Evaluation of Local Blood Flow Velocity in Proximal and Distal Coronary Arteries by Laser Doppler Method

1985 ◽  
Vol 107 (1) ◽  
pp. 10-15 ◽  
Author(s):  
F. Kajiya ◽  
G. Tomonaga ◽  
K. Tsujioka ◽  
Y. Ogasawara ◽  
H. Nishihara
Keyword(s):  
Blood Flow ◽  
Coronary Artery ◽  
Distal Portion ◽  
Laser Doppler ◽  
Laser Doppler Velocimeter ◽  
Local Blood Flow ◽  
Circumflex Coronary Artery ◽  
Axial Region ◽  
Velocity Waveform ◽  
Blood Flow Velocities

A high resolution laser Doppler velocimeter using an optical fiber was developed to evaluate detailed characteristics of phasic blood flow in the coronary artery. Local blood flow velocities were measured in the proximal (0.27 ± 0.05 cm i.d.) and the distal portion (0.09 ± 0.02 cm i.d.) of the left circumflex coronary artery of anesthetized, open-chest dogs. The velocity waveform in the central axial region of the vessel and the velocity profile across the vascular lumen were compared in the proximal and the distal portions.

scholarly journals Evaluation of Blood Flow Velocity in the Coronary Artery and Vein by Laser Doppler Velocimeter

1984 ◽  
Vol 4 (1) ◽  
pp. 39-40
Author(s):  
O. HIRAMATSU ◽  
G. TOMONAGA ◽  
K. MITO ◽  
K. TSUJIOKA ◽  
Y. OGASAWARA ◽  
...  
Keyword(s):  
Blood Flow ◽  
Coronary Artery ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Laser Doppler ◽  
Laser Doppler Velocimeter

Fluid Dynamics in Proximal and Distal Coronary Artery Measured by Laser Doppler Velocimeter

1984 ◽  
pp. 73-78 ◽  
Author(s):  
F. Kajiya ◽  
K. Tsujioka ◽  
G. Tomonaga ◽  
Y. Ogasawara ◽  
S. Tadaoka ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Coronary Artery ◽  
Laser Doppler ◽  
Laser Doppler Velocimeter

Effect of hyperoxia on regional blood flow after coronary occlusion in awake dogs

1980 ◽  
Vol 238 (2) ◽  
pp. H244-H248 ◽  
Author(s):  
F. Rivas ◽  
J. C. Rembert ◽  
R. J. Bache ◽  
F. R. Cobb ◽  
J. C. Greenfield
Keyword(s):  
Blood Flow ◽  
Coronary Artery ◽  
Myocardial Blood Flow ◽  
Regional Blood Flow ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion ◽  
Regional Myocardial Blood Flow ◽  
Circumflex Coronary Artery ◽  
Left Circumflex Coronary Artery ◽  
Oxygen Inhalation

The effect of 100% oxygen inhalation on regional transmural myocardial blood flow following 45 s of actue total left circumflex coronary artery occlusion was studied in six awake dogs chronically instrumented with a coronary occluder and catheters in the aorta and left atrium. After inhalation of either room air or 100% oxygen for at least 30 min and following the 45-s occlusion, transmural myocardial blood flow was determined with radioactive microspheres (7--10 micrometers). Each dog underwent two occlusions of the left circumflex coronary artery; one during inhalation of rrom air and the other during 100% oxygen. During room air inhalation, mean regional myocardial blood flow to nonischemic, intermediate, and ischemic regions was 0.92 +/- 0.05, 0.51 +/- 0.08, and 0.10 +/- 0.02 ml . min-1 . g-1, respectively. During 100% oxygen administration, flow was significantly diminished in each region to 0.75 +/- 0.04, 0.41 +/- 0.07, and 0.06 +/- 0.01 ml . min-1 . g-1, respectively. Transmural blood flow to each layer was uniformly reduced in all regions. These data indicate that 100% oxygen further reduces myocardial blood flow to ischemic regions.

Inhibition of adenosine-mediated coronary vasodilation exacerbates myocardial ischemia during exercise

1993 ◽  
Vol 265 (5) ◽  
pp. H1471-H1477 ◽  
Author(s):  
D. D. Laxson ◽  
D. C. Homans ◽  
R. J. Bache
Keyword(s):  
Blood Flow ◽  
Coronary Artery ◽  
Myocardial Ischemia ◽  
Myocardial Blood Flow ◽  
Coronary Perfusion Pressure ◽  
Coronary Perfusion ◽  
Coronary Vasodilation ◽  
Circumflex Coronary Artery ◽  
Left Circumflex Coronary Artery ◽  
Transmural Flow

Persisting coronary vasoconstrictor tone that is responsive to exogenous adenosine administration has been demonstrated during myocardial ischemia. Therefore, the role and extent of endogenous adenosine-mediated coronary vasodilation in opposing coronary vasoconstriction within regions of ischemic myocardium was investigated in 10 chronically instrumented exercising dogs. Studies were performed on dogs with left circumflex coronary artery stenosis during treadmill exercise (6.5 km/h, 6% grade), while myocardial blood flow was measured with radioactive microspheres. Blood flow was measured before and again after inhibition of the effects of endogenously produced adenosine through combined inactivation of adenosine and adenosine receptor antagonism by the administration of intracoronary adenosine deaminase (ADA) (5 micrograms.kg-1 x min-1 x 10 min) plus 8-phenyltheophylline (8-PT) (5 mg/kg i.v.), respectively. Coronary perfusion pressure was held equal during both conditions at approximately 41 mmHg with a hydraulic occluder. During exercise in the presence of a coronary stenosis, blood flow was reduced in all layers of myocardium in regions supplied by the stenosed left circumflex coronary artery compared with blood flow in regions of myocardium supplied by the nonstenotic left anterior descending coronary artery. After ADA plus 8-PT, myocardial blood flow (in ml.min-1 x g-1) was further reduced in all layers of myocardium in regions supplied by the stenotic left circumflex coronary artery compared with baseline (subendocardial layer 0.44 +/- 0.09 vs. 0.67 +/- 0.13 ml.min-1 x g-1, mean transmural flow 0.92 +/- 0.13 vs. 1.25 +/- 0.2 ml.min-1 x g-1, both P < 0.05). Blood flow in regions of myocardium supplied by the nonstenotic left anterior descending coronary artery were unchanged following ADA plus 8-PT.(ABSTRACT TRUNCATED AT 250 WORDS)

Assessment of local blood flow with laser Doppler flowmetry in irradiated mandibular and frontal bone, an experiment in Göttingen minipigs

2015 ◽  
Vol 43 (10) ◽  
pp. 2071-2077 ◽  
Author(s):  
Lucas J. Poort ◽  
Monique M.F. Bloebaum ◽  
Roland A. Böckmann ◽  
Ruud Houben ◽  
Marlies E.P.G. Granzier ◽  
...  
Keyword(s):  
Blood Flow ◽  
Laser Doppler Flowmetry ◽  
Frontal Bone ◽  
Laser Doppler ◽  
Local Blood Flow ◽  
Doppler Flowmetry

scholarly journals Evaluation of surface blood flow in intact and ruptured canine cruciate ligaments using laser Doppler flowmetry

2016 ◽  
Vol 29 (05) ◽  
pp. 361-368
Author(s):  
Joakim Testuz ◽  
Judith Howard ◽  
Antonio Pozzi ◽  
Ulrich Rytz ◽  
Christiane Krudewig ◽  
...  
Keyword(s):  
Blood Flow ◽  
Laser Doppler Flowmetry ◽  
Intraclass Correlation ◽  
Clinical Signs ◽  
Research Society ◽  
Distal Portion ◽  
Laser Doppler ◽  
Cruciate Ligaments ◽  
Doppler Flowmetry ◽  
Measurement Cycle

SummaryObjective: To evaluate the usefulness of laser Doppler flowmetry (LDF) to measure surface blood flow in canine cruciate ligaments, compare measurements in different sites of intact and partially ruptured canine cranial cruciate ligaments (CrCL) and intact caudal cruciate ligaments (CaCL), and investigate any association between surface blood flow in partially ruptured CrCL and synovitis or duration of clinical signs.Study design: Case-controlled clinical study.Animals: Sixteen dogs with partially ruptured CrCL and five dogs with intact CrCL.Methods: Blood cell flux (BCF) readings during three measurement cycles using LDF at two sites in each ligament (mid-substance and the distal portion of the CrCL, and mid-substance and the proximal portion of the CaCL) were recorded. Synovial changes were graded grossly and histologically using the Osteoarthritis Research Society International histopathology scoring system.Results: The within-run coefficients of variation (CV) for a single BCF measurement cycle were 12.2% and 12.7% in the ruptured and intact CrCL groups, respectively. The between-run CV for three measurement cycles was 20.8% and 14.8%, respectively. The intraclass correlation coefficient (ICC, absolute agreement) was 0.66 for a single measurement cycle and 0.86 for the average of three cycles.No difference in average BCF readings was found between any two sites in either group, but BCF readings in both CrCL sites were significantly higher in the ruptured CrCL group than the intact CrCL group. No associations between BCF and synovial grades or duration of lameness were identified.Conclusions: Laser Doppler flowmetry can be used to assess surface blood flow in intact and partially ruptured canine cruciate ligaments with acceptable precision. Using this method, surface blood flow appears greater in partially ruptured canine CrCL than intact CrCL. Further studies are required to determine if this is a sequela of trauma or synovitis.

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