Retinal Vascular Permeability Determined by Dual-Tracer Fluorescence Angiography

2001 ◽  
Vol 29 (8) ◽  
pp. 638-647 ◽  
Author(s):  
P. K. Russ ◽  
G. M. Gaylord ◽  
F. R. Haselton
Keyword(s):  
Vascular Permeability ◽  
Fluorescence Angiography ◽  
Dual Tracer ◽  
Retinal Vascular Permeability

scholarly journals AB039. BMP9 signaling maintains endothelial integrity and prevents hyperglycemia-induced retinal vascular permeability

2019 ◽  
Vol 4 ◽  
pp. AB039-AB039
Author(s):  
Naoufal Akla ◽  
Claire Viallard ◽  
Natalija Popovic ◽  
Cindy Lora Gil ◽  
Przemyslaw Sapieha ◽  
...  
Keyword(s):  
Vascular Permeability ◽  
Endothelial Integrity ◽  
Retinal Vascular Permeability

scholarly journals Betacellulin Induces Increased Retinal Vascular Permeability in Mice

PLoS ONE ◽  
2010 ◽  
Vol 5 (10) ◽  
pp. e13444 ◽  
Author(s):  
Bela Anand-Apte ◽  
Quteba Ebrahem ◽  
Alecia Cutler ◽  
Eric Farage ◽  
Masahiko Sugimoto ◽  
...  
Keyword(s):  
Vascular Permeability ◽  
Retinal Vascular Permeability

The inhibition of advanced glycation end-products-induced retinal vascular permeability by silver nanoparticles

Biomaterials ◽  
2010 ◽  
Vol 31 (8) ◽  
pp. 2260-2271 ◽  
Author(s):  
Sardarpasha Sheikpranbabu ◽  
Kalimuthu Kalishwaralal ◽  
Kyung-jin Lee ◽  
Ramanathan Vaidyanathan ◽  
Soo Hyun Eom ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Vascular Permeability ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
Retinal Vascular Permeability

scholarly journals Vitamin D3 Protects against Diabetic Retinopathy by Inhibiting High-Glucose-Induced Activation of the ROS/TXNIP/NLRP3 Inflammasome Pathway

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Li Lu ◽  
Qianyi Lu ◽  
Wei Chen ◽  
Jingwen Li ◽  
Chunxia Li ◽  
...  
Keyword(s):  
Vitamin D ◽  
Diabetic Retinopathy ◽  
Vascular Permeability ◽  
Nlrp3 Inflammasome ◽  
High Glucose ◽  
Cell Apoptosis ◽  
Vascular Endothelial Cell ◽  
Vascular Damage ◽  
Vascular Endothelial ◽  
Retinal Vascular Permeability

Purpose. This study aimed to evaluate the mechanisms underlying the effects of 1,25-dihydroxyvitamin D (vitamin D3) on diabetes-induced retinal vascular damage and retinal vascular endothelial cell apoptosis. Methods. Diabetic and control rats were randomly assigned to receive vitamin D3 or vehicle for 6 months. Additionally, human retinal microvascular endothelial cells (HRMECs) were incubated in normal or high-glucose medium with or without vitamin D3. Morphological changes in retinal tissues and retinal vascular permeability were examined, and cellular apoptosis was detected by fluorescence staining. Intracellular reactive oxygen species (ROS) levels were determined using fluorescent probes. Proteins were examined by Western blotting. Results. Vitamin D3 significantly downregulated intracellular ROS and inhibited TRX-interacting protein (TXNIP)/NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome pathway activation. Additionally, vitamin D3 reduced vascular endothelial growth factor (VEGF) expression and the Bax/Bcl-2 ratio. These changes were associated with retinal recovery and with decreases in retinal vascular permeability and retinal capillary cell apoptosis. Conclusions. Vitamin D3 decreases diabetes-induced ROS and exerts protective effects against retinal vascular damage and cell apoptosis in association with inhibition of the ROS/TXNIP/NLRP3 inflammasome pathway. Understanding the mechanisms of action of vitamin D3 has important implications for preventing and treating inflammatory-related illnesses such as diabetic retinopathy.

Retinal vascular permeability in diabetes

2010 ◽  
Author(s):  
S. V. Lopez-Quintero ◽  
E. W. Wolpert ◽  
X. Jing ◽  
D. Antonetti ◽  
J. M. Tarbell
Keyword(s):  
Vascular Permeability ◽  
Retinal Vascular Permeability

scholarly journals The EPAC–Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability

2017 ◽  
Vol 293 (2) ◽  
pp. 717-730 ◽  
Author(s):  
Carla J. Ramos ◽  
Chengmao Lin ◽  
Xuwen Liu ◽  
David A. Antonetti
Keyword(s):  
Vascular Permeability ◽  
Retinal Vascular Permeability

scholarly journals Negatively charged silver nanoparticles cause retinal vascular permeability by activating plasma contact system and disrupting adherens junction

2015 ◽  
Vol 10 (4) ◽  
pp. 501-511 ◽  
Author(s):  
Yan-Min Long ◽  
Xing-Chen Zhao ◽  
Allen C. Clermont ◽  
Qun-Fang Zhou ◽  
Qian Liu ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Vascular Permeability ◽  
Adherens Junction ◽  
Contact System ◽  
Retinal Vascular Permeability
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