Numerical Studies of Three-Dimensional Arterial Flows in Reverse Curvature Geometry: Part I—Peak Flow

1993 ◽  
Vol 115 (3) ◽  
pp. 316-326 ◽  
Author(s):  
R. K. Banerjee ◽  
Y. I. Cho ◽  
L. H. Back
Keyword(s):  
Shear Stress ◽  
Three Dimensional ◽  
Flow Simulation ◽  
Outer Wall ◽  
Momentum Effect ◽  
Centrifugal Effect ◽  
Stress Region ◽  
Secondary Motion ◽  
Low Shear Stress ◽  
Experimental Values

A three-dimensional flow simulation at Repeak = 192 and 580 was made in a smooth reverse curvature model that conformed to the gentle “S” shape from a human left femoral artery angiogram. The objective of this numerical investigation was to find the changes in pressure, shear stress, velocity profile, and particle path occurring in the double-curved arterial vessel. Due to the impingement of blood at the outer wall in the first bend region, the wall shear stress approached 40 dyne/cm2—a value over twice as large as in the straight upstream segment. Conversely, at the inner wall in the first bend, a low shear stress region was found where the value of the shear stress was consistently smaller than that in the straight section. The initiation of centrifugal effects caused by the first bend could clearly be seen at Repeak = 580, but due to the close proximity of the reverse curvature segment, the momentum effect due to the second bend overshadowed the centrifugal effect. Hence, only near the end of the second bend did the centrifugal effect due to the second bend result in a double-spiral-secondary motion. In addition, the numerically calculated pressure drop data were in agreement with prior experimental values.

Plaque and Shear Stress Distribution in Human Coronary Bifurcations: a Multi-Slice Computed Tomography Study

2007 ◽  
Author(s):  
Alina G. van der Giessen ◽  
Jolanda J. Wentzel ◽  
Frans N. van de Vosse ◽  
Antonius F. van der Steen ◽  
Pim J. de Feyter ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Shear Stress ◽  
Outer Wall ◽  
Atherosclerotic Plaques ◽  
Advanced Stage ◽  
Flow Divider ◽  
Low Shear Stress ◽  
Curved Vessels ◽  
Early Atherosclerosis ◽  
Low Shear

It is generally accepted that early atherosclerosis develops in low shear-stress (SS) regions such as the outer wall of arterial bifurcations and the inner bend of curved vessels (1). However, in clinical practice, it is common to observe atherosclerotic plaques at the flow-divider, or carina, of coronary bifurcations (2). Plaques at the carina are more frequently found in symptomatic patients, and may represent a more advanced stage of atherosclerosis. The carina is located in a region which is exposed to high SS. We hypothesize that if plaques are located in atheroprotective high SS regions, they have grown circumferentially from the atherogenic low SS regions.

scholarly journals Impact of Modified Spacer on Flow Pattern in Narrow Spacer-Filled Channels for Spiral-Wound Membrane Modules

Environments ◽  
2018 ◽  
Vol 5 (11) ◽  
pp. 116
Author(s):  
Zhiming Han ◽  
Mitsuharu Terashima ◽  
Bing Liu ◽  
Hidenari Yasui
Keyword(s):  
Shear Stress ◽  
Flow Pattern ◽  
Friction Factor ◽  
Flow Direction ◽  
Dead Zone ◽  
Three Dimensional ◽  
Stress Contour ◽  
Directional Change ◽  
Low Shear Stress ◽  
Membrane Modules

A modified spacer, which was constructed with arched filaments and zigzag filaments, was designed to improve vortex shedding and generate a directional change in flow patterns of membrane modules, especially in the vicinity of the feed spacer filament, which is most affected by fouling. A unit cell was investigated by using a three-dimensional computational fluid dynamics (CFD) model for hydrodynamic simulation. The results of CFD simulations were carried out for the fluid flow in order to understand the effect of the modified spacer on vortices to the performance of arched filaments at different distances. From 2D velocity vectors and shear stress contour mixing, the flow pattern and dead zone flushing were depicted. The ratio of low shear stress area to the total area increased with the inlet velocity closed to 20%. The energy consumption with respect to flow direction for the arched filament was 80% lower than that in the zigzag filament. Compared with previous commercial spacers’ simulation, the friction factor was lower when the main flow was normal to the arched filament and the modified friction factor was close to the commercial spacers. The homogenization was realized through the flow pattern created by the modified spacer.

Numerical Study of Turbulent Flow and Convective Heat Transfer Characteristics in Helical Rectangular Ducts

2014 ◽  
Vol 136 (12) ◽  
Author(s):  
Yunfei Xing ◽  
Fengquan Zhong ◽  
Xinyu Zhang
Keyword(s):  
Heat Transfer ◽  
Convective Heat Transfer ◽  
Convective Heat ◽  
Numerical Study ◽  
Rectangular Cross Section ◽  
Three Dimensional ◽  
Flow Characteristics ◽  
Axial Direction ◽  
Outer Wall ◽  
Centrifugal Effect

Three-dimensional turbulent forced convective heat transfer and its flow characteristics in helical rectangular ducts are simulated using SST k–ω turbulence model. The velocity field and temperature field at different axial locations along the axial direction are analyzed for different inlet Reynolds numbers, different curvatures, and torsions. The causes of heat transfer differences between the inner and outer wall of the helical rectangular ducts are discussed as well as the differences between helical and straight duct. A secondary flow is generated due to the centrifugal effect between the inner and outer walls. For the present study, the flow and thermal field become periodic after the first turn. It is found that Reynolds number can enhance the overall heat transfer. Instead, torsion and curvature change the overall heat transfer slightly. But the aspect ratio of the rectangular cross section can significantly affect heat transfer coefficient.

Pulsatile Non-Newtonian Flow Characteristics in a Three-Dimensional Human Carotid Bifurcation Model

1991 ◽  
Vol 113 (4) ◽  
pp. 464-475 ◽  
Author(s):  
K. Perktold ◽  
M. Resch ◽  
H. Florian
Keyword(s):  
Shear Stress ◽  
Carotid Sinus ◽  
Three Dimensional ◽  
Flow Characteristics ◽  
Outer Wall ◽  
Maximum Diameter ◽  
Newtonian Flow ◽  
Pulse Cycle ◽  
Flow Phenomena ◽  
Human Carotid

Numerical analysis of flow phenomena and wall shear stresses in the human carotid artery bifurcation has been carried out using a three-dimensional geometrical model. The primary aim of this study is the detailed discussion of non-Newtonian flow velocity and wall shear stress during the pulse cycle. A comparison of non-Newtonian and Newtonian results is also presented. The applied non-Newtonian behavior of blood is based on measured dynamic viscosity. In the foreground of discussion are the flow characteristics in the carotid sinus. The investigation shows complex flow patterns especially in the carotid sinus where flow separation occurs at the outer wall throughout the systolic deceleration phase. The changing sign of the velocity near the outer sinus wall results in oscillating shear stress during the pulse cycle. At the outer wall of the sinus at maximum diameter level the shear stress ranges from −1.92 N/m2 to 1.22 N/m2 with a time-averaged value of 0.04 N/m2. At the inner wall of the sinus at maximum diameter level the shear stress range is from 1.16 N/m2 to 4.18 N/m2 with a mean of 1.97 N/m2. The comparison of non-Newtonian and Newtonian results indicates unchanged flow phenomena and rather minor differences in the basic flow characteristics.

Three-Dimensional Steady Flow Through A Bifurcation

1990 ◽  
Vol 112 (2) ◽  
pp. 189-197 ◽  
Author(s):  
Chain-Nan Yung ◽  
Kenneth J. De Witt ◽  
Theo G. Keith
Keyword(s):  
Reynolds Number ◽  
Shear Stress ◽  
Steady Flow ◽  
Stokes Equations ◽  
Control Volume ◽  
Three Dimensional ◽  
Numerical Procedure ◽  
Simple Algorithm ◽  
Outer Wall ◽  
Navier Stokes

Steady flow of an incompressible, Newtonian fluid through a symmetric bifurcated rigid channel was numerically analyzed by solving the three-dimensional Navier-Stokes equations. The upstream Reynolds number ranged from 100 to 1500. The bifurcation was symmetrical with a branch angle of 60 deg and the area ratio of the daughter to the mother vessel was 2.0. The numerical procedure utilized a coordinate transformation and a control volume approach to discretize the equations to finite difference form and incorporated the SIMPLE algorithm in performing the calculation. The predicted velocity pattern was in qualitative agreement with experimental measurements available in the literature. The results also showed the effect of secondary flow which can not be predicted using previous two-dimensional simulations. A region of reversed flow was observed near the outer wall of the branch except for the case of the lowest Reynolds number. Particle trajectory was examined and it was found that no fluid particles remained within the recirculation zone. The shear stress was calculated on both the inner and the outer wall of the branch. The largest wall shear stress, located in the vicinity of the apex of the branch, was of the same order of magnitude as the level that can cause damage to the vessel wall as reported in a recent study.

Flow Analysis of a Porous Polymer-Based Three-Dimensional Cell Culture Device for Drug Screening

2018 ◽  
Author(s):  
Liang Ma ◽  
Lei Gao ◽  
Yichen Luo ◽  
Huayong Yang ◽  
Bin Zhang ◽  
...  
Keyword(s):  
Cell Culture ◽  
Shear Stress ◽  
Three Dimensional ◽  
Flow Simulation ◽  
3D Cell Culture ◽  
Porous Polymer ◽  
Poly Lactic Acid ◽  
Porous Scaffolds ◽  
3D Scaffold

A porous polymer-based three-dimensional (3D) cell culture device has been developed as an in vitro tissue model system for the cytotoxicity of anticancer drug test. The device had two chambers connected in tandem, each loaded with a 3D scaffold made of highly biocompatible poly (lactic acid) (PLA). Hepatoma cells (HepG2) and glioblastoma multiforme (GBM) cancer cells were cultured in the two separate porous scaffolds. A peristaltic pump was adopted to realize a perfusion cell culture. In this study, we focus on cell viability inside the 3D porous scaffolds under flow-induced shear stress effects. A flow simulation was conducted to predict the shear stress based on a realistic representation of the porous structure. The simulation results were correlated to the cell variability measurements at different flow rates. It is shown that the modeling approach presented in this paper can be useful for shear stress predication inside porous scaffolds and the computational fluid dynamics model can be an effective way to optimize the operation parameters of perfused 3D cell culture devices.

scholarly journals Enhanced discrete phase model for multiphase flow simulation of blood flow with high shear stress

2021 ◽  
Vol 104 (1) ◽  
pp. 003685042110080
Author(s):  
Zheqin Yu ◽  
Jianping Tan ◽  
Shuai Wang
Keyword(s):  
Blood Flow ◽  
Shear Stress ◽  
Multiphase Flow ◽  
Experimental Verification ◽  
Flow Simulation ◽  
Turbulence Models ◽  
Phase Model ◽  
Force Model ◽  
Discrete Phase Model ◽  
Discrete Phase

Shear stress is often present in the blood flow within blood-contacting devices, which is the leading cause of hemolysis. However, the simulation method for blood flow with shear stress is still not perfect, especially the multiphase flow model and experimental verification. In this regard, this study proposes an enhanced discrete phase model for multiphase flow simulation of blood flow with shear stress. This simulation is based on the discrete phase model (DPM). According to the multiphase flow characteristics of blood, a virtual mass force model and a pressure gradient influence model are added to the calculation of cell particle motion. In the experimental verification, nozzle models were designed to simulate the flow with shear stress, varying the degree of shear stress through different nozzle sizes. The microscopic flow was measured by the Particle Image Velocimetry (PIV) experimental method. The comparison of the turbulence models and the verification of the simulation accuracy were carried out based on the experimental results. The result demonstrates that the simulation effect of the SST k- ω model is better than other standard turbulence models. Accuracy analysis proves that the simulation results are accurate and can capture the movement of cell-level particles in the flow with shear stress. The results of the research are conducive to obtaining accurate and comprehensive analysis results in the equipment development phase.

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