scholarly journals Short-term plasticity impacts information transfer at glutamate synapses onto parvocellular neuroendocrine cells in the paraventricular nucleus of the hypothalamus

2011 ◽  
Vol 589 (17) ◽  
pp. 4259-4270 ◽  
Author(s):  
Vincent Marty ◽  
J. Brent Kuzmiski ◽  
Dinara V. Baimoukhametova ◽  
Jaideep S. Bains
Keyword(s):  
Paraventricular Nucleus ◽  
Information Transfer ◽  
Neuroendocrine Cells ◽  
Short Term ◽  
Short Term Plasticity ◽  
Glutamate Synapses

Interactions Between Asynchronous Release and Short-Term Plasticity in the Nucleus Accumbens Slice

2006 ◽  
Vol 95 (3) ◽  
pp. 2020-2023 ◽  
Author(s):  
Gregory O. Hjelmstad
Keyword(s):  
Nucleus Accumbens ◽  
Synaptic Transmission ◽  
Short Term ◽  
Short Term Plasticity ◽  
Releasable Pool ◽  
Readily Releasable Pool ◽  
Glutamate Synapses ◽  
Asynchronous Release

Glutamate synapses in the nucleus accumbens (NAc) display asynchronous release in response to trains of stimulation. However, it is unclear what role this asynchronous release plays in synaptic transmission in this nucleus. This process was studied, specifically looking at the interaction between short-term depression and asynchronous release. These results indicate that synchronous and asynchronous release do not compete for a depleted readily releasable pool of vesicles.

Stress-induced priming of glutamate synapses unmasks associative short-term plasticity

2010 ◽  
Vol 13 (10) ◽  
pp. 1257-1264 ◽  
Author(s):  
J Brent Kuzmiski ◽  
Vincent Marty ◽  
Dinara V Baimoukhametova ◽  
Jaideep S Bains
Keyword(s):  
Short Term ◽  
Short Term Plasticity ◽  
Glutamate Synapses

scholarly journals TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis

2021 ◽  
Author(s):  
Zhong-Jiao Jiang ◽  
Wenping Li ◽  
Li-Hua Yao ◽  
Brian S. Grewe ◽  
Andrea McGinley ◽  
...  
Keyword(s):  
Nervous System ◽  
Synaptic Vesicle ◽  
Neuronal Death ◽  
Physiological Role ◽  
Neuroendocrine Cells ◽  
Short Term ◽  
Widespread Distribution ◽  
Short Term Plasticity ◽  
Inhibitory Synaptic Transmission

AbstractTRPM7 contributes to a variety of physiological and pathological processes in many tissues and cells. With a widespread distribution in the nervous system, TRPM7 is involved in animal behaviors and neuronal death induced by ischemia. However, the physiological role of TRPM7 in CNS neuron remains unclear. Here, we identify endocytic defects in neuroendocrine cells and neurons from TRPM7 knockout (KO) mice, indicating a role of TRPM7 in synaptic vesicle endocytosis. Our experiments further pinpoint the importance of TRPM7 as an ion channel in synaptic vesicle endocytosis. Ca2+ imaging detects a defect in presynaptic Ca2+ dynamics in TRPM7 KO neuron, suggesting an importance of Ca2+ influx via TRPM7 in synaptic vesicle endocytosis. Moreover, the short-term depression is enhanced in both excitatory and inhibitory synaptic transmission from TRPM7 KO mice. Taking together, our data suggests that Ca2+ influx via TRPM7 may be critical for short-term plasticity of synaptic strength by regulating synaptic vesicle endocytosis in neurons.

scholarly journals TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Zhong-Jiao Jiang ◽  
Wenping Li ◽  
Li-Hua Yao ◽  
Badeia Saed ◽  
Yan Rao ◽  
...  
Keyword(s):  
Nervous System ◽  
Synaptic Vesicle ◽  
Neuronal Death ◽  
Physiological Role ◽  
Neuroendocrine Cells ◽  
Short Term ◽  
Widespread Distribution ◽  
Short Term Plasticity ◽  
Inhibitory Synaptic Transmission

TRPM7 contributes to a variety of physiological and pathological processes in many tissues and cells. With a widespread distribution in the nervous system, TRPM7 is involved in animal behaviors and neuronal death induced by ischemia. However, the physiological role of TRPM7 in CNS neuron remains unclear. Here, we identify endocytic defects in neuroendocrine cells and neurons from TRPM7 knockout (KO) mice, indicating a role of TRPM7 in synaptic vesicle endocytosis. Our experiments further pinpoint the importance of TRPM7 as an ion channel in synaptic vesicle endocytosis. Ca2+ imaging detects a defect in presynaptic Ca2+ dynamics in TRPM7 KO neuron, suggesting an importance of Ca2+ influx via TRPM7 in synaptic vesicle endocytosis. Moreover, the short-term depression is enhanced in both excitatory and inhibitory synaptic transmission from TRPM7 KO mice. Taken together, our data suggests that Ca2+ influx via TRPM7 may be critical for short-term plasticity of synaptic strength by regulating synaptic vesicle endocytosis in neurons.

scholarly journals Subcortical short‐term plasticity elicited by deep brain stimulation

2021 ◽  
Author(s):  
Mohammad Z. Awad ◽  
Ryan J. Vaden ◽  
Zachary T. Irwin ◽  
Christopher L. Gonzalez ◽  
Sarah Black ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Short Term ◽  
Short Term Plasticity ◽  
Deep Brain
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