The Effect of Stress Concentration on Bone Remodeling: Theoretical Predictions

1989 ◽  
Vol 111 (4) ◽  
pp. 355-360 ◽  
Author(s):  
K. Firoozbakhsh ◽  
M. Aleyaasin
Keyword(s):  
Stress Concentration ◽  
Bone Resorption ◽  
Bone Remodeling ◽  
Compressive Stress ◽  
Bone Structure ◽  
Compressive Load ◽  
Elliptical Hole ◽  
Special Cases ◽  
Theoretical Predictions ◽  
Elastic Coefficients

Theoretical predictions of internal bone remodeling around an elliptical hole are studied. The internal remodeling theory due to Cowin and Hegedus is employed. The bone is modeled as an initially homogeneous adaptive elastic plate with an elliptical hole under a superposed steady compressive load. It is shown that there will exist a final inhomogeneous remodeling distribution around the hole that will disappear away from the hole. The remodeling is such that the compressive stress concentration causes the bone structure to evolve to one of greater density and stiffer elastic coefficients. The speed of remodeling around the hole and its variation with respect to distance is investigated and discussed. It is shown that the rate of bone reinforcement in the area of compressive stress concentration is much higher than the rate of bone resorption in the area of existing tensile stress. Special cases of a circular hole and vertical and horizontal slots are studied and discussed.

scholarly journals Numerical Simulation of Strength, Deformation, and Failure Characteristics of Rock with Fissure Hole Defect

2020 ◽  
Vol 2020 ◽  
pp. 1-15 ◽  
Author(s):  
Shaojie Chen ◽  
Zhiguo Xia ◽  
Fan Feng
Keyword(s):  
Elastic Modulus ◽  
Stress Concentration ◽  
Compressive Stress ◽  
Failure Modes ◽  
Elliptical Hole ◽  
Major Axis ◽  
Minor Axis ◽  
Peak Strain ◽  
Secondary Cracks ◽  
The Right

Using discrete element software, namely, particle flow code as two-dimensional program (PFC2D), two types of models were established: vertical fissure hole combination and horizontal fissure hole combination with ratios of major and minor axis of ellipse being 1, 1.2, 1.5, 2, and 3, which corresponded to a total of ten samples. The failure mode, mechanical behavior, and stress state before and after crack generation in elliptical hole crack combination models with different ratios of major and minor axis were analyzed. The crack development, stress field evolution, and acoustic emission characteristics of the vertical fissure model and horizontal fissure model were studied at the optimized ratio of major and minor axis of ellipse being 1.5. The results showed that elliptical hole fissure with different ratios of major and minor axis resulted in the decrease in the strength and elastic modulus of rock and increase in the peak strain of rock. The effect of the horizontal fissure model on the peak strength, peak strain, and elastic modulus of rock was found to be greater than that of the vertical fissure hole model. Ellipses with different ratios of major and minor axis in various models slightly influenced the rock failure modes, and their failure modes corresponded to tensile shear failure and tensile failure. Before crack formation, the tensile stress concentration areas of each model were, respectively, distributed at the upper and lower ends of the vertical fissure and the major axis of ellipse, and the compressive stress concentration areas were distributed at both ends of the major axis of ellipse and the fissure in the horizontal direction. After the model failed, the compressive stress concentration areas of the vertical fissure model and the horizontal fissure model transferred to the left upper part and the right upper part of the model along the left end of the hole and the right end of the fissure, respectively. When the ratio of major and minor axis of ellipse was 1.5, cracks in the vertical model and the horizontal model of fissure developed along the axial direction at the ends of cracks and holes, respectively, and then secondary cracks were generated at the ends of left and right sides. The maximum compressive stress in each stage of the vertical fissure model was greater than that of the horizontal fissure model, and when the model was damaged, its stress release was more.

scholarly journals Cigarette smoke-associated inflammation impairs bone remodeling through NFκB activation

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Yi Lu ◽  
Yuanpu Peter Di ◽  
Ming Chang ◽  
Xin Huang ◽  
Qiuyan Chen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Resorption ◽  
Bone Formation ◽  
Bone Remodeling ◽  
Cigarette Smoke ◽  
Osteoblast Differentiation ◽  
Bone Structure ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Bone Homeostasis

Abstract Background Cigarette smoking constitutes a major lifestyle risk factor for osteoporosis and hip fracture. It is reported to impair the outcome of many clinical procedures, such as wound infection treatment and fracture healing. Importantly, although several studies have already demonstrated the negative correlation between cigarette consume and impaired bone homeostasis, there is still a poor understanding of how does smoking affect bone health, due to the lack of an adequately designed animal model. Our goal was to determine that cigarette smoke exposure impairs the dynamic bone remodeling process through induction of bone resorption and inhibition of bone formation. Methods We developed cigarette smoke exposure protocols exposing mice to environmental smoking for 10 days or 3 months to determine acute and chronic smoke exposure effects. We used these models, to demonstrate the effect of smoking exposure on the cellular and molecular changes of bone remodeling and correlate these early alterations with subsequent bone structure changes measured by microCT and pQCT. We examined the bone phenotype alterations in vivo and ex vivo in the acute and chronic smoke exposure mice by measuring bone mineral density and bone histomorphometry. Further, we measured osteoclast and osteoblast differentiation gene expression levels in each group. The function changes of osteoclast or osteoblast were evaluated. Results Smoke exposure caused a significant imbalance between bone resorption and bone formation. A 10-day exposure to cigarette smoke sufficiently and effectively induced osteoclast activity, leading to the inhibition of osteoblast differentiation, although it did not immediately alter bone structure as demonstrated in mice exposed to smoke for 3 months. Cigarette smoke exposure also induced DNA-binding activity of nuclear factor kappaB (NFκB) in osteoclasts, which subsequently gave rise to changes in bone remodeling-related gene expression. Conclusions Our findings suggest that smoke exposure induces RANKL activation-mediated by NFκB, which could be a “smoke sensor” for bone remodeling.

scholarly journals Stress analysis of infinite laminated composite plate with elliptical cutout under different in plane loadings in hygrothermal environment

2021 ◽  
Vol 8 (1) ◽  
pp. 1-12
Author(s):  
Ashok Magar ◽  
Achchhe Lal
Keyword(s):  
Stress Concentration ◽  
Stress Distribution ◽  
Composite Plate ◽  
Volume Fraction ◽  
Elliptical Hole ◽  
Laminated Composite ◽  
Laminated Composite Plate ◽  
Concentration Changes ◽  
Hygrothermal Environment ◽  
Plate Analysis

Abstract This paper presents the solution of stress distribution around elliptical cutout in an infinite laminated composite plate. Analysis is done for in plane loading under hygrothermal environment. The formulation to obtain stresses around elliptical hole is based on Muskhelishvili’s complex variable method. The effect of fibre angle, type of in plane loading, volume fraction of fibre, change in temperature, fibre materials, stacking sequence and environmental conditions on stress distribution around elliptical hole is presented. The study revealed, these factors have significant effect on stress concentration in hygrothermal environment and stress concentration changes are significant with change in temperature.

scholarly journals Pathogenic variants in GNPTAB and GNPTG encoding distinct subunits of GlcNAc-1-phosphotransferase differentially impact bone resorption in patients with mucolipidosis type II and III

2021 ◽  
Author(s):  
Giorgia Di Lorenzo ◽  
Lena M. Westermann ◽  
Timur A. Yorgan ◽  
Julian Stürznickel ◽  
Nataniel F. Ludwig ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Remodeling ◽  
Bone Cells ◽  
Collagen Crosslinks ◽  
Clinical Criteria ◽  
Pathogenic Variants ◽  
Bone Biopsies ◽  
Appropriate Therapy ◽  
Alpha Beta ◽  
Deficient Mice

Abstract Purpose Pathogenic variants in GNPTAB and GNPTG, encoding different subunits of GlcNAc-1-phosphotransferase, cause mucolipidosis (ML) II, MLIII alpha/beta, and MLIII gamma. This study aimed to investigate the cellular and molecular bases underlying skeletal abnormalities in patients with MLII and MLIII. Methods We analyzed bone biopsies from patients with MLIII alpha/beta or MLIII gamma by undecalcified histology and histomorphometry. The skeletal status of Gnptgkoand Gnptab-deficient mice was determined and complemented by biochemical analysis of primary Gnptgko bone cells. The clinical relevance of the mouse data was underscored by systematic urinary collagen crosslinks quantification in patients with MLII, MLIII alpha/beta, and MLIII gamma. Results The analysis of iliac crest biopsies revealed that bone remodeling is impaired in patients with GNPTAB-associated MLIII alpha/beta but not with GNPTG-associated MLIII gamma. Opposed to Gnptab-deficient mice, skeletal remodeling is not affected in Gnptgko mice. Most importantly, patients with variants in GNPTAB but not in GNPTG exhibited increased bone resorption. Conclusion The gene-specific impact on bone remodeling in human individuals and in mice proposes distinct molecular functions of the GlcNAc-1-phosphotransferase subunits in bone cells. We therefore appeal for the necessity to classify MLIII based on genetic in addition to clinical criteria to ensure appropriate therapy.

scholarly journals The Development of Molecular Biology of Osteoporosis

2021 ◽  
Vol 22 (15) ◽  
pp. 8182
Author(s):  
Yongguang Gao ◽  
Suryaji Patil ◽  
Jingxian Jia
Keyword(s):  
Bone Resorption ◽  
Molecular Biology ◽  
Bone Formation ◽  
Bone Mass ◽  
Bone Remodeling ◽  
Bone Cells ◽  
Cell Activity ◽  
Bone Cell ◽  
Bone Disorders ◽  
Molecular Aspects

Osteoporosis is one of the major bone disorders that affects both women and men, and causes bone deterioration and bone strength. Bone remodeling maintains bone mass and mineral homeostasis through the balanced action of osteoblasts and osteoclasts, which are responsible for bone formation and bone resorption, respectively. The imbalance in bone remodeling is known to be the main cause of osteoporosis. The imbalance can be the result of the action of various molecules produced by one bone cell that acts on other bone cells and influence cell activity. The understanding of the effect of these molecules on bone can help identify new targets and therapeutics to prevent and treat bone disorders. In this article, we have focused on molecules that are produced by osteoblasts, osteocytes, and osteoclasts and their mechanism of action on these cells. We have also summarized the different pharmacological osteoporosis treatments that target different molecular aspects of these bone cells to minimize osteoporosis.

scholarly journals Bone Remodeling and the Role of TRAF3 in Osteoclastic Bone Resorption

2018 ◽  
Vol 9 ◽  
Author(s):  
Brendan F. Boyce ◽  
Jinbo Li ◽  
Lianping Xing ◽  
Zhenqiang Yao
Keyword(s):  
Bone Resorption ◽  
Bone Remodeling ◽  
Osteoclastic Bone Resorption

scholarly journals Bisphosphonates

2006 ◽  
Vol 50 (4) ◽  
pp. 735-744 ◽  
Author(s):  
Michael McClung
Keyword(s):  
Bone Resorption ◽  
Bone Loss ◽  
Bone Turnover ◽  
Bone Structure ◽  
Clinical Settings ◽  
Low Bone Mass ◽  
Dosing Regimen ◽  
Drug Induced ◽  
Excellent Safety Profile ◽  
Reduce Fracture Risk

Osteoporosis is the result of bone loss due to an imbalance in bone turnover such that bone resorption exceeds bone formation. Bisphosphonates are potent inhibitors of osteoclast activity that reduce bone turnover and re-establish the balance between bone resorption and formation. In clinical studies, several bisphosphonates prevent bone loss, preserve bone structure, improve bone strength and, in patients with osteoporosis, substantially reduce fracture risk. They are effective in multiple clinical settings including postmenopausal osteoporosis, low bone mass in men and drug-induced bone loss. Intermittent oral dosing and intravenous administration are more convenient than the original daily dosing regimen. These drugs are generally well tolerated and have an excellent safety profile in that serious side effects are uncommon. Potent bisphosphonates are generally the preferred treatment option for most patients with or at risk for osteoporosis.

scholarly journals Bone remodeling stages under physiological conditions and glucocorticoid in excess: Focus on cellular and molecular mechanisms

2021 ◽  
Vol 12 (2) ◽  
pp. 212-227
Author(s):  
V. V. Povoroznyuk ◽  
N. V. Dedukh ◽  
M. A. Bystrytska ◽  
V. S. Shapovalov
Keyword(s):  
Growth Factors ◽  
Bone Resorption ◽  
Signaling Pathways ◽  
Bone Remodeling ◽  
Molecular Mechanisms ◽  
Signaling Molecules ◽  
Physiological Conditions ◽  
Bone Cell Differentiation ◽  
Repressive Effect

This review provides a rationale for the cellular and molecular mechanisms of bone remodeling stages under physiological conditions and glucocorticoids (GCs) in excess. Remodeling is a synchronous process involving bone resorption and formation, proceeding through stages of: (1) resting bone, (2) activation, (3) bone resorption, (4) reversal, (5) formation, (6) termination. Bone remodeling is strictly controlled by local and systemic regulatory signaling molecules. This review presents current data on the interaction of osteoclasts, osteoblasts and osteocytes in bone remodeling and defines the role of osteoprogenitor cells located above the resorption area in the form of canopies and populating resorption cavities. The signaling pathways of proliferation, differentiation, viability, and cell death during remodeling are presented. The study of signaling pathways is critical to understanding bone remodeling under normal and pathological conditions. The main signaling pathways that control bone resorption and formation are RANK / RANKL / OPG; M-CSF – c-FMS; canonical and non-canonical signaling pathways Wnt; Notch; MARK; TGFβ / SMAD; ephrinB1/ephrinB2 – EphB4, TNFα – TNFβ, and Bim – Bax/Bak. Cytokines, growth factors, prostaglandins, parathyroid hormone, vitamin D, calcitonin, and estrogens also act as regulators of bone remodeling. The role of non-encoding microRNAs and long RNAs in the process of bone cell differentiation has been established. MicroRNAs affect many target genes, have both a repressive effect on bone formation and activate osteoblast differentiation in different ways. Excess of glucocorticoids negatively affects all stages of bone remodeling, disrupts molecular signaling, induces apoptosis of osteocytes and osteoblasts in different ways, and increases the life cycle of osteoclasts. Glucocorticoids disrupt the reversal stage, which is critical for the subsequent stages of remodeling. Negative effects of GCs on signaling molecules of the canonical Wingless (WNT)/β-catenin pathway and other signaling pathways impair osteoblastogenesis. Under the influence of excess glucocorticoids biosynthesis of biologically active growth factors is reduced, which leads to a decrease in the expression by osteoblasts of molecules that form the osteoid. Glucocorticoids stimulate the expression of mineralization inhibitor proteins, osteoid mineralization is delayed, which is accompanied by increased local matrix demineralization. Although many signaling pathways involved in bone resorption and formation have been discovered and described, the temporal and spatial mechanisms of their sequential turn-on and turn-off in cell proliferation and differentiation require additional research.

scholarly journals Energy Metabolism of Bone

2017 ◽  
Vol 45 (7) ◽  
pp. 887-893 ◽  
Author(s):  
Katherine J. Motyl ◽  
Anyonya R. Guntur ◽  
Adriana Lelis Carvalho ◽  
Clifford J. Rosen
Keyword(s):  
Bone Remodeling ◽  
Energy Homeostasis ◽  
Bone Structure ◽  
Bone Cells ◽  
Bone Cell ◽  
Whole Body ◽  
Blood Calcium ◽  
Micro Cracks ◽  
Intimate Link ◽  
Body Energy

Biological processes utilize energy and therefore must be prioritized based on fuel availability. Bone is no exception to this, and the benefit of remodeling when necessary outweighs the energy costs. Bone remodeling is important for maintaining blood calcium homeostasis, repairing micro cracks and fractures, and modifying bone structure so that it is better suited to withstand loading demands. Osteoclasts, osteoblasts, and osteocytes are the primary cells responsible for bone remodeling, although bone marrow adipocytes and other cells may also play an indirect role. There is a renewed interest in bone cell energetics because of the potential for these processes to be targeted for osteoporosis therapies. In contrast, due to the intimate link between bone and energy homeostasis, pharmaceuticals that treat metabolic disease or have metabolic side effects often have deleterious bone consequences. In this brief review, we will introduce osteoporosis, discuss how bone cells utilize energy to function, evidence for bone regulating whole body energy homeostasis, and some of the unanswered questions and opportunities for further research in the field.

Sign in / Sign up

Export Citation Format

Share Document