scholarly journals Partial opening and subconductance gating of mechanosensitive ion channels in dystrophic skeletal muscle

2012 ◽  
Vol 590 (23) ◽  
pp. 6167-6185 ◽  
Author(s):  
Ivan Vasquez ◽  
Nhi Tan ◽  
Mark Boonyasampant ◽  
Kari A. Koppitch ◽  
Jeffry B. Lansman
Keyword(s):  
Skeletal Muscle ◽  
Ion Channels ◽  
Mechanosensitive Ion Channels ◽  
Partial Opening

scholarly journals Mechanosensitive ion channels in skeletal muscle: Molecular mechanisms of gating and blockade.

1993 ◽  
Vol 61 ◽  
pp. 41
Author(s):  
Tervl Elam ◽  
Alfredo Franco ◽  
Christine Haws ◽  
Bruce Winegar ◽  
Jeffry B. Lansman
Keyword(s):  
Skeletal Muscle ◽  
Ion Channels ◽  
Molecular Mechanisms ◽  
Mechanosensitive Ion Channels

scholarly journals Evidence TRPV4 contributes to mechanosensitive ion channels in mouse skeletal muscle fibers

Channels ◽  
2012 ◽  
Vol 6 (4) ◽  
pp. 246-254 ◽  
Author(s):  
Tiffany C. Ho ◽  
Natalie A. Horn ◽  
Tuan Huynh ◽  
Lucy Kelava ◽  
Jeffry B. Lansman
Keyword(s):  
Skeletal Muscle ◽  
Ion Channels ◽  
Muscle Fibers ◽  
Mouse Skeletal Muscle ◽  
Mechanosensitive Ion Channels ◽  
Skeletal Muscle Fibers

scholarly journals Biophysics and Modeling of Mechanotransduction in Neurons: A Review

Mathematics ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 323
Author(s):  
Martina Nicoletti ◽  
Letizia Chiodo ◽  
Alessandro Loppini
Keyword(s):  
Ion Channels ◽  
Cell Membrane ◽  
Sensory Neurons ◽  
Neuronal Cell ◽  
Molecular Processes ◽  
Biological Mechanisms ◽  
Mechanosensitive Ion Channels ◽  
Complex Interactions ◽  
Different Types ◽  
Intracellular Organelles

Mechanosensing is a key feature through which organisms can receive inputs from the environment and convert them into specific functional and behavioral outputs. Mechanosensation occurs in many cells and tissues, regulating a plethora of molecular processes based on the distribution of forces and stresses both at the cell membrane and at the intracellular organelles levels, through complex interactions between cells’ microstructures, cytoskeleton, and extracellular matrix. Although several primary and secondary mechanisms have been shown to contribute to mechanosensation, a fundamental pathway in simple organisms and mammals involves the presence of specialized sensory neurons and the presence of different types of mechanosensitive ion channels on the neuronal cell membrane. In this contribution, we present a review of the main ion channels which have been proven to be significantly involved in mechanotransduction in neurons. Further, we discuss recent studies focused on the biological mechanisms and modeling of mechanosensitive ion channels’ gating, and on mechanotransduction modeling at different scales and levels of details.

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