scholarly journals On the contribution of group III and IV muscle afferents to the circulatory response to rhythmic exercise in humans

2011 ◽  
Vol 589 (15) ◽  
pp. 3855-3866 ◽  
Author(s):  
Markus Amann ◽  
Sean Runnels ◽  
David E. Morgan ◽  
Joel D. Trinity ◽  
Anette S. Fjeldstad ◽  
...  
Keyword(s):  
Muscle Afferents ◽  
Circulatory Response ◽  
Group Iii ◽  
Rhythmic Exercise ◽  
Exercise In Humans

scholarly journals Group III/IV muscle afferents limit the intramuscular metabolic perturbation during whole body exercise in humans

2016 ◽  
Vol 594 (18) ◽  
pp. 5303-5315 ◽  
Author(s):  
Gregory M. Blain ◽  
Tyler S. Mangum ◽  
Simranjit K. Sidhu ◽  
Joshua C. Weavil ◽  
Thomas J. Hureau ◽  
...  
Keyword(s):  
Muscle Afferents ◽  
Whole Body ◽  
Group Iii ◽  
Metabolic Perturbation ◽  
Exercise In Humans

scholarly journals Group III and IV muscle afferents contribute to ventilatory and cardiovascular response to rhythmic exercise in humans

2010 ◽  
Vol 109 (4) ◽  
pp. 966-976 ◽  
Author(s):  
Markus Amann ◽  
Gregory M. Blain ◽  
Lester T. Proctor ◽  
Joshua J. Sebranek ◽  
David F. Pegelow ◽  
...  
Keyword(s):  
Perceived Exertion ◽  
Cardiovascular Response ◽  
Minute Ventilation ◽  
Muscle Afferents ◽  
Afferent Feedback ◽  
Central Projection ◽  
Cycling Exercise ◽  
Leg Cycling ◽  
Rhythmic Exercise ◽  
Exercise In Humans

We investigated the role of somatosensory feedback on cardioventilatory responses to rhythmic exercise in five men. In a double-blind, placebo-controlled design, subjects performed the same leg cycling exercise (50/100/150/325 ± 19 W, 3 min each) under placebo conditions (interspinous saline, L3–L4) and with lumbar intrathecal fentanyl impairing central projection of spinal opioid receptor-sensitive muscle afferents. Quadriceps strength was similar before and after fentanyl administration. To evaluate whether a cephalad migration of fentanyl affected cardioventilatory control centers in the brain stem, we compared resting ventilatory responses to hypercapnia (HCVR) and cardioventilatory responses to arm vs. leg cycling exercise after each injection. Similar HCVR and minor effects of fentanyl on cardioventilatory responses to arm exercise excluded direct medullary effects of fentanyl. Central command during leg exercise was estimated via quadriceps electromyogram. No differences between conditions were found in resting heart rate (HR), ventilation [minute ventilation (V̇e)], or mean arterial pressure (MAP). Quadriceps electromyogram, O2 consumption (V̇o2), and plasma lactate were similar in both conditions at the four steady-state workloads. Compared with placebo, a substantial hypoventilation during fentanyl exercise was indicated by the 8–17% reduction in V̇e/CO2 production (V̇co2) secondary to a reduced breathing frequency, leading to average increases of 4–7 Torr in end-tidal Pco2 ( P < 0.001) and a reduced hemoglobin saturation (−3 ± 1%; P < 0.05) at the heaviest workload (∼90% maximal V̇o2) with fentanyl. HR was reduced 2–8%, MAP 8–13%, and ratings of perceived exertion by 13% during fentanyl vs. placebo exercise ( P < 0.05). These findings demonstrate the essential contribution of muscle afferent feedback to the ventilatory, cardiovascular, and perceptual responses to rhythmic exercise in humans, even in the presence of unaltered contributions from other major inputs to cardioventilatory control.

scholarly journals μ‐Opioid Receptor‐Sensitive Muscle Afferents Contribute to the Circulatory Response to Exercise in Humans

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Markus Amann ◽  
Sean Runnels ◽  
David E Morgan ◽  
Joel Trinity ◽  
Anette Fjeldstad ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Muscle Afferents ◽  
Circulatory Response ◽  
Μ Opioid Receptor ◽  
Response To Exercise ◽  
Exercise In Humans

scholarly journals Group III and IV muscle afferents differentially affect the motor cortex and motoneurones in humans

2008 ◽  
Vol 586 (5) ◽  
pp. 1277-1289 ◽  
Author(s):  
P. G. Martin ◽  
N. Weerakkody ◽  
S. C. Gandevia ◽  
J. L. Taylor
Keyword(s):  
Motor Cortex ◽  
Muscle Afferents ◽  
Group Iii
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