Design and Development of a Novel Biostretch Apparatus for Tissue Engineering

2009 ◽  
Vol 132 (1) ◽  
Author(s):  
Qiming Pang ◽  
Jean W. Zu ◽  
Geoffrey M. Siu ◽  
Ren-Ke Li
Keyword(s):  
Tissue Engineering ◽  
Driving Force ◽  
Cyclic Stretch ◽  
Frequency Pattern ◽  
Engineering Research ◽  
New Apparatus ◽  
Culture Process ◽  
Engineered Tissue ◽  
Petri Dishes ◽  
Tissue Engineering Research

A uniaxial cyclic stretch apparatus is designed and developed for tissue engineering research. The biostretch apparatus employs noncontact electromagnetic force to uniaxially stretch a rectangular Gelfoam® or RTV silicon scaffold. A reliable controller is implemented to control four stretch parameters independently: extent, frequency, pattern, and duration of the stretch. The noncontact driving force together with the specially designed mount allow researchers to use standard Petri dishes and commercially available CO2 incubators to culture an engineered tissue patch under well-defined mechanical conditions. The culture process is greatly simplified over existing processes. Further, beyond traditional uniaxial stretch apparatuses, which provide stretch by fixing one side of the scaffolds and stretching the other side, the new apparatus can also apply uniaxial stretch from both ends simultaneously. Using the biostretch apparatus, the distributions of the strain on the Gelfoam® and GE RTV 6166 silicon scaffolds are quantitatively analyzed.

Development of a Uniaxial Cyclic Stretch Apparatus for Tissue Engineering

2009 ◽  
Author(s):  
Qiming Pang ◽  
Jean W. Zu ◽  
Geoffrey M. Siu ◽  
Ren-Ke Li
Keyword(s):  
Tissue Engineering ◽  
Driving Force ◽  
Mechanical Stimulus ◽  
Cyclic Stretch ◽  
Frequency Pattern ◽  
Engineering Research ◽  
Culture Process ◽  
Engineered Tissue ◽  
Petri Dishes ◽  
Tissue Engineering Research

A uniaxial cyclic stretch apparatus is designed and developed for tissue engineering research. The biostretch apparatus employs non-contact electromagnetic force to uniaxial stretch a rectangular Gelfoam® or RTV silicon scaffold. A reliable controller is implemented to independently control four stretch parameters: strength, frequency, pattern, and duration of the stretch time. The non-contact driving force and the specially designed mounting tray allow researchers to use standard Petri dishes and commercially available CO2 incubators to culture an engineered tissue patch with mechanical stimulus. The apparatus greatly simplifies the culture process over existing biostretch apparatuses. Further, unlike traditional uniaxial stretch apparatuses, which normally fix one side and stretch other side, the new biostretch apparatus can also apply uniaxial stretch from both ends simultaneously. Using the biostretch apparatus, the distribution of strain on the Gelfoam® and GE RTV 6166 silicon scaffold is quantitatively analyzed.

scholarly journals Prevention of Post-Operative Adhesions: A Comprehensive Review of Present and Emerging Strategies

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1027
Author(s):  
Ali Fatehi Hassanabad ◽  
Anna N. Zarzycki ◽  
Kristina Jeon ◽  
Jameson A. Dundas ◽  
Vishnu Vasanthan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Financial Burden ◽  
Adhesion Formation ◽  
Length Of Hospital Stay ◽  
Engineering Research ◽  
Surgical Adhesions ◽  
Preventative Strategy ◽  
Underlying Mechanisms ◽  
And Personalized Medicine ◽  
Tissue Engineering Research

Post-operative adhesions affect patients undergoing all types of surgeries. They are associated with serious complications, including higher risk of morbidity and mortality. Given increased hospitalization, longer operative times, and longer length of hospital stay, post-surgical adhesions also pose a great financial burden. Although our knowledge of some of the underlying mechanisms driving adhesion formation has significantly improved over the past two decades, literature has yet to fully explain the pathogenesis and etiology of post-surgical adhesions. As a result, finding an ideal preventative strategy and leveraging appropriate tissue engineering strategies has proven to be difficult. Different products have been developed and enjoyed various levels of success along the translational tissue engineering research spectrum, but their clinical translation has been limited. Herein, we comprehensively review the agents and products that have been developed to mitigate post-operative adhesion formation. We also assess emerging strategies that aid in facilitating precision and personalized medicine to improve outcomes for patients and our healthcare system.

ELECTROSPINNING OF BIOMATERIALS AND THEIR APPLICATIONS IN TISSUE ENGINEERING

Nano LIFE ◽  
2012 ◽  
Vol 02 (04) ◽  
pp. 1230010 ◽  
Author(s):  
JEN-CHIEH WU ◽  
H. PETER LORENZ
Keyword(s):  
Tissue Engineering ◽  
Electrospinning Process ◽  
Polymer Fibers ◽  
Nanometer Scale ◽  
High Porosity ◽  
Electrospinning Technique ◽  
Engineering Research ◽  
Fibrous Scaffolds ◽  
Surface Areas ◽  
Tissue Engineering Research

Electrospinning is a process for generating micrometer or nanometer scale polymer fibers with large surface areas and high porosity. For tissue engineering research, the electrospinning technique provides a quick way to fabricate fibrous scaffolds with dimensions comparable to the extracellular matrix (ECM). A variety of materials can be used in the electrospinning process, including natural biomaterials as well as synthetic polymers. The natural biomaterials have advantages such as excellent biocompatibility and biodegradability, which can be more suitable for making biomimic scaffolds. In the last two decades, there have been growing numbers of studies of biomaterial fibrous scaffolds using the electrospinning process. In this review, we will discuss biomaterials in the electrospinning process and their applications in tissue engineering.

Use of Fluorochrome Labels in In Vivo Bone Tissue Engineering Research

2010 ◽  
Vol 16 (2) ◽  
pp. 209-217 ◽  
Author(s):  
Steven M. van Gaalen ◽  
Moyo C. Kruyt ◽  
Ruth E. Geuze ◽  
Joost D. de Bruijn ◽  
Jacqueline Alblas ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Research ◽  
Tissue Engineering Research

Biological properties of a bionic scaffold for esophageal tissue engineering research

2019 ◽  
Vol 179 ◽  
pp. 208-217 ◽  
Author(s):  
Ruixia Hou ◽  
Xingyuan Wang ◽  
Qianqian Wei ◽  
Peipei Feng ◽  
Xianbo Mou ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Biological Properties ◽  
Engineering Research ◽  
Bionic Scaffold ◽  
Esophageal Tissue ◽  
Tissue Engineering Research

scholarly journals Elastin biology and tissue engineering with adult cells

2013 ◽  
Vol 4 (2) ◽  
pp. 173-185 ◽  
Author(s):  
Cassandra B. Saitow ◽  
Steven G. Wise ◽  
Anthony S. Weiss ◽  
John J. Castellot ◽  
David L. Kaplan
Keyword(s):  
Tissue Engineering ◽  
Normal Development ◽  
Elastic Fiber ◽  
Elastic Fibers ◽  
Accessory Proteins ◽  
Engineering Research ◽  
Elastin Gene ◽  
Tissue Engineering Research ◽  
Adult Cells

AbstractThe inability of adult cells to produce well-organized, robust elastic fibers has long been a barrier to the successful engineering of certain tissues. In this review, we focus primarily on elastin with respect to tissue-engineered vascular substitutes. To understand elastin regulation during normal development, we describe the role of various elastic fiber accessory proteins. Biochemical pathways regulating expression of the elastin gene are addressed, with particular focus on tissue-engineering research using adult-derived cells.

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