scholarly journals Long-term effect of neuronal nitric oxide synthase over-expression on cardiac neurotransmission mediated by a lentiviral vector

2009 ◽  
Vol 587 (14) ◽  
pp. 3629-3637 ◽  
Author(s):  
Lijun Wang ◽  
Dan Li ◽  
Tom A. Dawson ◽  
David J. Paterson
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Lentiviral Vector ◽  
Neuronal Nitric Oxide Synthase ◽  
Term Effect ◽  
Over Expression ◽  
Long Term Effect ◽  
Oxide Synthase

Chronic Blockade of Neuronal Nitric Oxide Synthase Does Not Affect Long-Term Control of Blood Pressure in Normal, Saline-Drinking or Deoxycorticosterone-Treated Rats

2003 ◽  
Vol 88 (2) ◽  
pp. 243-250 ◽  
Author(s):  
Rosemary Wangensteen ◽  
Juan Sainz ◽  
Isabel Rodríguez-Gomez ◽  
Juan Manuel Moreno ◽  
Antonio Osuna ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Nitric Oxide Synthase ◽  
Normal Saline ◽  
Neuronal Nitric Oxide Synthase ◽  
Oxide Synthase

scholarly journals Long-Term Consumption of High-Fat Diet in Rats: Effects on Microglial and Astrocytic Morphology and Neuronal Nitric Oxide Synthase Expression

2016 ◽  
Vol 37 (5) ◽  
pp. 783-789 ◽  
Author(s):  
Kinga Gzielo ◽  
Michal Kielbinski ◽  
Jakub Ploszaj ◽  
Krzysztof Janeczko ◽  
Stefan P. Gazdzinski ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
High Fat Diet ◽  
Neuronal Nitric Oxide Synthase ◽  
High Fat ◽  
Oxide Synthase

Estradiol increases urethral tone through the local inhibition of neuronal nitric oxide synthase expression

2008 ◽  
Vol 294 (3) ◽  
pp. R851-R857 ◽  
Author(s):  
Xavier Gamé ◽  
Julien Allard ◽  
Ghislaine Escourrou ◽  
Pierre Gourdy ◽  
Ivan Tack ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Structural Changes ◽  
Neuronal Nitric Oxide Synthase ◽  
Local Inhibition ◽  
Ovariectomized Mice ◽  
And Function ◽  
Oxide Synthase ◽  
Nnos Expression

Estrogens are known to modulate lower urinary tract (LUT) trophicity and neuronal nitric oxide synthase (nNOS) expression in several organs. The aim of this study was to explore the effects of endogenous and supraestrus levels of 17β-estradiol (E2) on LUT and urethral nNOS expression and function. LUT function and histology and urethral nNOS expression were studied in adult female mice subjected either to sham surgery, surgical castration, or castration plus chronic E2 supplementation (80 μg·kg−1·day−1, i.e., pregnancy level). The micturition pattern was profoundly altered by long-term supraestrus levels of E2 with decreased frequency paralleled by increased residual volumes higher than those of ovariectomized mice. Urethral resistance was increased twofold in E2-treated mice, with no structural changes in urethra, supporting a pure tonic mechanism. Acute nNOS inhibition by 7-nitroindazole decreased frequency and increased residual volumes in ovariectomized mice but had no additive effect on the micturition pattern of long-term supraestrus mice, showing that long-term supraestrus E2 levels and acute inhibition of nNOS activity had similar functional effects. Finally, E2 decreased urethral nNOS expression in ovariectomized mice. Long-term supraestrus levels of E2 increased urethral tone through inhibition of nNOS expression, whereas physiological levels of E2 had no effect.

scholarly journals Absence of cerebellar long-term depression in mice lacking neuronal nitric oxide synthase.

1997 ◽  
Vol 4 (1) ◽  
pp. 169-177 ◽  
Author(s):  
V Lev-Ram ◽  
Z Nebyelul ◽  
M H Ellisman ◽  
P L Huang ◽  
R Y Tsien
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Neuronal Nitric Oxide Synthase ◽  
Long Term Depression ◽  
Oxide Synthase
Sign in / Sign up

Export Citation Format

Share Document