scholarly journals MicroRNAs and exercise-induced skeletal muscle adaptations

2010 ◽  
Vol 588 (20) ◽  
pp. 3849-3850 ◽  
Author(s):  
Micah J. Drummond
Keyword(s):  
Skeletal Muscle ◽  
Muscle Adaptations ◽  
Exercise Induced ◽  
Skeletal Muscle Adaptations

scholarly journals AQP4-Dependent Water Transport Plays a Functional Role in Exercise-Induced Skeletal Muscle Adaptations

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e58712 ◽  
Author(s):  
Davide Basco ◽  
Bert Blaauw ◽  
Francesco Pisani ◽  
Angelo Sparaneo ◽  
Grazia Paola Nicchia ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Water Transport ◽  
Functional Role ◽  
Muscle Adaptations ◽  
Exercise Induced ◽  
Skeletal Muscle Adaptations

Dietary Fuels in Athletic Performance

2019 ◽  
Vol 39 (1) ◽  
pp. 45-73 ◽  
Author(s):  
Andreas Mæchel Fritzen ◽  
Anne-Marie Lundsgaard ◽  
Bente Kiens
Keyword(s):  
Skeletal Muscle ◽  
Exercise Training ◽  
Quick Recovery ◽  
Energy Demands ◽  
Daily Diet ◽  
Muscle Adaptations ◽  
Fat Stores ◽  
Exercise Induced ◽  
Skeletal Muscle Adaptations ◽  
Nutritional Strategies

Focusing on daily nutrition is important for athletes to perform and adapt optimally to exercise training. The major roles of an athlete's daily diet are to supply the substrates needed to cover the energy demands for exercise, to ensure quick recovery between exercise bouts, to optimize adaptations to exercise training, and to stay healthy. The major energy substrates for exercising skeletal muscles are carbohydrate and fat stores. Optimizing the timing and type of energy intake and the amount of dietary macronutrients is essential to ensure peak training and competition performance, and these strategies play important roles in modulating skeletal muscle adaptations to endurance and resistance training. In this review, recent advances in nutritional strategies designed to optimize exercise-induced adaptations in skeletal muscle are discussed, with an emphasis on mechanistic approaches, by describing the physiological mechanisms that provide the basis for different nutrition regimens.

scholarly journals Exercise-Induced Skeletal Muscle Adaptations Alter the Activity of Adipose Progenitor Cells

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0152129 ◽  
Author(s):  
Daniel Zeve ◽  
Douglas P. Millay ◽  
Jin Seo ◽  
Jonathan M. Graff
Keyword(s):  
Skeletal Muscle ◽  
Progenitor Cells ◽  
Muscle Adaptations ◽  
Exercise Induced ◽  
Skeletal Muscle Adaptations

scholarly journals Correction: AQP4-Dependent Water Transport Plays a Functional Role in Exercise-Induced Skeletal Muscle Adaptations

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
Author(s):  
Davide Basco ◽  
Bert Blaauw ◽  
Francesco Pisani ◽  
Angelo Sparaneo ◽  
Grazia Paola Nicchia ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Water Transport ◽  
Functional Role ◽  
Muscle Adaptations ◽  
Exercise Induced ◽  
Skeletal Muscle Adaptations

scholarly journals Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscle

2011 ◽  
Vol 110 (1) ◽  
pp. 264-274 ◽  
Author(s):  
Zhen Yan ◽  
Mitsuharu Okutsu ◽  
Yasir N. Akhtar ◽  
Vitor A. Lira
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Biogenesis ◽  
Contractile Activity ◽  
Fiber Type ◽  
Genetically Engineered ◽  
Type Transformation ◽  
Muscle Adaptations ◽  
Exercise Induced ◽  
Skeletal Muscle Adaptations ◽  
Muscle Contractile

Skeletal muscle exhibits superb plasticity in response to changes in functional demands. Chronic increases of skeletal muscle contractile activity, such as endurance exercise, lead to a variety of physiological and biochemical adaptations in skeletal muscle, including mitochondrial biogenesis, angiogenesis, and fiber type transformation. These adaptive changes are the basis for the improvement of physical performance and other health benefits. This review focuses on recent findings in genetically engineered animal models designed to elucidate the mechanisms and functions of various signal transduction pathways and gene expression programs in exercise-induced skeletal muscle adaptations.

Methylglyoxal reduces molecular responsiveness to 4 weeks of endurance exercise in mouse plantaris muscle

2022 ◽  
Author(s):  
Tatsuro Egawa ◽  
Takeshi Ogawa ◽  
Takumi Yokokawa ◽  
Kohei Kido ◽  
Katsumasa Goto ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Endurance Exercise ◽  
Mitochondrial Biogenesis ◽  
Insulin Signaling ◽  
Exercise Group ◽  
Voluntary Exercise ◽  
Plantaris Muscle ◽  
Muscle Adaptations ◽  
Exercise Induced ◽  
Skeletal Muscle Adaptations

Endurance exercise triggers skeletal muscle adaptations, including enhanced insulin signaling, glucose metabolism, and mitochondrial biogenesis. However, exercise-induced skeletal muscle adaptations may not occur in some cases, a condition known as exercise-resistance. Methylglyoxal (MG) is a highly reactive dicarbonyl metabolite and has detrimental effects on the body such as causing diabetic complications, mitochondrial dysfunction, and inflammation. This study aimed to clarify the effect of methylglyoxal on skeletal muscle molecular adaptations following endurance exercise. Mice were randomly divided into 4 groups (n = 12 per group): sedentary control group, voluntary exercise group, MG-treated group, and MG-treated with voluntary exercise group. Mice in the voluntary exercise group were housed in a cage with a running wheel, while mice in the MG-treated groups received drinking water containing 1% MG. Four weeks of voluntary exercise induced several molecular adaptations in the plantaris muscle, including increased expression of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC1α), mitochondria complex proteins, toll-like receptor 4 (TLR4), 72-kDa heat shock protein (HSP72), hexokinase II, and glyoxalase 1; this also enhanced insulin-stimulated Akt Ser473 phosphorylation and citrate synthase activity. However, these adaptations were suppressed with MG treatment. In the soleus muscle, the exercise-induced increases in the expression of TLR4, HSP72, and advanced glycation end products receptor 1 were inhibited with MG treatment. These findings suggest that MG is a factor that inhibits endurance exercise-induced molecular responses including mitochondrial adaptations, insulin signaling activation, and the upregulation of several proteins related to mitochondrial biogenesis, glucose handling, and glycation in primarily fast-twitch skeletal muscle.

Exercise and MEF2–HDAC interactions

2007 ◽  
Vol 32 (5) ◽  
pp. 852-856 ◽  
Author(s):  
Sean L. McGee
Keyword(s):  
Skeletal Muscle ◽  
Protein Kinase ◽  
Nuclear Export ◽  
Energy Homeostasis ◽  
Whole Body ◽  
Positive Health ◽  
Exercise Induced ◽  
Amp Activated Protein Kinase ◽  
Body Energy ◽  
Skeletal Muscle Adaptations

Exercise increases the metabolic capacity of skeletal muscle, which improves whole-body energy homeostasis and contributes to the positive health benefits of exercise. This is, in part, mediated by increases in the expression of a number of metabolic enzymes, regulated largely at the level of transcription. At a molecular level, many of these genes are regulated by the class II histone deacetylase (HDAC) family of transcriptional repressors, in particular HDAC5, through their interaction with myocyte enhancer factor 2 transcription factors. HDAC5 kinases, including 5′-AMP-activated protein kinase and protein kinase D, appear to regulate skeletal muscle metabolic gene transcription by inactivating HDAC5 and inducing HDAC5 nuclear export. These mechanisms appear to participate in exercise-induced gene expression and could be important for skeletal muscle adaptations to exercise.

Skeletal Muscle Adaptations to Prolonged Exposure to Extreme Altitude: A Role of Physical Activity?

2008 ◽  
Vol 9 (4) ◽  
pp. 311-317 ◽  
Author(s):  
Masao Mizuno ◽  
Gabrielle K Savard ◽  
Nils-Holger Areskog ◽  
Carsten Lundby ◽  
Bengt Saltin
Keyword(s):  
Physical Activity ◽  
Skeletal Muscle ◽  
Prolonged Exposure ◽  
Muscle Adaptations ◽  
Extreme Altitude ◽  
Skeletal Muscle Adaptations
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