scholarly journals Fibre type‐specific hypertrophy mechanisms in human skeletal muscle: potential role of myonuclear addition

2014 ◽  
Vol 592 (23) ◽  
pp. 5147-5148 ◽  
Author(s):  
James R. Bagley
Keyword(s):  
Skeletal Muscle ◽  
Fibre Type ◽  
Human Skeletal Muscle ◽  
Potential Role ◽  
Muscle Potential

scholarly journals Human skeletal muscle glycogen utilization in exhaustive exercise: role of subcellular localization and fibre type

2011 ◽  
Vol 589 (11) ◽  
pp. 2871-2885 ◽  
Author(s):  
Joachim Nielsen ◽  
Hans-Christer Holmberg ◽  
Henrik D. Schrøder ◽  
Bengt Saltin ◽  
Niels Ørtenblad
Keyword(s):  
Skeletal Muscle ◽  
Subcellular Localization ◽  
Muscle Glycogen ◽  
Fibre Type ◽  
Human Skeletal Muscle ◽  
Exhaustive Exercise ◽  
Skeletal Muscle Glycogen ◽  
Glycogen Utilization

scholarly journals Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle

Diabetologia ◽  
2009 ◽  
Vol 52 (5) ◽  
pp. 891-900 ◽  
Author(s):  
J. T. Treebak ◽  
C. Frøsig ◽  
C. Pehmøller ◽  
S. Chen ◽  
S. J. Maarbjerg ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Action ◽  
Human Skeletal Muscle ◽  
Potential Role ◽  
Post Exercise

The role of agrin during the maturation of human skeletal muscle fibres

2006 ◽  
Vol 99 (2-3) ◽  
pp. 1
Author(s):  
Fabio Ruzzier ◽  
Elena Bandi ◽  
Mihaela Jurdana ◽  
Paola Lorenzon ◽  
Marina Sciancalepore
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Muscle Fibres ◽  
Skeletal Muscle Fibres

scholarly journals Appendicular lean mass is lower in late compared with early perimenopausal women: potential role of FSH

2020 ◽  
Vol 128 (5) ◽  
pp. 1373-1380
Author(s):  
Young-Min Park ◽  
Catherine M. Jankowski ◽  
Cemal Ozemek ◽  
Kerry L. Hildreth ◽  
Wendy M. Kohrt ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Lean Mass ◽  
Potential Role ◽  
Appendicular Lean Mass ◽  
Vulnerable Period ◽  
Perimenopausal Women

Our data suggest that the late perimenopausal stage may be a vulnerable period for the loss of skeletal muscle, potentially related to elevations in FSH.

scholarly journals FGF-2–dependent signaling activated in aged human skeletal muscle promotes intramuscular adipogenesis

2021 ◽  
Vol 118 (37) ◽  
pp. e2021013118 ◽  
Author(s):  
Sebastian Mathes ◽  
Alexandra Fahrner ◽  
Umesh Ghoshdastider ◽  
Hannes A. Rüdiger ◽  
Michael Leunig ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Transcriptional Activation ◽  
Human Skeletal Muscle ◽  
Muscle Growth ◽  
Muscle Cells ◽  
Adeno Associated Virus ◽  
Adult Skeletal Muscle

Aged skeletal muscle is markedly affected by fatty muscle infiltration, and strategies to reduce the occurrence of intramuscular adipocytes are urgently needed. Here, we show that fibroblast growth factor-2 (FGF-2) not only stimulates muscle growth but also promotes intramuscular adipogenesis. Using multiple screening assays upstream and downstream of microRNA (miR)-29a signaling, we located the secreted protein and adipogenic inhibitor SPARC to an FGF-2 signaling pathway that is conserved between skeletal muscle cells from mice and humans and that is activated in skeletal muscle of aged mice and humans. FGF-2 induces the miR-29a/SPARC axis through transcriptional activation of FRA-1, which binds and activates an evolutionary conserved AP-1 site element proximal in the miR-29a promoter. Genetic deletions in muscle cells and adeno-associated virus–mediated overexpression of FGF-2 or SPARC in mouse skeletal muscle revealed that this axis regulates differentiation of fibro/adipogenic progenitors in vitro and intramuscular adipose tissue (IMAT) formation in vivo. Skeletal muscle from human donors aged >75 y versus <55 y showed activation of FGF-2–dependent signaling and increased IMAT. Thus, our data highlights a disparate role of FGF-2 in adult skeletal muscle and reveals a pathway to combat fat accumulation in aged human skeletal muscle.

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