scholarly journals Increase in Opening Angle in Hypertension Off-Loads the Intimal Stress: A Simulation Study

2009 ◽  
Vol 131 (11) ◽  
Author(s):  
Chong Wang ◽  
Ghassan S. Kassab
Keyword(s):  
Stress Distribution ◽  
Vascular Function ◽  
Vessel Wall ◽  
Circumferential Stress ◽  
Opening Angle ◽  
Protective Mechanism ◽  
Acute Hypertension ◽  
Physiological Loading ◽  
Intimal Layer ◽  
Large Opening

The stress distribution in the vessel wall has important bearing on vascular function including intima, media, and adventitia. The residual strain in the vessel wall has been thought to largely normalize the transmural stress distribution with slightly higher values at the intima. In hypertension, the compensatory increase in opening angle is thought to maintain a uniform stress distribution. We have recently shown that the circumferential stress at adventitia may exceed that at intima at physiological loading due to large opening angle (OA) in normal porcine coronary arteries. The objective of this study was to show that increases in opening angle subsequent hypertension can further shift the stress from the intima to the adventitia. The change in stress distribution during acute hypertension was calculated using available data on the changes in vessel geometry, material property, and internal pressure during hypertension. It was found that the increase in OA following acute hypertension off-loads the stress from intima to adventitia, therefore, relieving some of the stress increase in the intimal layer induced by the sudden pressure increase. This has important implications for hypertension where it may shift the excessive stress from the inner layer to the outer layer. This may be a protective mechanism for the intima layer in hypertension.

scholarly journals A New Observation on the Stress Distribution in the Coronary Artery Wall

2009 ◽  
Vol 131 (11) ◽  
Author(s):  
Chong Wang ◽  
Xiaomei Guo ◽  
Ghassan S. Kassab
Keyword(s):  
Coronary Artery ◽  
Stress Distribution ◽  
Vascular Function ◽  
Stress Gradient ◽  
Circumferential Stress ◽  
Wall Stress ◽  
Opening Angle ◽  
Porcine Coronary Artery ◽  
Physiological Loading ◽  
Health And Disease

The stress distribution in the vessel wall has an important bearing on vascular function in health and disease. We studied the relationship between the transmural stress distribution and the opening angle (OA) to determine the stress gradient. The simulation of wall stress was based on transmural measurements of strain and material properties of coronary arteries in reference to the zero-stress state. A one-layer model with material constants of the intact vessel was used to calculate the circumferential stress distribution. A sensitivity analysis using both one- and two-layer models (intima-media and adventitia layers) was carried out to study the effect of the OA on the circumferential stress distribution and average circumferential stress. A larger OA always shifts the circumferential stress from the intima-media to the adventitia layer. We report a new observation that the circumferential stress at the adventitia may exceed that at the intima at physiological loading due to the larger OA in the porcine coronary artery. This has important implications for growth and remodeling, where an increase in opening angle may shift excessive stress from the inner layer to the outer layer.

Residual Stress and Circumferential Stress Distribution in a Finite Element Model of the Arterial Wall

Volume 2 ◽  
2004 ◽  
Author(s):  
Nooshin Haghighipour ◽  
Mohammad Tafazzoli Shadpour ◽  
Albert Avolio
Keyword(s):  
Residual Stress ◽  
Finite Element ◽  
Stress Distribution ◽  
Tensile Stress ◽  
Arterial Wall ◽  
Stress Component ◽  
Circumferential Stress ◽  
Opening Angle ◽  
Human Aorta ◽  
Endothelial Lining

Stress distribution of the arterial wall is an important factor in biomechanics of arteries. It has been suggested that excessive stress leads to arterial degeneration and lesion formation. In addition to circumferential tensile stress caused by luminal pressure, arterial wall contains circumferential residual stress with compressive and tensile components with maximum values on intima and adventitia respectively. The compressive residual stress component compensates part of maximum tensile stress, and therefore decreases severity of tension on endothelial lining. If an arterial ring is cut in radial direction it opens. The degree of opening angle is a determinant of circumferential residual stress. In this investigation, Finite element modeling was used to evaluate circumferential residual stress in a typical model of cross section of human aorta with differing opening angle and Young’s modulus of elasticity. Results show that residual stress values are influenced by structural and mechanical parameters. Elevation of the opening angle and stiffening of the arterial wall resulted in increase of residual stress level.

Non-Euclidean Stress-Free Configuration of Arteries Accounting for Curl of Axial Strips Sectioned From Vessels

2013 ◽  
Vol 135 (11) ◽  
Author(s):  
Keiichi Takamizawa ◽  
Yasuhide Nakayama
Keyword(s):  
Residual Stress ◽  
Stress Distribution ◽  
Residual Stresses ◽  
Stress Analysis ◽  
Riemannian Geometry ◽  
Axial Stress ◽  
Circumferential Stress ◽  
Arterial Walls ◽  
Physiological Loading ◽  
Residual Strains

It is well known that arteries are subject to residual stress. In earlier studies, the residual stress in the arterial ring relieved by a radial cut was considered in stress analysis. However, it has been found that axial strips sectioned from arteries also curled into arcs, showing that the axial residual stresses were relieved from the arterial walls. The combined relief of circumferential and axial residual stresses must be considered to accurately analyze stress and strain distributions under physiological loading conditions. In the present study, a mathematical model of a stress-free configuration of artery was proposed using Riemannian geometry. Stress analysis for arterial walls under unloaded and physiologically loaded conditions was performed using exponential strain energy functions for porcine and human common carotid arteries. In the porcine artery, the circumferential stress distribution under physiological loading became uniform compared with that without axial residual strain, whereas a gradient of axial stress distribution increased through the wall thickness. This behavior showed almost the same pattern that was observed in a recent study in which approximate analysis accounting for circumferential and axial residual strains was performed, whereas the circumferential and axial stresses increased from the inner surface to the outer surface under a physiological condition in the human common carotid artery of a two-layer model based on data of other recent studies. In both analyses, Riemannian geometry was appropriate to define the stress-free configurations of the arterial walls with both circumferential and axial residual strains.

Effect of Residual Stress and Heterogeneity on Circumferential Stress in the Arterial Wall

2000 ◽  
Vol 122 (4) ◽  
pp. 454-456 ◽  
Author(s):  
S. J. Peterson ◽  
R. J. Okamoto
Keyword(s):  
Residual Stress ◽  
Stress Distribution ◽  
Material Properties ◽  
Arterial Wall ◽  
Circumferential Stress ◽  
Single Species ◽  
Opening Angle ◽  
Layer Model ◽  
Multiple Sources ◽  
The Media

Quantifying the stress distribution through the arterial wall is essential to studies of arterial growth and disease. Previous studies have shown that both residual stress, as measured by opening angle, and differing material properties for the media-intima and the adventitial layers affect the transmural circumferential stress σθ distribution. Because a lack of comprehensive data on a single species and artery has led to combinations from multiple sources, this study determined the sensitivity of σθ to published variations in both opening angle and layer thickness data. We fit material properties to previously published experimental data for pressure–diameter relations and opening angles of rabbit carotid artery, and predicted σθ through the arterial wall at physiologic conditions. Using a one-layer model, the ratio of σθ at the internal wall to the mean σθ decreased from 2.34 to 0.98 as the opening angle increased from 60 to 130 deg. In a two-layer model using a 95 deg opening angle, mean σθ in the adventitia increased (112 percent for 25 percent adventitia) and mean σθ in the media decreased (47 percent for 25 percent adventitia). These results suggest that both residual stress and wall layers have important effects on transmural stress distribution. Thus, experimental measurements of loading curves, opening angles, and wall composition from the same species and artery are needed to accurately predict the transmural stress distribution in the arterial wall. [S0148-0731(00)02204-4]

Research of the Connecting Form about the Spherical Shell and the Nozzle

2011 ◽  
Vol 413 ◽  
pp. 520-523
Author(s):  
Cai Xia Luo
Keyword(s):  
Finite Element ◽  
Stress Distribution ◽  
Finite Element Model ◽  
Spherical Shell ◽  
Maximum Stress ◽  
Peak Stress ◽  
Element Model ◽  
Small Opening ◽  
Large Opening ◽  
Reducing Stress

The Stress Distribution in the Connection of the Spherical Shell and the Opening Nozzle Is Very Complex. Sharp-Angled Transition and Round Transition Are Used Respectively in the Connection in the Light of the Spherical Shell with the Small Opening and the Large One. the Influence of the Two Connecting Forms on Stress Distribution Is Analyzed by Establishing Finite Element Model and Solving it. the Result Shows there Is Obvious Stress Concentration in the Connection. Round Transition Can Reduce the Maximum Stress in Comparison with Sharp-Angled Transition in both Cases of the Small Opening and the Large Opening, Mainly Reducing the Bending Stress and the Peak Stress, but Not the Membrane Stress. the Effect of Round Transition on Reducing Stress Was Not Significant. so Sharp-Angled Transition Should Be Adopted in the Connection when a Finite Element Model Is Built for Simplification in the Future.

Three-Dimensional Stress Distribution in Arteries

1983 ◽  
Vol 105 (3) ◽  
pp. 268-274 ◽  
Author(s):  
C. J. Chuong ◽  
Y. C. Fung
Keyword(s):  
Experimental Data ◽  
Stress Distribution ◽  
Vessel Wall ◽  
Strain Energy ◽  
Arterial Wall ◽  
Three Dimensional ◽  
Strain Energy Function ◽  
Exponential Form ◽  
Strain Relationship ◽  
Longitudinal Stretch

A three-dimensional stress-strain relationship derived from a strain energy function of the exponential form is proposed for the arterial wall. The material constants are identified from experimental data on rabbit arteries subjected to inflation and longitudinal stretch in the physiological range. The objectives are: 1) to show that such a procedure is feasible and practical, and 2) to call attention to the very large variations in stresses and strains across the vessel wall under the assumptions that the tissue is incompressible and stress-free when all external load is removed.

scholarly journals Revealing the Mass Loss Structures of Four Key Massive Binaries Using Optical Spectropolarimetry

2014 ◽  
Vol 9 (S307) ◽  
pp. 336-341
Author(s):  
Jamie R. Lomax
Keyword(s):  
Mass Loss ◽  
Binary Systems ◽  
Hot Spot ◽  
Polarized Light ◽  
Opening Angle ◽  
Geometric Information ◽  
Intrinsic Polarization ◽  
Polarization Component ◽  
Circumstellar Material ◽  
Large Opening

AbstractThe majority of massive stars are members of binary systems. However, in order to understand their evolutionary pathways, mass and angular momentum loss from these systems needs to be well characterized. Self-consistent explanations for their behavior across many wavelength regimes need to be valid in order to illuminate key evolutionary phases. I present the results of linear spectropolarimetric studies of three key binaries (β Lyrae, V356 Sgr, V444 Cyg, and WR 140) which reveal important geometric information about their circumstellar material. β Lyrae exhibits a repeatable discrepancy between secondary eclipse in the total and polarized light curves that indicates an accretion hot spot has formed on the edge of the disk in the system. The existence of this hot spot and its relationship to bipolar outflows within the system is important in the understanding of mass transfer dynamics in Roche-lobe overflow binaries. Preliminary work on V356 Sgr suggests the system maybe surrounded by a common envelope. V444 Cyg shows evidence that its shock creates a cone with a large opening angle of missing material around the WN star. This suggests the effects of radiative inhibition or braking, can be significant contributors to the location and shape of the shock within colliding wind binaries. The intrinsic polarization component of WR 140 is likely due to the formation of dust within the system near periastron passages. Continued work on these and additional objects will provide new and important constraints on the mass loss structures within binary systems.

scholarly journals Resistance and aerobic exercise protects against acute endothelial impairment induced by a single exposure to hypertension during exertion

2011 ◽  
Vol 110 (4) ◽  
pp. 1013-1020 ◽  
Author(s):  
Shane A. Phillips ◽  
Emon Das ◽  
Jingli Wang ◽  
Kirkwood Pritchard ◽  
David D. Gutterman
Keyword(s):  
Blood Pressure ◽  
Resistance Exercise ◽  
Aerobic Exercise ◽  
Vascular Function ◽  
Cardiovascular Health ◽  
Weight Lifting ◽  
Acute Hypertension ◽  
Before And After ◽  
Weight Lifters ◽  
Blood Pressure Responses

Resistance and aerobic exercise is recommended for cardiovascular health and disease prevention. However, the accompanying increase in arterial pressure during resistance exercise may be detrimental to vascular health. This study tests the vascular benefits of aerobic compared with resistance exercise on preventing impaired vascular function induced by a single weight lifting session that is associated with acute hypertension. Healthy, lean sedentary (SED) subjects, weight lifters, runners (>15 miles/wk), and cross trainers (chronic aerobic and resistance exercisers), underwent a single progressive leg press weight lifting session with blood pressure measurements. Brachial artery flow-mediated vasodilation (FMD; an index of arterial endothelial function) was determined using ultrasonography immediately before and after weight lifting. Sublingual nitroglycerin (0.4 mg) was used to determine endothelium-independent dilation after weight lifting. All subjects were normotensive with similar blood pressure responses during exercise. Baseline FMD was lower in runners (5.4 ± 0.5%; n = 13) and cross trainers (4.44 ± 0.3%; n = 13) vs. SED (8.5 ± 0.8%; n = 13; P = 0.037). Brachial FMD improved in conditioned weight lifters (to 8.8 ± 0.9%; P = 0.007) and runners (to 7.6 ± 0.6%; P < 0.001) but not cross trainers (to 5.3 ± 0.6%; P = NS) after acute hypertension. FMD was decreased in SED (to 5.7 ± 0.4%; P = 0.019). Dilation to nitroglycerin was similar among groups. These data suggest that endothelial responses are maintained after exposure to a single bout of weight lifting in resistance and aerobic athletes. Resistance and aerobic exercise may confer similar protection against acute vascular insults such as exertional hypertension.

Sign in / Sign up

Export Citation Format

Share Document