scholarly journals Spontaneous transient hyperpolarizations in the rabbit small intestine

2014 ◽  
Vol 592 (21) ◽  
pp. 4733-4745 ◽  
Author(s):  
Yoshihiko Kito ◽  
Masaaki Kurahashi ◽  
Retsu Mitsui ◽  
Sean M. Ward ◽  
Kenton M. Sanders
Keyword(s):  
Small Intestine ◽  
Rabbit Small Intestine

Isolation of plasma membranes of smooth muscle cells of the rabbit small intestine

1984 ◽  
Vol 97 (1) ◽  
pp. 134-136 ◽  
Author(s):  
V. K. Rybal'chenko ◽  
P. V. Pogrebnoi ◽  
T. G. Gruzina ◽  
V. I. Karamushka
Keyword(s):  
Smooth Muscle ◽  
Small Intestine ◽  
Smooth Muscle Cells ◽  
Plasma Membranes ◽  
Muscle Cells ◽  
Rabbit Small Intestine

EFFECT OF EHDP TREATMENT ON THE Na-DEPENDENT PHOSPHATE INFLUX IN RABBIT SMALL INTESTINE AND NERVE

1981 ◽  
pp. 185-189
Author(s):  
Giustina Danisi ◽  
Madeleine Rouiller ◽  
Josée Vitus ◽  
Petr Jirounek ◽  
Jean-Philippe Bonjour ◽  
...  
Keyword(s):  
Small Intestine ◽  
Rabbit Small Intestine ◽  
Phosphate Influx

Excitation conduction in Meissner's plexus of rabbit small intestine.

1977 ◽  
Vol 232 (2) ◽  
pp. E109
Author(s):  
S Yokoyama ◽  
T Ozaki ◽  
T Kajitsuka
Keyword(s):  
Small Intestine ◽  
Evoked Potentials ◽  
Longitudinal Muscle ◽  
Circular Muscle ◽  
Electrical Stimulus ◽  
High Frequencies ◽  
Nerve Impulses ◽  
Conduction Velocities ◽  
Rabbit Small Intestine ◽  
Recording Electrodes

Excitation conduction in Meissner's plexus of the rabit small intestine was investigated by analyzing the records of potentials evoked by a single electrical stimulus applied to this plexus. Experiments were performed on the Meissner's plexus that remained attached to the circular muscle after the longitudinal muscle and mucous membrane were removed from intestinal segment. Conduction velocities of nerve impulses were 0.3-0.7 m/s, chronaxie of the nerve bundle was 0.06-0.12 ms. While the distance between the stimulating and recording electrodes was increased, the latency of evoked potentials was prolonged, the number increased, and the amplitude decreased; no potentials could be recorded when the distance was more than 4 mm. Evoked potentials recorded at relatively long conduction distance were reduced in amplitude or abolished after a repeated stimulation with high frequencies above 50/s, after hexamethonium application, and in a state of lack of oxygen. It was concluded that, in Meissner's plexus, nerve impulses spread through multiple pathways and make synaptic transmission at a relatively short conduction distance.

scholarly journals GM-611, an acid-stablc erythromycin A derivative, induces contractions in the rabbit small intestine via the motiiin receptor

1995 ◽  
Vol 67 ◽  
pp. 191
Author(s):  
Ken-ichi Ozak ◽  
Hisanori Takanashi ◽  
Kenji Yogo ◽  
Michitaka Akima ◽  
Hiroshi Koga ◽  
...  
Keyword(s):  
Small Intestine ◽  
Rabbit Small Intestine ◽  
Erythromycin A

Escherichia coli heat-stable toxin: its effect on motility of the small intestine

1982 ◽  
Vol 242 (4) ◽  
pp. G360-G363 ◽  
Author(s):  
J. R. Mathias ◽  
J. Nogueira ◽  
J. L. Martin ◽  
G. M. Carlson ◽  
R. A. Giannella
Keyword(s):  
Escherichia Coli ◽  
Small Intestine ◽  
Action Potential ◽  
Myoelectric Activity ◽  
Complex Activity ◽  
E Coli ◽  
Heat Stable ◽  
Rabbit Small Intestine ◽  
Weight Substance

Escherichia coli heat-stable enterotoxin is a low-molecular-weight substance that has been shown to induce the active secretion of fluid and electrolytes in the small intestine. In this study, we have characterized the effects of purified E. coli heat-stable toxin (ST, strain 18D, serotype 042:K86:H37) on the motility of rabbit small intestine by using myoelectric recording techniques. Substances, such as cholera toxin, that activate the adenylate cyclase-cAMP system induced predominantly migrating action-potential complex activity. E. coli ST, a toxin that activates the guanylate cyclase-cGMP system, was infused into isolated in vivo ileal loops of New Zealand White rabbits. Inactivated toxin was also studied by exposing the ST to 1 mM dithiothreitol for 90 min. Active E. coli ST induced only repetitive bursts of action potentials. When the toxin was inactivated with dithiothreitol, no alteration in myoelectric activity was observed. We speculate that repetitive bursts of action-potential activity may represent a virulent factor of the bacterium, altering motor activity to slow transit and allowing for bacterial proliferation and invasion.

scholarly journals Motilin antagonistic activity of GM-I09 in the smooth muscle of the rabbit small intestine

1995 ◽  
Vol 67 ◽  
pp. 191
Author(s):  
Kenii Yogo ◽  
Hisanori Takanashi ◽  
Ken-ichi Ozaki ◽  
Makoto Ikuta ◽  
Michitaka Akima ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Small Intestine ◽  
Antagonistic Activity ◽  
Rabbit Small Intestine

Interaction of 2′,3′-di-O-nitro-5′-(N-ethylcarboxamido)adenosine with adenosine receptors in intestinal smooth muscle

1985 ◽  
Vol 63 (5) ◽  
pp. 449-452
Author(s):  
H. P. Baer ◽  
R. Vriend ◽  
A. Murji
Keyword(s):  
Smooth Muscle ◽  
Small Intestine ◽  
Adenosine Receptors ◽  
Neuroblastoma Cells ◽  
Major Effect ◽  
High Reactivity ◽  
Response Curves ◽  
Adenosine Receptor Agonists ◽  
Rabbit Small Intestine

The adenosine derivative, 2′3′-di-O-nitro-(5′-N-ethylcarboxamido)adenosine (DINECA), caused relaxation in several isolated smooth muscle preparations including guinea pig taenia caeci, beef coronary arteries, and rabbit small intestine. In rabbit small intestine the response profile of DINECA action differed from that of established adenosine receptor agonists and, in contrast with the latter, its relaxant effect was only partially reversed by the antagonist 8-p-sulfophenyltheophylline. Concentration–response curves to 5′-(N-ethylcarboxamido)adenosine (NECA), but not those to DINECA, were significantly shifted to the right by 100 μM of 8-sulfophenyltheophylline. Tissues exposed previously to DINECA became refractory to adenosine, an effect not observed with tissues exposed to NECA, suggesting that DINECA became bound to adenosine receptors. Adenylate cyclase from neuroblastoma cells, containing Ra-type adenosine receptors, was stimulated by 2-chloroadenosine and NECA but not by DINECA. The results suggest that most of the smooth muscle relaxant actions of DINECA are not due to interaction with adenosine receptors but are probably due to its function as a nitrate. However, DINECA appears to interact with adenosine receptors, causing long lasting inhibition of adenosine action in rabbit intestine. Such actions may contribute to the overall response to DINECA application in vivo, although lowering of blood pressure due to the high reactivity of the vasculature to nitrates may be the initial and major effect.

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