Designed PCL Nanofibers Fabricated Using a Modified Electrohydrodynamic Process for Tissue Engineering

2008 ◽  
Vol 130 (2) ◽  
Author(s):  
GeunHyung Kim ◽  
WanDoo Kim
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Blood Vessel ◽  
Computer Assisted ◽  
High Porosity ◽  
Cellular Behavior ◽  
Computer Assisted Design ◽  
Good Potential ◽  
Orthotropic Properties ◽  
Conical Electrode

An ideal scaffold should have good mechanical properties and provide a biologically functional implant site. Considering their large surface area, high porosity, and good interconnectivity of pores, electrospun micro-∕nanofibers have good potential as biomimic scaffolds. In this study, various poly(ε-carprolactone) webs consisting of uniaxially oriented micro-∕nanofibers were produced using an electrohydrodynamic process (electrospinning) with a conical electrode and two-axis collector. The oriented fibrous web showed mechanical orthotropic properties, which might be important for designing engineering scaffolds that mimic natural tissues, such as a blood vessel or ligament, which have orthotropic mechanical properties. In addition, the fabricated mats, which were electrospun using computer-assisted design, had good hydrophilic and good cellular behavior compared to a random fiber mat.

Biomineralization of Electrospun Nano-HA/PHB GTR Membrane

2007 ◽  
Vol 330-332 ◽  
pp. 695-698 ◽  
Author(s):  
Dong Hua Guan ◽  
Chun Peng Huang ◽  
Ji Liu ◽  
Kun Tian ◽  
Lin Niu ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Electrospinning Process ◽  
Nanometer Scale ◽  
High Porosity ◽  
The Novel ◽  
Mineral Crystal ◽  
Novel Technology ◽  
Air Jet

Poly 3-hydroxybutyrate (PHB) as a kind of polysaccharides has been proved promising for tissue engineering because of its biocompatibility and biodegradability. But its poor mechanical properties and hydrophilicity limit its application. In order to explore a new useful porch to improve the performance of PHB-based GTR membrane, membrane composed of nano-HA / PHB composite was manufactured through the air/jet electrospinning process which can potentially generate nanometer scale diameter fibers and enlarge surface area of materials while maintaining high porosity. Successively, the biomineralization behavior of the membrane in supersaturated calcification solution (SCS) was studied. The Results of this investigation show that the successfully manufactured porous nano-HA/PHB membrane has high activity in SCS and its ability of inducing the formation of mineral crystal in vitro than that of the unfilled PHB membrane. It can be concluded that the addition of nano-HA and the novel technology could improve the performance of the PHB-based GTR membrane.

Computational Design and Optimization of Nerve Guidance Conduits for Improved Mechanical Properties and Permeability

2019 ◽  
Vol 141 (5) ◽  
Author(s):  
Shuo Zhang ◽  
Sanjairaj Vijayavenkataraman ◽  
Geng Liang Chong ◽  
Jerry Ying Hsi Fuh ◽  
Wen Feng Lu
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Mechanical Strength ◽  
Tensile Modulus ◽  
Computational Design ◽  
Structural Features ◽  
Nerve Tissue ◽  
High Porosity ◽  
Engineering Research ◽  
Design And Optimization

Nerve guidance conduits (NGCs) are tubular tissue engineering scaffolds used for nerve regeneration. The poor mechanical properties and porosity have always compromised their performances for guiding and supporting axonal growth. Therefore, in order to improve the properties of NGCs, the computational design approach was adopted to investigate the effects of different NGC structural features on their various properties, and finally, design an ideal NGC with mechanical properties matching human nerves and high porosity and permeability. Three common NGC designs, namely hollow luminal, multichannel, and microgrooved, were chosen in this study. Simulations were conducted to study the mechanical properties and permeability. The results show that pore size is the most influential structural feature for NGC tensile modulus. Multichannel NGCs have higher mechanical strength but lower permeability compared to other designs. Square pores lead to higher permeability but lower mechanical strength than circular pores. The study finally selected an optimized hollow luminal NGC with a porosity of 71% and a tensile modulus of 8 MPa to achieve multiple design requirements. The use of computational design and optimization was shown to be promising in future NGC design and nerve tissue engineering research.

A facile green approach for fabricating bacterial cellulose scaffold with macroporous structure and cell affinity

2019 ◽  
Vol 34 (6) ◽  
pp. 442-452
Author(s):  
Meiling Zhong ◽  
Jinsheng Li ◽  
Aoqi Tang ◽  
Qi Zhang ◽  
Dehui Ji ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Bacterial Cellulose ◽  
Great Promise ◽  
High Porosity ◽  
Macroporous Structure ◽  
Gelatin Microspheres ◽  
Green Approach ◽  
Cell Affinity ◽  
Cellulose Surface

Bacterial cellulose holds great promise for tissue engineering, but its application is greatly limited due to the lack of large pores and poor cell affinity. In this study, macroporous bacterial cellulose was fabricated through the dissolution of gelatin microspheres, which were incorporated with bacterial cellulose during bacterial cellulose fabrication. Then, gelatin was immobilized onto bacterial cellulose surface via procyanidins crosslinking. The results confirmed that the scaffolds possessed interconnected macroporous structure, high porosity, good water uptake ability, and good mechanical properties. The results of evaluation of cells showed that cells migrated to the inner of macroporous affinitive bacterial cellulose and displayed better spreading as well as proliferation than that on pure bacterial cellulose surfaces. The macroporous affinitive bacterial cellulose show potential as a scaffold for tissue engineering.

scholarly journals Preparation of open-porous stereocomplex PLA/PBAT scaffolds and correlation between their morphology, mechanical behavior, and cell compatibility

RSC Advances ◽  
2018 ◽  
Vol 8 (23) ◽  
pp. 12933-12943 ◽  
Author(s):  
Yuan Kang ◽  
Peng Chen ◽  
Xuetao Shi ◽  
Guangcheng Zhang ◽  
Chaoli Wang
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Mechanical Behavior ◽  
High Porosity ◽  
Engineering Applications ◽  
Cell Compatibility ◽  
Biodegradable Scaffolds ◽  
Good Biocompatibility

For tissue engineering applications, it is essential that biodegradable scaffolds have accessible mechanical properties, high porosity, and good biocompatibility to support the formation of new tissues.

scholarly journals Evaluation of 3D hybrid microfiber/nanofiber scaffolds for bone tissue engineering

2014 ◽  
Vol 62 (3) ◽  
pp. 551-556 ◽  
Author(s):  
B. Ostrowska ◽  
J. Jaroszewicz ◽  
E. Zaczynska ◽  
W. Tomaszewski ◽  
W. Swieszkowski ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Mechanical Properties ◽  
Tissue Engineering ◽  
Scanning Electron Microscopy ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Hybrid Structures ◽  
High Porosity ◽  
Testing Stage ◽  
Scanning Electron

Abstract Fabrication of scaffolds for tissue engineering (TE) applications becomes a very important research topic in present days. The aim of the study was to create and evaluate a hybrid polymeric 3D scaffold consisted of nano and microfibers, which could be used for bone tissue engineering. Hybrid structures were fabricated using rapid prototyping (RP) and electrospinning (ES) methods. Electrospun nanofibrous mats were incorporated between the microfibrous layers produced by RP technology. The nanofibers were made of poly(L-lactid) and polycaprolactone was used to fabricate microfibers. The micro- and nanostructures of the hybrid scaffolds were examined using scanning electron microscopy (SEM). X-ray microtomographical (μCT) analysis and the mechanical testing of the porous hybrid structures were performed using SkyScan 1172 machine, equipped with a material testing stage. The scanning electron microscopy and micro-tomography analyses showed that obtained scaffolds are hybrid nanofibers/microfibers structures with high porosity and interconnected pores ranging from 10 to 500um. Although, connection between microfibrous layers and electrospun mats remained consistent under compression tests, addition of the nanofibrous mats affected the mechanical properties of the scaffold, particularly its elastic modulus. The results of the biocompatibility tests didn’t show any cytotoxic effects and no fibroblast after contact with the scaffold showed any damage of the cell body, the cells had proper morphologies and showed good proliferation. Summarizing, using RP technology and electrospinning method it is possible to fabricate biocompatible scaffolds with controllable geometrical parameters and good mechanical properties.

Preparation and properties of a biodegradable poly(lactide-co-glycolide)/poly(trimethylene carbonate) porous composite scaffold for bone tissue engineering

2020 ◽  
Vol 44 (34) ◽  
pp. 14632-14641 ◽  
Author(s):  
Jin Qi ◽  
Yu Zhang ◽  
Xiliang Liu ◽  
Qianmao Zhang ◽  
Chengdong Xiong
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Porous Scaffold ◽  
Composite Scaffold ◽  
High Porosity ◽  
Trimethylene Carbonate ◽  
Porous Composite ◽  
Biodegradable Poly ◽  
Good Biocompatibility ◽  
Interconnected Pore

New biodegradable PLGA/PTMC composite porous scaffold with high porosity, mechanical properties, significant homogeneous, interconnected pore network and good biocompatibility.

scholarly journals Mechanical Characterization of 3D-Printed Individualized Ti-Mesh (Membrane) for Alveolar Bone Defects

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Liyun Bai ◽  
Ping Ji ◽  
Xian Li ◽  
Hui Gao ◽  
Linlin Li ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Alveolar Bone ◽  
Mechanical Characterization ◽  
Computer Assisted ◽  
Titanium Mesh ◽  
Computer Assisted Design ◽  
3D Fea ◽  
3D Printed ◽  
Ti Mesh

Individualized titanium mesh holds many advantages over conventional mesh. There are few reports in the literature about the effect of mesh pore size and mesh thickness on the mechanical properties of titanium mesh. This study is designed to develop an individualized titanium mesh using computer-assisted design and additive manufacturing technology. This study will also explore the effect of different thicknesses and pore sizes of titanium mesh on its mechanical properties through 3D FEA. According to this study, the mechanical properties of titanium mesh increased when the thickness decreased (0.5 mm to 0.3 mm). With an increase in mesh diameter (3 mm to 5 mm), the mechanical properties of mesh decreased. The diameter of titanium mesh has less influence on its mechanical properties than does the thickness of the mesh. Titanium mesh with a thickness of 0.4 mm is strong enough and causes less stimulation to mucosa; therefore, it is more suitable for clinical use. In addition, parameters of titanium mesh should be decided clinically according to bone defect size, defect location, and force situation.

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