scholarly journals The transition from fetal growth restriction to accelerated postnatal growth: a potential role for insulin signalling in skeletal muscle

2009 ◽  
Vol 587 (17) ◽  
pp. 4199-4211 ◽  
Author(s):  
B. S. Muhlhausler ◽  
J. A. Duffield ◽  
S. E. Ozanne ◽  
C. Pilgrim ◽  
N. Turner ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Potential Role ◽  
Insulin Signalling ◽  
Postnatal Growth ◽  
Growth Restriction

scholarly journals The Role of Proteoglycans in Contributing to Placental Thrombosis and Fetal Growth Restriction

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Joanne M. Said
Keyword(s):  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Potential Role ◽  
Pregnancy Complication ◽  
Growth Restriction ◽  
Increased Risk ◽  
Fetus And Neonate

Fetal growth restriction is an important pregnancy complication that has major consequences for the fetus and neonate as well as an increased risk of long-term morbidity extending into adulthood. The precise aetiology of most cases of fetal growth restriction is unknown although placental thrombosis is a common feature in many of these cases. This paper will outline the potential role of proteoglycans in contributing to placental thrombosis and fetal growth restriction.

scholarly journals Fetal growth restriction shortens cardiac telomere length, but this is attenuated by exercise in early life

2018 ◽  
Vol 50 (11) ◽  
pp. 956-963
Author(s):  
S. A. Booth ◽  
G. D. Wadley ◽  
F. Z. Marques ◽  
M. E. Wlodek ◽  
F. J. Charchar
Keyword(s):  
Telomere Length ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Early Life ◽  
Protein Structures ◽  
Later Life ◽  
Postnatal Growth ◽  
Growth Restriction ◽  
Male Rats ◽  
Early Exercise

Background and aims: Fetal and postnatal growth restriction cause a predisposition to cardiovascular disease (CVD) in adulthood. Telomeres are repetitive DNA-protein structures that protect chromosome ends, and the loss of these repeats (a reduction in telomere length) is associated with CVD. As exercise preserves telomere length and cardiovascular health, the aim of this study was to determine the effects of growth restriction and exercise training on cardiac telomere length and telomeric genes. Methods and results: Pregnant Wistar Kyoto rats underwent bilateral uterine vessel ligation to induce uteroplacental insufficiency and fetal growth restriction (“Restricted”). Sham-operated rats had either intact litters (“Control”) or their litters reduced to five pups with slowed postnatal growth (“Reduced”). Control, Restricted, and Reduced male rats were assigned to Sedentary, Early exercise (5–9 wk of age), or Late exercise (20–24 wk of age) groups. Hearts were excised at 24 wk of age for telomere length and gene expression measurements by quantitative PCR. Growth restriction shortened cardiac telomere length ( P < 0.001), but this was rescued by early exercise ( P < 0.001). Early and Late exercise increased cardiac weight index ( P < 0.001), but neither this nor telomere length was associated with expression of the telomeric genes Tert, Terc, Trf2, Pnuts, or Sirt1. Discussion and conclusions: Growth restriction shortens cardiac telomere length, reflecting the cardiac pathologies associated with low birth weight. Exercise in early life may offer long-term protective effects on cardiac telomere length, which could help prevent CVD in later life.

Potential role of microRNA-424 in regulating ERRγ to suppress trophoblast proliferation and invasion in fetal growth restriction

Placenta ◽  
2019 ◽  
Vol 83 ◽  
pp. 57-62
Author(s):  
Zhiyong Zou ◽  
Zhiming He ◽  
Jian Cai ◽  
Linhuan Huang ◽  
Hui Zhu ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Potential Role ◽  
Growth Restriction ◽  
Proliferation And Invasion

FETAL GROWTH RESTRICTION WITH EARLY AND LATE MANIFESTATION, PROGNOSTIC MARKERS

2020 ◽  
pp. 27-30
Author(s):  
Yakubova D.I.
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Prenatal Screening ◽  
Prognostic Markers ◽  
Growth Restriction ◽  
Late Manifestation ◽  
Late Form ◽  
Early Manifestation

Objective of the study: Comprehensive assessment of risk factors, the implementation of which leads to FGR with early and late manifestation. To evaluate the results of the first prenatal screening: PAPP-A, B-hCG, made at 11-13 weeks. Materials and Methods: A retrospective study included 110 pregnant women. There were 48 pregnant women with early manifestation of fetal growth restriction, 62 pregnant women with late manifestation among them. Results of the study: The risk factors for the formation of the FGR are established. Statistically significant differences in the indicators between groups were not established in the analyses of structures of extragenital pathology. According to I prenatal screening, there were no statistical differences in levels (PAPP-A, b-hCG) in the early and late form of FGR.

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