scholarly journals Influence of intramuscular heat stimulation on modulation of nociception: complex role of central opioid receptors in descending facilitation and inhibition

2014 ◽  
Vol 592 (19) ◽  
pp. 4365-4380 ◽  
Author(s):  
Hao‐Jun You ◽  
Jing Lei ◽  
Gang Ye ◽  
Xiao‐Li Fan ◽  
Qiang Li
Keyword(s):  
Opioid Receptors ◽  
Heat Stimulation ◽  
Descending Facilitation

Role of Ca2+ channels on the hypothermic response produced by activation of κ-opioid receptors

2002 ◽  
Vol 72 (1-2) ◽  
pp. 93-99 ◽  
Author(s):  
Srinivas Gullapalli ◽  
Kumar V.S. Nemmani ◽  
Poduri Ramarao
Keyword(s):  
Opioid Receptors ◽  
Hypothermic Response ◽  
Ca2 Channels

Role of Mu and Delta Opioid Receptors and their Ligands, Î'-Endorphin and Pre-Pro-Enkephalin, in Stress-Induced Visceral Analgesia in Male and Female Mice

2017 ◽  
Vol 152 (5) ◽  
pp. S212
Author(s):  
Muriel H. Larauche ◽  
Nabila Moussaoui ◽  
Mandy Biraud ◽  
Won Ki Bae ◽  
Wendy Walwyn ◽  
...  
Keyword(s):  
Opioid Receptors ◽  
Male And Female ◽  
Female Mice ◽  
Delta Opioid Receptors

scholarly journals Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area   Opioid Receptors

2015 ◽  
Vol 35 (35) ◽  
pp. 12217-12231 ◽  
Author(s):  
L. Hipolito ◽  
A. Wilson-Poe ◽  
Y. Campos-Jurado ◽  
E. Zhong ◽  
J. Gonzalez-Romero ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Opioid Receptors ◽  
Inflammatory Pain ◽  
Self Administration ◽  
Ventral Tegmental

scholarly journals The role of delta opioid receptors in the anxiolytic actions of benzodiazepines

2006 ◽  
Vol 85 (3) ◽  
pp. 545-554 ◽  
Author(s):  
S PRIMEAUX ◽  
S WILSON ◽  
A MCDONALD ◽  
F MASCAGNI ◽  
M WILSON
Keyword(s):  
Opioid Receptors ◽  
Delta Opioid Receptors

κ- but not δ-opioid receptors mediate effects of ischemic preconditioning on both infarct and arrhythmia in rats

2001 ◽  
Vol 280 (1) ◽  
pp. H384-H391 ◽  
Author(s):  
Guan-Ying Wang ◽  
Song Wu ◽  
Jian-Ming Pei ◽  
Xiao-Chun Yu ◽  
Tak-Ming Wong
Keyword(s):  
Infarct Size ◽  
Opioid Receptors ◽  
Ischemic Preconditioning ◽  
Antiarrhythmic Action ◽  
Perfused Rat Heart ◽  
Calphostin C ◽  
Kinase C ◽  
Series Of Experiments ◽  
Pkc Inhibitors

Two series of experiments were performed in the isolated perfused rat heart to determine the role of κ- and δ-opioid receptors (OR) in cardioprotection of ischemic preconditioning (IP). In the first series of experiments, it was found that IP with two cycles of 5-min regional ischemia followed by 5-min reperfusion each reduced infarct size induced by 30-min ischemia, and the ameliorating effect of IP on infarct was attenuated with blockade of either 5 × 10−6 mol/l nor-binaltorphimine (nor-BNI), a selective κ-OR antagonist, or 5 × 10−6 mol/l naltrindole (NTD), a selective δ-OR antagonist. The second series showed that U50,488H, a selective κ-OR agonist, ord-Ala2-d-leu5-enkephalin (DADLE), a selective δ-OR agonist, dose dependently reduced the infarct size induced by ischemia, which mimicked the effects of IP. The effect of 10−5 mol/l U50,488H on infarct was significantly attenuated by blockade of protein kinase C (PKC) with specific PKC inhibitors, 5 × 10−6 mol/l chelerythrine or 8 × 10−7 mol/l calphostin C, as well as by blockade of ATP-sensitive K+ (KATP) channels with blockers of the channel, 10−5 mol/l glibenclamide or 10−4 mol/l 5-hydroxydecanoate. IP also reduced arrhythmia induced by ischemia. Nor-BNI, but not NTD, attenuated, while U50,488H, but not DADLE, mimicked the antiarrhythmic action of IP. In conclusion, the present study has provided first evidence that κ-OR mediates the ameliorating effects of IP on infarct and arrhythmia induced by ischemia, whereas δ-OR mediates the effects only on infarct. Both PKC and KATP channels mediate the effect of activation of κ-OR on infarct.

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