scholarly journals Heterogeneous responses of nucleus incertus neurons to corticotrophin-releasing factor and coherent activity with hippocampal theta rhythm in the rat

2013 ◽  
Vol 591 (16) ◽  
pp. 3981-4001 ◽  
Author(s):  
Sherie Ma ◽  
Anna Blasiak ◽  
Francisco E. Olucha-Bordonau ◽  
Anthony J. M. Verberne ◽  
Andrew L. Gundlach
Keyword(s):  
Theta Rhythm ◽  
Hippocampal Theta Rhythm ◽  
Corticotrophin Releasing Factor ◽  
Nucleus Incertus ◽  
Hippocampal Theta

Nucleus incertus contribution to hippocampal theta rhythm generation

2006 ◽  
Vol 23 (10) ◽  
pp. 2731-2738 ◽  
Author(s):  
A. Nuñez ◽  
A. Cervera-Ferri ◽  
F. Olucha-Bordonau ◽  
A. Ruiz-Torner ◽  
V. Teruel
Keyword(s):  
Theta Rhythm ◽  
Rhythm Generation ◽  
Hippocampal Theta Rhythm ◽  
Nucleus Incertus ◽  
Hippocampal Theta

scholarly journals Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory

2021 ◽  
Vol 15 ◽  
Author(s):  
Isis Gil-Miravet ◽  
Aroa Mañas-Ojeda ◽  
Francisco Ros-Bernal ◽  
Esther Castillo-Gómez ◽  
Hector Albert-Gascó ◽  
...  
Keyword(s):  
Theta Rhythm ◽  
Past Research ◽  
Memory Formation ◽  
Corticotrophin Releasing Factor ◽  
Peptidergic Innervation ◽  
Neuromedin B ◽  
Nucleus Incertus ◽  
Hippocampal Theta ◽  
With Memory

Telencephalic cognitive and emotional circuits/functions are strongly modulated by subcortical inputs. The main focus of past research on the nature of this modulation has been on the widespread monoamine projections to the telencephalon. However, the nucleus incertus (NI) of the pontine tegmentum provides a strong GABAergic and peptidergic innervation of the hippocampus, basal forebrain, amygdala, prefrontal cortex, and related regions; and represents a parallel source of ascending modulation of cognitive and emotional domains. NI GABAergic neurons express multiple peptides, including neuromedin-B, cholecystokinin, and relaxin-3, and receptors for stress and arousal transmitters, including corticotrophin-releasing factor and orexins/hypocretins. A functional relationship exists between NI neurons and their associated peptides, relaxin-3 and neuromedin-B, and hippocampal theta rhythm, which in turn, has a key role in the acquisition and extinction of declarative and emotional memories. Furthermore, RXFP3, the cognate receptor for relaxin-3, is a Gi/o protein-coupled receptor, and its activation inhibits the cellular accumulation of cAMP and induces phosphorylation of ERK, processes associated with memory formation in the hippocampus and amygdala. Therefore, this review summarizes the role of NI transmitter systems in relaying stress- and arousal-related signals to the higher neural circuits and processes associated with memory formation and retrieval.

Sign in / Sign up

Export Citation Format

Share Document