scholarly journals Are all spinal segments equal: intrinsic membrane properties of superficial dorsal horn neurons in the developing and mature mouse spinal cord

2012 ◽  
Vol 590 (10) ◽  
pp. 2409-2425 ◽  
Author(s):  
M. A. Tadros ◽  
B. M. Harris ◽  
W. B. Anderson ◽  
A. M. Brichta ◽  
B. A. Graham ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Membrane Properties ◽  
Superficial Dorsal Horn ◽  
Mouse Spinal Cord ◽  
Dorsal Horn Neurons ◽  
Spinal Segments ◽  
Mature Mouse ◽  
Intrinsic Membrane Properties

Developmental Changes in the Fidelity and Short-Term Plasticity of GABAergic Synapses in the Neonatal Rat Dorsal Horn

2008 ◽  
Vol 99 (6) ◽  
pp. 3144-3150 ◽  
Author(s):  
Rachel A. Ingram ◽  
Maria Fitzgerald ◽  
Mark L. Baccei
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Receptive Fields ◽  
Neuronal Firing ◽  
Neonatal Rat ◽  
Superficial Dorsal Horn ◽  
Short Term ◽  
Dorsal Horn Neurons ◽  
Gabaergic Synapses

The lower thresholds and increased excitability of dorsal horn neurons in the neonatal rat suggest that inhibitory processing is less efficient in the immature spinal cord. This is unlikely to be explained by an absence of functional GABAergic inhibition because antagonism of γ-aminobutyric acid (GABA) type A receptors augments neuronal firing in vivo from the first days of life. However, it is possible that more subtle deficits in GABAergic signaling exist in the neonate, such as decreased reliability of transmission or greater depression during repetitive stimulation, both of which could influence the relative excitability of the immature spinal cord. To address this issue we examined monosynaptic GABAergic inputs onto superficial dorsal horn neurons using whole cell patch-clamp recordings made in spinal cord slices at a range of postnatal ages (P3, P10, and P21). The amplitudes of evoked inhibitory postsynaptic currents (IPSCs) were significantly lower and showed greater variability in younger animals, suggesting a lower fidelity of GABAergic signaling at early postnatal ages. Paired-pulse ratios were similar throughout the postnatal period, whereas trains of stimuli (1, 5, 10, and 20 Hz) revealed frequency-dependent short-term depression (STD) of IPSCs at all ages. Although the magnitude of STD did not differ between ages, the recovery from depression was significantly slower at immature GABAergic synapses. These properties may affect the integration of synaptic inputs within developing superficial dorsal horn neurons and thus contribute to their larger receptive fields and enhanced afterdischarge.

In vivo characterization of colorectal and cutaneous inputs to lumbosacral dorsal horn neurons in the mouse spinal cord

Neuroscience ◽  
2016 ◽  
Vol 316 ◽  
pp. 13-25 ◽  
Author(s):  
K.E. Farrell ◽  
M.M. Rank ◽  
S. Keely ◽  
A.M. Brichta ◽  
B.A. Graham ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Mouse Spinal Cord ◽  
Dorsal Horn Neurons ◽  
In Vivo Characterization

scholarly journals A quantitative study of neurochemically defined populations of inhibitory interneurons in the superficial dorsal horn of the mouse spinal cord

Neuroscience ◽  
2017 ◽  
Vol 363 ◽  
pp. 120-133 ◽  
Author(s):  
Kieran A. Boyle ◽  
Maria Gutierrez-Mecinas ◽  
Erika Polgár ◽  
Nicole Mooney ◽  
Emily O'Connor ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Quantitative Study ◽  
Inhibitory Interneurons ◽  
Superficial Dorsal Horn ◽  
Mouse Spinal Cord
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