scholarly journals Resistance training alters skeletal muscle structure and function in human heart failure: effects at the tissue, cellular and molecular levels

2012 ◽  
Vol 590 (5) ◽  
pp. 1243-1259 ◽  
Author(s):  
Michael J. Toth ◽  
Mark S. Miller ◽  
Peter VanBuren ◽  
Nicholas G. Bedrin ◽  
Martin M. LeWinter ◽  
...  
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Resistance Training ◽  
Human Heart ◽  
Structure And Function ◽  
Human Heart Failure ◽  
Muscle Structure ◽  
And Function

scholarly journals Skeletal muscle mitochondrial density, gene expression, and enzyme activities in human heart failure: minimal effects of the disease and resistance training

2012 ◽  
Vol 112 (11) ◽  
pp. 1864-1874 ◽  
Author(s):  
Michael J. Toth ◽  
Mark S. Miller ◽  
Kimberly A. Ward ◽  
Philip A. Ades
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Skeletal Muscle ◽  
Resistance Training ◽  
Transcriptional Regulators ◽  
Structure And Function ◽  
Resistance Exercise Training ◽  
Mitochondrial Structure ◽  
Muscle Disuse ◽  
And Function

Impaired skeletal muscle energetics could adversely affect physical and metabolic function in patients with heart failure (HF). The effect of HF on aspects of mitochondrial structure and function, independent of muscle disuse and other disease-related confounding factors, however, is unclear. Moreover, no study has evaluated whether resistance exercise training, a modality that increases functional capacity, might derive its benefits through modulation of mitochondrial structure and function. Thirteen HF patients and 14 age- and physical activity-matched controls were evaluated for skeletal muscle mitochondrial size/content, gene expression, and enzyme activity before and after an 18-wk resistance exercise-training program. At baseline, HF patients and controls had similar mitochondrial fractional areas, although HF patients had larger average mitochondrion size ( P < 0.05) and a trend toward a reduced number of mitochondria ( P ≤ 0.10). No differences in the expression of transcriptional regulators or cytochrome oxidase subunits or the activity of mitochondrial and cytosolic enzymes were noted. Relationships among transcriptional regulators suggested that networks controlling mitochondrial content and gene expression are intact. Resistance training increased ( P < 0.01) mitochondrial transcription factor A expression in patients and controls, and this increase was related to improvements in muscle strength ( P = 0.05). Training did not, however, alter mitochondrial size/content, enzyme activities, or expression of other transcriptional regulators. In conclusion, our results suggest that the HF syndrome has minimal effects on skeletal muscle mitochondrial biology when the confounding effects of muscle disuse and other disease-related factors are removed. Moreover, the beneficial effects of resistance training on physical function in HF patients and controls are likely not related to alterations in mitochondrial biology.

scholarly journals Essential Role of Septin 7 in Skeletal Muscle Structure and Function

2020 ◽  
Vol 118 (3) ◽  
pp. 258a
Author(s):  
Laszlo Csernoch ◽  
Mónika Gönczi ◽  
Zsolt Ráduly ◽  
László Szabó ◽  
Nóra Dobrosi ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Essential Role ◽  
Structure And Function ◽  
Muscle Structure ◽  
And Function

scholarly journals S ‐glutathiolation impairs phosphoregulation and function of cardiac myosin‐binding protein C in human heart failure

2016 ◽  
Vol 30 (5) ◽  
pp. 1849-1864 ◽  
Author(s):  
Konstantina Stathopoulou ◽  
Ilka Wittig ◽  
Juliana Heidler ◽  
Angelika Piasecki ◽  
Florian Richter ◽  
...  
Keyword(s):  
Heart Failure ◽  
Protein C ◽  
Human Heart ◽  
Binding Protein ◽  
Cardiac Myosin ◽  
Human Heart Failure ◽  
Myosin Binding Protein ◽  
Myosin Binding Protein C ◽  
Myosin Binding ◽  
And Function

scholarly journals Effects of Ovariectomy on Skeletal Muscle Structure and Function in Young Female Rats: Protective Effects of the Flavanol (−)‐Epicatechin

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Viridiana Navarrrete ◽  
Marcos Ayala ◽  
Antonio Rodriguez ◽  
Francisco Villarreal ◽  
Israel Ramirez-Sanchez
Keyword(s):  
Skeletal Muscle ◽  
Young Female ◽  
Structure And Function ◽  
Female Rats ◽  
Protective Effects ◽  
Muscle Structure ◽  
And Function

scholarly journals Skeletal muscle structure and function in response to electrical stimulation in moderately impaired COPD patients

2007 ◽  
Vol 101 (6) ◽  
pp. 1236-1243 ◽  
Author(s):  
Simone Dal Corso ◽  
Lara Nápolis ◽  
Carla Malaguti ◽  
Ana Cristina Gimenes ◽  
André Albuquerque ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Electrical Stimulation ◽  
Structure And Function ◽  
Muscle Structure ◽  
Copd Patients ◽  
And Function

Antibody‐directed myostatin inhibition in 21‐mo‐old mice reveals novel roles for myostatin signaling in skeletal muscle structure and function

2010 ◽  
Vol 24 (11) ◽  
pp. 4433-4442 ◽  
Author(s):  
Kate T. Murphy ◽  
René Koopman ◽  
Timur Naim ◽  
Bertrand Léger ◽  
Jennifer Trieu ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Structure And Function ◽  
Muscle Structure ◽  
Myostatin Inhibition ◽  
And Function ◽  
Old Mice
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