scholarly journals Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice

2014 ◽  
Vol 592 (12) ◽  
pp. 2549-2561 ◽  
Author(s):  
Rachel A. Gioscia-Ryan ◽  
Thomas J. LaRocca ◽  
Amy L. Sindler ◽  
Melanie C. Zigler ◽  
Michael P. Murphy ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Age Related

Low-dose aspirin prevents age-related endothelial dysfunction in a mouse model of physiological aging

2008 ◽  
Vol 294 (4) ◽  
pp. H1562-H1570 ◽  
Author(s):  
Hélène Bulckaen ◽  
Gaétan Prévost ◽  
Eric Boulanger ◽  
Géraldine Robitaille ◽  
Valérie Roquet ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Dysfunction ◽  
Protective Effect ◽  
Structural Changes ◽  
Low Dose ◽  
Age Groups ◽  
Dose Aspirin ◽  
Age Related ◽  
Low Dose Aspirin ◽  
Old Mice

The age-related impairment of endothelium-dependent vasodilatation contributes to increased cardiovascular risk in the elderly. For primary and secondary prevention, aspirin can reduce the incidence of cardiovascular events in this patient population. The present work evaluated the effect of low-dose aspirin on age-related endothelial dysfunction in C57B/J6 aging mice and investigated its protective antioxidative effect. Age-related endothelial dysfunction was assessed by the response to acetylcholine of phenylephrine-induced precontracted aortic segments isolated from 12-, 36-, 60-, and 84-wk-old mice. The effect of low-dose aspirin was examined in mice presenting a decrease in endothelial-dependent relaxation (EDR). The effects of age and aspirin treatment on structural changes were determined in mouse aortic sections. The effect of aspirin on the oxidative stress markers malondialdehyde and 8-hydroxy-2′-deoxyguanosine (8-OhdG) was also quantified. Compared with that of 12-wk-old mice, the EDR was significantly reduced in 60- and 84-wk-old mice ( P < 0.05); 68-wk-old mice treated with aspirin displayed a higher EDR compared with control mice of the same age (83.9 ± 4 vs. 66.3 ± 5%; P < 0.05). Aspirin treatment decreased 8-OHdG levels ( P < 0.05), but no significant effect on intima/media thickness ratio was observed. The protective effect of aspirin was not observed when treatment was initiated in older mice (96 wk of age). It was found that low-dose aspirin is able to prevent age-related endothelial dysfunction in aging mice. However, the absence of this effect in the older age groups demonstrates that treatment should be initiated early on. The underlying mechanism may involve the protective effect of aspirin against oxidative stress.

Age-Related Endothelial Dysfunction

Drugs & Aging ◽  
2003 ◽  
Vol 20 (7) ◽  
pp. 527-550 ◽  
Author(s):  
Rachel L Matz ◽  
Ramaroson Andriantsitohaina
Keyword(s):  
Endothelial Dysfunction ◽  
Age Related

P168. Plasma nitrite reserve with exercise predicts age-related endothelial dysfunction in humans

Nitric Oxide ◽  
2006 ◽  
Vol 14 (4) ◽  
pp. 72
Author(s):  
Tienush Rassaf ◽  
Thomas Lauer ◽  
Christian Heiss ◽  
Jan Balzer ◽  
Petra Kleinbongard ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Age Related ◽  
Plasma Nitrite

Abstract 1421: In Vivo Measurement of Flow-Mediated Vasodilation in Living Rats using High Resolution Ultrasound: Age-Dependent Endothelial Dysfunction

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Christian Heiss ◽  
Richard E Sievers ◽  
Nicolas Amabile ◽  
Tony Y Momma ◽  
Shobha Natarajan ◽  
...  
Keyword(s):  
High Resolution ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Femoral Artery ◽  
Reactive Hyperemia ◽  
Surrogate Marker ◽  
Flow Measurements ◽  
Age Related ◽  
Age Dependent

In humans, endothelial function serves as a surrogate marker for cardiovascular health and is measured as changes in arterial diameter after temporary ischemia (flow-mediated dilation; FMD). We developed an FMD-related approach to study conduit artery vasodilation in living rats, and demonstrate a reduction in FMD in older versus younger animals consistent with age-related endothelial dysfunction. Diameter and Doppler-flow measurements were obtained from the femoral artery using high-resolution ultrasound (35 MHz). We observed dose-dependent vasodilation using both endothelium-dependent and endothelium-independent pharmacologic vasodilators (acetylcholine and nitroglycerine). Flow-dependent vasodilation was observed in response to flow increase induced both by adenosine and local saline infusion. Transient hindlimb ischemia led to reactive hyperemia with sequential flow velocity increase and femoral artery dilation, the latter of which was completely abolished by NO-synthase (NOS) inhibition with L-NMMA. To demonstrate its applicability in a model of endothelial dysfunction, we show that FMD is significantly reduced in older versus younger animals. While FMD was completely NOS-dependent in younger animals, NOS-dependent mechanisms accounted for only half of the FMD in older animals, with the remainder being blocked by charybdotoxin (CTx) and apamin suggesting contribution of endothelium-derived-hyperpolarizing-factor. Using this new integrative physiologic model to reproducibly study FMD in living rats, we show that age-dependent endothelial dysfunction is accompanied by a shift in mechanisms underlying vasodilatory endothelial function.

Systemic Markers of Inflammation, Endothelial Dysfunction, and Age-Related Maculopathy

2005 ◽  
Vol 140 (1) ◽  
pp. 35.e1-35.e12 ◽  
Author(s):  
Ronald Klein ◽  
Barbara E.K. Klein ◽  
Michael D. Knudtson ◽  
Tien Yin Wong ◽  
Anoop Shankar ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Markers Of Inflammation ◽  
Age Related

scholarly journals Chinese Adults Are Less Susceptible Than Whites to Age-Related Endothelial Dysfunction

1997 ◽  
Vol 30 (1) ◽  
pp. 113-118 ◽  
Author(s):  
Kam S. Woo ◽  
Jane A. McCrohon ◽  
Ping Chook ◽  
Mark R. Adams ◽  
Jacqui T.C. Robinson ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Chinese Adults ◽  
Age Related
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