Biomechanics of Growth, Remodeling, and Morphogenesis

1995 ◽  
Vol 48 (8) ◽  
pp. 487-545 ◽  
Author(s):  
Larry A. Taber
Keyword(s):  
Shape Change ◽  
Experimental Studies ◽  
Cell Movement ◽  
Theoretical Models ◽  
Cellular Level ◽  
Experimental Results ◽  
Future Research ◽  
Cell Sheets ◽  
Biomechanical Models ◽  
Division Cell

This review deals with biomechanical aspects of growth (mass change), remodeling (property change), and morphogenesis (shape change) in living systems. The emphasis is on theoretical models, but relevant experimental results also are discussed. As an aid to the reader, the fundamental biological terms and concepts are defined for the general problem and for each specific topic. At the outset, the processes involved in growth, remodeling, and morphogenesis are described and placed within the context of the evolution of species. Next, some of the analytical methods used in biomechanical models for these processes are presented. Then, applications of these and other techniques to specific systems are discussed, beginning at the cellular level and proceeding upward to the tissue and organ levels. At the cellular level, modeling and experimental studies are reviewed for cell division, cell movement, and pattern formation, and then morphogenetic mechanisms for epithelia (cell sheets) are discussed. At the tissue and organ levels, the musculoskeletal and cardiovascular systems are considered. Several models are described for growth, remodeling, and morphogenesis of bone, and mainly experimental results are examined in the cases of skeletal muscle, the heart, and arteries. Specific topics for the cardiovascular system include hypertrophy, residual stress, atherosclerosis, and embryonic development. Finally, some future research directions are suggested.

A Review of Theoretical and Experimental Research on Various Autofrettage Processes

2018 ◽  
Vol 140 (5) ◽  
Author(s):  
Rajkumar Shufen ◽  
Uday S. Dixit
Keyword(s):  
Experimental Studies ◽  
Theoretical Models ◽  
Pressure Vessels ◽  
Future Research ◽  
Spherical Vessel ◽  
Considerable Research ◽  
Wide Range ◽  
Set Up ◽  
Compressive Residual Stresses ◽  
Spherical Pressure

Autofrettage is a metal forming technique widely incorporated for strengthening the thick-walled cylindrical and spherical pressure vessels. The technique is based on the principle of initially subjecting the cylindrical or spherical vessel to partial plastic deformation and then unloading it; as a result of which compressive residual stresses are set up. On the basis of the type of the forming load, autofrettage can be classified into hydraulic, swage, explosive, thermal, and rotational. Considerable research studies have been carried out on autofrettage with a variety of theoretical models and experimental methods. This paper presents an extensive review of various types of autofrettage processes. A wide range of theoretical models and experimental studies are described. Optimization of an autofrettage process is also discussed. Based on the review, some challenging issues and key areas for future research are identified.

Fluid Flow Through Randomly Packed Monodisperse Fibers: The Kozeny-Carman Parameter Analysis

1997 ◽  
Vol 119 (1) ◽  
pp. 188-192 ◽  
Author(s):  
O. Rahli ◽  
L. Tadrist ◽  
M. Miscevic ◽  
R. Santini
Keyword(s):  
Fluid Flow ◽  
Experimental Studies ◽  
Theoretical Models ◽  
Experimental Results ◽  
Parameter Analysis ◽  
Flow Through Porous Media ◽  
Aspect Ratios ◽  
A Value ◽  
Flow Through ◽  
Permeability Increase

Experimental studies have been carried out on fluid flow through porous media made up of randomly packed monodisperse fibers. The permeability and the Kozeny-Carman parameter kk are deduced from experimental results. The variations of the permeability increase exponentially with the porosity. The parameter kk is a decreasing function of the porosity ε and tends asymptotically to a value close to that deduced from a modified Ergun relation. The important decrease, observed for small aspect ratios, is certainly an effect of the cut sections of fibers. The results in terms of parameter kk are systematically compared to those deduced from various theoretical models. The variation laws of the parameter kk, deduced from different models, present important discrepancies with our experimental results.

scholarly journals The role of memory in posttraumatic stress disorder: implications for clinical practice

2016 ◽  
Vol 38 (3) ◽  
pp. 119-127 ◽  
Author(s):  
Marcelo Montagner Rigoli ◽  
Gustavo Ramos Silva ◽  
Fernando Rainho de Oliveira ◽  
Giovanni Kuckartz Pergher ◽  
Christian Haag Kristensen
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Clinical Practice ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Traumatic Event ◽  
Experimental Studies ◽  
Theoretical Models ◽  
Social Consequences ◽  
Future Research

Abstract Introduction: Posttraumatic stress disorder (PTSD) is a highly prevalent disorder with important social consequences. Several models have been developed with the aim of understanding the mechanisms underlying its symptoms. Intrusions are idiosyncratic symptoms that commonly take the form of involuntary recollection of images or flashbacks about the traumatic event. Objective: To review how memory is conceptualized in each of these models and the implications for clinical practice. Methods: A narrative review of the literature was conducted through analysis of the perspectives of memory in theoretical models of PTSD. Results: Two main perspectives were identified: 1) models in which specific mechanisms of memory for processing traumatic events are proposed, especially those based on clinical studies, and 2) models in which common mnemonic mechanisms are utilized to explain the phenomenon, primarily based on basic experimental research studies investigating memory. The different theories based on these approaches have led to distinct psychotherapy interventions. Conclusion: In order to clarify these discrepancies, future research should aim for the methodological rigor of experimental studies, while maintaining the ecological applicability of findings. Cognitive experimental psychopathology is therefore an area on which research funding should be focused. Such studies could elucidate the role of mnemonic aspects in PTSD and how they impact psychological treatments.

Cooking Technologies

2017 ◽  
Author(s):  
Eric Blinman ◽  
James M. Heidke ◽  
Myles R. Miller
Keyword(s):  
Sonoran Desert ◽  
Experimental Studies ◽  
Theoretical Models ◽  
Future Research ◽  
Multiple Use ◽  
Pottery Production ◽  
Additional Food ◽  
Integrative Framework ◽  
Pottery Technology ◽  
The North

Inferences regarding pre-colonial southwestern cooking are limited by preservation and the ambiguity of multiple-use features. Documented techniques are stone boiling, pit roasting, boiling in pottery jars, and heating on comals or griddle stones, with fermentation as an additional food-processing category. The plastic nature of pottery allowed the design of vessel forms specifically for cooking, but storage rather than cooking was the original impetus for pottery production in the Sonoran Desert. The subsequent northward spread of pottery technology does appear to coincide with cooking use, despite initial inefficient vessel forms. Theoretical models and experimental studies have linked subsequent changes in vessel shape and surface texture with gains in efficiency once cooking jars were fully embraced by farming households. Fermentation evidence is arguable in the southern Southwest, and the apparent absence in the north is enigmatic. Residue studies and the use of cooking as an integrative framework hold potential for future research.

scholarly journals Experimental studies on the viscosity of Fe nanoparticles dispersed in ethylene glycol and water mixture

2016 ◽  
Vol 20 (5) ◽  
pp. 1661-1670 ◽  
Author(s):  
Amir Karimi ◽  
Sadatlu Abdolahi ◽  
Mehdi Ashjaee
Keyword(s):  
Ethylene Glycol ◽  
Base Fluid ◽  
Volume Concentration ◽  
Volume Fraction ◽  
Particle Volume Fraction ◽  
Experimental Studies ◽  
Theoretical Models ◽  
Experimental Results ◽  
Water Mixture ◽  
Fe Nanoparticles

In this paper, experimental studies are conducted in order to measure the viscosity of Fe nanoparticles dispersed in various weight concentration (25/75%, 45/55% and 55/45%) of ethylene glycol and water (EG-water) mixture. The experimental measurements are performed at various volume concentrations up to 2% and temperature ranging from 10?C to 60?C. The experimental results disclose that the viscosity of nanofluids increases with increase in Fe particle volume fraction, and decreases with increase in temperature. Maximum enhancement in viscosity of nanofluids is 2.14 times for 55/45% EG-water based nanofluid at 2% volume concentration compared to the base fluid. Moreover, some comparisons between experimental results and theoretical models are drawn. It is also observed that the prior theoretical models do not estimate the viscosity of nanofluid accurately. Finally, a new empirical correlation is proposed to predict the viscosity of nanofluids as a function of volume concentration, temperature, and the viscosity of base fluid.

Correlated Studies of Cellular Interactions Using TEM, Freeze Etching, and SEM

1974 ◽  
Vol 32 ◽  
pp. 320-321
Author(s):  
J. P. Revel
Keyword(s):  
Developmental Stages ◽  
Three Dimensional ◽  
Cell Movement ◽  
Cellular Interactions ◽  
Serial Sections ◽  
Cell Sheets ◽  
Freeze Etching ◽  
Early Developmental

Movement of individual cells or of cell sheets and complex patterns of folding play a prominent role in the early developmental stages of the embryo. Our understanding of these processes is based on three- dimensional reconstructions laboriously prepared from serial sections, and from autoradiographic and other studies. Many concepts have also evolved from extrapolation of investigations of cell movement carried out in vitro. The scanning electron microscope now allows us to examine some of these events in situ. It is possible to prepare dissections of embryos and even of tissues of adult animals which reveal existing relationships between various structures more readily than used to be possible vithout an SEM.

A Relativistic Newtonian Mechanics Predicts with Precision the Results of Recent Neutrino-Velocity Experiments

2014 ◽  
Vol 6 (1) ◽  
pp. 1032-1035 ◽  
Author(s):  
Ramzi Suleiman
Keyword(s):  
Null Hypothesis ◽  
Experimental Studies ◽  
Theoretical Models ◽  
Newtonian Mechanics ◽  
Speed Of Light ◽  
Symmetry Principle ◽  
Proposed Model ◽  
Significant Difference ◽  
The One ◽  
Complete Collapse

The research on quasi-luminal neutrinos has sparked several experimental studies for testing the "speed of light limit" hypothesis. Until today, the overall evidence favors the "null" hypothesis, stating that there is no significant difference between the observed velocities of light and neutrinos. Despite numerous theoretical models proposed to explain the neutrinos behavior, no attempt has been undertaken to predict the experimentally produced results. This paper presents a simple novel extension of Newton's mechanics to the domain of relativistic velocities. For a typical neutrino-velocity experiment, the proposed model is utilized to derive a general expression for . Comparison of the model's prediction with results of six neutrino-velocity experiments, conducted by five collaborations, reveals that the model predicts all the reported results with striking accuracy. Because in the proposed model, the direction of the neutrino flight matters, the model's impressive success in accounting for all the tested data, indicates a complete collapse of the Lorentz symmetry principle in situation involving quasi-luminal particles, moving in two opposite directions. This conclusion is support by previous findings, showing that an identical Sagnac effect to the one documented for radial motion, occurs also in linear motion.

RECLAMATION AND CULVERT CROSSINGS MADE OF CORRUGATED PIPES ON SPAWNING STREAMS

2020 ◽  
pp. 68-77
Author(s):  
O.N. CHERNYKH ◽  
◽  
A.V. RBURLACHENKO
Keyword(s):  
Single Point ◽  
Experimental Studies ◽  
Fish Passage ◽  
Future Research ◽  
Fish Stocks ◽  
Metal Structures ◽  
Natural Reproduction ◽  
Spiral Shape ◽  
Corrugated Metal ◽  
Spawning Streams

Recommendations are presented for solving issues that arise in the design and operation of tubular transport crossings of corrugated metal structures through spawning streams while ensuring the safety and natural reproduction of fish stocks. There are discussed the results of experimental studies of culverts made of metal corrugated pipes with a normal and spiral shape of corrugation the bottom of which is buried and filled with suitable granular material to the level of the natural channel of a small watercourse. It is established that when 10% of the area of the corrugated pipe is occupied by stone filling, its throughput is reduced by about 10-12%. Based on the review of the existing literature and the results of laboratory experiments, data is provided to estimate the values of the roughness coefficients of the composite cross-section of a single-point junction and directions for future research on culvert reclamation are outlined. Studying of the structure of the velocity distribution in culverts can lead to the improved conditions for fish passage without installing special structural elements in the transit path of the fish passage structure.

The Social Neuroscience of Cooperation

2018 ◽  
Author(s):  
Jay Joseph Van Bavel
Keyword(s):  
Theoretical Models ◽  
Brain Regions ◽  
Review Literature ◽  
Social Neuroscience ◽  
Future Research ◽  
A Value ◽  
Group Cooperation ◽  
Neural Processes ◽  
The Social ◽  
Cooperative Decision Making

We review literature from several fields to describe common experimental tasks used to measure human cooperation as well as the theoretical models that have been used to characterize cooperative decision-making, as well as brain regions implicated in cooperation. Building on work in neuroeconomics, we suggest a value-based account may provide the most powerful understanding the psychology and neuroscience of group cooperation. We also review the role of individual differences and social context in shaping the mental processes that underlie cooperation and consider gaps in the literature and potential directions for future research on the social neuroscience of cooperation. We suggest that this multi-level approach provides a more comprehensive understanding of the mental and neural processes that underlie the decision to cooperate with others.

Amruthapala (Decalepis arayalpathra (J. Joseph and V. Chandras.) Venter): A Comprehensive Review on Diversity, Therapeutic Uses, and Valorization of Bioactive Constituents

2019 ◽  
Vol 20 (5) ◽  
pp. 376-389 ◽  
Author(s):  
Sonali Mishra ◽  
Nupur Srivastava ◽  
Velusamy Sundaresan ◽  
Karuna Shanker
Keyword(s):  
Secondary Metabolite ◽  
Current Knowledge ◽  
Experimental Studies ◽  
Critical Discussion ◽  
Future Research ◽  
Bioactive Constituents ◽  
Medicinal Uses ◽  
Comprehensive Review ◽  
Therapeutic Uses ◽  
Decalepis Arayalpathra

Background: Decalepis arayalpathra (J. Joseph and V. Chandras.) Venter is used primarily for nutrition besides its therapeutic values. Traditional preparations/formulations from its tuber are used as a vitalizer and blood purifier drink. The folklore medicinal uses cover inflammation, cough, wound healing, antipyretic, and digestive system management. A comprehensive review of the current understanding of the plant is required due to emerging concerns over its safety and efficacy. Objective: The systematic collection of the authentic information from different sources with the critical discussion is summarised in order to address various issues related to botanical identity, therapeutic medicine, nutritional usage, phytochemical, and pharmacological potentials of the D. arayalpathra. Current use of traditional systems of medicine can be used to expand future research opportunities. Materials and Methods: Available scripted information was collected manually, from peered review research papers and international databases viz. Science Direct, Google Scholar, SciFinder, Scopus, etc. The unpublished resources which were not available in database were collected through the classical books of ‘Ayurveda’ and ‘Siddha’ published in regional languages. The information from books, Ph.D. and MSc dissertations, conference papers and government reports were also collected. We thoroughly screened the scripted information of classical books, titles, abstracts, reports, and full-texts of the journals to establish the reliability of the content. Results: Tuber bearing vanilla like signature flavor is due to the presence of 2-hydroxy-4-methoxybenzaldehyde (HMB). Among five other species, Decalepis arayalpathra (DA) has come under the ‘critically endangered’ category, due to over-exploitation for traditional, therapeutic and cool drink use. The experimental studies proved that it possesses gastro-protective, anti-tumor, and antiinflammatory activities. Some efforts were also made to develop better therapeutics by logical modifications in 2-Hydroxy-4-methoxy-benzaldehyde, which is a major secondary metabolite of D. arayalpathra. ‘Amruthapala’ offers the enormous opportunity to develop herbal drink with health benefits like gastro-protective, anti-oxidant and anti-inflammatory actions. Results: The plant has the potential to generate the investigational new lead (IND) based on its major secondary metabolite i.e. 2-Hydroxy-4-methoxy-benzaldehyde. The present mini-review summarizes the current knowledge on Decalepis arayalpathra, covering its phytochemical diversity, biological potentials, strategies for its conservation, and intellectual property rights (IPR) status. Chemical Compounds: 2-hydroxy-4-methoxybenzaldehyde (Pubchem CID: 69600), α-amyrin acetate (Pubchem CID: 293754), Magnificol (Pubchem CID: 44575983), β-sitosterol (Pubchem CID: 222284), 3-hydroxy-p-anisaldehyde (Pubchem CID: 12127), Naringenin (Pubchem CID: 932), Kaempferol (Pubchem CID: 5280863), Aromadendrin (Pubchem CID: 122850), 3-methoxy-1,2-cyclopentanedione (Pubchem CID: 61209), p-anisaldehyde (Pubchem CID: 31244), Menthyl acetate (Pubchem CID: 27867), Benzaldehyde (Pubchem CID: 240), p-cymene (Pubchem CID: 7463), Salicylaldehyde (Pubchem CID: 6998), 10-epi-γ-eudesmol (Pubchem CID: 6430754), α -amyrin (Pubchem CID: 225688), 3-hydroxy-4-methoxy benzaldehyde (Pubchem CID: 12127).

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