scholarly journals Electrical coupling synchronises spinal motoneuron activity during swimming in hatchlingXenopustadpoles

2009 ◽  
Vol 587 (18) ◽  
pp. 4455-4466 ◽  
Author(s):  
Hong-Yan Zhang ◽  
Wen-Chang Li ◽  
William J. Heitler ◽  
Keith T. Sillar
Keyword(s):  
Electrical Coupling ◽  
Spinal Motoneuron ◽  
Motoneuron Activity

The Influence of the Nigro-Neostriatal Dopamine Pathway on Spinal Motoneuron Activity

1971 ◽  
Vol 82 (2) ◽  
pp. 268-271 ◽  
Author(s):  
Nils-erik Andén ◽  
Knut Larsson ◽  
Göran Steg
Keyword(s):  
Spinal Motoneuron ◽  
Motoneuron Activity

scholarly journals Subthalamic nucleus stimulation reverses spinal motoneuron activity in parkinsonian patients

Brain ◽  
2011 ◽  
Vol 135 (1) ◽  
pp. 139-147 ◽  
Author(s):  
S. Raoul ◽  
V. Roualdes ◽  
C. Deligny ◽  
D. Leduc ◽  
J.-C. Lamy ◽  
...  
Keyword(s):  
Subthalamic Nucleus ◽  
Spinal Motoneuron ◽  
Subthalamic Nucleus Stimulation ◽  
Motoneuron Activity

scholarly journals Motoneuron firing properties are modified by trans-spinal direct current stimulation in rats

2019 ◽  
Vol 126 (5) ◽  
pp. 1232-1241 ◽  
Author(s):  
M. Bączyk ◽  
H. Drzymała-Celichowska ◽  
W. Mrówczyński ◽  
P. Krutki
Keyword(s):  
Direct Current ◽  
Firing Frequency ◽  
Spinal Motoneuron ◽  
Current Application ◽  
Electrophysiological Properties ◽  
Direct Current Stimulation ◽  
Anodal Polarization ◽  
Spinal Network ◽  
Motoneuron Activity ◽  
Firing Properties

Spinal polarization evoked by direct current stimulation [trans-spinal direct current stimulation (tsDCS)] is a novel method for altering spinal network excitability; however, it remains not well understood. The aim of this study was to determine whether tsDCS influences spinal motoneuron activity. Twenty Wistar rats under general pentobarbital anesthesia were subjected to 15 min anodal ( n = 10) or cathodal ( n = 10) tsDCS of 0.1 mA intensity, and the electrophysiological properties of their motoneurons were intracellularly measured before, during, and after direct current application. The major effects of anodal intervention included increased minimum firing frequency and the slope of the frequency-current ( f-I) relationship, as well as decreased rheobase and currents evoking steady-state firing (SSF). The effects of cathodal polarization included decreased maximum SSF frequency, decreased f-I slope, and decreased current evoking the maximum SSF. Notably, the majority of observed effects appeared immediately after the current onset, developed during polarization, and outlasted it for at least 15 min. Moreover, the effects of anodal polarization were generally more pronounced and uniform than those evoked by cathodal polarization. Our study is the first to present polarity-dependent, long-lasting changes in spinal motoneuron firing following tsDCS, which may aid in the development of more safe and accurate application protocols in medicine and sport. NEW & NOTEWORTHY Trans-spinal direct current stimulation induces significant polarity-dependent, long-lasting changes in the threshold and firing properties of spinal motoneurons. Anodal polarization potentiates motoneuron firing whereas cathodal polarization acts mainly toward firing inhibition. The alterations in rheobase and rhythmic firing properties are not restricted to the period of current application and can be observed long after the current offset.

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