A Musculoskeletal Model of the Equine Forelimb for Determining Surface Stresses and Strains in the Humerus—Part I. Mathematical Modeling

2008 ◽  
Vol 130 (4) ◽  
Author(s):  
Sarah Pollock ◽  
M. L. Hull ◽  
Susan M. Stover ◽  
Larry D. Galuppo
Keyword(s):  
Mathematical Model ◽  
Bone Graft ◽  
Cross Sections ◽  
Donor Site ◽  
Maximum Voluntary Contraction ◽  
Optimization Techniques ◽  
Autogenous Bone ◽  
Graft Material ◽  
Small Strains ◽  
A Site

Knowledge of the forces that act upon the equine humerus while the horse is standing and the resulting strains experienced by the bone is useful for the prevention and treatment of fractures and for assessing the proximolateral aspect of the bone as a site for obtaining autogenous bone graft material. The first objective was to develop a mathematical model to predict the loads on the proximal half of the humerus created by the surrounding musculature and ground reaction forces while the horse is standing. The second objective was to calculate surface bone stresses and strains at three cross sections on the humerus corresponding to the donor site for bone grafts, a site predisposed to stress fracture, and the middle of the diaphysis. A three-dimensional mathematical model employing optimization techniques and asymmetrical beam analysis was used to calculate shoulder muscle forces and surface strains on the proximal and mid-diaphyseal aspects of the humerus. The active shoulder muscles, which included the supraspinatus, infraspinatus, subscapularis, and short head of the deltoid, produced small forces while the horse is standing; all of which were limited to 4.3% of their corresponding maximum voluntary contraction. As a result, the strains calculated at the proximal cross sections of the humerus were small, with maximum compressive strains of −104με at the cranial aspect of the bone graft donor cross section. The middle of the diaphysis experienced larger strain magnitudes with compressive strains at the lateral and the caudal aspects and tensile strains at the medial and cranial aspects (−377με and 258με maximum values, respectively) while the horse is standing. Small strains at the donor bone graft site do not rule out using this location to harvest bone graft tissue, although strains while rising to a standing position during recovery from anesthesia are unknown. At the site common to stress fractures, small strains imply that the stresses seen by this region while the horse is standing, although applied for long periods of time, are not a cause of fracture in this location. Knowing the specific regions of the middle of the diaphysis of the humerus that experience tensile and compressive strains is valuable in determining optimum placement of internal fixation devices for the treatment of complete fractures.

scholarly journals Evaluation of New Octacalcium Phosphate-Coated Xenograft in Rats Calvarial Defect Model on Bone Regeneration

Materials ◽  
2020 ◽  
Vol 13 (19) ◽  
pp. 4391
Author(s):  
Yoona Jung ◽  
Won-Hyeon Kim ◽  
Sung-Ho Lee ◽  
Kyung Won Ju ◽  
Eun-Hee Jang ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Graft ◽  
Octacalcium Phosphate ◽  
Autogenous Bone ◽  
Graft Material ◽  
Calvarial Defect ◽  
Bone Area ◽  
Defect Model ◽  
Bone Graft Material ◽  
Experimental Group

Bone graft material is essential for satisfactory and sufficient bone growth which leads to a successful implant procedure. It is classified into autogenous bone, allobone, xenobone and alloplastic materials. Among them, it has been reported that heterogeneous bone graft material has a porous microstructure that increases blood vessels and bone formation, and shows faster bone formation than other types of bone graft materials. We observed new bone tissue formation and bone remodeling using Ti-oss® (Chiyewon Co., Ltd., Guri, Korea), a heterologous bone graft material. Using a Sprague–Dawley rat calvarial defect model to evaluate the bone healing effect of biomaterials, the efficacy of the newly developed xenograft Ti-oss® and Bio-Oss® (Geistilch Pharma AG, Wolhusen, Switzerland). The experimental animals were sacrificed at 8 and 12 weeks after surgery for each group and the experimental site was extracted. The average new bone area for the Ti-oss® experimental group at 8 weeks was 17.6%. The remaining graft material was 22.7% for the experimental group. The average new bone area for the Ti-oss® group was 24.3% at 12 weeks. The remaining graft material was 22.8% for the experimental group. It can be evaluated that the new bone-forming ability of Ti-oss® with octacalcium phosphate (OCP) has the bone-forming ability corresponding to the conventional products.

scholarly journals Bone-Forming Capabilities of a Newly Developed NanoHA Composite Alloplast Infused with Collagen: A Pilot Study in the Sheep Mandible

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Charles Marin ◽  
Ryo Jimbo ◽  
Fabio Cesar Lorenzoni ◽  
Lukasz Witek ◽  
Hellen Teixeira ◽  
...  
Keyword(s):  
Bone Ingrowth ◽  
Donor Site ◽  
Three Dimensional ◽  
Polyglycolic Acid ◽  
Autogenous Bone ◽  
Graft Material ◽  
Resorption Rate ◽  
Experimental Block ◽  
The Status

Lateral or vertical bone augmentation has always been a challenge, since the site is exposed to constant pressure from the soft tissue, and blood supply only exists from the donor site. Although, for such clinical cases, onlay grafting with autogenous bone is commonly selected, the invasiveness of the secondary surgical site and the relatively fast resorption rate have been reported as a drawback, which motivated the investigation of alternative approaches. This study evaluated the bone-forming capability of a novel nanoHA alloplast infused with collagen graft material made from biodegradable polylactic acid/polyglycolic acid versus a control graft material with the same synthesized alloplast without the nanoHA component and collagen infiltration. The status of newly formed bone and the resorption of the graft material were evaluated at 6 weeksin vivohistologically and three dimensionally by means of 3D microcomputed tomography. The histologic observation showed that newly formed bone ingrowth and internal resorption of the block were observed for the experimental blocks, whereas for the control blocks less bone ingrowth occurred along with lower resorption rate of the block material. The three-dimensional observation indicated that the experimental block maintained the external geometry, but at the same time successfully altered the graft material into bone. It is suggested that the combination of numerous factors contributed to the bone ingrowth and the novel development could be an alternative bone grafting choice.

scholarly journals Mandibular Reconstruction with Lateral Tibial Bone Graft: An Excellent Option for Oral and Maxillofacial Surgery

2017 ◽  
Vol 10 (4) ◽  
pp. 292-298 ◽  
Author(s):  
Ana Lucia Carpi Miceli ◽  
Livia Costa Pereira ◽  
Thiago da Silva Torres ◽  
MônicaDiuana Calasans-Maia ◽  
Rafael Seabra Louro
Keyword(s):  
Bone Graft ◽  
Orthognathic Surgery ◽  
Proximal Tibia ◽  
Donor Site ◽  
Maxillofacial Surgery ◽  
Lateral Approach ◽  
Autogenous Bone ◽  
Oral And Maxillofacial Surgery ◽  
Superficial Infection ◽  
Tibial Bone

Autogenous bone grafts are the gold standard for reconstruction of atrophic jaws, pseudoarthroses, alveolar clefts, orthognathic surgery, mandibular discontinuity, and augmentation of sinus maxillary. Bone graft can be harvested from iliac bone, calvarium, tibial bone, rib, and intraoral bone. Proximal tibia is a common donor site with few reported problems compared with other sites. The aim of this study was to evaluate the use of proximal tibia as a donor area for maxillofacial reconstructions, focusing on quantifying the volume of cancellous graft harvested by a lateral approach and to assess the complications of this technique. In a retrospective study, we collected data from 31 patients, 18 women and 13 men (mean age: 36 years, range: 19–64), who were referred to the Department of Oral and Maxillofacial Surgery at the Servidores do Estado Federal Hospital. Patients were treated for sequelae of orthognathic surgery, jaw fracture, nonunion, malunion, pathology, and augmentation of bone volume to oral implant. The technique of choice was lateral access of proximal tibia metaphysis for graft removal from Gerdy tubercle under general anesthesia. The mean volume of bone harvested was 13.0 ± 3.7 mL (ranged: 8–23 mL). Only five patients (16%) had minor complications, which included superficial infection, pain, suture dehiscence, and unwanted scar. However, none of these complications decreases the result and resolved completely. We conclude that proximal tibia metaphysis for harvesting cancellous bone graft provides sufficient volume for procedures in oral and maxillofacial surgery with minimal postoperative morbidity.

Topology and Shape Optimization of an Interbody Fusion Implant for Lumbar Spine Fixation

2003 ◽  
Author(s):  
Andre´s Tovar ◽  
Shawn E. Gano ◽  
John E. Renaud ◽  
James J. Mason
Keyword(s):  
Lumbar Spine ◽  
Shape Optimization ◽  
Bone Graft ◽  
Interbody Fusion ◽  
Optimization Techniques ◽  
Graft Material ◽  
Minimally Invasive Surgical ◽  
Flexion Extension ◽  
Topology And Shape Optimization ◽  
Spine Fixation

The goal of this research is to obtain the optimum design of a new interbody fusion implant for use in lumbar spine fixation. A new minimally invasive surgical technique for interbody fusion is currently in development. The procedure makes use of an interbody implant that is inserted between two vertebral bodies. The implant is packed with bone graft material that fuses the motion segment. The implant must be capable of retaining bone graft and supporting spinal loads while fusion occurs. Finite element-based optimization techniques are used to drive the design. The optimization process is performed in two stages: topology optimization and then shape optimization. The different load conditions analyzed include: flexion, extension, and lateral bending.

scholarly journals Microcomputed Tomography and Histological Study of Bone Regeneration Using Tooth Biomaterial with BMP-2 in Rabbit Calvarial Defects

Scanning ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Puneet Wadhwa ◽  
Jeong Hun Lee ◽  
Bing Cheng Zhao ◽  
HongXin Cai ◽  
Jae-Suk Rim ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Regeneration ◽  
Histological Study ◽  
Autogenous Bone Graft ◽  
Autogenous Bone ◽  
Control Group ◽  
Block Type ◽  
Graft Material ◽  
Synthetic Bone ◽  
Ct Analysis

Our study was aimed to analyze the osteoinductive effect of powdered and block type autogenous bone graft along with bone morphogenetic protein (BMP-2) as compared to synthetic bone graft. Three circular bicortical defects were made in the calvaria of each rabbit and randomly divided into three groups as follows: powdered tooth biomaterial+BMP-2, block tooth biomaterial+BMP-2, and control group: synthetic bone+BMP-2. The samples taken from these defects after 4 and 8 weeks were analyzed histologically along with micro CT analysis. In our study, both powered and block type tooth autogenous bone graft successfully stimulated mesenchymal cells leading to endochondral ossification and bone regeneration. We observed that the powered bone graft material which is acid insoluble especially is preferable as a carrier for BMP-2.

scholarly journals Conservative Technique Using Oral Dressing Material for Wound Dehiscence after Ridge Augmentation: A Technical Report with a Case Series

2021 ◽  
Vol 11 (13) ◽  
pp. 6115
Author(s):  
Jeong-Kui Ku ◽  
Yeong Kon Jeong ◽  
Yong-Suk Choi ◽  
Taeyeong Kim ◽  
In-Woo Cho ◽  
...  
Keyword(s):  
Conservative Treatment ◽  
Bone Graft ◽  
Case Series ◽  
Wound Dehiscence ◽  
Autogenous Bone ◽  
Collagen Membrane ◽  
Graft Material ◽  
Titanium Mesh ◽  
Ridge Augmentation ◽  
Secondary Healing

Wound dehiscence is the most frequent complication after ridge augmentation and causes postoperative infection, inadequate bone healing, or graft failure. In the oral cavity, conservative treatment for dehiscence is difficult to maintain until secondary healing occurs because of its normal flora, dynamic masticatory muscle movement, and humid environment. This paper reports an effective conservative method using an oral wound dressing material with an omnivec splint and presents three wound dehiscence cases: (1) autogenous tooth bone graft material with a collagen membrane, with dehiscence occurring at postoperative 5 days. (2) Autogenous bone graft covering titanium mesh, with dehiscence occurring at postoperative three weeks. The mesh was removed after 10 weeks with histologic analysis. (3) Autogenous bone and autogenous tooth bone graft covering a titanium mesh, with dehiscence occurring at postoperative 1 week. The exposed titanium mesh was maintained for 6 months after the graft. All cases achieved secondary healing and acceptable outcomes for a dental implant by conservative treatment without infection after the dehiscence after ridge augmentation.

Evaluation of the Mandible as an Alternative Autogenous Bone Source for Oral and Maxillofacial Reconstruction

2002 ◽  
Vol 30 (3) ◽  
pp. 260-264 ◽  
Author(s):  
M Güngörmüş ◽  
AB Yilmaz ◽  
Ü Ertaş ◽  
HM Akgül ◽  
MS Yavuz ◽  
...  
Keyword(s):  
Bone Graft ◽  
Anterior Part ◽  
Third Molar ◽  
Mental Foramen ◽  
Autogenous Bone ◽  
Graft Material ◽  
Reconstructive Procedures ◽  
Mandibular Symphysis ◽  
Safety Margins ◽  
Mandibular Body

The objective of this study was to quantify the amount of bone graft material present in the different regions of the mandible while avoiding the inferior alveolar neurovascular bundle, mental foramen and tooth injury. The study was carried out on 16 samples of dry, cadaverous skull. The dimensions of the anterior part of ascending ramus, mandibular symphysis and mandibular body in these samples were evaluated. The osteotomy lines in the anterior part of the ascending ramus were made in front of the mandibular canal from the mandibular notch to 3 mm posterior of the root of the third molar. The osteotomy line in the mandibular body was made just medial to the external oblique ridge from the ascending ramus to approximately 3 mm posterior to the mental foramen. Vertical osteotomy lines were then made from the cut ends of the first osteotomy down to the lower border of the mandible. The osteotomy lines in the mandibular symphysis were performed on the mandible with 5-mm safety margins caudal to the expected position of the mandibular dentition, anterior to the position of the mental foramen, and cephalad to the inferior border of the mandible. It was determined that the dimensions of the anterior part of the ascending ramus were 37.60 mm × 33.17 mm × 22.48 mm × 9.15 mm, and the thickest part of the graft material was 12.23 mm. The average horizontal length of the mandibular body bone was 35.10 mm, and the average vertical length was 19.13 mm. The dimensions of the bone graft obtained from the mandibular symphysis were 45.36 mm × 10.31 mm, and the average thickness was 9.63 mm. Based on the results of this study, it is apparent that the different regions of the mandible can reliably be selected as the harvest site in a variety of oral and maxillofacial reconstructive procedures.

scholarly journals Calcium silicate as a graft material for bone fractures: a systematic review

2018 ◽  
Vol 46 (7) ◽  
pp. 2537-2548 ◽  
Author(s):  
Marcelo Sanmartin de Almeida ◽  
Gustavo Vicentis de Oliveira Fernandes ◽  
Aline Muniz de Oliveira ◽  
José Mauro Granjeiro
Keyword(s):  
Systematic Review ◽  
Bone Graft ◽  
Calcium Silicate ◽  
Bone Fractures ◽  
Research Question ◽  
Evidence Base ◽  
Autogenous Bone ◽  
Graft Material ◽  
Bone Graft Material ◽  
Initial Research

Objective The goal of this review was to determine whether calcium silicate (wollastonite) as a bone graft material is a viable alternative to autogenous bone or whether the evidence base for its use is weak. Methods In this systematic review, electronic databases (MEDLINE/PubMed and BVS) were searched for relevant articles in indexed journals. Articles published in a 10-year period were identified (n = 48). After initial selection, 17 articles were assessed for eligibility; subsequently, seven articles were excluded and 10 articles were included. Results Among the studies included, 20% emphasized the importance of randomization, which adds reliability to the study, minimizing the risk of bias. High variability was observed in the material used, such as additives, amounts, dosage, and chemical alterations, rendering direct comparison among these studies impossible. The experimental periods varied considerably; one of the studies did not include statistical analysis, weakening the evaluation. Nonetheless, the true potential of wollastonite as a graft material conducive to new bone formation was reported in all studies. Conclusion The results support the use of wollastonite as a bone graft material. The initial research question was answered despite the significant variability observed among these preclinical studies, which hindered the precision of this analysis.

Sign in / Sign up

Export Citation Format

Share Document