Turbulent Stresses in the Region of a Hancock Porcine Bioprosthetic Aortic Valve

1985 ◽  
Vol 107 (3) ◽  
pp. 200-205 ◽  
Author(s):  
F. J. Walburn ◽  
H. N. Sabbah ◽  
P. D. Stein
Keyword(s):  
Shear Stress ◽  
Aortic Valve ◽  
Stroke Volume ◽  
Normal Stress ◽  
Reynolds Shear Stress ◽  
Laser Doppler Anemometer ◽  
Bioprosthetic Valve ◽  
Laser Doppler ◽  
Reynolds Stresses

The purpose of this study was to measure stresses associated with turbulence (Reynolds stresses), in the region of a 29-mm-dia porcine bioprosthetic valve (Hancock, Model 242). Studies were performed in an in vitro pulse duplicating system with the valve mounted in the aortic position. The Reynolds stresses were calculated from velocities obtained with a two channel laser Doppler anemometer. The largest Reynolds shear stress and normal stress occurred at the highest stroke volume used (80 mL). Averaged over ejection they were 38 dynes/cm2 and 380 dynes/cm2, respectively. The maximal instantaneous Reynolds shear stress was 2500 dynes/cm2 and the maximal instantaneous Reynolds normal stress was 6800 dynes/cm2. Stresses of these magnitudes are in the range reported to damage platelets.

Turbulent Stresses in the Region of Aortic and Pulmonary Valves

1982 ◽  
Vol 104 (3) ◽  
pp. 238-244 ◽  
Author(s):  
P. D. Stein ◽  
F. J. Walburn ◽  
H. N. Sabbah
Keyword(s):  
Shear Stress ◽  
Normal Stress ◽  
Blood Cells ◽  
Reynolds Shear Stress ◽  
Shear Stresses ◽  
Normal Stresses ◽  
Reynolds Stresses ◽  
Aortic Valves ◽  
Hot Film

The specific features of turbulent flow that are likely to be damaging to the blood cells and platelets are the stresses which are intrinsic to turbulence, known as Reynolds stresses. These include normal stresses as well as shear stresses. The purpose of this study is to determine the magnitude of the turbulent stresses that may occur during ejection in the vicinity of normal and diseased aortic valves near normal pulmonary valves. Both Reynolds normal stresses and Reynolds shear stresses were calculated from velocities obtained in vitro with a laser Doppler anemometer in the region of two severely stenotic and regurgitant human aortic valves. Reynolds normal stresses were also calculated from velocities obtained with a hot-film anemometer in 21 patients in the region of normal and diseased aortic valves. In seven of these patients, it was calculated in the region of the normal pulmonary valve. The Reynolds normal stress in patients with combined aortic stenosis and insufficiency was prominently higher than in patients with normal valves. In the former, the Reynolds normal stress during ejection transiently reached 18,000 dynes/cm2. This was in the range of the Reynolds normal stress observed in vitro. The Reynolds shear stress measured in vitro transiently reached 11,900 dynes/cm2 during ejection. Because the Reynolds normal stresses in the presence of the severely stenotic and regurgitant valves were comparable in vitro and in patients, it is likely that the Reynolds shear stress in patients is also comparable to values measured in vitro. These values were well above the stresses which, when sustained, have been shown to have a damaging effect upon blood cells and platelets.

Platelet membrane-coated nanoparticles target sclerotic aortic valves in ApoE−/− mice by multiple binding mechanisms under pathological shear stress

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
H Yang ◽  
Y Song ◽  
Z Huang ◽  
J Qian ◽  
Z Pang ◽  
...  
Keyword(s):  
Shear Stress ◽  
Aortic Valve ◽  
Aortic Valve Disease ◽  
Binding Capacity ◽  
Platelet Membrane ◽  
Valve Disease ◽  
Funding Source ◽  
Aortic Valves ◽  
Coated Nanoparticles

Abstract Background Aortic valve disease is the most common valvular heart disease leading to valve replacement. The efficacy of pharmacological therapy for aortic valve disease is limited by the high mechanical stress at the aortic valves impairing the binding rate. We aimed to identify nanoparticle coating with entire platelet membranes to fully mimic their inherent multiple adhesion mechanisms and target the sclerotic aortic valve of apolipoprotein E-deficient (ApoE−/−) mice based on their multiple sites binding capacity under high shear stress. Methods Considering the potent interaction of platelet membrane glycoproteins with components present in sclerotic aortic valves, platelet membrane-coated nanoparticles (PNPs) were synthetized and the binding capacity under high shear stress was evaluated in vitro and in vivo. Results Compared with PNPs bound intensity in the static station, 161%, 59%, and 39% of attached PNPs remained adherent on VWF-, collagen-, and fibrin-coated surfaces under shear stress of 25dyn/cm2 respectively. PNPs demonstrated effectively adhering to von Willebrand factor, collagen and fibrin under shear stresses in vitro. In an aortic valve disease model established in ApoE−/− mice, PNPs group exhibited significant increase of accumulation in the aortic valves compared with PBS and control NP group. PNPs displayed high degrees of proximity or co-localization with vWF, collagen and fibrin, which exhibited good targeting to sclerotic aortic valves by mimicking platelet multiple adhesive mechanisms. Conclusion PNPs could provide a promising platform for the molecular diagnosis and targeting treatment of aortic valve disease. Targeting combination Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): National Natural Science Foundation of China

Turbulent shear stress—Effect on mammalian cell culture and measurement using laser Doppler anemometer

1995 ◽  
Vol 50 (15) ◽  
pp. 2431-2440 ◽  
Author(s):  
Cynthia B. Elias ◽  
Rajiv B. Desai ◽  
Milind S. Patole ◽  
Jyeshtharaj B. Joshi ◽  
Raghunath A Mashelkar
Keyword(s):  
Cell Culture ◽  
Shear Stress ◽  
Mammalian Cell ◽  
Mammalian Cell Culture ◽  
Laser Doppler Anemometer ◽  
Laser Doppler ◽  
Turbulent Shear ◽  
Stress Effect ◽  
Turbulent Shear Stress

Numerical and theoretical investigation of pulsatile turbulent channel flows

2016 ◽  
Vol 792 ◽  
pp. 98-133 ◽  
Author(s):  
Chenyang Weng ◽  
Susann Boij ◽  
Ardeshir Hanifi
Keyword(s):  
Shear Stress ◽  
Reynolds Shear Stress ◽  
Nonlinear Effects ◽  
Turbulent Channel Flow ◽  
Theoretical Models ◽  
Phase Lag ◽  
Reynolds Stresses ◽  
Turbulent Eddies ◽  
Turbulent Channel Flows ◽  
Physical Features

A turbulent channel flow subjected to imposed harmonic oscillations is studied by direct numerical simulation (DNS) and theoretical models. Simulations have been performed for different pulsation frequencies. The time- and phase-averaged data have been used to analyse the flow. The onset of nonlinear effects during the production of the perturbation Reynolds stresses is discussed based on the DNS data, and new physical features observed in the DNS are reported. A linear model proposed earlier by the present authors for the coherent perturbation Reynolds shear stress is reviewed and discussed in depth. The model includes the non-equilibrium effects during the response of the Reynolds stress to the imposed periodic shear straining, where a phase lag exists between the stress and the strain. To validate the model, the perturbation velocity and Reynolds shear stress from the model are compared with the DNS data. The performance of the model is found to be good in the frequency range where quasi-static assumptions are invalid. The viscoelastic characteristics of the turbulent eddies implied by the model are supported by the DNS data. Attempts to improve the model are also made by incorporating the DNS data in the model.

Errors Characterization of a RANS Simulation

2021 ◽  
Author(s):  
Hugo D. Pasinato ◽  
Ezequiel Arthur Krumrick
Keyword(s):  
Shear Stress ◽  
Turbulent Flows ◽  
Reynolds Shear Stress ◽  
Strain Tensor ◽  
Numerical Code ◽  
Reynolds Stresses ◽  
Mean Velocity ◽  
Rans Simulation ◽  
Eddy Viscosity Model ◽  
The Mean

Abstract This research uses data from direct numerical simulation (DNS) to characterize the different errors associated with a Reynolds-averaged Navier-Stokes (RANS) simulation. The statistics from DNS (Reynolds stresses, kinetic energy of turbulence, $\kappa$, and dissipation of turbulence, $\epsilon$), are fed into a RANS simulation with the same Reynolds number, geometry, and numerical code used for DNS. Three integral metrics error based on the mean velocity, the moduli of the mean rate-of-strain tensor, and the wall shear stress are used to characterize the errors associated with the RANS technique, with the RANS model, and with the linear eddy viscosity model (LEVM). For developed and perturbed flow, it is found that the mean velocity of the RANS simulations with the DNS statistics is almost the same as the mean velocity from DNS data. This procedure enables the study of the relative importance of the different Reynolds stresses in a particular flow. It is shown that for the bounded perturbed turbulent flows studied here, almost all the necessary effects of turbulence are contained in the Reynolds shear stress.

scholarly journals Near-field flow structure of a confined wall jet on flat and concave rough walls

2008 ◽  
Vol 606 ◽  
pp. 27-49 ◽  
Author(s):  
I. ALBAYRAK ◽  
E. J. HOPFINGER ◽  
U. LEMMIN
Keyword(s):  
Shear Stress ◽  
Shear Layer ◽  
Outer Layer ◽  
Reynolds Shear Stress ◽  
Near Field ◽  
Wall Jet ◽  
Reynolds Stresses ◽  
Mean Flow ◽  
Free Jet ◽  
The Mean

Experimental results are presented of the mean flow and turbulence characteristics in the near field of a plane wall jet issuing from a nozzle onto flat and concave walls consisting of fixed sand beds. This is a flow configuration of interest for sediment erosion, also referred to as scouring. The measurements were made with an acoustic profiler that gives access to the three components of the instantaneous velocities. For the flat-wall flow, it is shown that the outer-layer spatial growth rate and the maxima of the Reynolds stresses approach the values accepted for the far field of a wall jet at a downstream distance x/b0 ≈ 8. These maxima are only about half the values of a plane free jet. This reduction in Reynolds stresses is also observed in the shear-layer region, x/b0 < 6, where the Reynolds shear stress is about half the value of a free shear layer. At distances x/b0 > 11, the maximum Reynolds shear stress approaches the value of a plane free jet. This change in Reynolds stresses is related to the mean vertical velocity that is negative for x/b0 < 8 and positive further downstream. The evolution of the inner region of the wall jet is found to be in good agreement with a previous model that explicitly includes the roughness length.On the concave wall, the mean flow and the Reynolds stresses are drastically changed by the adverse pressure gradient and especially by the development of Görtler vortices. On the downslope side of the scour hole, the flow is nearly separating with the wall shear stress tending to zero, whereas on the upslope side, the wall-friction coefficient is increased by a factor of about two by Görtler vortices. These vortices extend well into the outer layer and, just above the wall, cause a substantial increase in Reynolds shear stress.

Submerged wall jets subjected to injection and suction from the wall

2010 ◽  
Vol 653 ◽  
pp. 57-97 ◽  
Author(s):  
SUBHASISH DEY ◽  
TUSHAR K. NATH ◽  
SUJIT K. BOSE
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Turbulent Flow ◽  
Normal Stress ◽  
Reynolds Shear Stress ◽  
Flow Characteristics ◽  
Turbulent Energy ◽  
Third Order ◽  
Velocity Fluctuations ◽  
The Third

This paper presents an experimental study on turbulent flow characteristics in submerged plane wall jets subjected to injection (upward seepage) and suction (downward seepage) from the wall. The vertical distributions of time-averaged velocity components, turbulence intensity components and Reynolds shear stress at different horizontal distances are presented. The horizontal distributions of wall shear stress determined from the Reynolds shear stress profiles are also furnished. The flow field exhibits a decay of the jet velocity over a horizontal distance. The wall shear stress and the rate of decay of the jet velocity increase in the presence of injection and decrease with suction. Based on the two-dimensional Reynolds-averaged Navier–Stokes equations of a steady turbulent flow, the velocity and Reynolds shear stress distributions in the fully developed zone subjected to no seepage, injection and suction are theoretically computed. The response of the turbulent flow characteristics to injection and suction is analysed from the point of view of similarity characteristics, growth of the length scale and decay of the velocity and turbulence characteristics scales. The significant observation is that the velocity, Reynolds shear stress and turbulence intensities in the fully developed zone are reasonably similar under both injection and suction on applying the appropriate scaling laws. An analysis of the third-order moments of velocity fluctuations reveals that the inner layer of the jet is associated with the arrival of low-speed fluid streaks causing an effect of retardation. On the other hand, the upper layer of the jet is associated with the arrival of high-speed fluid streaks causing an effect of acceleration. Injection influences the near-wall distributions of the third-order moments by increasing the upward turbulent advection of the streamwise Reynolds normal stress. In contrast, suction influences the near-wall distributions of the third-order moments by increasing the downward turbulent advection of the streamwise Reynolds normal stress. Also, injection and suction change the vertical turbulent flux of the vertical Reynolds normal stress in a similar way. The streamwise turbulent energy flux travels towards the jet origin within the jet layer, while it travels away from the origin within the inner layer of the circulatory flow. The turbulent energy budget suggests that the turbulent and pressure energy diffusions oppose each other, and the turbulent dissipation lags the turbulent production. The quadrant analysis of velocity fluctuations reveals that the inward and outward interactions are the primary contributions to the Reynolds shear stress production in the inner and outer layers of the jet, respectively. However, injection induces feeble ejections in the vicinity of the wall.

Experimental Technique of Measuring Dynamic Fluid Shear Stress on the Aortic Surface of the Aortic Valve Leaflet

2011 ◽  
Vol 133 (6) ◽  
Author(s):  
Choon Hwai Yap ◽  
Neelakantan Saikrishnan ◽  
Gowthami Tamilselvan ◽  
Ajit P. Yoganathan
Keyword(s):  
Shear Stress ◽  
Aortic Valve ◽  
Steady Flow ◽  
Fluid Shear Stress ◽  
Shear Stresses ◽  
Straight Tube ◽  
Valve Leaflet ◽  
Fluid Shear ◽  
Valve Model

Aortic valve (AV) calcification is a highly prevalent disease with serious impact on mortality and morbidity. The exact cause and mechanism of the progression of AV calcification is unknown, although mechanical forces have been known to play a role. It is thus important to characterize the mechanical environment of the AV. In the current study, we establish a methodology of measuring shear stresses experienced by the aortic surface of the AV leaflets using an in vitro valve model and adapting the laser Doppler velocimetry (LDV) technique. The valve model was constructed from a fresh porcine aortic valve, which was trimmed and sutured onto a plastic stented ring, and inserted into an idealized three-lobed sinus acrylic chamber. Valve leaflet location was measured by obtaining the location of highest back-scattered LDV laser light intensity. The technique of performing LDV measurements near to biological surfaces as well as the leaflet locating technique was first validated in two phantom flow systems: (1) steady flow within a straight tube with AV leaflet adhered to the wall, and (2) steady flow within the actual valve model. Dynamic shear stresses were then obtained by applying the techniques on the valve model in a physiologic pulsatile flow loop. Results show that aortic surface shear stresses are low during early systole (<5dyn/cm2) but elevated to its peak during mid to late systole at about 18–20 dyn/cm2. Low magnitude shear stress (<5dyn/cm2) was observed during early diastole and dissipated to zero over the diastolic duration. Systolic shear stress was observed to elevate only with the formation of sinus vortex flow. The presented technique can also be used on other in vitro valve models such as congenitally geometrically malformed valves, or to investigate effects of hemodynamics on valve shear stress. Shear stress data can be used for further experiments investigating effects of fluid shear stress on valve biology, for conditioning tissue engineered AV, and to validate numerical simulations.

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