Fluid Dynamics of a Partially Collapsible Stenosis in a Flow Model of the Coronary Circulation

1996 ◽  
Vol 118 (4) ◽  
pp. 489-497 ◽  
Author(s):  
Maria Siebes ◽  
Charles S. Campbell ◽  
David Z. D’Argenio
Keyword(s):  
Pressure Drop ◽  
Flow Rate ◽  
Coronary Circulation ◽  
Intraluminal Pressure ◽  
Dimensional Changes ◽  
Area Reduction ◽  
Stenosis Severity ◽  
Flexible Wall ◽  
Drop Flow

The influence of passive vasomotion on the pressure drop-flow (ΔP-Q) characteristics of a partially compliant stenosis was studied in an in vitro model of the coronary circulation. Twelve stenosis models of different severities (50 to 90 percent area reduction) and degrees of flexible wall (0 to 1/2 of the wall circumference) were inserted into thin-walled latex tubing and pressure and flow data were collected during simulated cardiac cycles. In general, the pressure drop increased with increasing fraction of flexible wall for a given flow rate and stenosis severity. The magnitude of this effect was directly dependent upon the underlying stenosis severity. The diastolic ΔP-Q relationship of severe, compliant models exhibited features of partial collapse with an increase in pressure drop at a decreasing flow rate. It is concluded that passive vasomotion of a normal wall segment at an eccentric stenosis in response to periodic changes in intraluminal pressure causes dimensional changes in the residual lumen area which can strongly affect the hemodynamic characteristics of the stenosis during the cardiac cycle. This mechanism may have important implications for the onset of plaque fracture and the prediction of the functional significance of a coronary stenosis based on quantitative angiogram analysis.

scholarly journals Vascular Stenosis Asymmetry Influences Considerably Pressure Gradient and Flow Volume

2016 ◽  
pp. 63-69 ◽  
Author(s):  
L. NOVAKOVA ◽  
J. KOLINSKY ◽  
J. ADAMEC ◽  
J. KUDLICKA ◽  
J. MALIK
Keyword(s):  
Pressure Drop ◽  
Flow Volume ◽  
Hemodynamic Changes ◽  
Flow Measurements ◽  
Stenosis Severity ◽  
Vascular Stenosis ◽  
Particle Imaging ◽  
Different Levels ◽  
Volume Decrease

Vascular stenosis is often described only by its percentage in both clinical and scientific praxis. Previous studies gave inconclusive results regarding the effect of stenosis eccentricity on its hemodynamic effect. The aim of this experimental study was to investigate and quantify the effect of stenosis severity and eccentricity on the pressure drop. A combination of pressure and flow measurements by Particle Imaging Velocimetry (PIV) method was used. Models of the same stenosis significance but with different levels of eccentricity were studied in vitro by PIV. This study has shown that stenosis asymmetry is associated with more profound pressure drop and flow volume decrease. On the contrary, pressure drop and flow volume decrease were not further significantly influenced by the level of asymmetry. Hemodynamic changes associated with stenosis eccentricity must be taken into account in both clinical and scientific studies.

Diagnostic Uncertainties During Assessment of Serial Coronary Stenoses: An In Vitro Study

2014 ◽  
Vol 136 (2) ◽  
Author(s):  
Gavin A. D’Souza ◽  
Srikara V. Peelukhana ◽  
Rupak K. Banerjee
Keyword(s):  
Pressure Drop ◽  
Dynamic Pressure ◽  
Clinical Intervention ◽  
In Vitro Study ◽  
Gray Zone ◽  
Diagnostic Parameter ◽  
Fractional Flow ◽  
Flow Reserve ◽  
Stenosis Severity

Currently, the diagnosis of coronary stenosis is primarily based on the well-established functional diagnostic parameter, fractional flow reserve (FFR: ratio of pressures distal and proximal to a stenosis). The threshold of FFR has a “gray” zone of 0.75–0.80, below which further clinical intervention is recommended. An alternate diagnostic parameter, pressure drop coefficient (CDP: ratio of trans-stenotic pressure drop to the proximal dynamic pressure), developed based on fundamental fluid dynamics principles, has been suggested by our group. Additional serial stenosis, present downstream in a single vessel, reduces the hyperemic flow, Q˜h, and pressure drop, Δp˜, across an upstream stenosis. Such hemodynamic variations may alter the values of FFR and CDP of the upstream stenosis. Thus, in the presence of serial stenoses, there is a need to evaluate the possibility of misinterpretation of FFR and test the efficacy of CDP of individual stenoses. In-vitro experiments simulating physiologic conditions, along with human data, were used to evaluate nine combinations of serial stenoses. Different cases of upstream stenosis (mild: 64% area stenosis (AS) or 40% diameter stenosis (DS); intermediate: 80% AS or 55% DS; and severe: 90% AS or 68% DS) were tested under varying degrees of downstream stenosis (mild, intermediate, and severe). The pressure drop-flow rate characteristics of the serial stenoses combinations were evaluated for determining the effect of the downstream stenosis on the upstream stenosis. In general, Q˜h and Δp˜ across the upstream stenosis decreased when the downstream stenosis severity was increased. The FFR of the upstream mild, intermediate, and severe stenosis increased by a maximum of 3%, 13%, and 19%, respectively, when the downstream stenosis severity increased from mild to severe. The FFR of a stand-alone intermediate stenosis under a clinical setting is reported to be ∼0.72. In the presence of a downstream stenosis, the FFR values of the upstream intermediate stenosis were either within (0.77 for 80%–64% AS and 0.79 for 80%–80% AS) or above (0.88 for 80%–90% AS) the “gray” zone (0.75–0.80). This artificial increase in the FFR value within or above the “gray” zone for an upstream intermediate stenosis when in series with a clinically relevant downstream stenosis could lead to misinterpretation of functional stenosis severity. In contrast, a distinct range of CDP values was observed for each case of upstream stenosis (mild: 8–10; intermediate: 47–54; and severe: 130–155). The nonoverlapping range of CDP could better delineate the effect of the downstream stenosis from the upstream stenosis and allow for the accurate diagnosis of the functional severity of the upstream stenosis.

A Hemodynamic Comparison of Myocardial Bridging and Coronary Atherosclerotic Stenosis: A Computational Model with Experimental Evaluation

2020 ◽  
Author(s):  
Mohammadali Sharzehee ◽  
Yasamin Seddighi ◽  
Eugene A. Sprague ◽  
Ender A. Finol ◽  
Hai-Chao Han
Keyword(s):  
Pressure Drop ◽  
Experimental Results ◽  
Cfd Modeling ◽  
Patient Specific ◽  
Flow Loop ◽  
Myocardial Bridging ◽  
Atherosclerotic Stenosis ◽  
Stenosis Severity ◽  
The Difference

Abstract Myocardial bridging (MB) and coronary atherosclerotic stenosis can impair coronary blood flow and may cause myocardial ischemia or even stoke. It remains unclear how MB and stenosis are similar or different regarding their impacts on coronary hemodynamics. The purpose of this study was to compare the hemodynamic effects of MB and stenosis using experimental and computational fluid dynamics (CFD) approaches. For CFD modeling, three MB patients with different levels of lumen obstruction such as mild, moderate, and severe were selected. Patient-specific left anterior descending coronary artery models were reconstructed from biplane angiograms. For each MB patient, the virtually healthy and stenotic models were also simulated for comparison. In addition, an in vitro flow-loop was developed to evaluate the model-predicted pressure drop. The CFD modeling results demonstrated that the difference between MB and stenosis increased with increasing MB/stenosis severity and flow rate. Experimental results showed that increasing the MB length (by 140%) only had significant impact on the pressure drop in the severe MB (39% increase at the exercise). However, increasing the stenosis length dramatically increased the pressure drop in both moderate and severe stenoses at all flow rates (31% and 93% increase at the exercise, respectively). Both CFD and experimental results confirmed that the MB had a higher maximum and a lower mean pressure drop in comparison with the stenosis, regardless of MB/stenosis severity. A better understanding of MB and stenosis may improve the therapeutic strategies in coronary disease patients and prevent acute coronary syndromes.

scholarly journals Assessment of Different Pressure Drop-Flow Rate Equations in a Pressurized Porous Media Filter for Irrigation Systems

Water ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2179
Author(s):  
Jonathan Graciano-Uribe ◽  
Toni Pujol ◽  
Jaume Puig-Bargués ◽  
Miquel Duran-Ros ◽  
Gerard Arbat ◽  
...  
Keyword(s):  
Porous Media ◽  
Pressure Drop ◽  
Flow Rate ◽  
Cfd Simulation ◽  
Silica Sand ◽  
Rate Equations ◽  
Uncertainty Range ◽  
Head Losses ◽  
Computational Fluid Dynamics Cfd ◽  
Drop Flow

The small open area available at the slots of underdrains in pressurized granular bed filters for drip irrigation implies: (1) the existence of a region with non-uniform flow, and (2) local values of modified particle Reynolds number >500. These flow conditions may disagree with those accepted as valid for common pressure drop-flow rate correlations proposed for packed beds. Here, we carried out detailed computational fluid dynamics (CFD) simulations of a laboratory filter to analyze the results obtained with five different equations of head losses in porous media: (1) Ergun, (2) Darcy-Forchheimer, (3) Darcy, (4) Kozeny-Carman and (5) power function. Simulations were compared with experimental data at different superficial velocities obtained from previous studies. Results for two silica sand media indicated that all equations predicted total filter pressure drop values within the experimental uncertainty range when superficial velocities <38.3 m h−1. At higher flow rates, Ergun equation approximated the best to the observed results for silica sand media, being the expression recommended. A simple analytical model of the pressure drop along flow streamlines that matched CFD simulation results was developed.

Discordance between responses of contrast echo intensity to increased flow rate in human coronary circulation and in vitro

1992 ◽  
Vol 124 (2) ◽  
pp. 398-404 ◽  
Author(s):  
Daniele Rovai ◽  
Massimo Lombardi ◽  
Gianna Ghelardini ◽  
Mario Marzilli ◽  
Luigi Taddei ◽  
...  
Keyword(s):  
Flow Rate ◽  
Coronary Circulation ◽  
Echo Intensity

An Experimental Study of the Fluid Dynamics of Multiple Noncritical Stenoses

1977 ◽  
Vol 99 (2) ◽  
pp. 74-82 ◽  
Author(s):  
N. Talukder ◽  
P. E. Karayannacos ◽  
R. M. Nerem ◽  
J. S. Vasko
Keyword(s):  
Pressure Drop ◽  
Mean Flow ◽  
Number Range ◽  
In Vivo Experiments ◽  
Area Reduction ◽  
Individual Effects ◽  
The Mean ◽  
Percent Area

The effects of the number of stenoses and the distance between consecutive stenoses on the total pressure drop across a series of noncritical stenoses with 50 percent area reduction were determined experimentally. The mean flow rate was varied to correspond to a Reynolds number range of 30–280 and both in vitro and in vivo measurements of the pressure drop were carried out. Flow visualization studies also were performed. The pressure drop across a series of stenoses was found to increase linearly with the number of stenoses. Comparable results were obtained from the steady and pulsatile flow in vitro experiments as well as from the in vivo experiments. The results indicate that the total effect of a series of noncritical stenoses is approximately equal to the sum of their individual effects and that the combined effect of a series of noncritical stenoses thus can be critical.

In Vitro Pressure Flow Relationship in Model of Significant Coronary Artery Stenosis

2004 ◽  
Author(s):  
Abhijit Sinha Roy ◽  
Lloyd H. Back ◽  
Ronald W. Millard ◽  
Saeb Khoury ◽  
Rupak K. Banerjee
Keyword(s):  
Coronary Artery ◽  
Pressure Drop ◽  
Power Law ◽  
Flow Rate ◽  
In Vitro Model ◽  
Maximum Pressure ◽  
Vitro Model ◽  
Maximum Pressure Drop

Simultaneous measurement of pressure and flow rate has been found to be helpful in evaluating the physiologic significance of obstructive coronary artery disease and in the diagnosis of microvascular disease. This experimental study seeks to find important pressure-flow relationship in an in-vitro model of significant coronary artery stenoses using a non-Newtonian liquid, similar to blood showing a shear thinning behavior, using significant stenotic in-vitro model (minimal area stenosis = 90%). The geometry for the stenotic model is based on data provided in an in vivo study by Wilson et al., (1988). For 90% area stenosis, the maximum recorded pressure drop for steady flow rate of 55, 79 and 89 are 14, ~24 and ~32 mmHg respectively. The maximum pressure drop at flow rate of 115 ml/min (the physiological limit) is 50.3 mmHg respectively. Using a power law curve fit, the maximum pressure drop (in mmHg) related with flow rate (in ml/min) provided a power law index of 1.72. Shorter distal length than required in the in-vitro model did not allow the recording of complete pressure recovery. This preliminary data provides reference values for further experimentation both in vitro with pulsatile flow as in physiological conditions, and in vivo.

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