scholarly journals Blood flow restriction without sympathetic vasoconstriction in ageing skeletal muscle during exercise

2014 ◽  
Vol 592 (21) ◽  
pp. 4607-4608 ◽  
Author(s):  
Steven S. Segal
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Blood Flow Restriction ◽  
Flow Restriction ◽  
Sympathetic Vasoconstriction

scholarly journals Effects of combined treatment with blood flow restriction and low-current electrical stimulation on muscle hypertrophy in rats

2019 ◽  
Vol 127 (5) ◽  
pp. 1288-1296
Author(s):  
Madoka Yoshikawa ◽  
Takeshi Morifuji ◽  
Tomohiro Matsumoto ◽  
Noriaki Maeshige ◽  
Minoru Tanaka ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Electrical Stimulation ◽  
Muscle Hypertrophy ◽  
Combined Treatment ◽  
Blood Flow Restriction ◽  
Sectional Area ◽  
Cross Sectional ◽  
Flow Restriction ◽  
Skeletal Muscle Hypertrophy

This study aimed to clarify the effects of a combined treatment comprising blood flow restriction and low-current electrical stimulation on skeletal muscle hypertrophy in rats. Male Wistar rats were divided into control (Cont), blood flow restriction (Bfr), electrical stimulation (Es), or Bfr with Es (Bfr + Es) groups. Pressure cuffs (80 mmHg) were placed around the thighs of Bfr and Bfr + Es rats. Low-current Es was applied to calf muscles in the Es and Bfr + Es rats. In experiment 1, a 1-day treatment regimen (5-min stimulation, followed by 5-min rest) was delivered four times to study the acute effects. In experiment 2, the same treatment regimen was delivered three times/wk for 8 wk. Body weight, muscle mass, changes in maximal isometric contraction, fiber cross-sectional area of the soleus muscle, expression of phosphorylated and total-ERK1/2, phosphorylated-rpS6 Ser235/236, phosphorylated and total Akt, and phosphorylated-rpS6 Ser240/244 were measured. Bfr and Es treatment alone failed to induce muscle hypertrophy and increase the expression of phosphorylated rpS6 Ser240/244. Combined Bfr + Es upregulated muscle mass, increased the fiber cross-sectional area, and increased phosphorylated rpS6 Ser240/244 expression and phosphorylated rpS6 Ser235/236 expression compared with controls. Combined treatment with Bfr and low-current Es can induce muscle hypertrophy via activation of two protein synthesis signaling pathways. This treatment should be introduced for older patients with sarcopenia and others with muscle weakness. NEW & NOTEWORTHY We investigated the acute and chronic effect of low-current electrical stimulation with blood flow restriction on skeletal muscle hypertrophy and the mechanisms controlling the hypertrophic response. Low-current electrical stimulation could not induce skeletal muscle hypertrophy, but a combination treatment did. Blood lactate and growth hormone levels were increased in the early response. Moreover, activation of ERK1/2 and mTOR pathways were observed in both the acute and chronic response, which contribute to muscle hypertrophy.

scholarly journals The effects of practical vascular blood flow restriction training on skeletal muscle hypertrophy

2014 ◽  
Vol 11 (Suppl 1) ◽  
pp. P18 ◽  
Author(s):  
John O'Halloran ◽  
Bill Campbell ◽  
Nicholas Martinez ◽  
Shane O’Connor ◽  
Jonathan Fuentes ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Muscle Hypertrophy ◽  
Blood Flow Restriction ◽  
Flow Restriction ◽  
Skeletal Muscle Hypertrophy

Effects of Chronic Blood-Flow Restriction Exercise on Skeletal Muscle Size and Myogenic Satellite Cell Expression

2016 ◽  
Vol 48 ◽  
pp. 1032-1033
Author(s):  
Per Aagaard ◽  
Mikkel Jacobsen ◽  
Kasper Y. Jensen ◽  
Jakob L. Nielsen ◽  
Jens Bülow ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Satellite Cell ◽  
Blood Flow Restriction ◽  
Muscle Size ◽  
Flow Restriction ◽  
Cell Expression
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