scholarly journals State-dependent changes in astrocyte regulation of extrasynaptic NMDA receptor signalling in neurosecretory neurons

2011 ◽  
Vol 589 (16) ◽  
pp. 3929-3941 ◽  
Author(s):  
Tiffany M. Fleming ◽  
Victoria Scott ◽  
Krishna Naskar ◽  
Natalie Joe ◽  
Colin H. Brown ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Receptor Signalling ◽  
State Dependent ◽  
Neurosecretory Neurons

The inhibitory potency of local anesthetics on NMDA receptor signalling depends on their structural features

2012 ◽  
Vol 674 (1) ◽  
pp. 13-19 ◽  
Author(s):  
Carsten Gronwald ◽  
Vladimir Vegh ◽  
Markus W. Hollmann ◽  
Anke Hahnenkamp ◽  
Vladimir Garaj ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Local Anesthetics ◽  
Structural Features ◽  
Inhibitory Potency ◽  
Receptor Signalling

scholarly journals Suppression of Presynaptic Glutamate Release by Postsynaptic Metabotropic NMDA Receptor Signalling to Pannexin-1

2019 ◽  
Vol 40 (4) ◽  
pp. 729-742 ◽  
Author(s):  
Jennifer Bialecki ◽  
Allison Werner ◽  
Nicholas L. Weilinger ◽  
Catharine M. Tucker ◽  
Haley A. Vecchiarelli ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Glutamate Release ◽  
Pannexin 1 ◽  
Receptor Signalling

The influence of NMDA receptor agonist and antagonist on morphine state-dependent memory of passive avoidance in mice

Life Sciences ◽  
2005 ◽  
Vol 78 (2) ◽  
pp. 157-163 ◽  
Author(s):  
Majid Jafari-Sabet ◽  
Mohammad-Reza Zarrindast ◽  
Mehdi Rezayat ◽  
Ameneh Rezayof ◽  
Bijan Djahanguiri
Keyword(s):  
Nmda Receptor ◽  
Passive Avoidance ◽  
Receptor Agonist ◽  
State Dependent ◽  
Agonist And Antagonist

scholarly journals Phosphorylation-State-Dependent Regulation of NMDA Receptor Short-Term Plasticity Modifies Hippocampal Dendritic Ca2+ Transients

2010 ◽  
Vol 104 (4) ◽  
pp. 2203-2213 ◽  
Author(s):  
Debika Chatterjea ◽  
Edaeni Hamid ◽  
John P. Leonard ◽  
Simon Alford
Keyword(s):  
Nmda Receptor ◽  
Pyramidal Neurons ◽  
Long Term Potentiation ◽  
Receptor Activation ◽  
Short Term ◽  
Short Term Plasticity ◽  
State Dependent ◽  
Term Potentiation ◽  
Protocol Enhancement

N-methyl-d-aspartate (NMDA) receptor-mediated currents are enhanced by phosphorylation. We have investigated effects of phosphorylation-dependent short-term plasticity of NMDA receptor-mediated excitatory postsynaptic currents (EPSCs) on the induction of long-term depression (LTD). We confirmed in whole cell clamped CA1 pyramidal neurons that LTD is induced by pairing stimulus protocols. However, after serine-threonine phosphorylation was modified by postsynaptic introduction of a protein phosphatase-1 (PP1) inhibitor, the same pairing protocol evoked long-term potentiation (LTP). We determined effects of modification of phosphatase activity on evoked NMDA EPSCs during LTD induction protocols. During LTD induction, using a protocol pairing depolarization to –40 mV and 0.5 Hz stimulation, NMDA receptor-mediated EPSCs undergo a short-term enhancement at the start of the protocol. In neurons in which PP1 activity was inhibited, this short-term enhancement was markedly amplified. We then investigated the effect of this enhancement on Ca2+ entry during the start of the LTD induction protocol. Enhancement of NMDA receptor-mediated responses was accompanied by an amplification of induction protocol-evoked Ca2+ transients. Furthermore, this amplification required synaptic activation during the protocol, consistent with an enhancement of Ca2+ entry mediated by NMDA receptor activation. The sign of NMDA receptor-mediated long-term plasticity, whether potentiation or depression depends on the amplitude of the synaptic Ca2+ transient during induction. We conclude that short-term phosphorylation-dependent plasticity of the NMDA receptor-mediated EPSCs contributes significantly to the effect of phosphatase inhibition on the subsequent induction of LTD or LTP.

scholarly journals Correction: Caldendrin–Jacob: A Protein Liaison That Couples NMDA Receptor Signalling to the Nucleus

PLoS Biology ◽  
2009 ◽  
Vol 7 (1) ◽  
pp. e1000022
Author(s):  
Daniela C Dieterich ◽  
Anna Karpova ◽  
Marina Mikhaylova ◽  
Irina Zdobnova ◽  
Imbritt König ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Receptor Signalling

Involvement of central amygdala NMDA receptor mechanism in morphine state-dependent memory retrieval

2011 ◽  
Vol 69 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Abolfazl Ardjmand ◽  
Ameneh Rezayof ◽  
Mohammad-Reza Zarrindast
Keyword(s):  
Nmda Receptor ◽  
Memory Retrieval ◽  
Central Amygdala ◽  
State Dependent
Sign in / Sign up

Export Citation Format

Share Document