Modeling Population Kinetics of Free Fatty Acids in Isolated Rat Hepatocytes using Markov Chain Monte Carlo

2003 ◽  
Vol 31 (7) ◽  
pp. 854-866 ◽  
Author(s):  
Alessandra Pavan ◽  
Karl Thomaseth ◽  
Anna Valerio
Keyword(s):  
Fatty Acids ◽  
Monte Carlo ◽  
Markov Chain ◽  
Markov Chain Monte Carlo ◽  
Free Fatty Acids ◽  
Rat Hepatocytes ◽  
Isolated Rat Hepatocytes ◽  
Population Kinetics ◽  
Kinetics Of ◽  
Isolated Rat

Metabolism of some radiolabeled essential fatty acids in isolated rat hepatocytes is affected by dietary ethanol

Alcohol ◽  
2000 ◽  
Vol 21 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Kjetil Retterstøl ◽  
Anne Marie Lund ◽  
Siri Tverdal ◽  
Bjørn O Cristophersen
Keyword(s):  
Fatty Acids ◽  
Essential Fatty Acids ◽  
Rat Hepatocytes ◽  
Isolated Rat Hepatocytes ◽  
Isolated Rat

scholarly journals Oleic acid promotes the activation and translocation of phosphatidate phosphohydrolase from the cytosol to particulate fractions of isolated rat hepatocytes

1984 ◽  
Vol 219 (3) ◽  
pp. 911-916 ◽  
Author(s):  
C Cascales ◽  
E H Mangiapane ◽  
D N Brindley
Keyword(s):  
Fatty Acids ◽  
Endoplasmic Reticulum ◽  
Oleic Acid ◽  
Microsomal Fraction ◽  
Rat Hepatocytes ◽  
Total Activity ◽  
Cell Fractionation ◽  
Isolated Rat Hepatocytes ◽  
Phosphatidate Phosphohydrolase ◽  
Isolated Rat

The incubation of hepatocytes with 1-4mM-oleate increased the total activity of phosphatidate phosphohydrolase that was measured in the presence of Mg2+ to about 2-fold. This was accompanied by an increase in the proportion of the enzyme that was isolated with the particulate fractions. Conversely, the addition of up to 4mM-oleate decreased the recovery of phosphatidate phosphohydrolase in the cytosolic fraction from about 70% to 3% when hepatocytes were lysed with digitonin. Most of the increase in the membrane-associated phosphohydrolase activity was isolated after cell fractionation in the microsomal fraction that was enriched with the endoplasmic-reticulum marker arylesterase. It is proposed that the translocation of phosphatidate phosphohydrolase facilitates the increased synthesis of triacylglycerols in the liver when it is presented with an increased supply of fatty acids.

A mathematical model of the kinetics of 5-fluorouracil and its catabolites in freshly isolated rat hepatocytes

1984 ◽  
Vol 33 (17) ◽  
pp. 2727-2732 ◽  
Author(s):  
France Mentre ◽  
Jean-Louis Steimer ◽  
Jean-Pierre Sommadossi ◽  
Robert B. Diasio ◽  
Jean-Paul Cano
Keyword(s):  
Mathematical Model ◽  
Rat Hepatocytes ◽  
Isolated Rat Hepatocytes ◽  
Kinetics Of ◽  
Freshly Isolated Rat Hepatocytes ◽  
Isolated Rat
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