurate data. The combination of these two segments of laser scanning provides different areas of application. One of the applications is in the process of reconstruction of objects. Objects recorded with laser scanning technology and transferred into the final model represent the basis for building an object as it was original. In this paper, there will be shown two case studies based on usage of airborne and terrestrial laser scanning and processing of the data collected by them.

scholarly journals Weighing trees with lasers: advances, challenges and opportunities

2018 ◽  
Vol 8 (2) ◽  
pp. 20170048 ◽  
Author(s):  
M. I. Disney ◽  
M. Boni Vicari ◽  
A. Burt ◽  
K. Calders ◽  
S. L. Lewis ◽  
...  
Keyword(s):  
Laser Scanning ◽  
Large Scale ◽  
Three Dimensional ◽  
Point Clouds ◽  
3D Models ◽  
Tree Form ◽  
Form And Function ◽  
Challenges And Opportunities ◽  
And Function ◽  
Non Destructive

Terrestrial laser scanning (TLS) is providing exciting new ways to quantify tree and forest structure, particularly above-ground biomass (AGB). We show how TLS can address some of the key uncertainties and limitations of current approaches to estimating AGB based on empirical allometric scaling equations (ASEs) that underpin all large-scale estimates of AGB. TLS provides extremely detailed non-destructive measurements of tree form independent of tree size and shape. We show examples of three-dimensional (3D) TLS measurements from various tropical and temperate forests and describe how the resulting TLS point clouds can be used to produce quantitative 3D models of branch and trunk size, shape and distribution. These models can drastically improve estimates of AGB, provide new, improved large-scale ASEs, and deliver insights into a range of fundamental tree properties related to structure. Large quantities of detailed measurements of individual 3D tree structure also have the potential to open new and exciting avenues of research in areas where difficulties of measurement have until now prevented statistical approaches to detecting and understanding underlying patterns of scaling, form and function. We discuss these opportunities and some of the challenges that remain to be overcome to enable wider adoption of TLS methods.

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