Adaptive Thermal Modeling: A Concept for Measurement of Local Blood Perfusion in Heated Tissues

1986 ◽  
Vol 108 (4) ◽  
pp. 306-311 ◽  
Author(s):  
H. Arkin ◽  
M. M. Chen ◽  
K. R. Holmes
Keyword(s):  
Numerical Technique ◽  
Thermal Modeling ◽  
Blood Perfusion ◽  
Transient Temperature ◽  
Second Phase ◽  
Two Phase ◽  
Local Tissue ◽  
Transient Temperature Field ◽  
Near Future

A new Adaptive Thermal Modeling (ATM) method for the measurement of local tissue blood perfusion rate is introduced. The method is based on a two-phase numerical technique. The first phase includes a fast, finite difference scheme for solution of the transient temperature field. The second phase involves iterative corrections of the perfusion until the modeled temperatures coincide with those measured by the temperature sensors. The results obtained from computer generated “data”, as well as from laboratory experiments demonstrate the potential capability of the ATM method to continuously measure local perfusion rates in heated tissues. Rigorous analysis of the technique is planned for the near future so that it can be applied to in vivo measurements of local tissue blood perfusions.

scholarly journals Three-Dimensional Analysis of the In Vivo Motion of Implantable Cardioverter Defibrillator Leads

2021 ◽  
Author(s):  
Tamas Szili-Torok ◽  
Jens Rump ◽  
Torsten Luther ◽  
Sing-Chien Yap
Keyword(s):  
Three Dimensional ◽  
Second Phase ◽  
Two Phase ◽  
Maximum Curvature ◽  
Phase Study ◽  
Absolute Curvature ◽  
Icd Leads ◽  
Lead Testing ◽  
Design And Testing

Abstract Better understanding of the lead curvature, movement and their spatial distribution may be beneficial in developing lead testing methods, guiding implantations and improving life expectancy of implanted leads. Objective The aim of this two-phase study was to develop and test a novel biplane cine-fluoroscopy-based method to evaluate input parameters for bending stress in leads based on their in vivo 3D motion using precisely determined spatial distributions of lead curvatures. Potential tensile, compressive or torque forces were not subjects of this study. Methods A method to measure lead curvature and curvature evolution was initially tested in a phantom study. In the second phase using this model 51 patients with implanted ICD leads were included. A biplane cine-fluoroscopy recording of the intracardiac region of the lead was performed. The lead centerline and its motion were reconstructed in 3D and used to define lead curvature and curvature changes. The maximum absolute curvature Cmax during a cardiac cycle, the maximum curvature amplitude Camp and the maximum curvature Cmax@amp at the location of Camp were calculated. These parameters can be used to characterize fatigue stress in a lead under cyclical bending. Results The medians of Camp and Cmax@amp were 0.18 cm−1 and 0.42 cm−1, respectively. The median location of Cmax was in the atrium whereas the median location of Camp occurred close to where the transit through the tricuspid valve can be assumed. Increased curvatures were found for higher slack grades. Conclusion Our results suggest that reconstruction of 3D ICD lead motion is feasible using biplane cine-fluoroscopy. Lead curvatures can be computed with high accuracy and the results can be implemented to improve lead design and testing.

scholarly journals CFD Model for Aircraft Ground Deicing: Verification and Validation of an Extended Enthalpy-Porosity Technique in Particulate Two Phase Flows

Fluids ◽  
2021 ◽  
Vol 6 (6) ◽  
pp. 210
Author(s):  
Sami Ernez ◽  
François Morency
Keyword(s):  
Heat Transfer ◽  
Melting Process ◽  
Transient Temperature ◽  
Ice Melting ◽  
Two Phase ◽  
Transient Temperature Field ◽  
Proposed Model ◽  
Deicing Fluid ◽  
Cfd Method ◽  
Surface Ice

Researchers have focused in the last five years on modelling the aircraft ground deicing process using CFD (computational fluid dynamics) in order to reduce its costs and pollution. As preliminary efforts, those studies did not model the ice melting nor the diffusion between deicing fluids and water resulting from the melting process. This paper proposes a CFD method to simulate this process filling these gaps. A particulate two-phase flow approach is used to model the spray impact on ice near the contaminated surface. Ice melting is modelled using an extended version of the enthalpy-porosity technique. The water resulting from the melting process is diffused into the deicing fluid forming a single-phase film. This paper presents a new model of the process. The model is verified and validated through three steps. (i) verification of the species transport. (ii) validation of the transient temperature field of a mixture. (iii) validation of the convective heat transfer of an impinging spray. The permeability coefficient of the enthalpy-porosity technique is then calibrated. The proposed model proved to be a suitable candidate for a parametric study of the aircraft ground deicing process. On the validation test cases, the precision of heat transfer prediction exceeds 88%. The model has the ability of predicting the deicing time and the deicing fluid quantities needed to decontaminate a surface.

A Comparison of Tem and Apfim to the Interpretation of Modulated Microstructures

1985 ◽  
Vol 43 ◽  
pp. 70-71
Author(s):  
M.G. Burke ◽  
M.K. Miller
Keyword(s):  
Low Temperature ◽  
Microstructural Characterization ◽  
Superlattice Reflection ◽  
High Volume ◽  
Atom Probe ◽  
Dark Field ◽  
Miscibility Gap ◽  
Second Phase ◽  
Two Phase ◽  
Probe Field

Interpretation of fine-scale microstructures containing high volume fractions of second phase is complex. In particular, microstructures developed through decomposition within low temperature miscibility gaps may be extremely fine. This paper compares the morphological interpretations of such complex microstructures by the high-resolution techniques of TEM and atom probe field-ion microscopy (APFIM).The Fe-25 at% Be alloy selected for this study was aged within the low temperature miscibility gap to form a <100> aligned two-phase microstructure. This triaxially modulated microstructure is composed of an Fe-rich ferrite phase and a B2-ordered Be-enriched phase. The microstructural characterization through conventional bright-field TEM is inadequate because of the many contributions to image contrast. The ordering reaction which accompanies spinodal decomposition in this alloy permits simplification of the image by the use of the centered dark field technique to image just one phase. A CDF image formed with a B2 superlattice reflection is shown in fig. 1. In this CDF micrograph, the the B2-ordered Be-enriched phase appears as bright regions in the darkly-imaging ferrite. By examining the specimen in a [001] orientation, the <100> nature of the modulations is evident.

THE DYNAMIC FRACTURE OF TWO PHASE ALLOYS WITH SECOND PHASE INCLUSIONS

1985 ◽  
Vol 46 (C5) ◽  
pp. C5-251-C5-255
Author(s):  
S. Pytel ◽  
L. Wojnar
Keyword(s):  
Dynamic Fracture ◽  
Second Phase ◽  
Two Phase

Platelet Microtubules in Clot Structure Formation and Contractile Force Generation: Investigation of a Controversy

1986 ◽  
Vol 56 (01) ◽  
pp. 023-027 ◽  
Author(s):  
C J Jen ◽  
L V McIntire
Keyword(s):  
Network Formation ◽  
Contractile Force ◽  
Second Phase ◽  
Clot Retraction ◽  
Forming Process ◽  
Microtubule Organization ◽  
Physiological Processes ◽  
Fibrin Network ◽  
Two Parameters

SummaryWhether platelet microtubules are involved in clot retraction/ contraction has been controversial. To address this question we have simultaneously measured two clotting parameters, clot structural rigidity and isometric contractile force, using a rheological technique. For recalcified PRP clots these two parameters began rising together at about 15 min after CaCl2 addition. In the concentration range affecting microtubule organization in platelets, colchicine, vinca alkaloids and taxol demonstrated insignificant effects on both clotting parameters of a recalcified PRP clot. For PRP clots induced by adding small amounts of exogenous thrombin, the kinetic curves of clot rigidity were biphasic and without a lag time. The first phase corresponded to a platelet-independent network forming process, while the second phase corresponded to a platelet-dependent process. These PRP clots began generating contractile force at the onset of the second phase. For both rigidity and force parameters, only the second phase of clotting kinetics was retarded by microtubule affecting reagents. When PRP samples were clotted by adding a mixture of CaCl2 and thrombin, the second phase clotting was accelerated and became superimposed on the first phase. The inhibitory effects of micro tubule affecting reagents became less pronounced. Thrombin clotting of a two-component system (washed platelets/ purified fibrinogen) was also biphasic, with the second phase being microtubule-dependent. In conclusion, platelet microtubules are important in PRP clotted with low concentrations of thrombin, during which fibrin network formation precedes platelet-fibrin interactions. On the other hand they are unimportant if a PRP clot is induced by recalcification, during which the fibrin network is constructed in the presence of platelet-fibrin interactions. The latter is likely to be more analogous to physiological processes in vivo.

Behaviour of air injection nozzles in dissolved air flotation

1995 ◽  
Vol 31 (3-4) ◽  
pp. 25-35 ◽  
Author(s):  
E. M. Rykaart ◽  
J. Haarhoff
Keyword(s):  
Bubble Coalescence ◽  
Second Phase ◽  
Initial Growth ◽  
Two Phase ◽  
Dissolved Air Flotation ◽  
Nozzle Orifice ◽  
Pressure Release ◽  
Air Volume ◽  
Air Flotation ◽  
Dissolved Air

A simple two-phase conceptual model is postulated to explain the initial growth of microbubbles after pressure release in dissolved air flotation. During the first phase bubbles merely expand from existing nucleation centres as air precipitates from solution, without bubble coalescence. This phase ends when all excess air is transferred to the gas phase. During the second phase, the total air volume remains the same, but bubbles continue to grow due to bubble coalescence. This model is used to explain the results from experiments where three different nozzle variations were tested, namely a nozzle with an impinging surface immediately outside the nozzle orifice, a nozzle with a bend in the nozzle channel, and a nozzle with a tapering outlet immediately outside the nozzle orifice. From these experiments, it is inferred that the first phase of bubble growth is completed at approximately 1.7 ms after the start of pressure release.

Some 1-substitution derivatives of 4-aryl-2,3-dihalogeno-1-naphthols

1984 ◽  
Vol 49 (1) ◽  
pp. 110-121 ◽  
Author(s):  
Jiří Křepelka ◽  
Drahuše Vlčková ◽  
Milan Mělka
Keyword(s):  
Thionyl Chloride ◽  
Oxirane Ring ◽  
Secondary Amines ◽  
Two Phase ◽  
Lytic Effect ◽  
Primary And Secondary Amines ◽  
Phase Medium ◽  
Chloro Derivatives ◽  
Derivatives Of

Alkylation of derivatives of 4-aryl-1-naphthols (I-V) by 2,3-epoxypropyl chloride in methanolic sodium hydroxide gave epoxy derivatives VI, VIII, IX, XI and XII, apart from products of cleavage of the oxirane ring, VII and X. Analogous alkylation of compounds I, IV and V by 2-(N,N-diethylamino)ethyl chloride hydrochloride in a two-phase medium afforded basic ethers XIII to XV. The cleavage of the oxirane ring in compound VI by the action of primary and secondary amines, piperidine and substituted piperazines led to compounds XVI-XXIV. Reaction of thionyl chloride with compounds XXI, XXII and XXIV gave chloro derivatives XXV-XXVII.Exposure of compound XXII to 4-methylbenzenesulfonyl chloride produced compound XXVIII, retaining the secondary alcoholic group. In an antineoplastic screening in vivo none of the compounds prepared had an appreciable activity. Compound XVII, being an analogue of propranolol, was used in the test of isoproterenolic tachycardia, and showed a beta-lytic effect comparable with that of propranol.

scholarly journals A novel two-phase cycle algorithm for effective cyber intrusion detection in edge computing

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Yiguang Gong ◽  
Yunping Liu ◽  
Chuanyang Yin
Keyword(s):  
Intrusion Detection ◽  
Optimal Parameter ◽  
Edge Computing ◽  
Cloud Services ◽  
Second Phase ◽  
Pareto Optimal ◽  
Two Phase ◽  
Multi Objective ◽  
Phase Cycle ◽  
Positive Rate

AbstractEdge computing extends traditional cloud services to the edge of the network, closer to users, and is suitable for network services with low latency requirements. With the rise of edge computing, its security issues have also received increasing attention. In this paper, a novel two-phase cycle algorithm is proposed for effective cyber intrusion detection in edge computing based on a multi-objective genetic algorithm (MOGA) and modified back-propagation neural network (MBPNN), namely TPC-MOGA-MBPNN. In the first phase, the MOGA is employed to build a multi-objective optimization model that tries to find the Pareto optimal parameter set for MBPNN. The Pareto optimal parameter set is applied for simultaneous minimization of the average false positive rate (Avg FPR), mean squared error (MSE) and negative average true positive rate (Avg TPR) in the dataset. In the second phase, some MBPNNs are created based on the parameter set obtained by MOGA and are trained to search for a more optimal parameter set locally. The parameter set obtained in the second phase is used as the input of the first phase, and the training process is repeated until the termination criteria are reached. A benchmark dataset, KDD cup 1999, is used to demonstrate and validate the performance of the proposed approach for intrusion detection. The proposed approach can discover a pool of MBPNN-based solutions. Combining these MBPNN solutions can significantly improve detection performance, and a GA is used to find the optimal MBPNN combination. The results show that the proposed approach achieves an accuracy of 98.81% and a detection rate of 98.23% and outperform most systems of previous works found in the literature. In addition, the proposed approach is a generalized classification approach that is applicable to the problem of any field having multiple conflicting objectives.

scholarly journals A Decade in Trying to Increase Hand Hygiene—Finally Success

2020 ◽  
Vol 41 (S1) ◽  
pp. s93-s94
Author(s):  
Linda Huddleston ◽  
Sheila Bennett ◽  
Christopher Hermann
Keyword(s):  
Hand Hygiene ◽  
Hand Hygiene Compliance ◽  
Compliance Rate ◽  
Bloodstream Infections ◽  
Central Line ◽  
Second Phase ◽  
Two Phase ◽  
Hygiene Compliance ◽  
Tract Infections ◽  
The Voice

Background: Over the past 10 years, a rural health system has tried 10 different interventions to reduce hospital-associated infections (HAIs), and only 1 intervention has led to a reduction in HAIs. Reducing HAIs is a goal of nearly all hospitals, and improper hand hygiene is widely accepted as the main cause of HAIs. Even so, improving hand hygiene compliance is a challenge. Methods: Our facility implemented a two-phase longitudinal study to utilize an electronic hand hygiene reminder system to reduce HAIs. In the first phase, we implemented an intervention in 2 high-risk clinical units. The second phase of the study consisted of expanding the system to 3 additional clinical areas that had a lower incidence of HAIs. The hand hygiene baseline was established at 45% for these units prior to the voice reminder being turned on. Results: The system gathered baseline data prior to being turned on, and our average hand hygiene compliance rate was 49%. Once the voice reminder was turned on, hand hygiene improved nearly 35% within 6 months. During the first phase, there was a statistically significant 62% reduction in the average number of HAIs (catheter associated urinary tract infections (CAUTI), central-line–acquired bloodstream infections (CLABSIs), methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant organisms (MDROs), and Clostridiodes difficile experienced in the preliminary units, comparing 12 months prior to 12 months after turning on the voice reminder. In the second phase, hand hygiene compliance increased to >65% in the following 6 months. During the second phase, all HAIs fell by a statistically significant 60%. This was determined by comparing the HAI rates 6 months prior to the voice reminder being turned on to 6 months after the voice reminder was turned on. Conclusions: The HAI data from both phases were aggregated, and there was a statistically significant reduction in MDROs by 90%, CAUTIs by 60%, and C. difficile by 64%. This resulted in annual savings >$1 million in direct costs of nonreimbursed HAIs.Funding: NoneDisclosures: None

CLIL as a pathway for cross-curricular and translingual classroom practices: A comparative quantitative study on Scottish and Spanish teachers’ views

2021 ◽  
pp. 136216882110324
Author(s):  
Xabier San Isidro
Keyword(s):  
Conceptual Framework ◽  
Quantitative Study ◽  
Classroom Practice ◽  
Classroom Practices ◽  
Research Tool ◽  
Second Phase ◽  
Integrated Learning ◽  
Two Phase ◽  
Pilot Testing ◽  
Final Questionnaire

Despite the numerous attempts to characterize Content and Language Integrated Learning (CLIL), the specialized literature has shown a dearth of cross-contextual studies on how stakeholders conceptualize classroom practice. This article presents the results of a two-phase comparative quantitative study on teachers’ views on CLIL design, implementation and results in two different contexts, Scotland ( n = 127) and Spain ( n = 186). The first phase focused on the creation, pilot-testing and validation of the research tool. The second phase consisted in administering the final questionnaire and analysing the results. The primary goals were (1) to ascertain whether practitioners’ perceptions on CLIL effects and classroom practices match the topics addressed by research; and (2) to analyse and compare teachers’ views in the two contexts. The study offers interesting insights into the main challenges in integrating language and content. Besides providing a conceptual framework for identifiable classroom practice, findings revealed that both cohorts shared broadly similar perceptions, although the Spanish respondents showed more positive views and significantly higher support for this approach.

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