Relation Between Near-Wall Residence Times of Monocytes and Early Lesion Growth in the Rabbit Aorto–Celiac Junction

2003 ◽  
Vol 31 (1) ◽  
pp. 53-64 ◽  
Author(s):  
P. Worth Longest ◽  
Clement Kleinstreuer ◽  
George A. Truskey ◽  
John R. Buchanan
Keyword(s):  
Residence Times ◽  
Lesion Growth ◽  
Early Lesion ◽  
Near Wall

scholarly journals A Longitudinal Analysis of Early Lesion Growth in Presymptomatic Patients with Cerebral Adrenoleukodystrophy

2021 ◽  
Author(s):  
E.J. Mallack ◽  
G. Askin ◽  
S. van de Stadt ◽  
P.A. Caruso ◽  
P.L. Musolino ◽  
...  
Keyword(s):  
Longitudinal Analysis ◽  
Lesion Growth ◽  
Early Lesion

Measuring early lesion growth in boys with cerebral demyelinating adrenoleukodystrophy

Neurology ◽  
2019 ◽  
Vol 92 (15) ◽  
pp. 691-693
Author(s):  
Keith van Haren ◽  
Marc Engelen ◽  
Nicole Wolf
Keyword(s):  
Lesion Growth ◽  
Early Lesion

The Cellular Origin in Atheromatous Lesion

1970 ◽  
Vol 28 ◽  
pp. 202-203
Author(s):  
T. M. Murad ◽  
H. A. I. Newman ◽  
K. F. Kern
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Rabbit Aorta ◽  
Mixed Population ◽  
The Other ◽  
Cellular Origin ◽  
Ultrastructural Studies ◽  
Atherosclerotic Lesions ◽  
Show Evidence ◽  
Early Lesion

The origin of lipid containing cells in atheromatous lesion has been disputed. Geer in his study on atheromatous lesions of rabbit aorta, suggested that the early lesion is composed mainly of lipid-laden macrophages and the later lesion has a mixed population of macrophages and smooth muscle cells. Parker on the other hand, was able to show evidence that the rabbit lesion is primarily composed of lipid-laden cells of smooth muscle origin. The above studies and many others were done on an intact lesion without any attempt of cellular isolation previous to their ultrastructural studies. Cell isolation procedures have been established for atherosclerotic lesions through collagenase and elastase digestion Therefore this procedure can be utilized to identify the cells involved in rabbit atheroma.

Dosimetry with 188Re-labelled monoclonal anti-CD66 antibodies

2006 ◽  
Vol 45 (03) ◽  
pp. 134-138 ◽  
Author(s):  
T. Kull ◽  
N. M. Blumstein ◽  
D. Bunjes ◽  
B. Neumaier ◽  
A. K. Buck ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Bone Marrow ◽  
Gamma Camera ◽  
Absorbed Dose ◽  
Correlation Coefficients ◽  
Residence Times ◽  
Reliable Prediction ◽  
Red Bone Marrow ◽  
Antibody Preparation ◽  
Simplified Method

SummaryAim: For the therapeutic application of radiopharmaceuticals the activity is determined on an individual basis. Here we investigated the accuracy for a simplified assessment of the residence times for a 188Re-labelled anti-CD66 monoclonal antibody. Patients, methods: For 49 patients with high risk leukaemia (24 men, 25 women, age: 44 ± 12 years) the residence times were determined for the injected 188Re-labelled anti-CD66 antibodies (1.3 ± 0.4 GBq, 5–7 GBq/mg protein, >95% 188Re bound to the antibody) based on 5 measurements (1.5, 3, 20, 26, and 44 h p.i.) using planar conjugate view gamma camera images (complete method). In a simplified method the residence times were calculated based on a single measurement 3 h p.i. Results: The residence times for kidneys, liver, red bone marrow, spleen and remainder of body for the complete method were 0.4 ± 0.2 h, 1.9 ± 0.8 h, 7.8 ± 2.1 h, 0.6 ± 0.3 h and 8.6 ± 2.1 h, respectively. For all organs a linear correlation exists between the residence times of the complete method and the simplified method with the slopes (correlation coefficients R > 0.89) of 0.89, 0.99, 1.23, 1.13 and 1.09 for kidneys, liver, red bone marrow, spleen and remainder of body, respectively. Conclusion: The proposed approach allows reliable prediction of biokinetics of 188Re-labelled anti-CD66 monoclonal antibody biodistribution with a single study. Efficient pretherapeutic estimation of organ absorbed dose may be possible, provided that a more stable anti-CD66 antibody preparation is available.

NEAR-WALL CHARACTERISTICS OF AN IMPINGING GASOLINE SPRAY AT INCREASED AMBIENT PRESSURE AND WALL TEMPERATURE

2009 ◽  
Vol 19 (11) ◽  
pp. 997-1012 ◽  
Author(s):  
Jochen Stratmann ◽  
D. Martin ◽  
P. Unterlechner ◽  
R. Kneer
Keyword(s):  
Wall Temperature ◽  
Ambient Pressure ◽  
Near Wall

Nonisothermal Mixing of a Near-Wall Gas-Liquid Jet with a Flow in a Tube

2001 ◽  
Vol 32 (4-6) ◽  
pp. 7
Author(s):  
Viktor I. Terekhov ◽  
K. A. Sharov ◽  
N. E. Shishkin ◽  
V. P. Lebedev
Keyword(s):  
Liquid Jet ◽  
Near Wall
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