scholarly journals Maternal high-fat diet induces obesity and adrenal and thyroid dysfunction in male rat offspring at weaning

2012 ◽  
Vol 590 (21) ◽  
pp. 5503-5518 ◽  
Author(s):  
J. G. Franco ◽  
T. P. Fernandes ◽  
C. P. D. Rocha ◽  
C. Calviño ◽  
C. C. Pazos-Moura ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Thyroid Dysfunction ◽  
Male Rat ◽  
High Fat ◽  
Rat Offspring

Maternal high-fat diet during gestation and lactation alters hepatic gene expression in male rat offspring

Appetite ◽  
2011 ◽  
Vol 57 ◽  
pp. S15
Author(s):  
E.R. Ewald ◽  
B. Sun ◽  
R.H. Purcell ◽  
R.S. Lee ◽  
J.B. Potash ◽  
...  
Keyword(s):  
Gene Expression ◽  
High Fat Diet ◽  
Male Rat ◽  
Hepatic Gene Expression ◽  
High Fat ◽  
Rat Offspring

scholarly journals Maternal Melatonin Therapy Rescues Prenatal Dexamethasone and Postnatal High-Fat Diet Induced Programmed Hypertension in Male Rat Offspring

2015 ◽  
Vol 6 ◽  
Author(s):  
You-Lin Tain ◽  
Jiunn-Ming Sheen ◽  
Hong-Ren Yu ◽  
Chih-Cheng Chen ◽  
Mao-Meng Tiao ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Male Rat ◽  
High Fat ◽  
Rat Offspring

Perinatal exposure to chlorpyrifos and/or a high-fat diet is associated with liver damage in male rat offspring

2021 ◽  
pp. 203678
Author(s):  
Marion Guibourdenche ◽  
Hiba El Khayat El Sabbouri ◽  
Fidéline Bonnet ◽  
Narimane Djekkoun ◽  
Hafida Khorsi-Cauet ◽  
...  
Keyword(s):  
Liver Damage ◽  
High Fat Diet ◽  
Male Rat ◽  
Perinatal Exposure ◽  
High Fat ◽  
Rat Offspring

scholarly journals Maternal High-Fat Diet Modulates Cnr1 Gene Expression in Male Rat Offspring

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2885
Author(s):  
Dawid Gawliński ◽  
Kinga Gawlińska ◽  
Irena Smaga
Keyword(s):  
Gene Expression ◽  
High Fat Diet ◽  
Cpg Islands ◽  
Male Offspring ◽  
Epigenetic Mechanism ◽  
Male Rat ◽  
High Fat ◽  
Rat Offspring ◽  
Pregnancy And Lactation ◽  
Cnr1 Gene

In recent years, strong evidence has emerged that exposure to a maternal high-fat diet (HFD) provokes changes in the structure, function, and development of the offspring’s brain and may induce several neurodevelopmental and psychiatric illnesses. The aims of this study were to evaluate the effects of a maternal HFD during pregnancy and lactation on depressive-like behavior and Cnr1 gene expression (encoding the CB1 receptor) in brain structures of rat offspring and to investigate the epigenetic mechanism involved in this gene expression. We found that a maternal HFD during pregnancy and lactation induced a depressive-like phenotype at postnatal days (PNDs) 28 and 63. We found that a maternal HFD decreased the Cnr1 mRNA levels in the prefrontal cortex with the increased levels of miR-212-5p and methylation of CpG islands at the Cnr1 promoter and reduced the level of Cnr1 gene expression in the dorsal striatum with an increased level of miR-154-3p in adolescent male offspring. A contrasting effect of a maternal HFD was observed in the hippocampus, where upregulation of Cnr1 gene expression was accompanied by a decrease of miR-154-3p (at PNDs 28 and 63) and miR-212-5p (at PND 63) expression and methylation of CpG islands at the Cnr1 promoter in male offspring. In summary, we showed that a maternal HFD during pregnancy and lactation triggered several epigenetic mechanisms in the brains of rat offspring, which may be related to long-lasting alterations in the next generation and produce behavioral changes in offspring, including a depressive-like phenotype.

scholarly journals Maternal high-fat diet intensifies the metabolic response to stress in male rat offspring

2017 ◽  
Vol 14 (1) ◽  
Author(s):  
Roxana Karbaschi ◽  
Homeira Zardooz ◽  
Fariba Khodagholi ◽  
Leila Dargahi ◽  
Mina Salimi ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Metabolic Response ◽  
Male Rat ◽  
High Fat ◽  
Rat Offspring ◽  
Response To Stress

scholarly journals Maternal Manganese Restriction Increases Susceptibility to High-Fat Diet-Induced Dyslipidemia and Altered Adipose Function in WNIN Male Rat Offspring

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Manisha Ganeshan ◽  
Pothaganti B. Sainath ◽  
Inagadapa J. Naga Padmavathi ◽  
Lagishetty Venu ◽  
Yedla Durga Kishore ◽  
...  
Keyword(s):  
Body Composition ◽  
Lipid Metabolism ◽  
High Fat Diet ◽  
Control Diet ◽  
Male Rat ◽  
Restricted Diet ◽  
High Fat ◽  
Rat Offspring ◽  
Ad Libitum ◽  
Fat Feeding

Growthin uterois largely a reflection of nutrient and oxygen supply to the foetus. We studied the effects of Mn restrictionper se, maternal Mn restriction, and postnatal high-fat feeding in modulating body composition, lipid metabolism and adipocyte function in Wistar/NIN (WNIN) rat offspring. Female weanling, WNIN rats receivedad libitumfor 4 months, a control or Mn-restricted diet and were mated with control males. Some restricted mothers were rehabilitated with control diet from conception (MnRC) or parturition (MnRP), and their offspring were raised on control diet. Some restricted offspring were weaned onto control diet (MnRW), while others continued on restricted diet throughout (MnR). A set of offspring from each group was fed high-fat diet from 9 months onwards. Body composition, adipocytes function, and lipid metabolism were monitored in male rat offspring at regular intervals. Maternal manganese restriction increased the susceptibility of the offspring to high-fat-induced adiposity, dyslipidaemia, and a proinflammatory state but did not affect their glycemic or insulin status.

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